Article
Plant Sciences
Si-Lu Zhu, Mei-Ling Wang, Yue-Teng He, Shu-Wen Guo, Ting-Ting Li, Wei-Jie Peng, Dan Luo
Summary: Capsaicin elevates SIRT1 levels through TRPV1 pathway and suppresses IHG-induced endothelial cell senescence.
Article
Otorhinolaryngology
John R. R. Craig, Raven T. T. Dunn, Amrita Ray, Christian E. E. Keller, Edward L. L. Peterson, Jacob G. G. Eide
Summary: Autonomic nerve densities are equal in posterior nasal (PNN), posterolateral nasal (PLNN), and anterior ethmoid nerves (AEN). Rhinitis studies should investigate the efficacy of transecting PLNN and/or AEN in addition to PNN alone.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Article
Multidisciplinary Sciences
Nicole N. Scheff, Ian M. Wall, Sam Nicholson, Hannah Williams, Elyssa Chen, Nguyen H. Tu, John C. Dolan, Cheng Z. Liu, Malvin N. Janal, Nigel W. Bunnett, Brian L. Schmidt
Summary: Oral cancer patients experience sensitivity to spicy foods and liquids, but the mechanism behind this sensitivity is not yet understood. In a mouse model of oral cancer, researchers found increased expression of TRPV1 in trigeminal ganglion neurons, indicating an anatomical basis for chemosensitivity. They also discovered that PAR(2) plays a role in mediating the sensitivity induced by TRPV1 in tongue afferents in the oral cancer mouse model.
SCIENTIFIC REPORTS
(2022)
Review
Endocrinology & Metabolism
Gargi Mishra, Kristy L. Townsend
Summary: The homeostatic regulation of adipose tissue is crucial for maintaining energy balance and overall metabolism. While most research has focused on sympathetic nerves and norepinephrine, recent studies have shed light on the contributions of sensory nerves and neuropeptides to adipose tissue functions. This article provides an overview of the regulation, function, and plasticity of adipose tissue sensory nerves, highlighting their roles in important metabolic processes such as lipolysis and vascular control.
Review
Endocrinology & Metabolism
Gargi Mishra, Kristy L. Townsend
Summary: Homeostatic regulation of adipose tissue is crucial for maintaining energy balance and overall metabolism, and the peripheral nervous system plays a key role in this regulation. Sensory nerves contribute to the regulation of adipose functions, but their specific roles and contributions are still understudied.
Article
Microbiology
Emilie Vangrinsven, Aline Fastres, Bernard Taminiau, Frederic Billen, Georges Daube, Cecile Clercx
Summary: This study aimed to describe the nasal microbiota changes associated with canine fungal rhinitis compared to chronic idiopathic rhinitis and healthy controls, as well as characterize the nasal microbiota modifications after successful treatment of fungal rhinitis. The results showed significant alterations of the nasal microbiota in dogs with fungal rhinitis and chronic idiopathic rhinitis, characterized by a decrease in the relative abundance of Moraxella.
Article
Biochemistry & Molecular Biology
Suo Zou, Takahiro Shimizu, Atsushi Kurabayashi, Masaki Yamamoto, Shogo Shimizu, Youichirou Higashi, Nobutaka Shimizu, Takashi Karashima, Motoaki Saito
Summary: In this study, it was found that hydrogen sulfide pretreatment can prevent bladder dysfunction caused by cyclophosphamide treatment by suppressing the activity of bladder afferent nerves, rather than by inhibiting bladder inflammation. Therefore, hydrogen sulfide may be a new candidate as a protective drug for bladder dysfunction induced by cyclophosphamide chemotherapy.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Myung-A Jung, Hyun-Kyung Song, Kyuhyung Jo, Ami Lee, Youn-Hwan Hwang, Kon-Young Ji, Dong Ho Jung, Mudan Cai, Joo Young Lee, Bo-Jeong Pyun, Taesoo Kim
Summary: This study investigated the effects of Gleditsia sinensis extract (GSAE) on nasal inflammation in an ovalbumin (OVA)-induced allergic rhinitis (AR) mouse model. Oral administration of GSAE alleviated nasal symptoms and reduced levels of OVA-specific immunoglobulin E (IgE), interleukin (IL)-13, and histamine. GSAE also inhibited the accumulation of inflammatory cells, mast cells, goblet cells, and mucin 5AC (MUC5AC) in the nasal mucosa, and inhibited MUC5AC production in IL-4/IL-13-stimulated primary human nasal epithelial cells through the STAT3/STAT6 signaling pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Integrative & Complementary Medicine
Xiang Tan, Wenjing Pei, Chune Xie, Zhibin Wang, Jiali Liu, Yuan Cheng, Tangyou Mao, Lei Shi, Xingjie Zhao, Qiongqiong Lu, Zhongmei Sun, Fushun Kou, Hui Jiang, Junxiang Li
Summary: The study demonstrated that the use of Tongxie Anchang Decoction (TXACD) significantly improves visceral hypersensitivity in diarrhea-predominant irritable bowel syndrome (IBS-D) rats, as reflected in the decreased abdominal withdrawal reflex scores and serum levels of neuroendocrine factors, mitigated mast cells infiltration, and repression of NGF, TrkA, and TRPV1 expression.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Bo-Jeong Pyun, Kyuhyung Jo, Joo Young Lee, Ami Lee, Myung-A Jung, Youn-Hwan Hwang, Dong Ho Jung, Kon-Young Ji, Susanna Choi, Yun Hee Kim, Taesoo Kim
Summary: Caesalpinia sappan Linn. heartwood water extract (CSLW) has anti-inflammatory and antioxidant properties and can alleviate symptoms of allergic rhinitis (AR) by controlling the allergic inflammatory reaction of the nasal epithelium.
