Article
Medicine, General & Internal
Andrea Sturchio, Alok K. Dwivedi, Christina B. Young, Tarja Malm, Luca Marsili, Jennifer S. Sharma, Abhimanyu Mahajan, Emily J. Hill, Samir El Andaloussi, Kathleen L. Poston, Fredric P. Manfredsson, Lon S. Schneider, Kariem Ezzat, Alberto J. Espay
Summary: The study found that high soluble Aβ42 levels are associated with normal cognition and hippocampal volume despite increasing brain amyloidosis, suggesting that preserving high soluble Aβ42 levels could be important for maintaining cognitive function and hippocampal health.
Article
Biochemistry & Molecular Biology
Tsuyoshi Hamaguchi, Kenjiro Ono, Masahito Yamada
Summary: Deposition of amyloid beta protein in the brain is a characteristic of Alzheimer's disease, which can be transmitted between individuals through a prion-like mechanism. Pathological studies have shown that patients with iatrogenic Creutzfeldt-Jakob disease, caused by medical procedures such as human growth hormone injection and dura mater graft, also have cerebral amyloid beta protein deposition. Additionally, young patients with cerebral amyloid angiopathy-related cerebral hemorrhage, who have undergone neurosurgeries with or without dura mater graft in early childhood, suggest that the transmission of cerebral amyloid beta protein pathology is often through amyloid angiopathy rather than parenchymal deposition.
NEUROCHEMICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Katerina Konstantoulea, Patricia Guerreiro, Meine Ramakers, Nikolaos Louros, Liam D. Aubrey, Bert Houben, Emiel Michiels, Matthias De Vleeschouwer, Yulia Lampi, Luis F. Ribeiro, Joris Wit, Wei-Feng Xue, Joost Schymkowitz, Frederic Rousseau
Summary: The study found that proteins enriched in homologous sequences to Aβ aggregation-prone regions are present in Aβ plaques from AD patients, suggesting heterotypic amyloid interactions may occur. These proteins can modify Aβ assembly kinetics, fibril morphology, and deposition pattern in vitro. Additionally, it was discovered that transient expression of three of these proteins in an Aβ reporter cell line promotes Aβ amyloid aggregation, indicating a potential role of heterotypic APR interactions in amyloid-deposition diseases.
Article
Biochemistry & Molecular Biology
Bartlomiej Stanczykiewicz, Tomasz M. Goszczynski, Pawel Migdal, Marta Piksa, Krzysztof Pawlik, Jakub Gburek, Krzysztof Golab, Boguslawa Konopska, Agnieszka Zablocka
Summary: The research aims to determine the inhibitory activity of ovocystatin, a cysteine protease inhibitor isolated from egg white, on A beta 42 fibril formation in vitro. The results show that ovocystatin possesses A beta 42 anti-aggregation activity and inhibits A beta 42 oligomer toxicity in PC12 cells. This research may contribute to the development of potential substances to prevent or delay beta-amyloid aggregation, a major cause of Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Lifang Zhang, Jessica Cao, Haiqiang Yang, Phillip Pham, Umer Khan, Breanna Brown, Yanhong Wang, Tarek Zieneldien, Chuanhai Cao
Summary: Coffee consumption, regardless of brand or type, is beneficial for stalling the progression and development of A beta-related Alzheimer's disease (AD). All coffees tested have beneficial health effects for AD through lowering A beta 1-40 and A beta 1-42 production, with Dunkin' Donuts (R) medium roast coffee demonstrating the most consistent and optimal cell survival rates and A beta concentration, while Starbucks (R) coffee exhibited the highest cell toxicity rates among the tested coffees.
