Article
Pharmacology & Pharmacy
Xiao-Li Zhang, Qi Sun, Zhu-Sheng Quan, Liang Wu, Zi-Ming Liu, Yan-Qi Xia, Qian-Yi Wang, Yue Zhang, Jin-Xia Zhu
Summary: This study found that dopamine promotes the secretion of colonic glial cell-derived neurotrophic factor (GDNF) via D1 receptors on cholinergic neurons, while high concentrations of dopamine inhibit GDNF secretion via D2 receptors on enteric glial cells (EGCs) and/or cholinergic neurons.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Immunology
Jacob C. Zbesko, Jennifer Beischel Frye, Danielle A. Becktel, Diana K. Gerardo, Jessica Stokes, Kylie Calderon, Thuy-Vi V. Nguyen, Deepta Bhattacharya, Kristian P. Doyle
Summary: The text explores the activation of B-lymphocytes following stroke and their involvement in cognitive decline. The study found that B-lymphocytes, T-lymphocytes, and plasma cells progressively infiltrate the infarct between 2 and 7 weeks after stroke. Additionally, a population of IgA + plasma cells develop independently of CD4 + helper T-lymphocytes and MyD88 signaling, producing natural antibodies.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Immunology
Stuart G. Tangye, Karrnan Pathmanandavel, Cindy S. Ma
Summary: B cells play a crucial role in host defense against infectious diseases, generating robust antibody responses and contributing to humoral immunity and serological memory. However, they can also lead to various diseases, including autoimmunity and allergy. Understanding the molecular requirements for effective immune responses and controlling B-cell function is essential for disease prevention and treatment.
CURRENT OPINION IN IMMUNOLOGY
(2023)
Review
Nutrition & Dietetics
Liping Gan, Jinrong Wang, Yuming Guo
Summary: Polysaccharides are diverse molecules that can be extracted from a variety of edible materials. They interact with intestinal microbiota to have bioactive effects on human health. Recent research has focused on the roles of polysaccharides in gut health, obesity, and related disorders, and has explored the underlying mechanisms. This review provides insights into the structure and composition of polysaccharides and their effects on human health and disease.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Wei Song, Yuan-Jing Ren, Lu-Lu Liu, Ya-Ying Zhao, Qi-Fu Li, Hai-Bo Yang
Summary: The study revealed that curcumin induces apoptosis in HaCaT cells through both caspase-dependent and caspase-independent pathways, providing potential evidence for treating proliferative skin diseases, including skin cancer.
Article
Immunology
Anette T. Hansen Selno, Vadim V. V. Sumbayev, Bernhard F. F. Gibbs
Summary: Basophils play a crucial role in allergies and Th2-driven diseases by releasing inflammatory and immunomodulatory mediators. The responsiveness of basophils to IgE-mediated activation may be regulated by the expression of SERCA2, a calcium-regulating protein. This study found an inverse correlation between SERCA2 expression and basophil responsiveness, suggesting that SERCA2 may be an additional regulator of basophil reactivity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Andreas Walker, Tatjana Schwarz, Janine Brinkmann-Paulukat, Karin Wisskirchen, Christopher Menne, Elahe Salimi Alizei, Helenie Kefalakes, Martin Theissen, Daniel Hoffmann, Julian Schulze zur Wiesch, Mala K. K. Maini, Markus Cornberg, Anke R. M. Kraft, Verena Keitel, Hans H. H. Bock, Peter A. A. Horn, Robert Thimme, Heiner Wedemeyer, Falko M. M. Heinemann, Tom Luedde, Christoph Neumann-Haefelin, Ulrike Protzer, Joerg Timm
Summary: This study performed a high-resolution analysis of the core(18-27) specific CD8+ T cell and the selected escape pathways in patients with chronic HBV infection. The results demonstrate the promiscuous presentation of the core(18-27) epitope and the selection pressure on the epitope in the context of different HLA class I molecules. Some epitope variants showed evidence for impaired antigen processing and reduced presentation. These findings suggest the importance of considering epitope variants in T cell-based therapy strategies for chronic HBV infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Hongyan Ren, Tianyu Zhang, Yongren Wang, Qi Yao, Ziyu Wang, Luyao Zhang, Lixin Wang
