Article
Chemistry, Multidisciplinary
Florica Adriana Jerca, Cristina Muntean, Katrien Remaut, Valentin Victor Jerca, Koen Raemdonck, Richard Hoogenboom
Summary: Poly(2-isopropenyl-2-oxazoline) (PiPOx) is a functional polymer that shows great potential for developing smart biomaterials. In this study, PiPOx-based cationic charged polymethacrylamides with amino acid side chains were synthesized, which can complex siRNA and promote in vitro transfection. The structures and properties of the (co)polymers were investigated through various analyses, and cationic copolymers with tryptophan and valine or proline side chains showed high transfection efficiency and potent gene silencing.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Atsushi Tamura, Mamoru Osawa, Nobuhiko Yui
Summary: Doxorubicin (DOX)-conjugated acid-degradable polyrotaxanes (PRXs) were designed as supramolecular drug carriers that release drug-modified alpha-cyclodextrins (alpha-CDs) in acidic cellular environments. The acid-induced cleavage of acid-labile stopper molecules in PRXs leads to PRX dissociation and the release of DOX-modified alpha-CDs under acidic conditions. The DOX-conjugated PRXs showed significant cytotoxicity in colon-26 cells and the released DOX-modified alpha-CDs accumulated in cellular nuclei. Acid-degradable PRXs represent a promising framework for pH-responsive drug carriers, contributing to the development of cancer therapies.
Article
Biochemistry & Molecular Biology
Zahra Norouzi, Majid Abdouss
Summary: Electrospun nanofibers based on beta-cyclodextrin grafted chitosan were developed as a drug delivery system for sustained release of indomethacin. The nanofibers showed selective, effective, and safe drug release, with their properties confirmed by various analyses. The nanofibers exhibited good wettability and favorable phys-icomechanical properties, and did not significantly inhibit cell growth, making them a promising option for orthopedic applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
David Perez-Alfonso, Manuel Lopez-Lopez, Pilar Lopez-Cornejo, Lucia Romero-Azogil, Elena Benito, Maria de Gracia Garcia-Martin, Clara B. Garcia-Calderon, Ivan V. Rosado, Fernando R. Balestra, Pablo Huertas, Margarita Garcia-Calderon, Maria Luisa Moya
Summary: In this study, a sugar-based cationic polymer PUArab derived from l-arabinitol was prepared and its interactions with linear calf thymus DNA and circular plasmid pEGFP-C1 were investigated at different N/P ratios. The polyplexes were characterized by several techniques, showing charge inversion and conformational changes in response to the nucleic acid architecture. PUArab exhibited low toxicity in various cell lines and showed potential as a vector in gene transfection based on transfection efficiency at different N/P ratios.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Applied
Junxin Zhao, Maomao Ma, Xianghui Yan, Dongman Wan, Zheling Zeng, Ping Yu, Deming Gong
Summary: The study successfully immobilized lipase on functionalized magnetic nanocomposites, showing higher stability and activity. The immobilized lipase exhibited good activity and stability under high temperature and alkaline conditions.
