Article
Oncology
Feng Li, Syeda Qasim, Dapeng Li, Q. Ping Dou
Summary: In-depth insights on cancer biology have highlighted the important roles of epigenetic mechanisms in tumorigenesis. Targeting the cancer epigenome with epi-drugs, including phytochemicals like EGCG, offers promising strategies for cancer chemoprevention and therapy. However, there are limitations to using EGCG as an epigenetic modulator in cancer treatment.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Sze Wan Hung, Yiran Li, Xiaoyan Chen, Kai On Chu, Yiwei Zhao, Yingyu Liu, Xi Guo, Gene Chi-Wai Man, Chi Chiu Wang
Summary: Green tea, with its main component EGCG, shows potential in suppressing reproductive cancers by regulating autophagy and other cellular processes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Mathis Ralaivao, Jade Lucas, Fernando Rocha, Berta N. Estevinho
Summary: In this study, EGCG was successfully microencapsulated using the spray-drying technique, with different biopolymers as encapsulating agents. The morphology and surface characteristics of the microparticles varied depending on the encapsulating agent used. The release of EGCG was complete and fast, with release achieved in less than 21 minutes. The encapsulation efficiency ranged between 78.5% and 100.0%. The Weibull model was found to best fit the experimental release data of EGCG.
Article
Medicine, Research & Experimental
Atala B. Jena, Umesh C. Dash, Asim K. Duttaroy
Summary: This study investigated the interaction between curcumin and EGCG, plant-derived compounds, with NLRP3 complex using in silico approach. The results showed that curcumin and EGCG had higher binding affinity for NLRP3 protein compared to other complex proteins, suggesting their potential impact on the complex's function. Protein-protein interaction studies further confirmed the efficacy of these compounds in hindering the formation of NLRP3 complex. The therapeutic effect of curcumin and EGCG may be mediated by preventing the development of the NLRP3 complex.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, Research & Experimental
Chia-Pei Chen, Tsung-Chen Su, Meei-Ju Yang, Wen-Ting Chen, An-Ci Siao, Ling-Ru Huang, Yen-Yue Lin, Yow-Chii Kuo, Jia-Fang Chung, Ching-Feng Cheng, Hui-Chen Ku, Yung-Hsi Kao
Summary: Green tea epigallocatechin gallate (EGCG) inhibits 3T3-L1 cell growth through the miR-143/MAPK7 pathway, indicating the crucial role of miR-143 in the regulation of fat cell proliferation by EGCG.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Medicinal
Eman A. Mazyed, Doaa A. Helal, Mahmoud M. Elkhoudary, Ahmed G. Abd Elhameed, Mohamed Yasser
Summary: This study aimed to enhance the bioavailability of EGCG utilizing nanospanlastics, with the optimized formula (F4) showing prolonged drug release and improved characteristics compared to niosomes.
Article
Virology
Rackhyun Park, Minsu Jang, Yea-In Park, Yeonjeong Park, Woochul Jung, Jayhyun Park, Junsoo Park
Summary: Recent studies have shown that green tea polyphenols have an inhibitory effect on coronavirus replication, with significant results observed in a mouse model.
Article
Biochemistry & Molecular Biology
Jiayin Liu, Hossein Ghanizadeh, Xinmao Li, Zhengyuan Han, Youwen Qiu, Yao Zhang, Xiuling Chen, Aoxue Wang
Summary: In this study, the interaction between trypsin and EGCG was investigated through various techniques, revealing that increasing EGCG concentration leads to larger aggregates of the complexes and changes in the conformation and microenvironment of trypsin.
Article
Engineering, Civil
Zhen Xu, Xuanqi Liu, Cuimin Feng, Shu Zhu, Ying Li, Ziyu Guo, Xinyi Chen
Summary: Research has shown that the presence of low concentration Ca2+ inhibits the disinfection effect of EGCG, while higher concentrations enhance its effects. As Ca2+ concentration increases, the proportion of damaged bacteria also increases.
AQUA-WATER INFRASTRUCTURE ECOSYSTEMS AND SOCIETY
(2021)
Review
Biochemistry & Molecular Biology
Victor Valverde-Salazar, Daniel Ruiz-Gabarre, Vega Garcia-Escudero
Summary: Alzheimer's disease (AD) is a common form of dementia characterized by memory decline, cognitive impairment, and several pathological changes in the brain. Oxidative stress and inflammation play important roles in the development of AD. Green tea and its active compound EGCG have shown potential therapeutic effects in modulating AD through their antioxidative and anti-inflammatory properties. EGCG can regulate inflammatory processes, reduce protein aggregation, and promote neuronal survival pathways, making it a suitable candidate for the treatment of neurodegenerative disorders involving oxidative stress and inflammation.
Article
Immunology
Yucheol Cheong, Minjin Kim, Jina Ahn, Hana Oh, Jongkwan Lim, Wonil Chae, Seung Won Yang, Min Seok Kim, Ji Eun Yu, Sanguine Byun, Yo Han Jang, Baik Lin Seong
Summary: The study investigated the potential use of catechins derived from green tea as adjuvants for subunit and inactivated vaccines, demonstrating their ability to enhance immune responses and provide protection against vaccines, including influenza virus.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Food Science & Technology
Wen-Ting Chen, Meei-Ju Yang, Yi-Wei Tsuei, Tsung-Chen Su, An-Ci Siao, Yow-Chii Kuo, Ling-Ru Huang, Yi Chen, Sy-Jou Chen, Po-Chuan Chen, Ching-Feng Cheng, Hui-Chen Ku, Yung-Hsi Kao
Summary: This study investigates the effect of epigallocatechin gallate (EGCG) on the growth of white and beige preadipocytes by modulating the miR-let-7a and HMGA2 pathways. The results show that EGCG inhibits the growth of 3T3-L1 and D12 preadipocytes, upregulates miR-let-7a expression, and downregulates HMGA2 mRNA and protein levels. Overexpression of miR-let-7a and HMGA2 antagonizes the inhibitory effects of EGCG on cell growth. Therefore, EGCG acts on preadipocytes through the miR-let-7a/HMGA2 pathway to inhibit their growth.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Paulina Aguilera, Camilo Berrios-Pasten, Marcelo Veloso, Matias Galvez-Silva, Florian Turbant, Rosalba Lagos, Frank Wien, Veronique Arluison, Andres E. Marcoleta
Summary: Epigallocatechin gallate (EGCG), a green tea flavonoid, can interfere with the formation of MccE492 amyloid fibers, resulting in the formation of amorphous aggregates and small oligomers. Although the aggregation process is not completely prevented, EGCG is still an interesting inhibitor of MccE492 and other bacterial amyloids.
Article
Immunology
Ting Gao, Fei Ye, Yiqing Tan, Mingzheng Peng, Fangyan Yuan, Zewen Liu, Danna Zhou, Keli Yang, Wei Liu, Rui Guo, Tengfei Zhang, Lin Zheng, Rui Zhou, Yongxiang Tian
Summary: Epigallocatechin gallate (EGCG), a green tea polyphenol, has antibacterial effects against Streptococcus suis (S. suis) by inhibiting its growth, reducing its pathogenicity, and decreasing hemolytic activity and biofilm formation. EGCG may serve as a potential compound for the treatment of S. suis infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chao Xin, Mengya Zhao, Jiahui Wang, Zhenyu Wang
Summary: DEH, a glucose-lowering complex with superior hypoglycemic effect, effectively improves insulin resistance, reduces fasting blood glucose, hepatic gluconeogenesis, and increases hepatic glycogen synthesis and storage in mice, representing a potential novel strategy for the treatment of type 2 diabetes.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
