Review
Chemistry, Multidisciplinary
Ya-Qiong Yan, Hao Wang, Yuliang Zhao
Summary: Radionuclide imaging is a premier imaging method in clinical practice, utilizing PET and SPECT to detect anatomical abnormalities. Peptides as targeting vectors for contrast agents offer high specificity and low toxicity. Radiolabeled peptide probes have become essential tools for clinical radionuclide diagnosis.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Rongji Zhu, Peiling Dai, Jun Yang, Jie Zhou, Jin Zhang, Kenneth Yin Zhang, Yonghua Li, Shujuan Liu, Kenneth Kam-Wing Lo, Qiang Zhao
Summary: In this study, dual-emissive iridium(III) complexes were developed to exhibit phosphorescence responses to copper(II) ions at a distinct wavelength from oxygen quenching. These complexes demonstrated colorimetric phosphorescence response in aqueous solutions under different copper(II) and oxygen conditions. In cellular imaging, the intensity and lifetime of green phosphorescence can be modulated by variation in oxygen concentration without affecting the response of red phosphorescence towards intracellular copper(II) ions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Analytical
Jiaying Guo, Bin Fang, Hua Bai, Limin Wang, Bo Peng, Xu-Jun Qin, Li Fu, Chuanhao Yao, Lin Li, Wei Huang
Summary: Mitochondria, as the powerhouses of cells, are crucial for energy metabolism. Abnormalities in their structure and function can lead to various diseases. Therefore, the rapid, sensitive, and simultaneous detection of analytes related to mitochondrial diseases is of great importance for human health.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Zhi-Xiang Han, Jie Xiong, Tian-Bing Ren, Xiao-Bing Zhang
Summary: This article introduces the current research status and future prospects of dual-target-activated fluorescent probes. Dual-target-activated fluorescent probes have the advantages of avoiding nonspecific activation and false positive results in complicated environments.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Polymer Science
Shuying Li, Yanjuan Wu, Xiukun Xue, Siyuan Liu
Summary: In this study, a versatile nanodrug, PVPt@Cy NPs, was developed to achieve synchronous chemotherapy, photodynamic therapy (PDT), and photothermal therapy (PTT) for cancer treatment. The nanodrug demonstrated enhanced anticancer efficiency with NIR irradiation and showed strong NIR fluorescence and photothermal imaging in tumor-bearing mice. PVPt@Cy NPs have enormous potential in combined chemo-phototherapy and bioimaging.
Article
Chemistry, Analytical
Zhongyong Xu, Shufan Si, Zhijun Zhang, Huiya Tan, Tianyi Qin, Zhonglin Wang, Dong Wang, Lei Wang, Bin Liu
Summary: A novel probe design strategy utilizing two same reacting groups was proposed in this study, simplifying the synthesis route and minimizing interference from competing species. The probe showed distinguishable fluorescence peak wavelengths towards low and high concentration ranges of Cys, emitting green and blue light respectively. This simpler strategy for sensing different concentration ranges of Cys may inspire more probe design in the future.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Physical
Cheng-Ruei Yang, Yu-Syuan Lin, Ren-Siang Wu, Chin-Jung Lin, Han-Wei Chu, Chih-Ching Huang, Anisha Anand, Binesh Unnikrishnan, Huan-Tsung Chang
Summary: A ratiometric fluorescent probe based on o-phenylenediamine-derived carbonized polymer dots (o-PD CPDs) was developed for real-time intracellular detection of singlet oxygen (1O2). The o-PD CPDs can produce 1O2 and selectively quench the yellow fluorescence, allowing for the selective detection of 1O2 against other reactive oxygen species (ROS). The probe was successfully applied to monitor 1O2 level in the intracellular environment and detect 1O2 and other ROS species in an inflammatory neutrophil cell model.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Review
Chemistry, Inorganic & Nuclear
Wei Quan, Wenhui Song, Qian Zhang, Huawei Huang, Weiying Lin
Summary: The liver, as the metabolic and detoxification center, plays a vital role in various physiological processes. Normal liver function is crucial for maintaining overall health, while abnormal liver function can lead to liver diseases. Early diagnosis of liver diseases is essential for timely treatment. The use of fluorescent probes for detecting biomarkers of liver diseases has provided valuable insights for pathological studies, drug development, and disease diagnosis and treatment in recent years. This review summarizes the progress of fluorescence probes in detecting hepatopathy-related biomarkers and discusses the current challenges and future directions. The development of long wavelength probes, multi-detection probes, quantitative analysis probes, and multi-modal probes is expected to be a popular trend. This review aims to facilitate the development of novel fluorescent probes for disease detection and provide guidance for diagnosis and treatment.