Article
Materials Science, Ceramics
Pei Yan Hao, Hui Yun Zhou, Li Jun Ren, Hui Jie Zheng, Jia Nan Tong, Ya Wei Chen, Hyun Jin Park
Summary: In this study, the β-cyclodextrin-grafted chitosan/glycerophosphate (CD-g-CS/GP) hydrogels were successfully synthesized and exhibited great potential for the controlled release of hydrophobic drugs. The hydrogels had a short gelation time, superior injection performance, suitable swelling behavior, and enhanced solubility and bioavailability of curcumin. Furthermore, the hydrogels showed good hemocompatibility and antibacterial activity against Staphylococcus aureus and Escherichia coli.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Zhongbin Zhang, Jinqing Chen, Linghui Zou, Jing Tang, Jiaxin Zheng, Meijiao Luo, Gang Wang, Dan Liang, Yuyang Li, Ben Chen, Hongjun Yan, Wenya Ding
Summary: CD-CS-BA-NPs were successfully prepared and demonstrated enhanced elimination of S. aureus biofilm, providing a potential reference for the development of anti-biofilm agents.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Lin Xiao, Weichang Xu, Lixia Huang, Jili Liu, Guang Yang
Summary: This study prepared nanocomposite (NC) pastes with unique viscoelastic properties and pH-responsive drug delivery ability. The NC pastes were made from gelatin and beta-cyclodextrin-grafted chitosan nanoparticles through host-guest interactions. The results showed that the NC pastes had reversible shear-thinning and self-healing properties, and could release drugs in a simulated tumoral microenvironment.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2023)
Article
Environmental Sciences
Lixun Zhang, Sunny C. Jiang, Yuntao Guan
Summary: A new composite material composed of poly(allyltrimethylammonium) grafted chitosan and biochar was introduced for efficient removal of selenate from water, exhibiting rapid and high-capacity adsorption with a pseudo-second-order kinetics model. The material showed great potential for removing anionic heavy metal ions due to its high efficiency and versatile application in a wide pH range. The main mechanisms of selenate removal were attributed to electrostatic interactions and redox-complexation interactions with specific functional groups on the composite.
ENVIRONMENTAL RESEARCH
(2021)
Article
Food Science & Technology
Jiaolong Wang, Zhiguo Jiang
Summary: The p-hydroxybenzoic acid-grafted chitosan conjugates showed enhanced antioxidant and antimicrobial activities, making them suitable for applications in active packaging, antioxidants, and preservatives. Products with higher grafting degrees exhibited stronger biological activities.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Shunyao Zhang, Atsushi Tamura, Nobuhiko Yui
Summary: The carboxylation modification of beta-CD PRXs significantly enhances their intracellular uptake efficiency, especially in both MSR-A positive and negative cells compared to unmodified beta-CD PRXs, with no cytotoxicity demonstrated in cell lines tested.
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
(2021)
Article
Polymer Science
Eva Mueller, Sebastian Himbert, Madeline J. Simpson, Markus Bleuel, Maikel C. Rheinstadter, Todd Hoare
Summary: The study demonstrates a novel approach for preparing degradable temperature/pH dual-responsive microgels with potential applications in drug delivery. These microgels exhibit dual-responsive swelling properties and degradability, making them suitable for drug delivery applications requiring dual pH/temperature-specific delivery at infection sites or cancer.
Article
Biochemistry & Molecular Biology
Jiying Men, Hongxing Shi, Chengya Dong, Yuanyuan Yang, Yuanrui Han, Ruixin Wang, Yiqing Zhang, Ting Zhao, Jun Li
Summary: A novel adsorbent with high adsorption capacity for cationic dyes was synthesized by graft polymerization of sodium 4-styrene sulfonate on the surface of magnetic chitosan microspheres. The adsorption performance was influenced by various experimental conditions, and the maximum adsorption capacity was found to be 989 mg/g at pH 1 and 25 degrees C. The grafted microspheres showed excellent adsorption capacity for methylene blue in aqueous solution.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Zahra Norouzi, Majid Abdouss
Summary: Considering the depletion of water resources, wastewater treatment is important for protecting the ecosystem and efficient use of water resources. In this study, beta-cyclodextrin was grafted onto chitosan to form beta-cyclodextrin grafted chitosan, which was further improved by developing nanofibers. The blend nanofibers were fabricated by electrospinning and their performance as molecular filters for removing hazardous materials from wastewater was investigated.
Article
Polymer Science
Priya Dhiman, Meenakshi Bhatia
Summary: In this study, quaternized cyclodextrin grafted chitosan nanoparticles entrapping ciprofloxacin were successfully prepared, showing sustained release behavior and high encapsulation efficiency.
