Article
Chemistry, Analytical
Jian Lv, Xiao-Yuan Wang, Xin-Yue Zhou, Da-Wei Li, Ruo-Can Qian
Summary: This study presents a strategy for single cell perfusion and fluorescence labeling based on nanoscale glass nanopipettes. The use of the nanopipettes enables special perfusion and high-resolution fluorescence labeling of different subcellular regions in single cells of interest. The feasibility of the nanopipette-dependent targeted delivery is demonstrated through the study of various fluorescent probes. The findings highlight the valuable ability of the nanopipette-based method for the analysis of specially defined subcellular regions and its potential applications in single cell surgery, subcellular manipulation, and gene delivery.
ANALYTICAL CHEMISTRY
(2022)
Article
Engineering, Environmental
Zihua Shao, Jintang Wang, Echuan Wang, Yujing Bai, Jian Li, Kaihe Lv, Chenlong Fu, Ren Wang, Longqiao Chen, Jinsheng Sun
Summary: This study proposes a novel method to improve the efficiency of natural gas hydrate exploitation by using polysaccharide-coated calcium oxide microcapsules as an in-situ heat source. By altering the preparation method, the heat release time is prolonged, and the hydration resistance mechanism of hydrophobic modification and multilayer coatings is revealed. Ultimately, this method successfully reduces the methane release rate and improves the efficiency of hydrate exploitation.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Food Science & Technology
Yuyan Xu, Mingsheng Dong, Hongmei Xiao, Siew Young Quek, Yukiharu Ogawa, Guangyuan Ma, Chuang Zhang
Summary: Probiotic powders produced by spray drying have advantages of high efficiency, cost-saving, and good powder properties. However, the harsh drying and digestion processes can reduce cell viability, limiting the effectiveness of live cells. Therefore, there is a need to develop targeted delivery systems using spray drying to protect bacteria and maintain their physiological functions. This review highlights recent studies on spray-dried targeted delivery vehicles for probiotics, focusing on strategies to protect bacteria, particle formation mechanism, and the targeted release and colonization of live cells. Further research is needed to improve the functional properties of microcapsules and understand the effects of spray drying on bacterial physiology for industrialization and commercialization.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Microbiology
Hongyang Lin, Yang Yang, Yongxia Li, Xuedong Feng, Qiuhong Li, Xiaoyin Niu, Yanfei Ma, Aijv Liu
Summary: In this study, SiO2 microspheres were used as templates to produce chitosan/polylactic acid bio-microcapsules via layer-by-layer assembly. The microcapsules isolated bacteria, providing them with a separate microenvironment and enhancing their ability to adapt to adverse conditions. The results showed that the bio-microcapsules had large fractions of mesoporous, and they demonstrated a high removal rate of toluene under unfavorable environmental conditions. The LBL microcapsules also maintained a high level of operational stability and reduced the death rate of bacteria, making them effective for bioremediation of organic contaminants in groundwater.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Roman Verkhovskii, Alexey Ermakov, Olga Sindeeva, Ekaterina Prikhozhdenko, Anastasiia Kozlova, Oleg Grishin, Mikhail Makarkin, Dmitry Gorin, Daniil Bratashov
Summary: Drug carriers based on polyelectrolyte microcapsules controlled by an external magnetic field show promise as a drug delivery system. However, the impact of capsule parameters on their behavior in vivo remains unclear. This study demonstrates how microcapsules of different sizes interact with vital organs, blood cells, and magnetic fields, affecting circulation time, cytotoxicity, and hemotoxicity. Small capsules circulate longer without affecting blood cells, while larger capsules are quickly filtered, inhibit macrophage proliferation, and cause hemolysis depending on concentration. These findings suggest potential strategies to optimize microcapsule parameters for efficient drug delivery without adverse effects on blood flow or cells.
Article
Biochemistry & Molecular Biology
Zheng Wu, Jun Shi, Pingan Song, Jingguo Li, Shaokui Cao
Summary: In this study, a pH/NIR multi-responsive drug delivery platform was successfully fabricated using a layer-by-layer approach, consisting of hollow hydroxyapatite, chitosan/hyaluronic acid multilayers, gold nanorods, and MXene. The system exhibited excellent photothermal conversion efficiency and biocompatibility, with outstanding drug release performance under acidic conditions and effective activation by near-infrared light.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Nanoscience & Nanotechnology
De Gong, Nuoer Celi, Deyuan Zhang, Jun Cai
Summary: This study proposes a strategy of magnetic biohybrid microrobot multimers (BMMs) based on Chlorella for targeted drug delivery. The microrobot units, magnetized Chlorella cells loaded with doxorubicin, can reconfigure into chain-like BMMs via attraction-induced self-assembly and disassemble reversibly via repulsion. These BMMs exhibit diverse swimming modes and high maneuverability, demonstrating great potential for targeted anticancer therapy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Ming Liu, Leyu Bi, Wenlin Jiang, Zixin Zeng, Sai-Wing Tsang, Francis R. Lin, Alex K. -Y. Jen
Summary: An introduced co-solvent strategy is utilized to disassemble the micelles formed by amphiphilic self-assembled monolayer (SAM) molecules, reducing the energetic barrier for densely packed SAM formation and universally enhancing the power conversion efficiencies (PCEs) of PSCs using MeO-2PACz, 2PACz, and CbzNaph SAM hole-selective layers. The champion device processed from CbzNaph using this co-solvent achieves a high PCE of 24.98% and improved stability.
