Article
Allergy
Frederik Bloch Jessen, Charlotte G. Mortz, Esben Eller, Julie H. Gudichsen, Emil A. Baekdal, Carsten Bindslev-Jensen
Summary: This retrospective study compared the severity of symptoms and threshold values in children and adults with peanut allergy challenged in an open or double-blind, placebo-controlled protocol. The study found no difference in severity of symptoms or threshold values between the two challenge types, but a higher proportion of children experienced Grade 3 symptoms in the double-blind group. The findings suggest that open food challenges can be as effective as double-blind, placebo-controlled food challenges when strict objective stop criteria and trained staff are employed.
Article
Engineering, Environmental
Xu Han, Hui Chen, Man Deng, Bibai Du, Lixi Zeng
Summary: This study analyzed SCCPs and MCCPs in commonly used infant foods in the Chinese market and found that CP concentrations were highest in whole milk samples and for the first time detected in baby purees. The estimated MOE values suggested no health risks from CP contamination in infant foods. Principal component analysis showed that foods of animal origin were more influenced by MCCPs.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Allergy
Vicki McWilliam, Carina Venter, Matthew Greenhawt, Kirsten P. Perrett, Mimi L. K. Tang, Jennifer J. Koplin, Rachel L. Peters
Summary: Early introduction of allergenic foods is the most promising strategy for preventing food allergy in infants, but translating guidelines into practical strategies remains a challenge. While Australia has seen high support and adoption of revised guidelines, it has not significantly reduced food allergy prevalence. The uptake of guidelines in other countries is unclear, and further research is needed to understand prevention strategies and the role of environmental factors.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Pediatrics
Frida Stromberg Celind, Emma Goksor, Elisabeth Carlen, Birte Schilling, Bernt Alm, Goran Wennergren
Summary: A study found that infants born in 2018 introduced eggs, fish, and gluten earlier in their diet compared to those born in 2003, potentially reducing the risk of developing allergies. Current childcare recommendations are being followed.
Article
Nutrition & Dietetics
Bozena Cukrowska, Aldona Ceregra, Elzbieta Maciorkowska, Barbara Surowska, Maria Agnieszka Zegadlo-Mylik, Ewa Konopka, Ilona Trojanowska, Magdalena Zakrzewska, Joanna Beata Bierla, Mateusz Zakrzewski, Ewelina Kanarek, Ilona Motyl
Summary: Probiotics were found to significantly improve the severity of AD symptoms in children under 2 years old with both AD and CMP allergy, with the effect still noticeable after three months. Probiotics had a main effect on patients sensitized to allergens, but this effect diminished after nine months. Further research is needed to assess the impact of probiotic supplementation on immune tolerance development.
Review
Nutrition & Dietetics
Katerina Bajerova, Silvia Salvatore, Christophe Dupont, Philippe Eigenmann, Mikael Kuitunen, Rosan Meyer, Carmen Ribes-Koninckx, Raanan Shamir, Hania Szajewska, Yvan Vandenplas
Summary: This review summarizes the current evidence on the Cow's Milk-related Symptom Score (CoMiSS), which is a clinical tool used to assess symptoms possibly related to cow's milk intake. It found that CoMiSS can be used to predict the response to a cow's milk-free diet in infants and diagnose cow's milk allergy in children.
Article
Allergy
Marta Krawiec, Suzana Radulovic, Ru-Xin Foong, Andreina Marques-Mejias, Irene Bartha, Matthew Kwok, Zainab Jama, Faye Harrison, Cristian Ricci, Gideon Lack, George Du Toit, Alexandra F. Santos
Summary: This study assessed the accuracy of current and new diagnostic tests compared to the gold standard DBPCFC, and found that BAT was the best diagnostic test in terms of accuracy and reduction in OFC.