JOURNAL OF POLYMER RESEARCH
(2021)
Article
Chemistry, Physical
Karam Nashwan Al-Milaji, Vinod Radhakrishnan, Prajakta Kamerkar, Hong Zhao
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2018)
Review
Chemistry, Multidisciplinary
Xiaokang Ding, Shun Duan, Xuejia Ding, Runhui Liu, Fu-Jian Xu
ADVANCED FUNCTIONAL MATERIALS
(2018)
Article
Engineering, Electrical & Electronic
Zhen Li, Karam Nashwan Al-Milaji, Hong Zhao, Da-Ren Chen
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2019)
Article
Chemistry, Multidisciplinary
Karam Nashwan Al-Milaji, Hong Zhao
Article
Chemistry, Multidisciplinary
Xin Jin, Yan-Hua Xiong, Xin-Yang Zhang, Renxian Wang, Yonggang Xing, Shun Duan, Dafu Chen, Wei Tian, Fu-Jian Xu
ADVANCED FUNCTIONAL MATERIALS
(2019)
Article
Nanoscience & Nanotechnology
Yujie Sun, Yu-Qing Zhao, Qiang Zeng, Yu-Wei Wu, Yang Hu, Shun Duan, Zhihui Tang, Fu-Jian Xu
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Biochemistry & Molecular Biology
Xin-Yang Zhang, Yu-Qing Zhao, Yidan Zhang, Anzhi Wang, Xiaokang Ding, Yang Li, Shun Duan, Xuejia Ding, Fu-Jian Xu
Article
Chemistry, Multidisciplinary
Yu-Qing Zhao, Yujie Sun, Yidan Zhang, Xiaokang Ding, Nana Zhao, Bingran Yu, Hong Zhao, Shun Duan, Fu-Jian Xu
Article
Biochemistry & Molecular Biology
Jiamin Lian, Haifeng Xu, Shun Duan, Xuejia Ding, Yang Hu, Nana Zhao, Xiaokang Ding, Fu-Jian Xu
Article
Chemistry, Multidisciplinary
Wei Tong, Xin Yao, Shun Duan, Bingran Yu, Xiaokang Ding, Xuejia Ding, Fu-Jian Xu
Article
Engineering, Biomedical
Yu-Qing Zhao, Ji-Hao Yang, Xiaokang Ding, Xuejia Ding, Shun Duan, Fu-Jian Xu
BIOACTIVE MATERIALS
(2020)
Article
Materials Science, Biomaterials
Yidan Zhang, Xiang Zhang, Yu-Qing Zhao, Xin-Yang Zhang, Xiaokang Ding, Xuejia Ding, Bingran Yu, Shun Duan, Fu-Jian Xu
BIOMATERIALS SCIENCE
(2020)
Article
Chemistry, Multidisciplinary
Ranran Wang, Xiaoguang Dai, Shun Duan, Nana Zhao, Fu-Jian Xu
Article
Materials Science, Biomaterials
Wei Tong, Yanhua Xiong, Shun Duan, Xiaokang Ding, Fu-Jian Xu
BIOMATERIALS SCIENCE
(2019)
Article
Nanoscience & Nanotechnology
Qijin Huang, Karam Nashwan Al-Milaji, Hong Zhao
ACS APPLIED NANO MATERIALS
(2018)
Article
Chemistry, Multidisciplinary
Laetitia Bardet, Herve Roussel, Stefano Saroglia, Masoud Akbari, David Munoz-Rojas, Carmen Jimenez, Aurore Denneulin, Daniel Bellet
Summary: The thermal instability of silver nanowires leads to increased electrical resistance in AgNW networks. Understanding the relationship between structural and electrical properties of AgNW networks is crucial for their integration as transparent electrodes in flexible optoelectronics. In situ X-ray diffraction measurements were used to study the crystallographic evolution of Ag-specific Bragg peaks during thermal ramping, revealing differences in thermal and structural transitions between bare and SnO2-coated AgNW networks.