FRONTIERS IN NUTRITION
(2022)
Article
Nanoscience & Nanotechnology
Ana R. Araujo, Juan Correa, Vicente Dominguez-Arca, Rui L. Reis, Eduardo Fernandez-Megia, Ricardo A. Pires
Summary: In this study, the synthesis of nanosized, functional gallic acid-based dendrimers is described, which interact with Aβ species and remodel them into noncytotoxic aggregates. The multivalent presentation of gallic acid on the dendrimer surface enhances their ability to interact with Aβ, inhibiting fibrillization and disrupting preformed fibrils.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Biochemistry & Molecular Biology
Yukihiro Saito, Kazufumi Nakamura, Hiroshi Ito
Summary: Cardiac involvement significantly affects the prognosis of patients with systemic amyloidosis. Therapeutic methods have been developed for ATTR amyloidosis and AL amyloidosis, which show cardiac involvement, leading to improved prognosis. However, there is currently no established method for removing deposited amyloid, and further research is needed for protecting cardiovascular cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Takumi Nakamura, Takeshi Kawarabayashi, Tetsuya Ueda, Sachiko Shimomura, Masaki Hoshino, Ken Itoh, Kazushige Ihara, Shigeyuki Nakaji, Masamitsu Takatama, Yoshio Ikeda, Mikio Shoji
Summary: This study measured the plasma levels of total ApoE, ApoE2, ApoE3, and ApoE4 in 498 participants using mass spectrometry. The results showed that plasma ApoE levels are associated with lipids and multiple metabolic pathways, but not directly with aging or Alzheimer's disease biomarkers. These findings provide new insights into the mechanisms by which peripheral ApoE4 influences the progression of Alzheimer's disease and atherosclerosis.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Konstantin Yenkoyan, Tigran Margaryan, Senik Matinyan, Vergine Chavushyan, Margarita Danielyan, Tigran Davtyan, Michail Aghajanov
Summary: This study investigated the development of Alzheimer's disease and the brain's defense mechanisms against chronic injuries. The results showed that injection of beta-amyloid can induce stem cell proliferation and neurogenesis, but this process is incomplete and leads to neural stem cell immaturity. The study suggests that enhancing adult neurogenesis may be a promising strategy for preventing and treating Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Debasis Saha, Biman Jana
Summary: This study investigates the intermediates in the fibril formation pathway of A beta(13-42) oligomers and identifies their stable conformations and structural features. Residues 30-36 are found to play a crucial role in fibril formation.
Article
Multidisciplinary Sciences
Myungwoon Lee, Wai-Ming Yau, John M. Louis, Robert Tycko
Summary: The study finds that A beta 42 fibrils exhibit polymorphism and have different molecular structures. Two qualitatively different structures of A beta 42 fibrils are reported using cryo-EM methods, derived from AD brain tissue. These results demonstrate a greater range of structural variations in A beta 42 fibrils than seen in previous studies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biotechnology & Applied Microbiology
Sayali Chandrashekhar Deolankar, Mohammad Altaf Najar, Shamprasad Varija Raghu, Thottethodi Subrahmanya Keshava Prasad
Summary: Using quantitative proteomics, this study identified significantly altered proteins and post-translational modifications associated with Aβ42 expression in a D. melanogaster model for AD. These proteins are involved in biological processes related to neuronal damage, neuroplasticity, and AD progression. The findings provide new insights into altered protein dynamics relevant to AD pathogenesis.
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2022)
Article
Neurosciences
Anja Hviid Simonsen, Christian Sandoe Musaeus, Gitte Lund Christensen, Steen Gregers Hasselbalch, Gunhild Waldemar
Summary: The study found a significant increase in A beta(1-42) levels in the cerebrospinal fluid over a period of twelve years, independent of changes in tau. Thus, awareness of this upward trend is crucial during diagnosis and selection of historical samples for research purposes.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Neurosciences
Md. Tanvir Kabir, Md. Sahab Uddin, Sonia Zaman, Yesmin Begum, Ghulam Md Ashraf, May N. Bin-Jumah, Simona G. Bungau, Shaker A. Mousa, Mohamed M. Abdel-Daim
Summary: Research indicates that neurodegenerative diseases like AD are associated with biometal imbalance and toxic metal accumulation, leading to neurotoxic activities and cell death. Aberrant expression of endogenous proteins related to metal transport is linked to AD pathogenesis.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jairo Salazar, Joana Poejo, Ana M. Mata, Alejandro K. Samhan-Arias, Carlos Gutierrez-Merino
Summary: This study designed a hydrophobic peptide mimicking the interaction between calmodulin (CaM) and amyloid beta (1-42), and found that the synthetic peptide is a potent inhibitor of the formation of A beta(1-42):CaM and A beta(1-42):calbindin-D28k complexes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)