期刊
NANOSCALE
卷 7, 期 37, 页码 15185-15190出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5nr03303a
关键词
-
类别
资金
- NCI Centers of Cancer Nanotechnology Excellence (CCNE) Program [U54CA119338]
- Start-up fund from Nanjing University
- NATIONAL CANCER INSTITUTE [U54CA119338] Funding Source: NIH RePORTER
Tumor targeting agents including antibodies, peptides, and small molecules, are often used to improve the delivery efficiency of nanoparticles. Despite numerous studies investigating the abilities of targeting agents to increase the accumulation of nanosized therapeutics within diseased tissues, little attention has been focused on how these ligands can affect the self-assembly of the nanoparticle's modified polymer constituents upon chemical conjugation. Here we present an actively tumor targeted nanoparticle constructed via the self-assembly of a folate modified heparin. Folate conjugation unexpectedly allowed the self-assembly of heparin, where a majority of the folate molecules (>80%) resided inside the core of the nanoparticle. The folate-heparin nanoparticles could also physically encapsulate lipophilic fluorescent dyes, enabling the use of the constructs as activatable fluorescent probes for targeted in vivo tumor imaging.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据