Article
Biochemistry & Molecular Biology
Laura Ferre-Gonzalez, Carmen Pena-Bautista, Lourdes alvarez-Sanchez, Ines Ferrer-Cairols, Miguel Baquero, Consuelo Chafer-Pericas
Summary: The clinical validation of an Alzheimer's disease diagnosis model based on lipid peroxidation compounds showed satisfactory diagnostic indexes and a new screening tool incorporating the ApoE genotype was developed to improve identification of patients at higher risk of developing AD and enhance diagnostic accuracy.
Review
Clinical Neurology
Francisco Lopera, Nilton Custodio, Mariana Rico-Restrepo, Ricardo F. Allegri, Jose Domingo Barrientos, Estuardo Garcia Batres, Ismael L. Calandri, Cristian Calero Moscoso, Paulo Caramelli, Juan Carlos Duran Quiroz, Angela Marie Jansen, Alberto Jose Mimenza Alvarado, Ricardo Nitrini, Jose F. Parodi, Claudia Ramos, Andrea Slachevsky, Sonia Maria Dozzi Brucki
Summary: Alzheimer's disease is a significant burden in Latin America and the Caribbean due to limited access to diagnosis and treatment, fragmented healthcare systems, and various barriers such as genetic heterogeneity and social determinants of health. To address these issues, a group of experts convened a virtual meeting to discuss best practices and recommendations, including additional training for healthcare workers, adapted cognitive tests, expanded healthcare insurance coverage, and gene variant detection strategies.
FRONTIERS IN NEUROLOGY
(2023)
Review
Geriatrics & Gerontology
Kai Liu, Jiasong Li, Raksha Raghunathan, Hong Zhao, Xuping Li, Stephen T. C. Wong
Summary: Alzheimer's disease (AD) is a major neurodegenerative disease that poses a significant social and economic burden with unclear pathogenesis and limited treatment options. Traditional diagnostic methods have limitations, while label-free optical imaging techniques offer potential for more accurate and detailed analysis of AD biomarkers.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Mathematical & Computational Biology
Yiming Li, Wei-Wen Hsu
Summary: This article presents a nonparametric classification approach for imbalanced data in longitudinal and high-dimensional settings. The proposed method shows improvements in imbalanced classification while maintaining low computational complexity and providing meaningful feature selection.
STATISTICS IN MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Bartosz Twarowski, Mariola Herbet
Summary: Alzheimer's disease is an incurable form of senile dementia and a leading cause of death. Inflammation, specifically the release of mediators by inflammatory cells, can contribute to neuronal degeneration and disease progression in Alzheimer's. The pathomechanism of neuroinflammation in Alzheimer's disease is still not fully understood, but studying it could lead to the development of early diagnostic methods and new therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Andrew B. Caldwell, Qing Liu, Can Zhang, Gary P. Schroth, Douglas R. Galasko, Kevin D. Rynearson, Rudolph E. Tanzi, Shauna H. Yuan, Steven L. Wagner, Shankar Subramaniam
Summary: This study characterized the endotypes associated with Alzheimer's disease through RNA-seq analysis of neurons derived from early-onset Alzheimer's patients. The identified endotypes were used as evaluation metrics for screening gamma secretase drugs. The results showed that the drug treatment could partially restore neuronal state and improve the disease by influencing cell cycle and cell differentiation.
ALZHEIMERS & DEMENTIA
(2022)
Review
Biochemistry & Molecular Biology
Vasileios Papaliagkas, Kallirhoe Kalinderi, Patroklos Vareltzis, Despoina Moraitou, Theodora Papamitsou, Maria Chatzidimitriou
Summary: Alzheimer's disease (AD) is a rapidly growing disease that urgently requires early diagnosis and treatment. Cerebrospinal fluid (CSF), which directly contacts the brain's extracellular space, is the most useful biological fluid for reflecting molecular events in the brain. Proteins and molecules that reflect the pathogenesis of AD, including neurodegeneration, accumulation of Abeta, hyperphosphorylation of tau protein, and apoptosis, can be used as biomarkers. The most commonly used CSF biomarkers for AD are total tau, phospho-tau, and Abeta42.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Genetics & Heredity
Chiara Villa, Andrea Stoccoro
Summary: Alzheimer's disease is a progressive neurodegenerative disorder that leads to cognitive impairment and dementia in older individuals. Detection of altered epigenetic signatures in blood may assist in the early diagnosis and treatment of the disease.