Article
Chemistry, Multidisciplinary
Nathalia Cancino-Fuentes, Arnau Manasanch, Joana Covelo, Alex Suarez-Perez, Enrique Fernandez, Stratis Matsoukis, Christoph Guger, Xavi Illa, Anton Guimera-Brunet, Maria V. Sanchez-Vives
Summary: This study provides a comprehensive characterization of graphene-based solution-gated field-effect transistors (gSGFETs) for brain recordings, highlighting their potential clinical applications.
Article
Chemistry, Multidisciplinary
Sikandar Aftab, Hailiang Liu, Dhanasekaran Vikraman, Sajjad Hussain, Jungwon Kang, Abdullah A. Al-Kahtani
Summary: This study examines the effects of hybrid nanoparticles made of NiO@rGO and NiO@CNT on the active layers of polymer solar cells and X-ray photodetectors. The findings show that these hybrid nanoparticles can enhance the charge carrier capacities and exciton dissociation properties of the active layers. Among the tested configurations, the NiO@CNT device demonstrates superior performance in converting sunlight into electricity, and achieves the best sensitivity for X-ray detection.
Article
Chemistry, Multidisciplinary
Hyo Jung Shin, Seung Gyu Choi, Fengrui Qu, Min-Hee Yi, Choong-Hyun Lee, Sang Ryong Kim, Hyeong-Geug Kim, Jaewon Beom, Yoonyoung Yi, Do Kyung Kim, Eun-Hye Joe, Hee-Jung Song, Yonghyun Kim, Dong Woon Kim
Summary: This study investigates the role of SOX9 in reactive astrocytes following ischemic brain damage using a PLGA nanoparticle plasmid delivery system. The results demonstrate that PLGA nanoparticles can reduce ischemia-induced neurological deficits and infarct volume, providing a potential opportunity for stroke treatment.
Article
Chemistry, Multidisciplinary
Anurag Chaudhury, Koushik Debnath, Nikhil R. Jana, Jaydeep K. Basu
Summary: The study investigates the interaction between nanoparticles and cell membranes, and identifies key parameters, including charge, crowding, and membrane fluidity, that determine the adsorbed concentration and unbinding transition of nanoparticles.
Article
Chemistry, Multidisciplinary
Sina Sadeghi, Fazel Bateni, Taekhoon Kim, Dae Yong Son, Jeffrey A. Bennett, Negin Orouji, Venkat S. Punati, Christine Stark, Teagan D. Cerra, Rami Awad, Fernando Delgado-Licona, Jinge Xu, Nikolai Mukhin, Hannah Dickerson, Kristofer G. Reyes, Milad Abolhasani
Summary: In this study, an autonomous approach for the development of lead-free metal halide perovskite nanocrystals is presented, which integrates a modular microfluidic platform with machine learning-assisted synthesis modeling. This approach enables rapid and optimized synthesis of copper-based lead-free nanocrystals.
Article
Chemistry, Multidisciplinary
Zahir Abbas, Nissar Hussain, Surender Kumar, Shaikh M. Mobin
Summary: The rational construction of free-standing and flexible electrodes for electrochemical energy storage devices is an emerging research focus. In this study, a redox-active metal-organic framework (MOF) was prepared on carbon nanofibers using an in situ approach, resulting in a flexible electrode with high redox-active behavior and unique properties such as high flexibility and lightweight. The prepared electrode showed excellent cyclic retention and rate capability in supercapacitor applications. Additionally, it could be used as a freestanding electrode in flexible devices at different bending angles.
Article
Chemistry, Multidisciplinary
Lishan Zhang, Xiaoting Zhang, Hui Ran, Ze Chen, Yicheng Ye, Jiamiao Jiang, Ziwei Hu, Miral Azechi, Fei Peng, Hao Tian, Zhili Xu, Yingfeng Tu
Summary: Photodynamic therapy (PDT) is a promising local treatment modality in cancer therapy, but its therapeutic efficacy is restricted by ineffective delivery of photosensitizers and tumor hypoxia. In this study, a phototactic Chlorella-based near-infrared (NIR) driven green affording-oxygen microrobot system was developed for enhanced PDT. The system exhibited desirable phototaxis and continuous oxygen generation, leading to the inhibition of tumor growth in mice. This study demonstrates the potential of using a light-driven green affording-oxygen microrobot to enhance photodynamic therapy.
