Article
Health Care Sciences & Services
Youlim Kim, Tai Sun Park, Tae-Hyung Kim, Chin Kook Rhee, Changhwan Kim, Jae Seung Lee, Woo Jin Kim, Seong Yong Lim, Yong Bum Park, Kwang Ha Yoo, Sang-Do Lee, Yeon-Mok Oh, Ji-Yong Moon
Summary: This study observed worse outcomes in terms of exacerbation rate and change in lung function for COPD patients with occupational exposure. This suggests that occupational exposure is not only a risk factor for COPD, but may also have a prognostic impact on COPD.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Environmental Sciences
Yalan Xiao, Xiaoying Gu, Hongtao Niu, Xia Meng, Lina Zhang, Jianying Xu, Lan Yang, Jianping Zhao, Xiangyan Zhang, Chunxue Bai, Jian Kang, Pixin Ran, Huahao Shen, Fuqiang Wen, Kewu Huang, Yahong Chen, Tieying Sun, Guangliang Shan, Yingxiang Lin, Sinan Wu, Jianguo Zhu, Ruiying Wang, Zhihong Shi, Yongjian Xu, Xianwei Ye, Yuanlin Song, Qiuyue Wang, Yumin Zhou, Liren Ding, Diandian Li, Wanzhen Yao, Yanfei Guo, Fei Xiao, Yong Lu, Xiaoxia Peng, Biao Zhang, Dan Xiao, Zuomin Wang, Hong Zhang, Xiaoning Bu, Xiaolei Zhang, Li An, Shu Zhang, Zhixin Cao, Qingyuan Zhan, Yuanhua Yang, Lirong Liang, Bin Cao, Huaping Dai, Tangchun Wu, Jiang He, Haidong Kan, Renjie Chen, Ting Yang, Chen Wang
Summary: The study found that residential greenness in China is associated with better lung function and lower prevalence of COPD, particularly among middle-aged and young individuals, females, and non-smokers. These findings provide a scientific basis for healthy community planning.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Claire Philippat, Anne Boudier, Nicolas Jovanovic, Joane Quentin, Yoann Gioria, Cathrine Thomsen, Sam Bayat
Summary: This study of 433 mother-child pairs found no evidence that prenatal exposure to PFAS affects respiratory health in early childhood.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Yacong Bo, Ly-yun Chang, Cui Guo, Changqing Lin, Alexis K. H. Lau, Tony Tam, Xiang Qian Lao
Summary: Reduced exposure to PM2.5 pollution was associated with improvements in lung function parameters and a decreased risk of COPD development. Strategies aimed at reducing air pollution may effectively combat the risk of developing COPD.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Bian-Bian Lv, Chun-Lan Yang, Zhu-Xia Tan, Ling Zheng, Meng-Die Li, Ya-Lin Jiang, Ling Liu, Min-Min Tang, Dong-Xu Hua, Jin Yang, De-Xiang Xu, Hui Zhao, Lin Fu
Summary: This study found that blood cadmium concentration is strongly associated with the decline of pulmonary function in COPD patients, and there is a dose-dependent relationship. In addition, there is an inverse correlation between cadmium concentration and telomerase subunit TERT. The study also found that TERT mediates 29.53%, 37.50%, and 19.48% of CD-induced declines in FVC, FEV1, and FEV1%, respectively. Therefore, blood cadmium concentration may cause pulmonary function decline in COPD patients by inducing TERT degradation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Respiratory System
Lina Nurhussien, Choong-Min Kang, Petros Koutrakis, Brent A. Coull, Mary B. Rice
Summary: The study found associations between daily pollutant exposure and lung function in COPD patients, particularly in those with higher blood eosinophil levels. This highlights the importance of addressing air pollution exposure among COPD patients and the need for further research on whether eosinophil levels serve as a biomarker for susceptibility to air pollution in COPD.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Environmental Sciences
Wen-Jing Wang, Kun Peng, Xue Lu, Yan-Yan Zhu, Zhao Li, Qing-Hua Qian, Ya-Xin Yao, Lin Fu, Yan Wang, Yi-Chao Huang, Hui Zhao, Hua Wang, De -Xiang Xu, Zhu-Xia Tan