Article
Medicine, General & Internal
Carmen Pena-Bautista, Lourdes Alvarez-Sanchez, Marta Roca, Lorena Garcia-Valles, Miguel Baquero, Consuelo Chafer-Pericas
Summary: The study reveals that plasma lipid profiles have the potential to be used for early detection and diagnosis of Alzheimer's disease. Among the lipid families, diglycerols, lysophosphatidylethanolamines, lysophosphatidylcholines, monoglycerides, and sphingomyelins are important lipids associated with the progression of the disease. Monoglycerides show potential utility in Alzheimer's disease detection.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Bocwinska-Kiluk Beata, Jelski Wojciech, Kornhuber Johannes, Lewczuk Piotr, Mroczko Barbara
Summary: There is a lack of empirical research on non-pharmacological interventions for Alzheimer's disease (AD) globally. This paper examines the biochemical, clinical, and social aspects of AD in relation to psychological interventions and their impact on patients' quality of life. Despite limited research, psychological interventions based on biochemical and other studies show potential for improving emotional well-being and slowing disease progression in AD patients. However, no effective methods of AD treatment have been established to date.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biotechnology & Applied Microbiology
Xiaotong Sun, Xu Sun, Qingfeng Wang, Xiang Wang, Luying Feng, Yifan Yang, Ying Jing, Canjun Yang, Sheng Zhang
Summary: In recent years, a large number of elderly people worldwide have been suffering from Alzheimer's disease (AD), which has significantly affected their quality of life. To intervene early in the progression of the disease, accurate, convenient, and low-cost detection technologies are gaining attention. Biosensors, with their multiple merits, are frequently used in the detection and assessment of AD. Behavioral detection is a prospective and objective way to diagnose AD at an early stage, providing a safer and more comfortable environment compared to invasive methods. It is also more economical than neuroimaging tests. This review discusses cutting-edge biosensor-based devices and their effectiveness in AD diagnosis, highlighting the potential of behavior detection sensors in different application scenarios.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Li Li, Rendong He, Haili Yan, Zhengwei Leng, Shuang Zhu, Zhanjun Gu
Summary: This review provides a brief overview and analysis of the development of nanotechnology in Alzheimer's disease (AD). Through bibliometric analysis, the publishing trend, countries/institutions, reference sources, and research hotspots of AD-related nanotechnology are analyzed and visualized. The key roles of nanotechnology in both diagnostic and therapeutic aspects of AD are summarized, along with the potential nanotoxicity of nanomaterials. The review also highlights the prospects for the development of nanotechnology in AD applications.
Article
Biochemistry & Molecular Biology
Lourdes Alvarez-Sanchez, Carmen Pena-Bautista, Laura Ferre-Gonzalez, Laura Cubas, Angel Balaguer, Bonaventura Casanova-Estruch, Miguel Baquero, Consuelo Chafer-Pericas
Summary: This study aims to evaluate the use of several plasma biomarkers to develop an early and specific screening method for Alzheimer's disease (AD). The results show that plasma p-Tau181 and GFAP levels are higher in AD dementia patients and have significant correlations with clinical AD characteristics. Plasma NfL levels are higher in frontotemporal dementia (FTD) patients but not significantly correlated with AD. The developed partial least squares (PLS) diagnosis model shows good accuracy in distinguishing AD patients from subjective cognitive impairment (SCI) patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Miriam T. Ashford, Rema Raman, Garrett Miller, Michael C. Donohue, Ozioma C. Okonkwo, Monica Rivera Mindt, Rachel L. Nosheny, Godfrey A. Coker, Ronald C. Petersen, Paul S. Aisen, Michael W. Weiner
Summary: The analysis of ethnocultural and socioeconomic composition of ADNI participants revealed that a low percentage of individuals from underrepresented populations and those with less than 12 years of education were included in the study. Furthermore, individuals with less than 12 years of education had a higher rate of screening fails. Our findings suggest that ADNI results may not be entirely generalizable to ethnoculturally diverse and low education populations.
ALZHEIMERS & DEMENTIA
(2022)
Article
Biophysics
Yong Luo, Jingyu Chen, Jiahui Liang, Yizhen Liu, Conghui Liu, Yibiao Liu, Tailin Xu, Xueji Zhang
Summary: Ultrasound-enhanced catalytic hairpin assembly (UECHA) is an enzyme-free, isothermal signal amplification strategy that utilizes a portable acoustic-drive platform with functionalized microspheres to enrich biomarkers and enhance fluorescence. It allows for direct and quantitative measurement of Alzheimer's disease biomarkers, providing a new perspective for early screening.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Geriatrics & Gerontology
Dario Moreno-Agostino, Alejandro de la Torre-Luque, Leandro da Silva-Sauer, Bruce W. Smith, Bernardino Fernandez-Calvo
Summary: The research found that both individual and social resilience resources are negatively related to depressive and anxiety symptoms in adults regardless of age, with direct and indirect effects on emotional symptoms. This pattern of relationships was found to be invariant across age groups.