Article
Allergy
Jennifer Dantzer, Joan Dunlop, Kevin J. Psoter, Corinne Keet, Robert Wood
Summary: Baked milk oral immunotherapy (BMOIT) has shown safety and efficacy in treating children with baked milk allergy. After 12 months of treatment, the majority of participants in the BMOIT group were able to tolerate higher doses of baked milk protein compared to the placebo group. Dose-related adverse reactions were common but mild. BMOIT increased cow's milk-sIgG4 levels and decreased casein IgE levels.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Nutrition & Dietetics
Carina Venter, Raanan Shamir, David Mark Fleischer
Summary: Early life feeding practices can impact long-term health, particularly in the development of non-communicable diseases. Breastfeeding and the introduction of solids play a crucial role in preventing allergies and promoting adequate infant growth. The use of plant-based infant formulas is becoming popular, but their effects on growth and food allergies need to be considered.
Article
Nutrition & Dietetics
Edyta Krzych-Falta, Monika E. Czerwinska, Slawomir Bialek, Konrad Furmanczyk, Boleslaw Samolinski, Blazej Grodner, Adam Sybilski, Grazyna Nowicka, Oksana Wojas
Summary: Nasal provocation tests have the potential to be an alternative to oral food challenges due to their valuable assessment possibilities. However, standardization of the methodology is necessary to determine the threshold dose and develop a lyophilisate form. This study aimed to establish the methodological foundation for nasal food allergen provocation tests.
Review
Nutrition & Dietetics
Carlo Caffarelli, Arianna Giannetti, Arianna Rossi, Giampaolo Ricci
Summary: Eggs are essential in the human diet, but they are also the most common food allergen. This paper highlights the importance of eggs in a child's diet and analyzes the risk factors for developing egg allergies. It also discusses interventions to reduce the occurrence of food allergies and provides a synthesis of the research study based on the latest guidelines and position papers.
Review
Allergy
L. Sandra Vale, Monique Lobb, J. Merryn Netting, Kevin Murray, Rhonda Clifford, E. Dianne Campbell, M. Sandra Salter
Summary: Food allergy is a significant issue worldwide, especially in Western countries. Research on food allergy prevention guidelines found that there are significant differences in recommendations, with guidelines generally scoring higher in quality compared to advice documents.
WORLD ALLERGY ORGANIZATION JOURNAL
(2021)
Article
Food Science & Technology
Jiachen Liang, Baodong Zheng, Yi Zhang, Hongliang Zeng
Summary: This article systematically reviews the immunoglobulin E mechanisms in food allergies, the structures of intestinal microorganisms, the microbiota mechanisms alleviating food allergies, and the mechanisms of dietary components alleviating food allergies. Imbalanced helper T cell and microbiota ratios are the cause of food allergies, and the microbiota alleviate food allergies through different mechanisms. Carbohydrates, proteins, high-fat diets, and polyphenols can all alleviate food allergies by modulating microbiota and immune cells.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Allergy
Eric Lee, Elizabeth H. Barnes, Sam Mehr, Dianne E. Campbell
Summary: In this retrospective cohort study on children with acute FPIES in Australia, rice, cow's milk, and soya were identified as the most common triggers. Vaginal delivery may have a protective effect against the development of multiple FPIES and severe reactions. Patients with fish-induced FPIES took longer to outgrow their reactions compared to those with rice or grains-induced FPIES.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Food Science & Technology
Natalia Zofia Maryniak, Mette Halkjaer Stage, Anne-Sofie Ravn Ballegaard, Ana Isabel Sancho, Egon Bech Hansen, Katrine Lindholm Bogh
Summary: Currently, there are no specific recommendations for using any particular infant formula to prevent cow's milk allergy. There is increasing interest in alternative infant formulas made from milk proteins from animals other than cows, but their ability to prevent cow's milk allergy has not been studied.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Review
Allergy
Giulia C. Spolidoro, Yohannes Tesfaye Amera, Mohamed Mustafa Ali, Sungkutu Nyassi, Daniil Lisik, Athina Ioannidou, Graciela Rovner, Ekaterina Khaleva, Carina Venter, Ronald van Ree, Margitta Worm, Berber Vlieg-Boerstra, Aziz Sheikh, Antonella Muraro, Graham Roberts, Bright Nwaru
Summary: The latest estimates of food allergy prevalence and trends in Europe show an increase in self-reported food allergy and sensitization rates. This may be due to a real increase in the prevalence, increased awareness, increased evaluation of food types, or increased number of studies. Future studies need to use standardized methods, including double-blinded placebo-controlled food challenge, to minimize potential biases.