Summary: Accumulating evidences show that long-term exposure to atmospheric fine particles and air pollutants increases the risk of COPD. Cadmium (Cd) is an important toxic substance in these pollutants. A mouse model was established to demonstrate that respiratory Cd exposure induces COPD-like lung injury.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Medicine, General & Internal
Kewu Huang, Kian Fan Chung, Ting Yang, Jianying Xu, Lan Yang, Jianping Zhao, Xiangyan Zhang, Chunxue Bai, Jian Kang, Pixin Ran, Huahao Shen, Fuqiang Wen, Yahong Chen, Tieying Sun, Guangliang Shan, Yingxiang Lin, Guodong Xu, Sinan Wu, Ying Wang, Xiaoying Gu, Ruiying Wang, Zhihong Shi, Yongjian Xu, Xianwei Ye, Yuanlin Song, Qiuyue Wang, Yumin Zhou, Wen Li, Liren Ding, Chun Wan, Wanzhen Yao, Yanfei Guo, Fei Xiao, Yong Lu, Xiaoxia Peng, Dan Xiao, Xiaoning Bu, Hong Zhang, Xiaolei Zhang, Li An, Shu Zhang, Zhixin Cao, Qingyuan Zhan, Yuanhua Yang, Lirong Liang, Wenjun Wang, Huaping Dai, Bin Cao, Jiang He, Chen Wang
Summary: This study investigated the prevalence and heterogeneity of COPD with concomitant features of asthma in Chinese adult population, finding a prevalence of 1.62% in adults and 15.2% in COPD patients. COPD patients with asthma diagnosis or wheeze were older and had worse lung function compared to those with high bronchodilator response.
FRONTIERS IN MEDICINE
(2022)
Article
Critical Care Medicine
Jean Bourbeau, Dany Doiron, Sharmistha Biswas, Benjamin M. Smith, Andrea Benedetti, Jeffrey R. Brook, Shawn D. Aaron, Kenneth R. Chapman, Paul Hernandez, Francois Maltais, Darcy D. Marciniuk, Denis O'Donnell, Don D. Sin, Brandie Walker, Liesel Dsilva, Gilbert Nadeau, Valerie Coats, Chris Compton, Bruce E. Miller, Wan C. Tan
Summary: Outdoor air pollution is associated with lower lung function and COPD, with possible interactions with dysanapsis.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Medicine, General & Internal
Stephanie A. Christenson, Benjamin M. Smith, Mona Bafadhel, Nirupama Putcha
Summary: Chronic obstructive pulmonary disease (COPD) is a global health problem that leads to high morbidity, mortality, and healthcare utilization. Its main causes are exposure to harmful particles, such as tobacco smoke and pollutants. Recent research has shown that various factors throughout the life course increase the risk of developing COPD. Innovations in omics and imaging techniques have provided greater understanding of the disease's pathophysiology, potentially leading to advancements in its prevention, diagnosis, and treatment. This review focuses on recent advances in the epidemiology, pathophysiology, imaging, diagnosis, and treatment of COPD.
Review
Medicine, Research & Experimental
Michael C. Ferrera, Wassim W. Labaki, MeiLan K. Han
Summary: COPD is a common respiratory disorder with high morbidity and mortality, often underdiagnosed until clinical advancement. Research focuses on early changes for better diagnosis and identifying patients for early intervention. Treatment options have significantly expanded in the past 20 years with new medications and procedures.
ANNUAL REVIEW OF MEDICINE, VOL 72, 2021
(2021)
Review
Medicine, General & Internal
Alejandra Ramirez-Venegas, Francisco Montiel-Lopez, Ramces Falfan-Valencia, Gloria Perez-Rubio, Raul H. Sansores
Summary: This review explores the natural history of lung decline in COPD patients associated with biomass exposure, indicating that these patients may represent a distinct phenotype of COPD with slower lung function decline compared to smokers. Further research is needed to fully characterize this subgroup of COPD variants.
