Article
Biochemistry & Molecular Biology
Peixian Chen, Yumin Cao, Shenren Chen, Zhike Liu, Shiyi Chen, Yali Guo
Summary: This study evaluated the effects of genetic variations in organic cation transporter genes on the response to metformin treatment in diabetic patients. The results showed significant associations between variations in SLC47A1 and SLC47A2 genes and metformin efficacy, suggesting that these variations could be predictors of insulin resistance.
Article
Health Care Sciences & Services
Malek Zihlif, Amer Imraish, Baeth Al-Rawashdeh, Aya Qteish, Raihan Husami, Rawand Husami, Farah Tahboub, Yazun Jarrar, Su-Jun Lee
Summary: This study found a statistically significant association between multiple ADAM33 genetic polymorphisms and IgE levels, particularly showing a significant relationship between V4 polymorphism and IgE levels in both adults and children. Such findings add to the growing evidence that the ADAM33 gene has a major impact on IgE levels among asthmatic patients of Jordanian origin.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Allergy
Zaid W. El-Husseini, Judith M. Vonk, Maarten van den Berge, Reinoud Gosens, Gerard H. Koppelman
Summary: Through correlation analysis, we identified 69 asthma-associated single nucleotide polymorphisms (SNPs), with 20 SNPs being associated with multiple traits. The most pleiotropic SNP was annotated to SMAD3 gene. There were a total of 42 SNPs associated with eosinophil counts, 18 SNPs associated with airway obstruction, and 21 SNPs associated with atopy. We also identified genetically driven pathways regulating eosinophilia and found drug targets for eosinophilic asthma.
CLINICAL AND TRANSLATIONAL ALLERGY
(2023)
Article
Genetics & Heredity
Byung-Woo Yoon, Hyun-Tae Shin, Jehyun Seo
Summary: This study provides insights into the genetic causes of differences in vitamin D concentrations among individuals of diverse ancestries. The analysis reveals distinct genetic patterns among different populations, with the genetic risk score for vitamin D concentration highest in Europeans followed by East Asians and Africans. The study suggests that genetic factors play a more significant role in vitamin D concentration differences than latitude effects.
Article
Medicine, General & Internal
Hua Huang, Jiangyan He, Dongyang Deng, Rong Chen, Yiyuan Zhou
Summary: This retrospective study aims to identify the single nucleotide polymorphisms (SNPs) of 5,10-methylenetetrahydrofolate reductase (MTHFR) (C677T, A1298C), methionine synthase reductase (MTRR) (A66G) and explore their correlation with folate metabolism risk in pregnant women. The study analyzed the demographic data of 8735 pregnant women and tested their blood samples. The results showed that certain genotypes of MTHFR C677T and MTRR A66G were significantly related to the risk levels of folate metabolism.
Article
Agriculture, Dairy & Animal Science
Xufang Ren, Zi Guan, Haiying Li, Junhui Wen, Xiurong Zhao, Gang Wang, Xinye Zhang, Huie Wang, Li Zhang, Fuqing Yu, Lujiang Qu
Summary: This study investigated the population genetic structure and admixture of 5 Chinese gamecock breeds and their admixture with 9 other indigenous Chinese chicken breeds. The results showed that different gamecock breeds were grouped into different clusters. Gene flow was observed between gamecocks and indigenous chickens. Ancestral component analysis revealed the important role of modern domestic chickens in the history of Chinese gamecock domestication and evolution.
Article
Biochemistry & Molecular Biology
Jordi Olloquequi, Patricia Castro-Santos, Roberto Diaz-Pena
Summary: Latin-American populations have been underrepresented in genomic studies of drug response and disease susceptibility. This study compared the frequency of gene variants involved in drug response among a Chilean population and others using the 1000 Genomes Project data. Several gene variants were found to have low prevalence in Chileans compared to other populations, and two markers showed significant differences between different Mapuche ancestry groups. These findings emphasize the importance of considering ancestry in pharmacogenetic studies and provide a pharmacogenetic landscape of an understudied Latin American population.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Agnieszka Jelen, Rafal Swiechowski, Marta Zebrowska-Nawrocka, Aleksandra Salagacka-Kubiak, Dagmara Szmajda-Krygier, Piotr Ga Lecki, Ewa Balcerczak
Summary: This study evaluated the association between ABCB1 gene polymorphism and depression, as well as the effectiveness of its treatment. The results showed that T-129C does not play an important role in rDD development, but other studied SNPs do have an additive impact on the course of depression and its treatment effectiveness.