ADVANCED MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Laura Sanchez-Garcia, Eric Volta-Duran, Eloi Parlade, Elisa Mazzega, Alejandro Sanchez-Chardi, Naroa Serna, Hector Lopez-Laguna, Mara Mitstorfer, Ugutz Unzueta, Esther Vazquez, Antonio Villaverde, Ario de Marco
Summary: Nanobodies are valuable tools in advanced therapeutic strategies, but their small size and limited valence for interactions may pose restrictions for in vivo applications. Modular protein constructs have been designed to fuse nanobodies with protein domains, promoting self-assembly into stable nanoparticles with maintained specificity for targets.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Food Science & Technology
Sofia F. Reis, Vitor J. Martins, Rita Bastos, Tania Lima, Viviana G. Correia, Benedita A. Pinheiro, Lisete M. Silva, Angelina S. Palma, Paula Ferreira, Manuel Vilanova, Manuel A. Coimbra, Elisabete Coelho
Summary: This study aims to investigate the feasibility of brewer's spent yeast (BSY) microcapsules as oral carriers for food and biomedical applications. The results demonstrate that BSY microcapsules have strong resistance to digestion and are rich in (beta 1 -> 3)-glucans, which can be recognized by the human Dectin-1 immune receptor. Additionally, the digested material is recognized by various lectins related to (beta 1 -> 3)-glucans, glycogen, and mannans.
Review
Chemistry, Multidisciplinary
Xiaoyu Li, Charos Omonova Tuychi Qizi, Amari Mohamed Khamis, Can Zhang, Zhigui Su
Summary: This article introduces the application of nanotechnology in improving immune cell function, focusing on the technology and challenges of enhancing cytoplasmic delivery of bioactive molecules to immune cells. It also discusses the potential of using nanotechnology to treat immune cell-related diseases and develop immune therapies.
PHARMACEUTICAL RESEARCH
(2022)
Review
Immunology
Bruna Clemente, Maxime Denis, Camila Pedroso Silveira, Francesca Schiavetti, Michela Brazzoli, Daniela Stranges
Summary: This article discusses the successful strategy of directly targeting antigens to immune cells, particularly dendritic cells, to develop innovative and potent vaccines. It explores the potential specific targets for immune system-directed mRNA delivery and the different targeting ligand classes and delivery systems used for this purpose.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Olga Gusliakova, Ekaterina S. Prikhozhdenko, Valentina O. Plastun, Oksana A. Mayorova, Natalia A. Shushunova, Arkady S. Abdurashitov, Oleg A. Kulikov, Maxim A. Abakumov, Dmitry A. Gorin, Gleb B. Sukhorukov, Olga A. Sindeeva
Summary: The problem of reducing side effects in drug distribution for kidney disease treatment can be solved with targeted drug delivery. This study focuses on using polyelectrolyte capsules injected through the renal artery to achieve prolonged local drug release and capillary retention. The method is non-invasive and suitable for long-term experiments in mice. The study also explores the effects of capsule size and dosage on target kidney blood flow, and suggests a combination of endovascular surgery and injection of polymer microcapsules as a successful strategy for treating nephropathies.
Review
Food Science & Technology
Mohammad Mahdi Rostamabadi, Seid Reza Falsafi, Katsuyoshi Nishinari, Hadis Rostamabadi
Summary: Efficient delivery systems, such as seed gum-based vehicles (SGVs), play a pivotal role in promoting the biological and functional properties of bioactive molecules. SGVs offer controlled delivery, improved bioavailability, and stability for bioactives. This article provides a comprehensive overview of seed gum-based nano- and microdevices as delivery systems for bioactive molecules, highlighting their structural properties, health benefits, and strategies for modification.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Materials Science, Biomaterials
Yanchao Mao, Yujia Zhang, Yue Yu, Nanhang Zhu, Xiaoxi Zhou, Guohao Li, Qiangying Yi, Yao Wu
Summary: Due to their high-specific binding toward targets and fast and convenient separation operations, immunomagnetic beads (IMBs) are widely used in the capture and detection of circulating tumor cells (CTCs). In this study, a supramolecular layer-by-layer (LBL) self-assembly strategy was proposed to construct the IMBs, which showed high sensitivity, specificity and good biocompatibility for capturing and detecting CTCs. The captured cells can be further recultured directly, demonstrating the huge potential of the IMBs for in vitro detection in clinical practices.