FRONTIERS IN MEDICINE
(2021)
Article
Critical Care Medicine
Siddharth S. Madapoosi, Charmion Cruickshank-Quinn, Kristopher Opron, John R. Erb-Downward, Lesa A. Begley, Gen Li, Igor Barjaktarevic, R. Graham Barr, Alejandro P. Comellas, David J. Couper, Christopher B. Cooper, Christine M. Freeman, MeiLan K. Han, Robert J. Kaner, Wassim Labaki, Fernando J. Martinez, Victor E. Ortega, Stephen P. Peters, Robert Paine, Prescott Woodruff, Jeffrey L. Curtis, Gary B. Huffnagle, Kathleen A. Stringer, Russell P. Bowler, Charles R. Esther, Nichole Reisdorph, Yvonne J. Huang
Summary: The study found that lung microbiota and metabolites are associated with clinical markers in patients with milder COPD, suggesting their potential collaborative roles in disease pathogenesis.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Medicine, General & Internal
Xiaoyan Gai, Brian Allwood, Yongchang Sun
Summary: The burden of chronic airway diseases, including chronic obstructive pulmonary disease (COPD), continues to increase, especially in low- and middle-income countries. Post-tuberculosis lung disease (PTLD), characterized by chronic lung changes after the cure of pulmonary tuberculosis (TB), may be associated with the pathogenesis of COPD. However, data on PTLD's prevalence, clinical manifestations, computed tomography features, lung function impairment patterns, and influencing factors are limited. More research is needed to elucidate the pathogenesis of PTLD.
CHINESE MEDICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Belen Callejon-Leblic, Saida Sanchez Espirilla, Carolina Gotera-Rivera, Rafael Santana, Isabel Diaz-Olivares, Jose M. Marin, Ciro Casanova Macario, Borja Garcia Cosio, Antonia Fuster, Ingrid Solanes Garcia, Juan P. de-Torres, Nuria Feu Collado, Carlos Cabrera Lopez, Carlos Amado Diago, Amparo Romero Plaza, Luis Alejandro Padron Fraysse, Eduardo Marquez Martin, Margarita Marin Royo, Eva Balcells Vilarnau, Antonia Llunell Casanovas, Cristina Martinez Gonzalez, Juan Bautista Galdiz Iturri, Celia Lacarcel Bautista, Jose Luis Gomez-Ariza, Antonio Pereira-Vega, Luis Seijo, Jose Luis Lopez-Campos, German Peces-Barba, Tamara Garcia-Barrera
Summary: This study found that the severity of chronic obstructive pulmonary disease (COPD) and lung cancer (LC) significantly impact the elemental composition of human serum. These findings may pave the way for the potential use of elements as biomarkers for the diagnosis and prognosis of these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Critical Care Medicine
Gang Wang, Jenny Hallberg, Rosa Faner, Hans-Jacob Koefoed, Simon Kebede Merid, Susanna Klevebro, Sophia Bjorkander, Olena Gruzieva, Goran Pershagen, Marianne van Hage, Stefano Guerra, Matteo Bottai, Antonios Georgelis, Ulrike Gehring, Anna Bergstrom, Judith M. Vonk, Inger Kull, Gerard H. Koppelman, Alvar Agusti, Erik Melen
Summary: Recent evidence emphasizes the significance of optimal lung development during childhood for lifelong health. This study explored the plasticity of individual lung function states during childhood and found that catch-up and growth failure were associated with respiratory symptoms, airflow limitation, and small airway dysfunction in adulthood.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Environmental Sciences
Femke Bouma, Gerard Hoek, Gerard H. Koppelman, Judith M. Vonk, Jules Kerckhoffs, Roel Vermeulen, Ulrike Gehring
Summary: This study investigated the association between long-term exposure to ultrafine particles (UFP) and allergic sensitization in children. The findings showed no significant association between UFP exposure and sensitization to inhalant and food allergens. However, NO2, PM2.5, PM2.5 absorbance, and PM10 were found to be associated with sensitization to food allergens.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Pauline Kiss, Myrna M. T. de Rooij, Gerard H. Koppelman, Jolanda Boer, Judith M. Vonk, Roel Vermeulen, Lenny Hogerwerf, Hendrika A. M. Sterk, Anke Huss, Lidwien A. M. Smit, Ulrike Gehring
Summary: This study found that adolescents living closer to livestock farms had lower lung function compared to those living farther away. There is an association between closer proximity to farms and poorer lung function.
ENVIRONMENTAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Amir Hossein Alizadeh Bahmani, Elise M. A. Slob, Lizan D. Bloemsma, Susanne Brandstetter, Paula Corcuera-Elosegui, Mario Gorenjak, Susanne Harner, Simone Hashimoto, Anna M. Hedman, Michael Kabesch, Gerard H. Koppelman, Javier Korta-Murua, Aletta D. Kraneveld, Anne H. Neerincx, Marielle W. Pijnenburg, Maria Pino-Yanes, Uros Potocnik, Olaia Sardon-Prado, Susanne J. H. Vijverberg, Christine Wolff, Mahmoud Abdel-Aziz, Anke H. Maitland-van der Zee
Summary: This multicountry, observational, case-control study aimed to compare treatment regimens, inhaler techniques, medication adherence, and other characteristics of controlled and uncontrolled pediatric asthma. The study found that children in higher treatment steps had a higher risk of uncontrolled asthma, and the risk was also associated with a larger change in lung function post and pre-salbutamol. However, adherence and inhaler techniques were not related to the risk of uncontrolled asthma. Other factors, such as environmental factors and biological profiles, may influence the risk of uncontrolled asthma in this population.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Review
Respiratory System
Anna Rattu, Ekaterina Khaleva, Chris Brightling, Sven-Erik Dahlen, Apostolos Bossios, Louise Fleming, Kian Fan Chung, Erik Melen, Ratko Djukanovic, Rekha Chaudhuri, Andrew Exley, Gerard H. Koppelman, Arnaud Bourdin, Franca Rusconi, Celeste Porsbjerg, Courtney Coleman, Clare Williams, Hanna Nielsen, Elizabeth Davin, Phil Taverner, Sofia Romagosa Vilarnau, Graham Roberts
Summary: The recommendations of the National Institutes of Health (NIH) on outcome measurement instruments for asthma are widely used in clinical practice and research. However, there is no consensus on which outcome measures are important to patients with severe asthma and are valid for this population. Guidelines recommend the use of patient-reported outcome measures (PROMs) to evaluate treatment response, but do not provide specific instruments. Additionally, the outcomes that patients consider important, such as quality of life, are not consistently considered by physicians when evaluating treatment response.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Microbiology
Evy Maas, John Penders, Koen Venema
Summary: This study investigated the relationships between fungi and bacteria using a complex computer-controlled in vitro model of the colon. The results showed that cross-kingdom interactions exist between fungi and bacteria, and they can influence each other. These findings are important for understanding the role of the microbial community in the human gut.
Article
Microbiology
Evy Maas, John Penders, Koen Venema
Summary: Most studies on the human gut microbiota focus on bacteria, but recent research indicates that intestinal fungi are also important for maintaining health. This study analyzed the mycobiome of healthy individuals and its interaction with the bacterial component of the microbiome. The results showed a lower diversity of fungi compared to bacteria, with significant inter-individual variation. Positive correlations were observed between certain fungi and bacteria, including those associated with alleviating inflammatory bowel disease. Further research is needed to investigate the importance of these correlations and distinguish between gut colonizers and transient species.
Article
Public, Environmental & Occupational Health
Sophie Kienhorst, Moniek H. D. van Aarle, Quirijn Jobsis, Michiel A. G. E. Bannier, Elin T. G. H. Kersten, Jan Damoiseaux, Onno C. P. van Schayck, Peter J. F. M. Merkus, Gerard Koppelman, Frederik-Jan van Schooten, Agnieszka Smolinska, Edward Dompeling
Summary: This study evaluates the application of a breath test in preschool children with asthma-like symptoms. The test predicts a diagnosis of asthma by analyzing the exhaled breath. The study also explores the relationship between other biological parameters and the odors in the breath.
