Article
Neurosciences
Jonathan Aow, Tzu-Rung Huang, Gopal Thinakaran, Edward H. Koo
Summary: In this study, the researchers found that there was a significant early and aberrant Bace1-mediated APP cleavage in the presence of APP/Bace1 co-expression. This led to disturbances in the trafficking of full-length APP (fl-APP) from the secretory pathway, resulting in a substantial loss of surface fl-APP and a marked reduction in APP internalization. Therefore, caution is needed when interpreting results where APP is detected only with a C-terminal tag in the presence of Bace1 co-expression, and previous findings may need to be reinterpreted if it is unclear whether fl-APP is present in normal physiological levels.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Clinical Neurology
Lou Grangeon, Camille Charbonnier, Aline Zarea, Stephane Rousseau, Anne Rovelet-Lecrux, David Bendetowicz, Marion Lemaitre, Cecile Malrain, Muriel Quillard-Muraine, Kevin Cassinari, David Maltete, Jeremie Pariente, Olivier Moreaud, Eloi Magnin, Benjamin Cretin, Marie-Anne Mackowiak, Adeline Rollin Sillaire, Martine Vercelletto, Elsa Dionet, Olivier Felician, Pauline Rod-Olivieri, Catherine Thomas-Anterion, Gaelle Godeneche, Mathilde Sauvee, Leslie Cartz-Piver, Isabelle Le Ber, Valerie Chauvire, Therese Jonveaux, Anna-Chloe Balageas, Annie Laquerriere, Charles Duyckaerts, Anne Vital, Andre Maues de Paula, David Meyronet, Lucie Guyant-Marechal, Didier Hannequin, Elisabeth Tournier-Lasserve, Dominique Campion, Gael Nicolas, David Wallon
Summary: This study retrospectively analyzed the clinical, radiological, and neuropathological features of 43 APP duplication carriers from 24 French families, and compared them to 40 APP-negative CAA controls. The findings showed that the phenotypes and imaging features of APP duplication carriers were heterogeneous and lacked correlation with duplication size, making them an interesting model for studying cerebral amyloid angiopathy (CAA).
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Business
Ibrahim Alnawas, Amr Al Khateeb, Kamel El Hedhli
Summary: This study examines the impact of a comprehensive set of app-related factors on cognitive and emotional app relationship quality, as well as their differential effects on app stickiness. The results show that functional and offering factors have a greater impact on cognitive app relationship quality, while experiential and relational factors have a stronger impact on emotional app relationship quality. Additionally, cognitive app relationship quality has a stronger effect on app stickiness compared to emotional app relationship quality.
JOURNAL OF RETAILING AND CONSUMER SERVICES
(2023)
Article
Agriculture, Dairy & Animal Science
Fengmei Yu, Muhammad Akmal Raheem, Yang Tan, Muhammad Ajwad Rahim, Lisha Zha, Jun Zhang, Zhiwei Zhu, Zhonghua Li, Fangfang Chen
Summary: Rab22a is an important small GTPase protein involved in intracellular transportation and regulation of proteins. It plays a crucial role in antigens uptake, transportation, regulation of endosome morphology, and transport of antigens to MHC molecules. This study investigated the relationship between chicken Rab22a (cRab22a) and BF/cIi molecules. The results showed that cRab22a regulates the expression of BF and cIi genes indirectly, and it is localized with cIi in the endosome. The Switch regions of cRab22a are key domains that affect intracellular localization and colocalization of the cIi molecule.
Article
Biochemistry & Molecular Biology
Marta Dratwa, Barbara Wysoczanska, Wioletta Brankiewicz, Martyna Stachowicz-Suhs, Joanna Wietrzyk, Rafal Matkowski, Marcin Ekiert, Jolanta Szelachowska, Adam Maciejczyk, Mariusz Szajewski, Maciej Baginski, Katarzyna Bogunia-Kubik
Summary: This study investigated the molecular mechanisms of TERT upregulation in breast cancer, including genetic variability and telomere length, as well as the expression of TERT, MYC, TP53, and SP1 genes in BC patients and BC organoids. Results showed correlations between TERT genotypes, TP53 expression, and telomere length, suggesting TERT genetic variability may serve as potential biomarkers for breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Psychiatry
Laure Fivel, Marine Mondino, Jerome Brunelin, Frederic Haesebaert
Summary: The processing of basic auditory features in schizophrenia has been extensively studied, with abnormalities found in pitch perception, intensity, duration, and sound localization. However, the relationship between basic auditory processing and symptom severity remains inconclusive. Patients with schizophrenia exhibit deficits in all basic auditory features, indicating the importance of further research and potential remediation strategies.