AGING & MENTAL HEALTH
(2022)
Article
Clinical Neurology
Ritwik Ghosh, Subhrajyoti Biswas, Arnab Mandal, Kaustav De, Srijit Bandyopadhyay, Sona Singh Sardar, Arpan Mandal, Julian Benito-Leon
Summary: This case report describes a 14-year-old Indian girl with scrub typhus-associated abducens nerve palsy, who did not exhibit fever and the classic dermatological manifestation of the disease. The patient responded well to doxycycline therapy after common infectious, autoimmune, and neoplastic causes were excluded.
NEURO-OPHTHALMOLOGY
(2022)
Article
Clinical Neurology
Subhrajyoti Biswas, Ritwik Ghosh, Dipayan Roy, Adrija Ray, Kaustav De, Subrata Biswas, Dinabandhu Naga, Julian Benito-Leon
Summary: Scrub typhus, a mite-born rickettsial zoonosis, can lead to a variety of clinical manifestations including limbic encephalitis. This case report highlights the successful diagnosis and treatment of scrub typhus associated encephalitis in a previously healthy young Indian woman.
Article
Audiology & Speech-Language Pathology
Mariana L. Martins, Melyssa K. C. Galdino, Bernardino Fernandez-Calvo, Fatima C. A. Branco-Barreiro, Thiago P. Fernandes, Marine R. D. da Rosa
Summary: The study aimed to investigate the direct and indirect effects of resilience, personality traits, and psychiatric symptoms on tinnitus perception. The results showed that resilience and psychiatric symptoms did not have a direct or indirect influence on tinnitus annoyance, severity, or loudness. However, there was a direct association of resilience with annoyance and neuroticism trait with tinnitus severity and annoyance.
JOURNAL OF THE AMERICAN ACADEMY OF AUDIOLOGY
(2022)
Article
Clinical Neurology
Leandro da Silva-Sauer, Ricardo Basso Garcia, Alan Ehrich de Moura, Bernardino Fernandez-Calvo
Summary: The study aimed to verify whether working memory can be measured by the d2 Test of Attention, and the results suggest that working memory may be a secondary construct assessed by this instrument.
APPLIED NEUROPSYCHOLOGY-ADULT
(2022)
Article
Geriatrics & Gerontology
Ana Nieto, Israel Contador, David L. Palenzuela, Pablo Ruisoto, Francisco Ramos, Bernardino Fernandez-Calvo
Summary: This study compared the differential significance of resilience and optimism, along with external locus of control (ELC), in predicting burnout and work engagement. The results showed that resilience and optimism were the best predictors of work engagement, while external locus of control was the main explanatory factor for burnout.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2022)
Review
Cell Biology
Israel Contador, Patricia Alzola, Yaakov Stern, Alejandro de la Torre-Luque, Felix Bermejo-Pareja, Bernardino Fernandez-Calvo
Summary: This study conducted a systematic review and meta-analyses to examine the effect of socio-behavioral cognitive reserve proxies on cognitive decline after stroke. The findings showed that high education is associated with a decreased rate of post-stroke dementia, and other CR proxies demonstrate a protective effect against non-dementia cognitive decline after stroke. The results suggest that CR may prevent cognitive decline after stroke, but this effect can be influenced by different factors such as the CR proxy and individual characteristics.
AGEING RESEARCH REVIEWS
(2023)
Article
Environmental Sciences
Ruben Juy, Ana Nieto, Israel Contador, Francisco Ramos, Bernardino Fernandez-Calvo
Summary: This study investigated the prevalence of burnout syndrome (BS) and its associated psychosocial factors in Spanish occupational therapists (OTs), as well as its relationship with health. Results showed that emotional exhaustion was the most common symptom, and emotional management and social support were protective factors. This highlights the importance of raising awareness and promoting well-being and health among OTs.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Clinical Neurology
Joenilton Saturnino Caze da Silva, Fabiola da Silva Albuquerque, Flavio Freitas Barbosa, Leandro Da Silva-Sauer, Bernardino Fernandez-Calvo
Summary: This study examined the performance of young and older adults on memory questions and found that older adults only used memory strategy for solving questions based on the temporal element, while young adults used both memory and non-memory strategies. This suggests that aging leads to a reduction in memory strategies.