Article
Physiology
Sarah M. Russel, Raluca E. Gosman, Katherine Gonzalez, Joshua Wright, Dennis O. Frank-Ito
Summary: This study aimed to characterize the response of different nasal morphologies to airflow-related variables during rapid/deep inspiration. The results showed that notched nasal vestibules had higher resistance values and airflow velocities, while standard nasal vestibules had higher mucosal heat flux. Different nasal phenotypes may predispose individuals to exercise-induced rhinitis.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Otorhinolaryngology
Thiago Carvalho, Joao Ferreira de Mello Jr, Elia Tamaso Espin Garcia Caldini, Daniel Calduro Salgado, Nicole Mary Garcia de Carvalho, Nilsa Regina Damaceno-Rodrigues, Richard Louis Voegels
Summary: This study found that nerve growth factor and perivascular innervation were associated with the intensity of symptoms in patients with allergic rhinitis, but not in those with idiopathic rhinitis.
INTERNATIONAL ARCHIVES OF OTORHINOLARYNGOLOGY
(2023)
Article
Allergy
Olivia Larsson, Ola Sunnergren, Claus Bachert, Susanna Kumlien Georen, Lars Olaf Cardell
Summary: This study examined the disturbance in the SP-TLR axis in patients with allergic rhinitis. It was found that TLR4 expression was delayed and prolonged, NEP expression was lower, and NK1 receptor expression was increased in AR patients compared to healthy controls. SP-induced regulation of TLR4 was disrupted in AR, suggesting an altered innate immune response that may contribute to prolonged responses to infection in AR.
CLINICAL AND TRANSLATIONAL ALLERGY
(2021)
Article
Plant Sciences
Yuanyuan Ding, Yuejin Wang, Yonghui Zhang, Baowen Dang, Shiting Hu, Chenrui Zhao, Yihan Huang, Guodong Zheng, Tianyou Ma, Tao Zhang
Summary: This study found that alpha-linolenic acid (ALA) can reduce inflammation and allergic symptoms of allergic rhinitis (AR), and improve epithelial barrier functions. The results suggest that ALA may be a potential therapeutic drug for AR.
Article
Integrative & Complementary Medicine
Xiangli Zhuang, Bo Wu, Caixia Qiu, Si Ai, Jian Zheng
Summary: XGND may interfere with the Fyn-STAT5 pathway by reducing the expression of Fyn and SCF and upregulating STAT5 and IL-10, thereby inhibiting proliferation and degranulation of mast cells, correcting Th1/Th2 immune imbalance, and then alleviating the immune response of AR fibroblasts. This study revealed the possible regulatory mechanism of XGND in AR and laid an experimental foundation for improving the clinical efficacy of AR and enriching the clinical medication for AR.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Otorhinolaryngology
Katleen Martens, Emiel Vanhulle, An-Sofie Viskens, Brecht Steelant, Peter W. Hellings, Kurt Vermeire
Summary: This study found that fluticasone propionate has preventive potential in SARS-CoV-2 infection, as it can prevent virus-induced epithelial barrier disruption and infection, as well as reduce ACE2 expression.