Article
Chemistry, Multidisciplinary
Yujin Li, Jing Xu, Xinqi Luo, Futing Wang, Zhong Dong, Ke-Jing Huang, Chengjie Hu, Mengyi Hou, Ren Cai
Summary: In this study, hollow heterostructured materials were constructed using an innovative template-engaged method as cathodes for zinc-ion batteries. The materials exhibited fast Zn2+ transport channels, improved electrical conductivity, and controlled volume expansion during cycling. The designed structure allowed for an admirable reversible capacity and high coulombic efficiency.
Article
Chemistry, Multidisciplinary
Paritosh Mahato, Shashi Shekhar, Rahul Yadav, Saptarshi Mukherjee
Summary: This study comprehensively elucidates the role of the core and electrostatic surface of metal nanoclusters in catalytic reduction reactions. The electrostatic surface dramatically modulates the reactivity of metal nanoclusters.
Article
Chemistry, Multidisciplinary
Pei Liu, Mengdi Liang, Zhengwei Liu, Haiyu Long, Han Cheng, Jiahe Su, Zhongbiao Tan, Xuewen He, Min Sun, Xiangqian Li, Shuai He
Summary: This study demonstrates a simple and environmentally-friendly method for the synthesis of zinc oxide nanozymes (ZnO NZs) using wasted hop extract (WHE). The WHE-ZnO NZs exhibit exceptional peroxidase-like activity and serve as effective catalysts for the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide (H2O2). In addition, a straightforward colorimetric technique for detecting both H2O2 and glucose was developed using the WHE-ZnO NZs as peroxidase-like catalysts.
Article
Chemistry, Multidisciplinary
Hyunkyu Oh, Young Jun Lee, Eun Ji Kim, Jinseok Park, Hee-Eun Kim, Hyunsoo Lee, Hyunjoo Lee, Bumjoon J. Kim
Summary: Mesoporous carbon particles have unique structural properties that make them suitable as support materials for catalytic applications. This study investigates the impact of channel nanostructures on the catalytic activity of porous carbon particles (PCPs) by fabricating PCPs with controlled channel exposure on the carbon surface. The results show that PCPs with highly open channel nanostructures exhibit significantly higher catalytic activity compared to those with closed channel nanostructures.
Article
Chemistry, Multidisciplinary
Yunjie Lu, Zhaohui Li, Zewei Li, Shihao Zhou, Ning Zhang, Jianming Zhang, Lu Zong
Summary: A tough, long-lasting adhesive and highly conductive nanocomposite hydrogel (PACPH) was fabricated via the synergy of interfacial entanglement and adhesion group densification. PACPH possesses excellent mechanical properties, interfacial adhesion strength, and conductivity, making it a promising material for long-term monitoring of human activities and electrocardiogram signals.
Article
Chemistry, Multidisciplinary
Zichao Wei, Audrey Vandergriff, Chung-Hao Liu, Maham Liaqat, Mu-Ping Nieh, Yu Lei, Jie He
Summary: We have developed a simple method to prepare polymer-grafted plasmonic metal nanoparticles with pH-responsive surface-enhanced Raman scattering. By using pH-responsive polymers as ligands, the aggregation of nanoparticles can be controlled, leading to enhanced SERS. The pH-responsive polymer-grafted nanoparticles show high reproducibility and sensitivity in solution, providing a novel approach for SERS without the need for sample pre-concentration.
Article
Chemistry, Multidisciplinary
Melis Ozge Alas Colak, Ahmet Gungor, Merve Buldu Akturk, Emre Erdem, Rukan Genc
Summary: This research investigates the effect of functionalizing carbon dots with hydroxyl polymers on their performance as electrode materials in a supercapacitor. The results show that the functionalized carbon dots exhibit excellent electrochemical performance and improved stability.