Article
Immunology
Xiaoming Zhang, Laura Kracht, Antonio M. Lerario, Marissa L. Dubbelaar, Nieske Brouwer, Evelyn M. Wesseling, Erik W. G. M. Boddeke, Bart J. L. Eggen, Susanne M. Kooistra
Summary: This study provides insight into epigenetic profiles and transcription factor networks associated with transcriptional signatures of tolerized and trained microglia in vivo, leading to a better understanding of innate immune memory of microglia.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Chemistry, Multidisciplinary
Huizhe Wang, Xiaohui Xiong, Jiaqi Zhang, Meicen Wu, Yinhui Gu, Yanli Chen, Yueqing Gu, Peng Wang
Summary: This study found that CycNHOH NPs and CypNHOH NPs can activate innate immunity by accelerating the DNA damage process through phototherapy and releasing immunogenic cell death, providing a new direction for the development of photo-immunotherapy.
Review
Biochemistry & Molecular Biology
Zhiyuan Zhang, Ruiying Niu, Longhao Zhao, Yufei Wang, Guangwei Liu
Summary: Neutrophils, a crucial part of the innate immune system, play various roles in disease defense including phagocytosis, degranulation, production of reactive oxygen species, and the formation of NETs. Recent research has shown that NETs have bidirectional regulation in cancer, both promoting and inhibiting its development. Understanding the molecular and cellular mechanisms behind NET formation in cancer is crucial for developing new therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Xiao Wang, Huawei Xia, Shengde Liu, Lili Cao, Fuping You
Summary: The emergence of life-threatening viruses poses challenges to public health, with epigenetics playing a crucial role in host-virus interactions. Understanding these interactions through an epigenetic lens may offer therapeutic opportunities. This review discusses the roles of chromatin remodeling, histone modification, and m6A RNA modification in modulating chromatin openness during host defense against viruses, highlighting the need for future research in this area.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Otorhinolaryngology
Henrique Ochoa Scussiatto, Kristen E. Wroblewski, Kristina L. Pagel, L. Phillip Schumm, Martha K. McClintock, Murray Ramanathan Jr, Helen H. Suh, Jayant M. Pinto
Summary: This study found that long-term exposure to PM2.5 air pollution is associated with rhinitis in older adults. The immune factors IL-3, IL-12, and IFN-γ are also found to play a role in this relationship.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Review
Immunology
Haidy A. Saleh, Mohamed H. Yousef, Anwar Abdelnaser
Summary: The innate immune response triggers inflammation and maintains immune homeostasis through epigenetic modifications. Studies have shown the significant impact of epigenetic changes in inflammatory diseases and tumor development, while also highlighting the potential of naturally-derived phytochemicals in regulating these processes.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Gastroenterology & Hepatology
Hua-Jun Zhao, Yi-Fei Hu, Qiu-Ju Han, Jian Zhang
Summary: This review provides a detailed explanation of the immunological and biological characteristics of chronic hepatitis B virus infection, as well as the escape mechanisms of the virus. It also discusses novel immune-based therapies for treating hepatitis B virus.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Oncology
Anneloes van Duijn, Sjoerd H. Van der Burg, Ferenc A. Scheeren
Summary: This article focuses on the interactions between myeloid immune cells and anti-tumor immune responses in the tumor microenvironment. Blocking the CD47/SIRP alpha axis can enhance adaptive immune response. The potential therapeutic role of CD47/SIRP alpha axis is discussed in tumors with acquired resistance to classic immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Cell Biology
Arailym Aronova, Federica Tosato, Nawraa Naser, Yaw Asare
Summary: Innate immune pathways play a crucial role in the development of atherosclerosis and targeting these pathways may effectively reduce the risk of cardiovascular disease. Understanding the interplay between these pathways and the long-term reprogramming of immune cells is essential for the development of targeted therapeutic interventions.
Review
Microbiology
Xiaojiao Fan, Lianying Jiao, Tengchuan Jin
Summary: This article summarizes the recent advances in understanding the activation and immune regulation mechanisms of the PYHIN family during microbial infection, and provides accurate insights into the signaling mechanisms of PYHIN family receptors through structural characterizations of AIM2, IFI16, p202, and p204.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Integrative & Complementary Medicine
Wei Meng, Li Yu, Xiong Chan, Liu Yefang, Liang Fanrong, Mao Bing, Miao Tiwei, Huang Ying, Zhu Yijing, Fu Juanjuan
Summary: Chronic respiratory diseases (CRDs) are common globally and acupuncture, derived from Traditional Chinese Medicine, has been proven effective and safe for treating CRDs. Recent scientific research has advanced our understanding of the diverse immune regulatory mechanisms underlying the beneficial effects of acupuncture. This knowledge provides a scientific basis for the clinical use of acupuncture in the treatment of CRDs.