Letter
Otorhinolaryngology
P. W. Hellings, W. J. Fokkens, R. Orlandi, G. F. Adriaensen, I. Alobid, F. M. Baroody, L. Bjermer, B. A. Senior, A. Cervin, N. A. Cohen, J. Constantinidis, E. De Corso, M. Desrosiers, Z. Diamant, R. G. Douglas, S. Gane, P. Gevaert, J. K. Han, R. J. Harvey, C. Hopkins, R. C. Kern, B. N. Landis, J. T. Lee, S. E. Lee, A. Leunig, V. J. Lund, M. Bernal-Sprekelsen, J. Mullol, C. Philpott, E. Prokopakis, S. Reitsma, D. Ryan, S. Salmi, G. Scadding, R. J. Schlosser, A. Steinsvik, P. V. Tomazic, E. Van Staeyen, T. Van Zele, O. Vanderveken, A-S Viskens, D. Conti, M. Wagenmann
Review
Otorhinolaryngology
Amarbir S. S. Gill, Jeremiah A. A. Alt, Kara Y. Y. Detwiller, Nicholas R. R. Rowan, Stacey T. T. Gray, Peter W. W. Hellings, Shyam R. R. Joshi, Jivianne T. T. Lee, Zach M. M. Soler, Bruce K. K. Tan, Jennifer L. L. Taylor-Cousar, Sarah K. K. Wise, Tara J. J. Wu, Daniel M. M. Beswick
Summary: This systematic review examined the management strategies for chronic rhinosinusitis with asthma (CRSwA). The results showed that medication, endoscopic sinus surgery, and biologic medications can improve quality of life and asthma control in CRSwA patients. It is recommended to treat CRSwA in a stepwise manner, starting with non-biologic medications and escalating to second-line treatments, while also managing asthma concurrently.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Article
Otorhinolaryngology
W. J. Fokkens, An-Sofie Viskens, Vibeke Backer, Diego Conti, Eugenio de Corso, Philippe Gevaert, Glenis K. Scadding, Martin Wagemann, Manuel Bernal Sprekelsen, Adam Chaker, Enrico Heffler, Joseph K. Han, Elizabeth Van Staeyen, Claire Hopkins, Joaquim Mullol, Anju Peters, Sietze Reitsma, Brent A. Senior, Peter W. Hellings
Summary: Severe chronic rhinosinusitis with nasal polyps (CRSwNP) is a debilitating disease with significant impact on quality of life, often characterized by type 2 inflammatory reaction and comorbidities like asthma, allergies, and NSAID-Exacerbated Respiratory Disease. The European Forum for Research and Education in Allergy and Airway diseases presents practical guidelines for patients undergoing biologic treatment, including updated criteria for patient selection and recommendations for monitoring drug effects and making treatment decisions. Gaps in current knowledge and unmet needs in the field are also discussed.
Article
Otorhinolaryngology
Martin Desrosiers, Zuzana Diamant, Paolo W. Castelnuovo, Peter W. K. Hellings, Joseph K. T. Han, Anju T. Peters, Jared G. Silver, Steven G. Smith, Abigail R. Fuller, Ana R. H. Sousa, Robert H. Chan, Philippe Gevaert, SYNAPSE Study Investigators
Summary: In the SYNAPSE study, mepolizumab given every 4 weeks showed sustained clinical benefits in patients with severe CRSwNP even after discontinuation, including reduction in nasal polyp size, improvement in symptoms and quality of life, and reduction in corticosteroid use and sinus surgeries.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Review
Allergy
A. Wautlet, C. Bachert, M. Desrosiers, Peter W. Hellings, Anju T. Peters
Summary: Chronic rhinosinusitis with nasal polyps is a prevalent condition that has significant implications for both patients and society. The development of biologic medications has proven to be effective in treating this condition, leading to improvements in patient outcomes and quality of life. This review examines the treatment options and explores the available evidence regarding patient selection, monitoring after treatment initiation, and comparisons with other treatment options such as sinus surgery.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Allergy
Jorge F. Maspero, Asif H. Khan, Carl Philpott, Peter W. Hellings, Claire Hopkins, Martin Wagenmann, Shahid Siddiqui, Jerome Msihid, Scott Nash, Chien-Chia Chuang, Siddhesh Kamat, Paul J. Rowe, Yamo Deniz, Juby A. Jacob-Nara
Summary: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a type 2 inflammatory disease with severe symptoms. This study compared the physical and mental health-related quality of life (HRQoL) and overall health status of severe CRSwNP patients with the general population and other chronic diseases. The results showed that the HRQoL of CRSwNP patients was lower than the general population and similar to diseases such as diabetes and asthma.