REGENERATIVE BIOMATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Laetitia Bardet, Herve Roussel, Stefano Saroglia, Masoud Akbari, David Munoz-Rojas, Carmen Jimenez, Aurore Denneulin, Daniel Bellet
Summary: The thermal instability of silver nanowires leads to increased electrical resistance in AgNW networks. Understanding the relationship between structural and electrical properties of AgNW networks is crucial for their integration as transparent electrodes in flexible optoelectronics. In situ X-ray diffraction measurements were used to study the crystallographic evolution of Ag-specific Bragg peaks during thermal ramping, revealing differences in thermal and structural transitions between bare and SnO2-coated AgNW networks.
Article
Chemistry, Multidisciplinary
Nathalia Cancino-Fuentes, Arnau Manasanch, Joana Covelo, Alex Suarez-Perez, Enrique Fernandez, Stratis Matsoukis, Christoph Guger, Xavi Illa, Anton Guimera-Brunet, Maria V. Sanchez-Vives
Summary: This study provides a comprehensive characterization of graphene-based solution-gated field-effect transistors (gSGFETs) for brain recordings, highlighting their potential clinical applications.
Article
Chemistry, Multidisciplinary
Sikandar Aftab, Hailiang Liu, Dhanasekaran Vikraman, Sajjad Hussain, Jungwon Kang, Abdullah A. Al-Kahtani
Summary: This study examines the effects of hybrid nanoparticles made of NiO@rGO and NiO@CNT on the active layers of polymer solar cells and X-ray photodetectors. The findings show that these hybrid nanoparticles can enhance the charge carrier capacities and exciton dissociation properties of the active layers. Among the tested configurations, the NiO@CNT device demonstrates superior performance in converting sunlight into electricity, and achieves the best sensitivity for X-ray detection.
Article
Chemistry, Multidisciplinary
Hyo Jung Shin, Seung Gyu Choi, Fengrui Qu, Min-Hee Yi, Choong-Hyun Lee, Sang Ryong Kim, Hyeong-Geug Kim, Jaewon Beom, Yoonyoung Yi, Do Kyung Kim, Eun-Hye Joe, Hee-Jung Song, Yonghyun Kim, Dong Woon Kim
Summary: This study investigates the role of SOX9 in reactive astrocytes following ischemic brain damage using a PLGA nanoparticle plasmid delivery system. The results demonstrate that PLGA nanoparticles can reduce ischemia-induced neurological deficits and infarct volume, providing a potential opportunity for stroke treatment.
Article
Chemistry, Multidisciplinary
Anurag Chaudhury, Koushik Debnath, Nikhil R. Jana, Jaydeep K. Basu
Summary: The study investigates the interaction between nanoparticles and cell membranes, and identifies key parameters, including charge, crowding, and membrane fluidity, that determine the adsorbed concentration and unbinding transition of nanoparticles.
Article
Chemistry, Multidisciplinary
Sina Sadeghi, Fazel Bateni, Taekhoon Kim, Dae Yong Son, Jeffrey A. Bennett, Negin Orouji, Venkat S. Punati, Christine Stark, Teagan D. Cerra, Rami Awad, Fernando Delgado-Licona, Jinge Xu, Nikolai Mukhin, Hannah Dickerson, Kristofer G. Reyes, Milad Abolhasani
Summary: In this study, an autonomous approach for the development of lead-free metal halide perovskite nanocrystals is presented, which integrates a modular microfluidic platform with machine learning-assisted synthesis modeling. This approach enables rapid and optimized synthesis of copper-based lead-free nanocrystals.
Article
Chemistry, Multidisciplinary
Zahir Abbas, Nissar Hussain, Surender Kumar, Shaikh M. Mobin
Summary: The rational construction of free-standing and flexible electrodes for electrochemical energy storage devices is an emerging research focus. In this study, a redox-active metal-organic framework (MOF) was prepared on carbon nanofibers using an in situ approach, resulting in a flexible electrode with high redox-active behavior and unique properties such as high flexibility and lightweight. The prepared electrode showed excellent cyclic retention and rate capability in supercapacitor applications. Additionally, it could be used as a freestanding electrode in flexible devices at different bending angles.