Summary: Research has shown that DRibbles can efficiently induce proliferation and activation of human B cells, leading to the production of chemokines, cytokines and hematopoietic growth factors. Human B cells can effectively phagocytose DRibbles and cross-present antigens to activate memory T cells. These findings suggest the potential for clinical application of B-DRibbles vaccines.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell & Tissue Engineering
Marine Charrier, Judith Lorant, Rafael Contreras-Lopez, Gautier Tejedor, Christophe Blanquart, Blandine Lieubeau, Cindy Schleder, Isabelle Leroux, Sophie Deshayes, Jean-Francois Fonteneau, Candice Babarit, Antoine Hamel, Armelle Magot, Yann Pereon, Sabrina Viau, Bruno Delorme, Patricia Luz-Crawford, Guillaume Lamirault, Farida Djouad, Karl Rouger
Summary: The study demonstrates that hMuStem cells possess an immunosuppressive phenotype and can inhibit T-cell proliferation and cytotoxic response while promoting the generation of regulatory T cells through both direct contact and secretion of soluble factors. The secretion profile of hMuStem cells is shown to be superior to that of BM-MSCs. These findings reinforce the candidacy of hMuStem cells as therapeutic agents for MDs.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Immunology
Kirsty R. Field, Kathleen M. Wragg, Wen Shi Lee, Marc Rigau, Adam P. Uldrich, Stephen J. Kent, Jennifer A. Juno
Summary: V?9Vd2 T cells can recognize various molecules associated with cellular stress or transformation, providing a unique avenue for the treatment of cancers or infectious diseases. Enhancing the cytotoxic effector function of V?9Vd2 T cells is one potential avenue through which the immunotherapeutic potential of this subset may be improved.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jorge Mansilla-Soto, Justin Eyquem, Sascha Haubner, Mohamad Hamieh, Judith Feucht, Noemie Paillon, Andres Ernesto Zucchetti, Zhuoning Li, Maria Sjostrand, Pieter L. Lindenbergh, Michelle Saetersmoen, Anton Dobrin, Mathieu Maurin, Archana Iyer, Andreina Garcia Angus, Matthew M. Miele, Zeguo Zhao, Theodoros Giavridis, Sjoukje J. C. van der Stegen, Fella Tamzalit, Isabelle Riviere, Morgan Huse, Ronald C. Hendrickson, Claire Hivroz, Michel Sadelain
Summary: HLA-independent T cell receptors (HIT receptors) are a novel type of chimeric antigen receptors that can effectively target tumors with low antigen expression, surpassing the sensitivity of CD28-based receptors. They offer high antigen sensitivity and can recognize tumors beyond the capabilities of other CAR designs. The functional persistence of HIT T cells can be enhanced by coexpression of CD80 and 4-1BBL. HIT receptors have been validated in xenograft mouse models, targeting CD19 and CD70 in B cell leukemia and acute myeloid leukemia, respectively.
Article
Immunology
Clarissa Heck, Sophie Steiner, Eva M. Kaebisch, Marco Frentsch, Friedrich Wittenbecher, Carmen Scheibenbogen, Leif G. Hanitsch, Axel Nogai, Philipp le Coutre, Lars Bullinger, Igor-Wolfgang Blau, Il-Kang Na
Summary: This study revealed quantitative and functional B cell defects in multiple myeloma patients undergoing auto-HSCT, leading to compromised immune defense. Stimulation with CD40L/IL-21 partially restored TD B cell function, indicating potential extrinsic drivers of the functional B cell defect. Testing CD4+, CD19+, memory B cells, and MZ-like B cells as biomarkers in prospective studies is suggested.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Andrea Vecchione, Rachel Madley, Nichole Danzl, Chiara Borsotti, Mohsen Khosravi Marharlooei, Hao-Wei Li, Grace Nauman, Xiaolan Ding, Siu-Hong Ho, Georgia Fousteri, Megan Sykes
Summary: Interactions between B cells and CD4(+) T cells play a central role in the development of Type 1 Diabetes (T1D). Our study used a personalized immune (PI) mouse model to generate human immune systems de novo from hematopoietic stem cells (HSCs) of patients with T1D or healthy controls (HCs). T1D-derived immune systems showed increased numbers of Tph-like and Tfh cells compared to HC-derived PI mice. Our findings suggest that T1D HSCs are genetically programmed to produce increased proportions of T cells that promote the development of unconventional, possibly autoreactive memory B cells.
CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Casper Marsman, Dorit Verhoeven, Jana Koers, Theo Rispens, Anja ten Brinke, S. Marieke van Ham, Taco W. Kuijpers
Summary: The present study establishes optimized protocols for B-cell differentiation and Ig secretion in primary human B-cell and PBMC cultures, which require low amounts of cells and are suitable for clinical and research studies on B-cell-mediated diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Thet Su Win, William J. Crisler, Beatrice Dyring-Andersen, Rachel Lopdrup, Jessica E. Teague, Qian Zhan, Victor Barrera, Shannan Ho Sui, Sotirios Tasigiorgos, Naoka Murakami, Anil Chandraker, Stefan G. Tullius, Bohdan Pomahac, Leonardo Riella, Rachael A. Clark
Summary: This study analyzed rejection in face transplant patients and found that different rejection grades had unique immune responses, with grade 3 rejection leading to tissue injury. The study suggests enhancing cutaneous immunoregulatory networks as a potential strategy to combat rejection.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Allergy
Veronique Bordas-Le Floch, Nathalie Berjont, Thierry Batard, Nirupama Varese, Robyn E. O'Hehir, Walter G. Canonica, Menno C. van Zelm, Laurent Mascarell
Summary: This study found that after house dust mite immunotherapy, there is a significant increase in HDM-specific serum IgG2 responses among high responders. Subjects benefiting the most from HDM-AIT show a higher correlation between HDM-specific IgG2, IgE, and/or IgG4 responses, which may help differentiate between high and low responders.
Article
Immunology
Annieck M. Diks, Pauline Versteegen, Cristina Teodosio, Rick J. Groenland, Bas de Mooij, Anne-Marie Buisman, Alba Torres-Valle, Martin Perez-Andres, Alberto Orfao, Guy A. M. Berbers, Jacques J. M. van Dongen, Magdalena A. Berkowska
Summary: This study used high-dimensional flow cytometry to investigate changes in B cells after administration of an acellular pertussis booster vaccine. The results showed that the expansion and maturation of plasma cells were the most significant cellular changes post-vaccination, and were more pronounced in individuals primed with whole-cell vaccine.
Article
Allergy
Craig McKenzie, Nirupama Varese, Pei Mun Aui, Simone Reinwald, Bruce D. Wines, P. Mark Hogarth, Francis Thien, Mark Hew, Jennifer M. Rolland, Robyn E. O'Hehir, Menno C. van Zelm
Summary: Sublingual immunotherapy for grass pollen allergy can modify allergic rhinitis and increase allergen-specific IgG(4). This study found that SLIT induces two transcriptionally unique subsets of B memory cells, and the changes in surface-expressed proteins on these subsets can be used as early biomarkers for treatment effects.
Article
Clinical Neurology
Casper L. de Mol, Marvin M. van Luijn, Karim L. Kreft, Kirsten I. M. Looman, Menno C. van Zelm, Tonya White, Henriette A. Moll, Joost Smolders, Rinze F. Neuteboom
Summary: This study aimed to assess whether polygenic risk scores for MS are associated with changes in the blood B-cell compartment in children. The results showed that a naive B-cell-MS-PRS was significantly associated with lower naive B-cell numbers and higher frequencies and absolute numbers of memory B cells in children. The findings suggest that specific genetic risk variants may impact the composition of the blood B-cell compartment during childhood, potentially influencing MS pathophysiology later in life.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Letter
Allergy
Gemma E. Hartley, Emily S. J. Edwards, Nirupama Varese, Irene Boo, Pei M. Aui, Scott J. Bornheimer, P. Mark Hogarth, Heidi E. Drummer, Robyn E. O'Hehir, Menno C. van Zelm
Correction
Immunology
Bruce D. Wines, Liriye Kurtovic, Halina M. Trist, Sandra Esparon, Ester Lopez, Klasina Chappin, Li-Jin Chan, Francesca L. Mordant, Wen Shi Lee, Nicholas A. Gherardin, Sheila K. Patel, Gemma E. Hartley, Phillip Pymm, James P. Cooney, James G. Beeson, Dale I. Godfrey, Louise M. Burrell, Menno C. van Zelm, Adam K. Wheatley, Amy W. W. Chung, Wai-Hong Tham, Kanta Subbarao, Stephen J. Kent, P. Mark Hogarth
FRONTIERS IN IMMUNOLOGY
(2023)
Letter
Allergy
Nathalie Berjont, Veronique Bordas-Le Floch, Robyn E. O'Hehir, Walter G. Canonica, Menno C. van Zelm, Thierry Batard, Laurent Mascarell
Article
Allergy