COORDINATION CHEMISTRY REVIEWS
(2023)
Review
Chemistry, Inorganic & Nuclear
Jingting Zhan, Wenhui Song, Enxiang Ge, Lixuan Dai, Weiying Lin
Summary: Reversible fluorescent probes have been widely used in biological research due to their ability to observe dynamic changes of biomolecules in real-time. This review categorizes reversible fluorescent probes into six groups based on the principles of reversible reactions and focuses on their interactions with physiological compounds and small molecule compounds or microenvironments. Representative examples of reversible processes, including complex reactions, addition reactions, redox reactions, and spiral cyclization, are reviewed to demonstrate the potential of reversible fluorescent probes for visualizing intracellular dynamic changes. Furthermore, the challenges and future directions of utilizing reversible fluorescent probes in biological applications are discussed.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Pejman Shahrokhi, Arezou Masteri Farahani, Mohammad Tamaddondar
Summary: Nuclear medicine techniques like SPECT and PET are highly sensitive methods for diagnostic imaging and radionuclide therapy. The development of radiolabeled vitamins for targeted tumor imaging and treatment is increasing.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jingsheng Huang, Yuyan Jiang, Jingchao Li, Jiaguo Huang, Kanyi Pu
Summary: This study introduces two chemiluminophores with record long NIR emission, caged with different cleavable moieties to produce NIR chemiluminescence probes capable of detecting reactive oxygen species or enzyme reactions in deep tissues. These molecular scaffolds provide a new approach for in vivo turn-on imaging of versatile biomarkers.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Biochemistry & Molecular Biology
Ho Ying Low, Chang-Tong Yang, Bin Xia, Tao He, Winnie Wing Chuen Lam, David Chee Eng Ng
Summary: Quantitative nuclear imaging techniques are in high demand for disease diagnostics and cancer theranostics. Liposomal radiotracers have been rapidly developing as novel nuclear imaging probes, with their physicochemical properties and structural characteristics addressed for stability and specific targeting. Various radionuclide labeling methods have been summarized to obtain radiolabeled liposomes for in vivo biodistribution and targeting studies.
Review
Chemistry, Inorganic & Nuclear
Fang Wang, Kaijie Wang, Qing Kong, Jing Wang, Dazhou Xi, Bowen Gu, Sheng Lu, Tingwen Wei, Xiaoqiang Chen
Summary: This review describes the development of fluorescence probes for Zn2+ since 2015, highlighting their high sensitivities and selectivities. The probes are organized according to different fluorophore families and mainly discussed based on their mode of action.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Chemistry, Inorganic & Nuclear
Deming He, Lishen Zhang, Yuanqiang Sun
Summary: Pyronine dyes have gained considerable attention as powerful fluorescence imaging tools due to their tunable photo physical properties. By modifying the Pyronine platform, versatile fluorescent probes with diverse functionalities can be obtained, making them suitable for in vivo and in vitro bioimaging.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Chemistry, Analytical
Zixuan Zhan, Yongcheng Dai, Qiuyan Li, Yi Lv
Summary: Small molecules-based bioluminescence and chemiluminescence probes have emerged as powerful tools for biomarkers imaging without requiring excitation light source, showing intriguing properties and fast development. However, probes for reactive species have not been reviewed comprehensively in the past decade. Recent research indicates the significant potential of these probes in the field of biomedical imaging.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Review
Nanoscience & Nanotechnology
Alexander Zheleznyak, Monica Shokeen, Samuel Achilefu
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2018)
Article