JOURNAL OF TRADITIONAL CHINESE MEDICINE
(2022)
Review
Immunology
Trevor Ung, Nakisha S. Rutledge, Adam M. Weiss, Aaron P. Esser-Kahn, Peter Deak
Summary: This article summarizes the recent advancements in immunology and chemistry in targeted vaccine technology, including cellular targets, methods of targeting, and their effects on immune responses. The relationships between vaccine targets and subsequent adaptive immune responses are crucial for effective vaccine design, potentially leading to more effective, disease-specific vaccines.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Tianmeng Yan, Zhenying Zhang
Summary: Bullous pemphigoid (BP) is an autoimmune blistering disease primarily affecting elderly individuals. It presents with heterogeneous manifestations, typically characterized by microscopically subepidermal separation and mixed inflammatory infiltrate. The development mechanism of BP remains unclear. B cells are involved in pathogenic autoantibody production, and other immune cells such as T cells, type II inflammatory cytokines, eosinophils, mast cells, neutrophils, and keratinocytes also contribute to the pathogenesis of BP. This review focuses on the roles and crosstalk between innate and adaptive immune cells in BP.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
George W. Burke III, Alla Mitrofanova, Antonio Fontanella, Gaetano Ciancio, David Roth, Phil Ruiz, Carolyn Abitbol, Jayanthi Chandar, Sandra Merscher, Alessia Fornoni
Summary: This article focuses on the podocyte as the target of circulating factors causing recurrent proteinuria in patients with FSGS after kidney transplantation. Studies involving pre- and post-reperfusion biopsies, as well as in vitro podocyte liquid biopsies/assays, have provided insights into new pathways and potential therapeutic targets. The successful use of immunomodulating agents, such as rituximab and abatacept, suggests direct effects on the podocyte beyond immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Xinrui Wang, Donghong Yu, Lu Chen
Summary: The widespread use of antibiotics has led to a global issue of pathogen resistance. Traditional mechanisms of resistance have focused on genetic and biochemical factors, but there is evidence that epigenetic modifications also play a role. This review discusses the effects of DNA modification, histone modification, rRNA methylation, and non-coding RNAs on antimicrobial resistance, and highlights the role of DNA methyltransferases and non-coding RNAs in regulating gene expression and adaptation to antibiotic stress. Epigenetics offers new avenues for antibiotic target selection and the development of novel antibiotics.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Allergy
Robert Naclerio, Ignacio J. Ansotegui, Jean Bousquet, G. Walter Canonica, Gennaro D'Amato, Nelson Rosario, Ruby Pawankar, David Peden, Karl-Christian Bergmann, Leonard Bielory, Luis Caraballo, Lorenzo Cecchi, S. Alfonso M. Cepeda, Herberto Jose Chong Neto, Carmen Galan, Sandra N. Gonzalez Diaz, Samar Idriss, Todor Popov, German D. Ramon, Erminia Ridolo, Menachem Rottem, Wisuwat Songnuan, Philip Rouadi
WORLD ALLERGY ORGANIZATION JOURNAL
(2020)
Review
Allergy
Michael Levin, Ignacio J. Ansotegui, Jonathan Bernstein, Yoon-Seok Chang, Manana Chikhladze, Motohiro Ebisawa, Alessandro Fiocchi, Enrico Heffler, Bryan Martin, Mario Morais-Almeida, Nikolaos G. Papadopoulos, David Peden, Gary W. K. Wong
WORLD ALLERGY ORGANIZATION JOURNAL
(2020)
Review
Allergy
Mario Morais-Almeida, Rita Aguiar, Bryan Martin, Ignacio J. Ansotegui, Motohiro Ebisawa, L. Karla Arruda, Marco Caminati, Giorgio Walter Canonica, Tara Carr, Geoffrey Chupp, Jonathan Corren, Ignacio Davila, Hae-Sim Park, Nicola A. Hanania, Lanny Rosenwasser, Mario Sanchez-Borges, J. Christian Virchow, Anahi Yanez, Jonathan A. Bernstein, Luis Caraballo, Yoon-Seok Chang, Manana Chikhladze, Alessandro Fiocchi, Sandra N. Gonzalez-Diaz, Luciana Kase Tanno, Michael Levin, Jose Antonio Ortega-Martell, Giovanni Passalacqua, David B. Peden, Philip W. Rouadi, James L. Sublett, Gary W. K. Wong, Eugene R. Bleecker
WORLD ALLERGY ORGANIZATION JOURNAL
(2020)
Letter
Toxicology
Allison J. Burbank, Michelle L. Hernandez, Carole Robinette, Ting Wang, Haibo Zhou, Neil Alexis, William D. Bennett, David B. Peden
INHALATION TOXICOLOGY
(2020)
Article
Microbiology
Amir Barzin, John L. Schmitz, Samuel Rosin, Rameet Sirpal, Martha Almond, Carole Robinette, Samantha Wells, Michael Hudgens, Andrew Olshan, Stephanie Deen, Patrick Krejci, Eugenia Quackenbush, Kevin Chronowski, Caleb Cornaby, Janette Goins, Linda Butler, Julia Aucoin, Kim Boyer, Janet Faulk, Devena Alston-Johnson, Cristen Page, Yijun Zhou, Lynne Fiscus, Blossom Damania, Dirk P. Dittmer, David B. Peden