Article
Plant Sciences
Kevin A. Bird, Michael A. Hardigan, Aaron P. Ragsdale, Steven J. Knapp, Robert VanBuren, Patrick P. Edger
Summary: The research revealed that the two octoploid strawberry species are monophyletic sister lineages. Genetic clustering results showed substructure between North and South American F. chiloensis populations. Model-based and tree-based methods supported gene flow within and among the two octoploid species, including newly identified admixture in the Hawaiian F. chiloensis subsp. sandwicensis population.
AMERICAN JOURNAL OF BOTANY
(2021)
Article
Biochemistry & Molecular Biology
Maria Radanova, Mariya Levkova, Galya Mihaylova, Rostislav Manev, Margarita Maneva, Rossen Hadgiev, Nikolay Conev, Ivan Donev
Summary: There is a growing interest in studying single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes, as they may be associated with susceptibility, prognosis, and treatment response in colorectal cancer (CRC). These miRNA-SNPs could serve as non-invasive biomarkers for early detection of CRC. However, contradictory findings have been reported when different research groups investigated the same SNP in a gene for a specific miRNA, highlighting the need for more case-control studies involving participants from different ethnic backgrounds. According to our review, three miRNA-SNPs - miR-146a rs2910164, miR-27a rs895819, and miR-608 rs4919510 - appear to be promising prognostic, diagnostic, and predictive biomarkers for CRC.
Article
Plant Sciences
Lovepreet Singh, Yanqi Wu, James D. McCurdy, Barry R. Stewart, Marilyn L. Warburton, Brian S. Baldwin, Hongxu Dong
Summary: This study investigated the genetic diversity of 206 bermudagrass accessions using genetic markers. Four subpopulations were identified, indicating a high level of genetic variation in bermudagrass. These findings provide valuable resources for further breeding programs and cultivar development.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Siqing Ma, Zhiying Luo, Xinmin Zhou, Honghao Zhou, Ling Chen, Wei Zhang
Summary: Warfarin is commonly used for preventing thromboembolism, with vitamin K playing a crucial role in its anticoagulant effect. Variations in NPC1L1 and p53 genes were investigated for their impact on warfarin dosage, revealing that CYP2C9*3 and VKORC1 rs9923231 are likely independent predictors of warfarin stable dose in Chinese heart valve replacement surgical patients.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Prajjval Pratap Singh, Sachin Kumar, Nagarjuna Pasupuleti, P. R. Weerasooriya, George van Driem, Kamani H. Tennekoon, Niraj Rai, Gyaneshwer Chaubey, R. Ranasinghe
Summary: The Sinhalese population in Sri Lanka has been genetically studied, revealing their homogeneity and a trace of North Indian affiliation.
Article
Biochemistry & Molecular Biology
Justyna Basak, Danuta Piotrzkowska, Ireneusz Majsterek, Ewa Kucharska
Summary: Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system with no cure and unclear etiology. This study aimed to identify SNPs associated with an increased risk of developing MS. The findings suggest that the GG AGO1 rs636832 and AA GEMIN4 rs7813 genotypes are associated with an increased risk of MS.
Article
Immunology
Linfa Chen, Xinglan Chen, Yajun Wang, Shengnan Li, Shaoting Huang, Zhaochun Wu, Jiawen He, Shaofeng Chen, Fu Deng, Peiyi Zhu, Wangtao Zhong, Bin Zhao, Guoda Ma, You Li
Summary: This study evaluated the correlation between calgranulin gene variants and susceptibility to ischemic stroke in the Southern Chinese population. The results showed that certain calgranulin gene variants were associated with an increased or decreased risk of stroke. Additionally, specific haplotypes were also linked to an increased risk of stroke. Furthermore, the gene variants were associated with stroke subtypes and clinical characteristics.
JOURNAL OF INFLAMMATION RESEARCH
(2022)