Biochemical Research Methods
Rebecca C. Gilson, Rui Tang, Krishna Sharmah Gautam, Dorota Grabowska, Samuel Achilefu
BIOCONJUGATE CHEMISTRY
(2019)
Article
Oncology
Rosa Nguyen, Ardiana Moustaki, Jacqueline L. Norrie, Shantel Brown, Walter J. Akers, Abbas Shirinifard, Michael A. Dyer
CLINICAL CANCER RESEARCH
(2019)
Article
Multidisciplinary Sciences
Cong-Lin Liu, Xian Zhang, Jing Liu, Yunzhe Wang, Galina K. Sukhova, Gregory R. Wojtkiewicz, Tianxiao Liu, Rui Tang, Samuel Achilefu, Matthias Nahrendorf, Peter Libby, Junli Guo, Jin-Ying Zhang, Guo-Ping Shi
NATURE COMMUNICATIONS
(2019)
Article
Chemistry, Multidisciplinary
Rui Tang, Alexander Zheleznyak, Matthew Mixdorf, Anchal Ghai, Julie Prior, Kvar C. L. Black, Monica Shokeen, Nathan Reed, Pratim Biswas, Samuel Achilefu
Review
Chemistry, Multidisciplinary
Suman B. Mondal, Shaw-Wei D. Tsen, Samuel Achilefu
ADVANCED FUNCTIONAL MATERIALS
(2020)
Article
Engineering, Biomedical
Jingyi Luan, Anushree Seth, Rohit Gupta, Zheyu Wang, Priya Rathi, Sisi Cao, Hamed Gholami Derami, Rui Tang, Baogang Xu, Samuel Achilefu, Jeremiah J. Morrissey, Srikanth Singamaneni
NATURE BIOMEDICAL ENGINEERING
(2020)
Article
Oncology
Kinan Alhallak, Jennifer Sun, Katherine Wasden, Nicole Guenthner, Julie O'Neal, Barbara Muz, Justin King, Daniel Kohnen, Ravi Vij, Samuel Achilefu, John F. DiPersio, Abdel Kareem Azab
Summary: This study developed nanoparticle-based bispecific T-cell engagers (nanoBiTEs) and nanoparticles targeting multiple cancer antigens (nanoMuTEs), overcoming the major limitations of current T-cell-based immunotherapy. These novel nanoparticles have a long half-life, enabling once-a-week administration while maintaining efficacy, with nanoMuTEs targeting multiple cancer antigens showing greater efficacy in myeloma cells.
Article
Chemistry, Analytical
Owen Peng, Walter Akers, Mikhail Y. Berezin
Summary: Cold stress injury to plants is a complex process that affects metabolism and growth. Fluorescence lifetime imaging (FLIM) is a sensitive method for rapid injury assessment, showing higher sensitivity than traditional methods.
CURRENT ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Physical
Megan S. Michie, Baogang Xu, Gail Sudlow, Luke E. Springer, Christine T. N. Pham, Samuel Achilefu
Summary: In this study, NIR dye-peptide conjugates were synthesized and it was found that a peptide-driven strategy can alter the aggregation states of molecular probes in aqueous solutions, leading to effective imaging of inflammatory arthritis joints. The results suggest that peptide plays a dominant role in controlling the photophysical properties of these bioconjugates.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Hematology
Sena Kim, Sora Lim, Boram Kim, Julie Ritchey, Kiran Vij, Julie Prior, Lynne Marsala, Alyssa Stoner, Feng Gao, Samuel Achilefu, Matthew L. Cooper, John F. DiPersio, Jaebok Choi
Summary: By blocking the IFNGR signaling pathway, S100A9 is upregulated in T cells and acts as a novel suppressor of graft-versus-host disease (GVHD) while preserving graft-versus-leukemia (GVL) effects. In both mouse models of allo-HSCT and xenogeneic human peripheral blood mononuclear cell transplantation, overexpression of S100A9 or administration of anti-IFNGR antibody improved GVHD without compromising GVL and reduced T-cell trafficking to GVHD target organs.
Article
Rheumatology
Shaw-Wei D. Tsen, Luke E. Springer, Krishna Sharmah Gautam, Rui Tang, Kexian Liang, Gail Sudlow, Amir Kucharski, Christine T. N. Pham, Samuel Achilefu
Summary: LS301 selectively accumulates in regions of joint pathology in mouse models of RA, with a positive correlation with disease severity. Whole-body near-infrared imaging with LS301 allows tracking of spontaneous disease remission and therapeutic response after dexamethasone treatment. Histological analysis shows preferential accumulation of LS301 within chondrocytes and articular cartilage in arthritic mice, with colocalization observed between LS301 and pANXA2 in joint tissue.