Emily S. J. Edwards, Samar Ojaimi, James Ngui, Go Hun Seo, Jihye Kim, Sanjeev Chunilal, Deborah Yablonski, Robyn E. O'Hehir, Menno C. van Zelm
Summary: This study found that mutations in the LCP2 gene may lead to combined immunodeficiency and early-onset immune dysregulation. The authors investigated a patient with specific antibody deficiency, autoimmunity, and inflammatory bowel disease and identified compound heterozygous missense variants in the proline-rich repeat domain of the SLP76 protein.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Holly A. Fryer, Gemma E. Hartley, Emily S. J. Edwards, Nirupama Varese, Irene Boo, Scott J. Bornheimer, P. Mark Hogarth, Heidi E. Drummer, Robyn E. O'Hehir, Menno C. van Zelm
Summary: Following the COVID-19 pandemic, novel vaccines have successfully reduced severe disease and death. Despite lower antibody responses, adenoviral vector vaccines are nearly as effective as mRNA vaccines in providing protection against severe disease. This study evaluated the antibody and memory B cell responses elicited by the adenoviral vector vaccine ChAdOx1 (AstraZeneca), compared to the mRNA vaccine BNT162b2 (Pfizer-BioNTech), and found that ChAdOx1 induced immune memory that conferred effective protection against severe COVID-19.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Thierry Batard, Walter G. Canonica, Oliver Pfaar, Mohamed H. Shamji, Robyn E. O'Hehir, Menno C. van Zelm, Laurent Mascarell
Summary: Allergy to house dust mites (HDM) is a common respiratory disease that affects over 500 million people worldwide. The two main species of HDM, Dermatophagoides pteronyssinus and D. farinae, are major sources of indoor allergens that trigger allergic inflammation. While symptomatic drugs can help alleviate symptoms, allergen immunotherapy is the only curative treatment for IgE-mediated type I respiratory allergies. This article reviews recent advances in various routes of immunotherapy, with a focus on subcutaneous (SCIT) and sublingual (SLIT) immunotherapy, which have transformed allergic treatments by improving symptoms and quality of life for patients.
MOLECULAR IMMUNOLOGY
(2023)
Article
Neurosciences
Annieck M. M. Diks, Cristina Teodosio, Bas de Mooij, Rick J. J. Groenland, Brigitta A. E. Naber, Inge F. F. de Laat, Sandra A. A. Vloemans, Susan Rohde, Marien I. I. de Jonge, Linda Lorenz, Debbie Horsten, Jacques J. M. van Dongen, Magdalena A. A. Berkowska, Henne Holstege
Summary: The rs72824905 SNP in the PLCG2 gene is associated with protection against several dementia subtypes and increased likelihood of longevity. In human circulating peripheral immune cells, this variant has a slight impact on immune system function across multiple cell types. Carriers of the variant show increased sensitivity in B cells and myeloid cells, and elevated ROS production in myeloid cells.
MOLECULAR NEURODEGENERATION
(2023)
Article
Ophthalmology
Kiki van Bilsen, Daphne P. C. Vergouwen, Mirjam E. J. van Velthoven, Tom O. A. R. Missotten, Saskia M. M. Rombach, Menno C. C. van Zelm, Magdalena A. A. Berkowska, P. Martin van Hagen, Robert W. A. M. Kuijpers, Jan A. M. van Laar
Summary: This study reports the long-term effect of rituximab in scleritis and determines the value of B-cell monitoring for predicting relapses.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Medicine, Research & Experimental
Annieck M. Diks, Hans de Graaf, Cristina Teodosio, Rick J. Groenland, Bas de Mooij, Muktar Ibrahim, Alison R. Hill, Robert C. Read, Jacques J. M. van Dongen, Magdalena A. Berkowska
Summary: This study used high-dimensional flow cytometry to monitor the cellular responses to Bordetella pertussis challenge in the blood of 15 healthy donors. The results showed that individuals protected against colonization exhibited different early cellular responses compared to colonized individuals. These early cellular immune responses can be further characterized and potentially linked to an efficient mucosal immune response, ultimately evaluating the protective efficacy of new B. pertussis vaccine candidates.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Meeting Abstract
Medicine, General & Internal
Emily S. J. Edwards, Julian Bosco, Josh Chatelier, Go Hun Seo, Rin Khang, Pei M. Aui, Robyn E. O'Hehir, Menno C. van Zelm
INTERNAL MEDICINE JOURNAL
(2022)