Article
Chemistry, Multidisciplinary
Lishan Zhang, Xiaoting Zhang, Hui Ran, Ze Chen, Yicheng Ye, Jiamiao Jiang, Ziwei Hu, Miral Azechi, Fei Peng, Hao Tian, Zhili Xu, Yingfeng Tu
Summary: Photodynamic therapy (PDT) is a promising local treatment modality in cancer therapy, but its therapeutic efficacy is restricted by ineffective delivery of photosensitizers and tumor hypoxia. In this study, a phototactic Chlorella-based near-infrared (NIR) driven green affording-oxygen microrobot system was developed for enhanced PDT. The system exhibited desirable phototaxis and continuous oxygen generation, leading to the inhibition of tumor growth in mice. This study demonstrates the potential of using a light-driven green affording-oxygen microrobot to enhance photodynamic therapy.
Article
Chemistry, Multidisciplinary
Yujin Li, Jing Xu, Xinqi Luo, Futing Wang, Zhong Dong, Ke-Jing Huang, Chengjie Hu, Mengyi Hou, Ren Cai
Summary: In this study, hollow heterostructured materials were constructed using an innovative template-engaged method as cathodes for zinc-ion batteries. The materials exhibited fast Zn2+ transport channels, improved electrical conductivity, and controlled volume expansion during cycling. The designed structure allowed for an admirable reversible capacity and high coulombic efficiency.
Article
Chemistry, Multidisciplinary
Paritosh Mahato, Shashi Shekhar, Rahul Yadav, Saptarshi Mukherjee
Summary: This study comprehensively elucidates the role of the core and electrostatic surface of metal nanoclusters in catalytic reduction reactions. The electrostatic surface dramatically modulates the reactivity of metal nanoclusters.
Article
Chemistry, Multidisciplinary
Pei Liu, Mengdi Liang, Zhengwei Liu, Haiyu Long, Han Cheng, Jiahe Su, Zhongbiao Tan, Xuewen He, Min Sun, Xiangqian Li, Shuai He
Summary: This study demonstrates a simple and environmentally-friendly method for the synthesis of zinc oxide nanozymes (ZnO NZs) using wasted hop extract (WHE). The WHE-ZnO NZs exhibit exceptional peroxidase-like activity and serve as effective catalysts for the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide (H2O2). In addition, a straightforward colorimetric technique for detecting both H2O2 and glucose was developed using the WHE-ZnO NZs as peroxidase-like catalysts.
Article
Chemistry, Multidisciplinary
Hyunkyu Oh, Young Jun Lee, Eun Ji Kim, Jinseok Park, Hee-Eun Kim, Hyunsoo Lee, Hyunjoo Lee, Bumjoon J. Kim
Summary: Mesoporous carbon particles have unique structural properties that make them suitable as support materials for catalytic applications. This study investigates the impact of channel nanostructures on the catalytic activity of porous carbon particles (PCPs) by fabricating PCPs with controlled channel exposure on the carbon surface. The results show that PCPs with highly open channel nanostructures exhibit significantly higher catalytic activity compared to those with closed channel nanostructures.
Article
Chemistry, Multidisciplinary
Yunjie Lu, Zhaohui Li, Zewei Li, Shihao Zhou, Ning Zhang, Jianming Zhang, Lu Zong
Summary: A tough, long-lasting adhesive and highly conductive nanocomposite hydrogel (PACPH) was fabricated via the synergy of interfacial entanglement and adhesion group densification. PACPH possesses excellent mechanical properties, interfacial adhesion strength, and conductivity, making it a promising material for long-term monitoring of human activities and electrocardiogram signals.
Article
Chemistry, Multidisciplinary
Zichao Wei, Audrey Vandergriff, Chung-Hao Liu, Maham Liaqat, Mu-Ping Nieh, Yu Lei, Jie He
Summary: We have developed a simple method to prepare polymer-grafted plasmonic metal nanoparticles with pH-responsive surface-enhanced Raman scattering. By using pH-responsive polymers as ligands, the aggregation of nanoparticles can be controlled, leading to enhanced SERS. The pH-responsive polymer-grafted nanoparticles show high reproducibility and sensitivity in solution, providing a novel approach for SERS without the need for sample pre-concentration.
Article
Chemistry, Multidisciplinary
Melis Ozge Alas Colak, Ahmet Gungor, Merve Buldu Akturk, Emre Erdem, Rukan Genc
Summary: This research investigates the effect of functionalizing carbon dots with hydroxyl polymers on their performance as electrode materials in a supercapacitor. The results show that the functionalized carbon dots exhibit excellent electrochemical performance and improved stability.