Article
Allergy
Wouter W. de Weger, Vibeke M. Bruinenberg, Jeroen H. Gerrits, Lidy van Lente, Catherina E. M. Herpertz, Gerbrich N. van Der Meulen, Aline B. Sprikkelman, Gerard H. Koppelman, Arvid W. A. Kamps
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Editorial Material
Allergy
Yidan Sun, Elin T. G. Kersten, Cancan Qi, Gerard H. Koppelman
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Allergy
Andres Cardenas, Raj P. Fadadu, Gerard H. Koppelman
Summary: This article provides a narrative review of epigenetic research on the relationship between the environment and allergies. The review highlights the importance of DNA methylation as an epigenetic modification and discusses the findings from previous studies and recent research. Overall, the results suggest that there are consistent associations between environmental exposures and DNA methylation changes related to allergic diseases. The review also suggests recommendations for future research in this field.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Daniel Aguilar, Nathanael Lemonnier, Erik Melen, Mariona Bustamante, Olena Gruzieva, Stefano Guerra, Thomas Keil, Gerard H. Koppelman, Juan C. Celedon, Josep M. Anto, Jean Bousquet
Summary: The concept of one-airway-one-disease may oversimplify the links between allergic diseases. Genomic studies suggest that rhinitis alone and rhinitis with asthma are operated by distinct pathways. In this MeDALL study, the human interactome was used to differentiate molecular mechanisms associated with two phenotypes of allergic rhinitis: rhinitis alone and rhinitis with asthma. There were significant differences in the interactome topology and pathways associated with each phenotype. The findings suggest that rhinitis alone and rhinitis with asthma should be considered as two distinct diseases.
SCIENTIFIC REPORTS
(2023)
Article
Respiratory System
E. de Poel, S. Spelier, M. C. Hagemeijer, P. van Mourik, S. W. F. Suen, A. M. Vonk, J. E. Brunsveld, G. N. Ithakisiou, E. Kruisselbrink, H. Oppelaar, G. Berkers, K. M. de Winter de Groot, S. Heida-Michel, S. R. Jans, H. van Panhuis, M. Bakker, R. van der Meer, J. Roukema, E. Dompeling, E. J. M. Weersink, G. H. Koppelman, A. R. Blaazer, J. E. Muijlwijk-Koezen, C. K. van der Ent, J. M. Beekman
Summary: By using patient-derived intestinal organoids (PDIOs), a study shows that PDE4 inhibitors can increase CFTR function in people with cystic fibrosis (pwCF). This research demonstrates the feasibility of high-throughput compound screening using PDIOs and highlights the potential of drug repurposing for pwCF carrying non-F508del genotypes that are currently ineligible for therapies.
JOURNAL OF CYSTIC FIBROSIS
(2023)
Article
Respiratory System
Zaid W. El-Husseini, Dmitry Khalenkow, Andy Lan, Thys van der Molen, Chris Brightling, Alberto Papi, Klaus F. Rabe, Salman Siddiqui, Dave Singh, Monica Kraft, Bianca Beghe, Maarten van den Berge, Djoke van Gosliga, Martijn C. Nawijn, Stefan Rose-John, Gerard H. Koppelman, Reinoud Gosens
Summary: This study investigated the role of sIL-6Rα in amplifying IL-6 signaling in bronchial epithelial cells, and developed an IL-6+sIL-6Rα gene signature that may be used to select asthma patients who potentially respond to anti-IL-6 therapy.
RESPIRATORY RESEARCH
(2023)
Review
Respiratory System
Nazanin Kermani, Ali Versi, Aurore Gay, Jelmer Vlasma, Akshaya Keerthi Saikumar Jayalatha, Gerard H. Koppelman, Martijn Nawijn, Alen Faiz, Maarten van den Berge, Ian M. Adcock, Kian Fan Chung
Summary: This article introduces the use of bioinformatic approaches to analyze large omics datasets and define the inflammatory and cellular functional pathways associated with different molecular endotypes in severe asthma. Additionally, it discusses the role of mast cell activation and macrophage dysfunction in asthma.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2023)