Article
Allergy
Marta Vazquez-Ortiz, Claudia Gore, Cherry Alviani, Elizabeth Angier, Katharina Blumchen, Pasquale Comberiati, Bettina Duca, Audrey DunnGalvin, Teresa Garriga-Baraut, M. Hazel Gowland, Britt Egmose, Rebecca Knibb, Ekaterina Khaleva, Charlotte G. Mortz, Oliver Pfaar, Helena Pite, Marcia Podesta, Alexandra F. Santos, Silvia Sanchez-Garcia, Frans Timmermans, Graham Roberts
Summary: This article summarizes practical resources to support the implementation of guidelines for adolescents and young adults with asthma and allergies in clinical practice. The study found that the identified resources cover various topics and target different stakeholders such as healthcare professionals, adolescents and young adults, parents/caregivers, schools, workplaces, and communities. However, most of the resources are web-based and in English, with limited evidence basis.
Review
Respiratory System
Ekaterina Khaleva, Anna Rattu, Chris Brightling, Andrew Bush, Apostolos Bossios, Arnaud Bourdin, Kian Fan Chung, Rekha Chaudhuri, Courtney Coleman, Sven-Erik Dahlen, Ratko Djukanovic, Antoine Deschildre, Louise Fleming, Stephen J. Fowler, Atul Gupta, Eckard Hamelmann, Simone Hashimoto, Gunilla Hedlin, Gerard H. Koppelman, Erik Melen, Clare S. Murray, Charles Pilette, Celeste Porsbjerg, Katharine C. Pike, Franca Rusconi, Clare Williams, Birgit Ahrens, Peter Alter, Freja Anckers, Maarten van den Berge, Katharina Blumchen, Guy Brusselle, Graham W. Clarke, Danen Cunoosamy, Barbro Dahlen, Piers Dixey, Andrew Exley, Urs Frey, Erol A. Gaillard, Lisa Giovannini-Chami, Jonathan Grigg, Diana Hartenstein, Liam G. Heaney, Bulent Karadag, Susanne Kaul, Inger Kull, Amelia Licari, Anke H. Maitland-van der Zee, Vera Mahler, Ann-Marie M. Schoos, Prasad Nagakumar, Jenny Negus, Hanna Nielsen, James Paton, Marielle Pijnenburg, Valeria Ramiconi, Sofia Romagosa Vilarnau, Stefania Principe, Niels Rutjes, Sejal Saglani, Paul Seddon, Florian Singer, Heribert Staudinger, Steve Turner, Susanne Vijverberg, Tonya Winders, Valentyna Yasinska, Graham Roberts
Summary: The COMSA Working Group developed two Core Outcome Measures (COM) sets for paediatric and adult severe asthma, including FEV1 as z-scores, frequency of severe exacerbations and oral corticosteroid use. These COM sets will inform future clinical trials, enhance comparability of biological therapies' efficacy and effectiveness, and assess their socioeconomic value.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Review
Respiratory System
Courtney Coleman, Ekaterina Khaleva, Anna Rattu, Betty Frankemolle, Hanna Nielsen, Graham Roberts, Clare Williams
Summary: This narrative review aims to capture severe asthma patients' perceptions about non-response and response to biological therapy. By combining relevant published and grey literature, we have provided a description of adult patients' perceptions of response to biological therapy in severe asthma. However, there is a lack of qualitative research focused on this topic that needs to be addressed.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Allergy
Mauro Tutino, Raquel Granell, John A. Curtin, Sadia Haider, Sara Fontanella, Clare S. Murray, Graham Roberts, S. Hasan Arshad, Stephen Turner, Andrew P. Morris, Adnan Custovic, Angela Simpson
Summary: This study found that the asthma-risk variant rs2305480 in the 17q12-21 locus is no longer associated with an increased risk of persistent wheeze when there is an interaction with early-life dog ownership, but no such interaction was observed with cat ownership.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Allergy
Kirsty Logan, Henry T. T. Bahnson, Alyssa Ylescupidez, Kirsten Beyer, Johanna Bellach, Dianne E. E. Campbell, Joanna Craven, George Du Toit, E. N. Clare Mills, Michael R. R. Perkin, Graham Roberts, Ronald van Ree, Gideon Lack
Summary: This study demonstrates the significant reduction in peanut allergy risk with early peanut introduction. The effect is observed across different risk groups and is more pronounced with earlier age of introduction.