Review
Allergy
Philip W. Rouadi, Samar A. Idriss, Robert M. Naclerio, David B. Peden, Ignacio J. Ansotegui, Giorgio Walter Canonica, Sandra Nora Gonzalez-Diaz, Nelson A. Rosario Filho, Juan Carlos Ivancevich, Peter W. Hellings, Margarita Murrieta-Aguttes, Fares H. Zaitoun, Carla Irani, Marilyn R. Karam, Jean Bousquet
WORLD ALLERGY ORGANIZATION JOURNAL
(2020)
Letter
Critical Care Medicine
Michelle L. Hernandez, Sally Ivins, Kelly Chason, Allison J. Burbank, Meghan E. Rebuli, Aaron Kobernick, Stephen A. Schworer, Haibo Zhou, Neil E. Alexis, David B. Peden
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Allergy
Nelson Augusto Rosario Filho, Marilyn Urrutia-Pereira, Gennaro D'Amato, Lorenzo Cecchi, Ignacio J. Ansotegui, Carmen Galan, Anna Pomes, Margarita Murrieta-Aguttes, Luis Caraballo, Philip Rouadi, Isabella Annesi-Maesano, Ruby Pawankar, Herberto J. Chong-Neto, David B. Peden
Summary: Indoor environments significantly contribute to human exposure to air pollutants, especially affecting the health of children and adults. Education, community, and health professional involvement can help reduce household pollutants and promote health.
WORLD ALLERGY ORGANIZATION JOURNAL
(2021)
Article
Allergy
Luciana Kase Tanno, Pascal Demoly, Bryan Martin, Jonathan Berstein, Mario Morais-Almeida, Michael Levin, Alessandro Fiocchi, Mario Sanchez-Borges, Luis R. Caraballo, Gary Wong, Jose Antonio Ortega-Martell, Philip Rouadi, Anahi Yanez, Liang Lu Wang, David B. Peden, Manana Chikhladze, Sandra N. Gonzalez-Diaz, Jean-Francois Fontainet, James Sublett, Yoon-Seok Chang, Giovanni Passalacqua, Ignacio J. Ansotegui, Motohiro Ebisawa, Gianenrico Senna, Marco Caminati
Summary: The COVID-19 outbreak posed unprecedented challenges to the world, prompting the allergy societies to produce guidance documents. An international survey revealed that managing allergic patients during the pandemic does not increase the risk of contracting COVID-19. This data can serve as a starting point for feedback on recommendations and new strategies for healthcare professionals.
WORLD ALLERGY ORGANIZATION JOURNAL
(2021)
Editorial Material
Respiratory System
Isabella Annesi-Maesano, Francesco Forastiere, John Balmes, Erika Garcia, Jack Harkema, Stephen Holgate, Frank Kelly, Haneen Khreis, Barbara Hoffmann, Cara Nichole Maesano, Rob McConnell, David Peden, Kent Pinkerton, Tamara Schikowski, George Thurston, Laura S. Van Winkle, Christopher Carlsten
EUROPEAN RESPIRATORY JOURNAL
(2021)
Editorial Material
Allergy
David B. Peden
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Computer Science, Information Systems
Ridwan Alam, David B. Peden, John C. Lach
Summary: This study explores inferring respiratory parameters from wearable ECG and wrist motion signals and proposes a modular and generalizable classification-regression pipeline to learn context-conditioned inference models, including physical activity. Evaluations on data from 15 subjects highlight the potential of wearable sensors not only in continuous monitoring, but also in designing biomarker-driven preventive measures.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2021)
Article
Biochemistry & Molecular Biology
Qing Jiang, Suji Im, James G. Wagner, Michelle L. Hernandez, David B. Peden
Summary: Studies have shown that gamma T has unique antioxidant and anti-inflammatory activities compared to alpha T, providing superior protection for mitochondrial function.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Health Care Sciences & Services
Karamarie Fecho, Stanley C. Ahalt, Stephen Appold, Saravanan Arunachalam, Emily Pfaff, Lisa Stillwell, Alejandro Valencia, Hao Xu, David B. Peden
Summary: This study demonstrates the use of the open-source ICEES as a tool for exposing and exploring integrated clinical and environmental data. The results show significant associations between factors such as proximity to major roadways or highways, exposure to high levels of particulate matter or ozone, female sex, Caucasian race, low residential density, lack of health insurance, low household income, and asthma exacerbations.
JMIR FORMATIVE RESEARCH
(2022)
Article
Respiratory System
William D. Bennett, Allison Burbank, Martha Almond, Jihong Wu, Agathe Ceppe, Michelle Hernandez, Richard C. Boucher, David B. Peden
Summary: The study showed that inhaling 7% hypertonic saline can acutely enhance mucociliary clearance in asthmatic patients, but this effect is not sustained 4 hours post-treatment. While not supporting maintenance therapy, these findings suggest a benefit for treating acute exacerbations in patients with moderate-severe asthma.