JOURNAL OF ASTHMA AND ALLERGY
(2023)
Review
Environmental Sciences
Paulien Verscheure, Olivier Honnay, Niko Speybroeck, Robin Daelemans, Nicolas Bruffaerts, Brecht Devleesschauwer, Tobias Ceulemans, Laura Van Gerven, Raf Aerts, Rik Schrijvers
Summary: The increase in allergies to aeroallergens is attributed to interactions with environmental and lifestyle changes, with environmental nitrogen pollution potentially being a key driver. While the ecological impact of nitrogen pollution is well understood, its indirect effect on allergies in humans is not well documented. This literature review focuses on the impact of nitrogen pollution on plant communities, plant productivity, and pollen properties, and how these changes contribute to allergy burden. The majority of studies have examined the impact of atmospheric nitrogen pollution on pollen and allergens, leading to allergy symptoms, but limited research has been conducted on the impact of soil and aqueous nitrogen pollution on pollen allergenic reactivity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Medicine, Research & Experimental
Birgit Coucke, Anais Van Hoylandt, Mark Jorissen, Jeroen Meulemans, Thomas Decramer, Johannes van Loon, Vincent Vander Poorten, Tom Theys, Laura Van Gerven
Summary: This study aims to investigate the use of autologous leukocyte- and platelet-rich fibrin (L-PRF) membranes as an alternative to commercially available fibrin sealants in endoscopic endonasal transsphenoidal approaches (EETA) for skull base reconstruction. The trial will be conducted in three different centers in Belgium, with patients randomized into L-PRF group and commercially available fibrin sealants group. The primary endpoint is postoperative cerebrospinal fluid leakage, and secondary endpoints include identification of risk factors for reconstruction failure, assessment of rhinological symptoms, and interference with postoperative imaging.
Letter
Allergy
Diego M. Conti, Peter W. Hellings, Zuzana Diamant, Leif Bjermer, Milos Jesenak, Vibeke Backer, Wytske Fokkens, Susanne Lau, Elizabeth Van Staeyen, Glenis K. Scadding
Summary: This paper examines the epidemiology of comorbidities in asthmatic patients, focusing on the relevance of chronic rhinosinusitis (CRS) with or without nasal polyps (CRSwNP or CRSsNP) as an important comorbidity that is often overlooked. The authors argue that CRS should have been included in the analysis due to its high incidence, its association with asthma, and the impact it has on asthma control and severity. They suggest that targeted therapies used for severe asthma may also be effective for the treatment of nasal polyps.
ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY
(2023)
Meeting Abstract
Allergy
Amber Luong, Joshua Levy, Ludger Klimek, Richard Harvey, Jared Silver, Steven Smith, Abby Fuller, Robert Chan, Peter Hellings
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Allergy
Dorien Van Broeck, Brecht Steelant, Glenis Scadding, Peter W. Hellings
Summary: Nonsteroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (N-ERD) is a clinical syndrome characterized by nasal polyposis, asthma, and intolerance to aspirin/NSAID. It affects approximately 15% cases of severe asthma, 10% of nasal polyps and 9% of rhinosinusitis. N-ERD results in associated asthma exacerbations, oral corticosteroids bursts, corticosteroid-dependent disease, and multiple endoscopic sinus surgeries. Unknown influences cause polyp epithelium to release alarmins, activating lymphoid cells and causing complex type 2 inflammation. Treatment strategies for N-ERD include drug therapies, aspirin desensitization, monoclonal antibodies, and other therapies associated.
FRONTIERS IN ALLERGY
(2023)
Article
Allergy
Patricia K. Kakobo, Hilaire K. Kalala, Joseph K. Kelekele, Paulin B. Mutombo, Dieudonne T. Nyembue, Peter W. Hellings, Jean-Marie N. Kayembe
Summary: This study aims to identify the determinants of uncontrolled allergic rhinitis (UCAR) in a hospital setting in Kinshasa, Democratic Republic of Congo. The study found that factors associated with UCAR include age below 30 years, low vitamin D level, and persistent as well as moderate to severe allergic rhinitis.
FRONTIERS IN ALLERGY
(2023)
Article
Microbiology
Saartje Uyttebroek, Laura Bessems, Willem-Jan Metsemakers, Yves Debaveye, Laura Van Gerven, Lieven Dupont, Melissa Depypere, Jeroen Wagemans, Rob Lavigne, Maya Merabishvili, Jean-Paul Pirnay, David Devolder, Isabel Spriet, Jolien Onsea
Summary: This study investigated the stability of bacteriophage preparations used in the treatment of various infections. The results showed that the titer of bacteriophages decreased after storage, indicating the importance of maintaining therapeutic concentrations. The study also found that storing bacteriophage solutions in polypropylene syringes helped maintain stability. Nasal irrigation or infusion through a catheter did not affect the titer of bacteriophages.
MICROBIOLOGY SPECTRUM
(2023)
Meeting Abstract
Gastroenterology & Hepatology
M. Cuende-Estevez, S. Cuypers, W. Backaert, H. Hussein, I. Appeltans, K. Bellens, J. Vanoirbeek, L. Van Gerven, J. Aguilera-Lizarraga, G. Boeckxstaens
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
