期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 20, 期 1, 页码 323-331出版社
IOS PRESS
DOI: 10.3233/JAD-2010-1363
关键词
Alzheimer's disease; amyloid-beta peptide; cerebellum; ionic zinc; SLC30A3
资金
- Natural Science Foundation of China [30770680]
- Program for New Century Excellent Talents in University [NCET-04-0288]
- China Postdoctoral Science Foundation [2005037008]
- Specialized Research Fund for the Doctoral Program of Higher Education [SRFDP-20060159001]
The presence of senile plaques containing abundant amyloid-beta (A beta) peptide is one of the major pathological hallmarks of Alzheimer's disease (AD). Recent studies support the notion that overexpression of zinc transporters (ZnT) is involved in zinc metabolic disturbances and A beta aggregation in AD brains. Here we present data showing an elevated expression of zinc transporter 3 (ZnT3) protein, revealed by immunoblotting assay, in the cerebellum of the amyloid-beta protein precursor (A beta PP)/presenilin 1 (PS1) transgenic mouse. Confocal microscopic and autometallographic results showed that ZnT3 immunofluorescence and zinc ions were predominantly located in the amyloid plaques. ZnT3 protein was abundantly distributed throughout the plaques, whereas zinc ions were mainly located in the peripheral parts of rosette-shaped plaques with a lightly stained center. Collectively, our results suggest that ZnT3 protein is involved in the A beta aggregation in the cerebellum of the A beta PP/PS1 mouse.
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