Review
Pediatrics
Ru-Xin Foong, Nandinee B. Patel, Paul Turner, Graham C. Roberts, Adam T. Fox
Summary: Fatal anaphylaxis to food is rare but avoidable. Reviewing food allergy-related deaths reveals common themes and risk factors. This review aims to provide key messages for healthcare professionals and patients, with supporting evidence, to prevent such fatalities. An endorsed information leaflet is proposed for wider dissemination of the recommendations.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Review
Respiratory System
Anna Rattu, Ekaterina Khaleva, Chris Brightling, Sven-Erik Dahlen, Apostolos Bossios, Louise Fleming, Kian Fan Chung, Erik Melen, Ratko Djukanovic, Rekha Chaudhuri, Andrew Exley, Gerard H. Koppelman, Arnaud Bourdin, Franca Rusconi, Celeste Porsbjerg, Courtney Coleman, Clare Williams, Hanna Nielsen, Elizabeth Davin, Phil Taverner, Sofia Romagosa Vilarnau, Graham Roberts
Summary: The recommendations of the National Institutes of Health (NIH) on outcome measurement instruments for asthma are widely used in clinical practice and research. However, there is no consensus on which outcome measures are important to patients with severe asthma and are valid for this population. Guidelines recommend the use of patient-reported outcome measures (PROMs) to evaluate treatment response, but do not provide specific instruments. Additionally, the outcomes that patients consider important, such as quality of life, are not consistently considered by physicians when evaluating treatment response.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Allergy
Graham Roberts, Henry T. Bahnson, George Du Toit, Colin O'Rourke, Michelle L. Sever, Erica Brittain, Marshall Plaut, Gideon Lack
Summary: In order to prevent peanut allergy, the key is to introduce peanut products early and target the right population. Targeting only high-risk infants with severe eczema reduces the disease burden by only 4.6%. The greatest reduction in peanut allergy is seen when the intervention is targeted at larger but lower-risk groups. The preventive benefit decreases as the age at introduction increases, and it is recommended to introduce peanut products at 4 to 6 months of life.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Allergy
Paxton Loke, Brian P. Vickery, Stacie M. Jones, Rachel L. Peters, Graham Roberts, Jennifer J. Koplin
Summary: Standard care for food allergies focused on avoidance and treatment of adverse reactions. Immunotherapy for preschool-age children shows potential but balancing intervention timing is challenging. This review examines early food allergen immunotherapy in preschoolers and highlights research gaps.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Review
Respiratory System
Ekaterina Khaleva, Anna Rattu, Chris Brightling, Andrew Bush, Arnaud Bourdin, Apostolos Bossios, Kian Fan Chung, Rekha Chaudhuri, Courtney Coleman, Ratko Djukanovic, Sven-Erik Dahlen, Andrew Exley, Louise Fleming, Stephen J. Fowler, Atul Gupta, Eckard Hamelmann, Gerard H. Koppelman, Erik Melen, Vera Mahler, Paul Seddon, Florian Singer, Celeste Porsbjerg, Valeria Ramiconi, Franca Rusconi, Valentyna Yasinska, Graham Roberts
Summary: This study systematically reviewed the definitions of response to biologics for severe asthma and found that although high-quality definitions are available, most are based on minimal clinically important difference (MCID) or minimal important difference (MID), which may not be sufficient to justify the cost-effectiveness of continuing biologics.