PSYCHIATRY RESEARCH
(2023)
Article
Multidisciplinary Sciences
Siyu Huo, Changhai Tian, Muhua Zheng, Shuguang Guan, Changsong Zhou, Zonghua Liu
Summary: In this study, a new feature of chimera states was observed in the human cortical network using neural mass oscillators, revealing a positive correlation between synchronization preference of local regions and the symmetry of connectivity. By utilizing the concept of effective symmetry, hierarchical trees were constructed to explain the multiple brain rhythms observed in experiments. These results suggest a generic principle for complex brain networks to support diverse functional patterns.
NATIONAL SCIENCE REVIEW
(2021)
Article
Business
Thomas Schulz, Sina Zimmermann, Markus Boehm, Heiko Gewald, Helmut Krcmar
Summary: In recent years, there has been a shift from goods-dominant to service-dominant business logic, with companies like Daimler AG and the BMW Group providing services in addition to products. Despite the potential for smart mobility, services like the Reach Now app have relatively low user numbers.
TECHNOLOGICAL FORECASTING AND SOCIAL CHANGE
(2021)
Article
Psychology, Multidisciplinary
Tinggui Chen, Chu Zhang, Jianjun Yang, Guodong Cong
Summary: This paper examines the quantitative relationship between user online reviews and APP downloads. By analyzing user comments, companies can uncover user needs and preferences, enabling accurate market positioning and iterative innovation to increase APP downloads. The results show that user needs and satisfaction have a significant impact on download volume.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Cell Biology
Maria Pagnon de la Vega, Vilmantas Giedraitis, Wojciech Michno, Lena Kilander, Goekhan Guener, Mara Zielinski, Malin Lowenmark, RoseMarie Brundin, Torsten Danfors, Linda Soderberg, Irina Alafuzoff, Lars N. G. Nilsson, Anna Erlandsson, Dieter Willbold, Stephan A. Mueller, Gunnar F. Schroeder, Jorg Hanrieder, Stefan F. Lichtenthaler, Lars Lannfelt, Dag Sehlin, Martin Ingelsson
Summary: Point mutations in the APP gene cause familial Alzheimer's disease by altering A beta generation or conformation. The Uppsala APP mutation is the first reported deletion causing autosomal dominant AD, leading to early symptom onset and rapid disease progression. This mutation affects APP processing and accelerates the formation of unique fibrils and amyloid plaques in the brain.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Xuewen Zhang, Nianping Wu, Huili Huang, Shi Li, Shicheng Liu, Rui Zhang, Yuan Huang, Hao Lyu, Shuai Xiao, Declan William Ali, Marek Michalak, Xing-Zhen Chen, Cefan Zhou, Jingfeng Tang
Summary: PTTG1 is a bona fide β-catenin binding protein that positively regulates Wnt/β-catenin signaling by inhibiting the destruction complex assembly and promoting β-catenin stabilization and nuclear localization. PTTG1's subcellular distribution is regulated by its phosphorylation status. It is highly expressed in hepatocellular carcinoma (HCC) and associated with poor patient prognosis, as it promotes the proliferation and metastasis of HCC cells.
Article
Engineering, Chemical
Xi-Bao Zhang, Zheng-Hong Luo
Summary: This study investigated the gas-liquid slip velocity distribution in bubble columns using CFD-PBM simulations, finding that slip velocities decrease with increasing radial position but generally increase with higher superficial gas velocities. Additionally, a strong linear relationship between local slip velocities and local heat transfer coefficients was observed in the fully developed region.
Article
Chemistry, Analytical
Ilaria De Santis, Luca Lorenzini, Marzia Moretti, Elisa Martella, Enrico Lucarelli, Laura Calza, Alessandro Bevilacqua
Summary: The introduction of co-density distribution maps (cDDMs) provides comprehensive information about the absolute and relative position, as well as local abundance of molecules, enhancing the reliability and accuracy of colocalization analysis. They also offer new avenues for research and biomedical considerations, serving as a potential improvement for a large number of biomedical studies.
Article
Construction & Building Technology
Jiwang Jiang, Ying Li, Yuan Zhang, Hussain U. Bahia
Summary: This study proposes a novel method to characterise the distribution of mortar film thickness in asphalt mixture using image processing. The results show that binder modification and compaction temperature have significant effects on the mortar film distribution. The correlation between mortar film thickness and mixture cracking resistance is analyzed using mortar film parameters.
INTERNATIONAL JOURNAL OF PAVEMENT ENGINEERING
(2022)
Article
Environmental Sciences
Yi Han, Lan Yang, Kun Jia, Jie Li, Siyuan Feng, Wei Chen, Wenwu Zhao, Paulo Pereira
Summary: This study analyzed the spatial distribution characteristics of the COVID-19 pandemic in Beijing, identifying two stages of development and highlighting population density and distance to Xinfadi market as critical factors influencing the transmission. The findings can contribute valuable information for the global fight against COVID-19.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