APPLIED NEUROPSYCHOLOGY-ADULT
(2023)
Article
Oncology
Clare E. Weeden, Velimir Gayevskiy, Claire Marceaux, Daniel Batey, Tania Tan, Kenta Yokote, Nina Tubau Ribera, Allison Clatch, Susan Christo, Charis E. Teh, Andrew J. Mitchell, Marie Trussart, Lucille C. Rankin, Andreas Obers, Jackson A. McDonald, Kate D. Sutherland, Varun J. Sharma, Graham Starkey, Rohit D'Costa, Phillip Antippa, Tracy Leong, Daniel Steinfort, Louis Irviing, Charles Swanton, Claire L. Gordon, Laura K. Mackay, Terence P. Speed, Daniel H. D. Gray, Marie-Liesse Asselin-Labat
Summary: Tissue-resident memory T (TRM) cells play a crucial role in local immune defense against infection and cancer progression. This study shows that chronic inflammation affects TRM activation and TRM cells present in tissues prior to tumor onset impact cancer evolution. In preclinical models, pre-existing TRM-like cells enhance immune cell recruitment, leading to tumor immune evasion and resistance to immune checkpoint inhibitors. These findings highlight the importance of TRM-like activity in shaping tumor immunogenicity and influencing immunotherapy outcomes.
Article
Neurosciences
Suellen Marinho Andrade, Leandro da Silva-Sauer, Carolina Dias de Carvalho, Elidianne Layanne Medeiros de Araujo, Eloise de Oliveira Lima, Fernanda Maria Lima Fernandes, Karen Lucia de Araujo Freitas Moreira, Maria Eduarda Camilo, Lisieux Marie Marinho dos Santos Andrade, Daniel Tezoni Borges, Edson Meneses da Silva Filho, Ana Raquel Lindquist, Rodrigo Pegado, Edgard Morya, Seidi Yonamine Yamauti, Nelson Torro Alves, Bernardino Fernandez-Calvo, Jose Mauricio Ramos de Souza Neto
Summary: This study aims to investigate the impact of acetylcholinesterase inhibitors treatment on cognitive function in Alzheimer's Disease (AD). Through EEG observations on 70 AD patients, a machine learning algorithm was used to identify four brain regions that are associated with the treatment response of tDCS plus cognitive intervention.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Public, Environmental & Occupational Health
Fatima Cuadrado, Adoracion Antoli, Bernardino Fernandez-Calvo, Julia Vacas
Summary: This article investigates how different framings of Alzheimer's disease (AD) impact attitudes and emotions towards the disease. Two studies were conducted, one focusing on the individual with AD and the other on the relationship between the individual with AD and their family. The results show that positive framings lead to more positive attitudes and emotions, while negative framings trigger negative emotions. Reframing AD is crucial for changing attitudes and reducing stigma associated with the disease.
PATIENT EDUCATION AND COUNSELING
(2023)
Article
Geriatrics & Gerontology
Leandro da Silva-Sauer, Ricardo Basso Garcia, Egina Karoline Goncalves Fonseca, Bernardino Fernandez-Calvo
Summary: This study reveals that regular physical activity can help alleviate the adverse effects of caregiver burden on somatic health among caregivers of people with dementia. Encouraging and endorsing physical activity interventions for caregivers may provide significant benefits for their health and overall well-being.
Article
Geriatrics & Gerontology
Sayonara P. da Silva, Carla C. M. de Castro, Livia N. Rabelo, Rovena C. Engelberth, Bernardino Fernandez-Calvo, Felipe P. Fiuza
Summary: This study explores the regional differences in A beta deposition in the brains of Alzheimer's disease (AD) patients and finds associations with age, gender, and education. Additionally, the study reveals correlations between A beta burden and inflammatory proteins.
Article
Materials Science, Biomaterials
Shiyao Li, Yi Ju, Jiajing Zhou, Matthew Faria, Ching-Seng Ang, Andrew J. Mitchell, Qi-Zhi Zhong, Tian Zheng, Stephen J. Kent, Frank Caruso
Summary: This study systematically examined the effects of different precoating strategies on nanoparticle-immune cell interactions, and found that precoating with fetal bovine serum significantly reduced the association between nanoparticles and leukocytes.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)