Review
Allergy
Berber Vlieg-Boerstra, Marion Groetch, Emilia Vassilopoulou, Rosan Meyer, Kirsi Laitinen, Anne Swain, Raquel Durban, Olga Benjamin, Rachelle Bottse, Kate Grimshaw, Merryn Netting, Liam O'Mahony, Nicolette de Jong, Isabel J. Skypala
Summary: This review assesses the relationship between nutrition, immune function, and allergic disease from a clinical perspective, and proposes an immune-supportive diet as an adjuvant therapy for allergic disease. The proposed diet consists of a diverse range of fresh, whole, and minimally processed plant-based and fermented foods supplemented with nuts, omega-3-rich foods and animal-based products.
Article
Multidisciplinary Sciences
Sofia Sirvent, Andres F. Vallejo, Emma Corden, Ying Teo, James Davies, Kalum Clayton, Eleanor G. Seaby, Chester Lai, Sarah Ennis, Rfeef Alyami, Gemma Douilhet, Lareb S. N. Dean, Matthew Loxham, Sarah Horswill, Eugene Healy, Graham Roberts, Nigel J. Hall, Peter S. Friedmann, Harinder Singh, Clare L. Bennett, Michael R. Ardern-Jones, Marta E. Polak
Summary: Regulation of cutaneous immunity is compromised in inflammatory skin disease, such as atopic dermatitis. A study investigating molecular crosstalk in atopic dermatitis patients exposed to house dust mite has revealed a distinct dichotomy in patient responsiveness and identified potential therapeutic targets for modulation of metallothionein expression. The presence of hub structures where Langerhans cells and T cells co-localize suggests their role in the reactivity to house dust mite.
NATURE COMMUNICATIONS
(2023)
Article
Allergy
Michelle L. Sever, Agustin Calatroni, Graham Roberts, George du Toit, Henry T. Bahnson, Suzana Radulovic, David Larson, Margie Byron, Alexandra F. Santos, Michelle F. Huffaker, Lisa M. Wheatley, Gideon Lack
Summary: The LEAP study team developed an algorithm to determine peanut allergy status when OFC is not available. The algorithm showed a high accuracy and can be used in the LEAP Trio study.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Allergy
Stefania Arasi, Ulugbek Nurmatov, Audrey Dunn-Galvin, Graham Roberts, Paul J. Turner, Sayantani B. Shinder, Ruchi Gupta, Philippe Eigenmann, Anna Nowak-Wegrzyn, Ignacio J. Ansotegui, Montserrat Fernandez Rivas, Stavros Petrou, Luciana K. Tanno, Marta Vazquez-Ortiz, Brian Vickery, Gary Wong, Montserrat Alvaro-Lozano, Miqdad Asaria, Philippe Begin, Martin Bozzola, Robert Boyle, Helen Brough, Victoria Cardona, R. Sharon Chinthrajah, Antonella Cianferoni, Antoine Deschildre, David Fleischer, Flavio Gazzani, Jennifer Gerdts, Marilena Giannetti, Matthew Greenhawt, Maria Antonieta Guzman, Elham Hossny, Paula Kauppi, Carla Jones, Francesco Lucidi, Olga Patricia Monge Ortega, Daniel Munblit, Antonella Muraro, Giovanni Pajno, Marcia Podesta, Pablo Rodriguez del Rio, Maria Said, Alexandra Santos, Marcus Shaker, Hania Szajewska, Carina Venter, Cristopher Warren, Tonya Winders, Motohiro Ebisawa, Alessandro Fiocchi
Summary: A global consensus has been achieved on the development of the DEFASE scoring system for the severity of food allergy, which considers the overall disease spectrum. Further validation and implementation in research settings and clinical practice are planned.
WORLD ALLERGY ORGANIZATION JOURNAL
(2023)