ARTHRITIS RESEARCH & THERAPY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anchal Ghai, Alexander Zheleznyak, Matt Mixdorf, Julie O'Neal, Julie Ritchey, Michael Rettig, John DiPersio, Monica Shokeen, Samuel Achilefu
Summary: This study demonstrates the feasibility of [Zr-89]DFO-elotuzumab as a companion diagnostic for CS1-targeted therapies.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Chemistry, Multidisciplinary
Daniel D. Lane, Kvar C. L. Black, Ramesh Raliya, Nathan Reed, Nalinikanth Kotagiri, Rebecca Gilson, Rui Tang, Pratim Biswas, Samuel Achilefu
Article
Chemistry, Multidisciplinary
Rebecca C. Gilson, Kvar C. L. Black, Daniel D. Lane, Samuel Achilefu
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2017)
Article
Chemistry, Multidisciplinary
Laetitia Bardet, Herve Roussel, Stefano Saroglia, Masoud Akbari, David Munoz-Rojas, Carmen Jimenez, Aurore Denneulin, Daniel Bellet
Summary: The thermal instability of silver nanowires leads to increased electrical resistance in AgNW networks. Understanding the relationship between structural and electrical properties of AgNW networks is crucial for their integration as transparent electrodes in flexible optoelectronics. In situ X-ray diffraction measurements were used to study the crystallographic evolution of Ag-specific Bragg peaks during thermal ramping, revealing differences in thermal and structural transitions between bare and SnO2-coated AgNW networks.
Article
Chemistry, Multidisciplinary
Nathalia Cancino-Fuentes, Arnau Manasanch, Joana Covelo, Alex Suarez-Perez, Enrique Fernandez, Stratis Matsoukis, Christoph Guger, Xavi Illa, Anton Guimera-Brunet, Maria V. Sanchez-Vives
Summary: This study provides a comprehensive characterization of graphene-based solution-gated field-effect transistors (gSGFETs) for brain recordings, highlighting their potential clinical applications.
Article
Chemistry, Multidisciplinary
Sikandar Aftab, Hailiang Liu, Dhanasekaran Vikraman, Sajjad Hussain, Jungwon Kang, Abdullah A. Al-Kahtani
Summary: This study examines the effects of hybrid nanoparticles made of NiO@rGO and NiO@CNT on the active layers of polymer solar cells and X-ray photodetectors. The findings show that these hybrid nanoparticles can enhance the charge carrier capacities and exciton dissociation properties of the active layers. Among the tested configurations, the NiO@CNT device demonstrates superior performance in converting sunlight into electricity, and achieves the best sensitivity for X-ray detection.
Article
Chemistry, Multidisciplinary
Hyo Jung Shin, Seung Gyu Choi, Fengrui Qu, Min-Hee Yi, Choong-Hyun Lee, Sang Ryong Kim, Hyeong-Geug Kim, Jaewon Beom, Yoonyoung Yi, Do Kyung Kim, Eun-Hye Joe, Hee-Jung Song, Yonghyun Kim, Dong Woon Kim
Summary: This study investigates the role of SOX9 in reactive astrocytes following ischemic brain damage using a PLGA nanoparticle plasmid delivery system. The results demonstrate that PLGA nanoparticles can reduce ischemia-induced neurological deficits and infarct volume, providing a potential opportunity for stroke treatment.
Article
Chemistry, Multidisciplinary
Anurag Chaudhury, Koushik Debnath, Nikhil R. Jana, Jaydeep K. Basu
Summary: The study investigates the interaction between nanoparticles and cell membranes, and identifies key parameters, including charge, crowding, and membrane fluidity, that determine the adsorbed concentration and unbinding transition of nanoparticles.
Article
Chemistry, Multidisciplinary
Sina Sadeghi, Fazel Bateni, Taekhoon Kim, Dae Yong Son, Jeffrey A. Bennett, Negin Orouji, Venkat S. Punati, Christine Stark, Teagan D. Cerra, Rami Awad, Fernando Delgado-Licona, Jinge Xu, Nikolai Mukhin, Hannah Dickerson, Kristofer G. Reyes, Milad Abolhasani
Summary: In this study, an autonomous approach for the development of lead-free metal halide perovskite nanocrystals is presented, which integrates a modular microfluidic platform with machine learning-assisted synthesis modeling. This approach enables rapid and optimized synthesis of copper-based lead-free nanocrystals.
Article
Chemistry, Multidisciplinary
Zahir Abbas, Nissar Hussain, Surender Kumar, Shaikh M. Mobin
Summary: The rational construction of free-standing and flexible electrodes for electrochemical energy storage devices is an emerging research focus. In this study, a redox-active metal-organic framework (MOF) was prepared on carbon nanofibers using an in situ approach, resulting in a flexible electrode with high redox-active behavior and unique properties such as high flexibility and lightweight. The prepared electrode showed excellent cyclic retention and rate capability in supercapacitor applications. Additionally, it could be used as a freestanding electrode in flexible devices at different bending angles.
Article
Chemistry, Multidisciplinary
Lishan Zhang, Xiaoting Zhang, Hui Ran, Ze Chen, Yicheng Ye, Jiamiao Jiang, Ziwei Hu, Miral Azechi, Fei Peng, Hao Tian, Zhili Xu, Yingfeng Tu
Summary: Photodynamic therapy (PDT) is a promising local treatment modality in cancer therapy, but its therapeutic efficacy is restricted by ineffective delivery of photosensitizers and tumor hypoxia. In this study, a phototactic Chlorella-based near-infrared (NIR) driven green affording-oxygen microrobot system was developed for enhanced PDT. The system exhibited desirable phototaxis and continuous oxygen generation, leading to the inhibition of tumor growth in mice. This study demonstrates the potential of using a light-driven green affording-oxygen microrobot to enhance photodynamic therapy.
Article
Chemistry, Multidisciplinary
Yujin Li, Jing Xu, Xinqi Luo, Futing Wang, Zhong Dong, Ke-Jing Huang, Chengjie Hu, Mengyi Hou, Ren Cai
Summary: In this study, hollow heterostructured materials were constructed using an innovative template-engaged method as cathodes for zinc-ion batteries. The materials exhibited fast Zn2+ transport channels, improved electrical conductivity, and controlled volume expansion during cycling. The designed structure allowed for an admirable reversible capacity and high coulombic efficiency.
Article
Chemistry, Multidisciplinary
Paritosh Mahato, Shashi Shekhar, Rahul Yadav, Saptarshi Mukherjee
Summary: This study comprehensively elucidates the role of the core and electrostatic surface of metal nanoclusters in catalytic reduction reactions. The electrostatic surface dramatically modulates the reactivity of metal nanoclusters.
Article
Chemistry, Multidisciplinary
Pei Liu, Mengdi Liang, Zhengwei Liu, Haiyu Long, Han Cheng, Jiahe Su, Zhongbiao Tan, Xuewen He, Min Sun, Xiangqian Li, Shuai He
Summary: This study demonstrates a simple and environmentally-friendly method for the synthesis of zinc oxide nanozymes (ZnO NZs) using wasted hop extract (WHE). The WHE-ZnO NZs exhibit exceptional peroxidase-like activity and serve as effective catalysts for the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide (H2O2). In addition, a straightforward colorimetric technique for detecting both H2O2 and glucose was developed using the WHE-ZnO NZs as peroxidase-like catalysts.
Article
Chemistry, Multidisciplinary
Hyunkyu Oh, Young Jun Lee, Eun Ji Kim, Jinseok Park, Hee-Eun Kim, Hyunsoo Lee, Hyunjoo Lee, Bumjoon J. Kim
Summary: Mesoporous carbon particles have unique structural properties that make them suitable as support materials for catalytic applications. This study investigates the impact of channel nanostructures on the catalytic activity of porous carbon particles (PCPs) by fabricating PCPs with controlled channel exposure on the carbon surface. The results show that PCPs with highly open channel nanostructures exhibit significantly higher catalytic activity compared to those with closed channel nanostructures.
Article
Chemistry, Multidisciplinary
Yunjie Lu, Zhaohui Li, Zewei Li, Shihao Zhou, Ning Zhang, Jianming Zhang, Lu Zong
Summary: A tough, long-lasting adhesive and highly conductive nanocomposite hydrogel (PACPH) was fabricated via the synergy of interfacial entanglement and adhesion group densification. PACPH possesses excellent mechanical properties, interfacial adhesion strength, and conductivity, making it a promising material for long-term monitoring of human activities and electrocardiogram signals.
Article
Chemistry, Multidisciplinary
Zichao Wei, Audrey Vandergriff, Chung-Hao Liu, Maham Liaqat, Mu-Ping Nieh, Yu Lei, Jie He
Summary: We have developed a simple method to prepare polymer-grafted plasmonic metal nanoparticles with pH-responsive surface-enhanced Raman scattering. By using pH-responsive polymers as ligands, the aggregation of nanoparticles can be controlled, leading to enhanced SERS. The pH-responsive polymer-grafted nanoparticles show high reproducibility and sensitivity in solution, providing a novel approach for SERS without the need for sample pre-concentration.
Article
Chemistry, Multidisciplinary
Melis Ozge Alas Colak, Ahmet Gungor, Merve Buldu Akturk, Emre Erdem, Rukan Genc
Summary: This research investigates the effect of functionalizing carbon dots with hydroxyl polymers on their performance as electrode materials in a supercapacitor. The results show that the functionalized carbon dots exhibit excellent electrochemical performance and improved stability.
