Review
Oncology
Elvan Wiyarta, Darrin Ananda Nugraha, Muhammad Indera Ramadani, Gita Fajri Gustya, Muhammad Farrasy Ammar, Hana Dzakira Edwar, Nildza Kheirizzad, Mutiah Nurul Mukhlisah, Erlina Burhan, Elisna Syahruddin
Summary: This review addresses the diagnostic value and clinical utility of tumor-educated platelets (TEPs) in adult patients with lung cancer. The findings suggest that TEPs have high sensitivity and specificity, indicating their potential as an effective diagnostic biomarker for lung cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Dermatology
J. Chen, C. Li, H. Li, H. Yu, X. Zhang, M. Yan, Y. Guo, Z. Yao
Summary: The study identified two distinct clusters in Chinese psoriasis population, one with an early onset, low eosinophil level, T(H)17 polarization, and a strong T(H)2 component. These results provide insights into the pathogenesis of psoriasis in the Chinese population.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Chiao-Hsu Ke, Cheng-Chi Liu, Shang-Lin Wang, Chen-Si Lin
Summary: The study found that D-dimer values significantly increased in dogs with tumors, and significantly decreased after the removal of primary tumors. Furthermore, other hemostatic parameters were correlated to tumor burden. These parameters could be potential biomarkers for canine tumors.
Article
Oncology
Thomas E. Stinchcombe, Xiaofei Wang, Robert C. Doebele, Leylah M. Drusbosky, David E. Gerber, Leora Horn, Erin M. Bertino, Geoff Liu, Liza C. Villaruz, D. Ross Camidge
Summary: Brigatinib demonstrates activity in ALK-positive NSCLC patients with disease progression after treatment with second-generation ALK inhibitors.
Article
Medicine, General & Internal
Wei Yu, Qianqian Wang, Meili Ge, Xue Shi
Summary: Cluster analysis of lymphocyte subset can classify newly diagnosed IAA patients into 4 distinctive subgroups with similar immune patterns. The clusters of lymphocyte subset are closely correlated with disease severity and treatment response of IAA. Lymphocyte subset clustering may serve as a promising tool for assessing disease severity and treatment efficacy in newly diagnosed IAA patients.
ANNALS OF MEDICINE
(2022)
Review
Oncology
Isabel Heidrich, Thaer S. A. Abdalla, Matthias Reeh, Klaus Pantel
Summary: Colorectal cancer is a common malignancy with high mortality rates, often due to tumor cells spreading through the blood. Liquid biopsy, which analyzes circulating tumor cells and cell-free DNA in the blood, offers new diagnostic and therapeutic opportunities for colorectal cancer patients. It has the potential to improve early detection, monitor disease progression, and guide personalized treatment strategies.
Article
Medicine, Research & Experimental
Yumin Zhu, Siqi Wang, Xiaochen Xi, Minfeng Zhang, Xiaofan Liu, Weina Tang, Peng Cai, Shaozhen Xing, Pengfei Bao, Yunfan Jin, Weihao Zhao, Yinghui Chen, Huanan Zhao, Xiaodong Jia, Shanshan Lu, Yinying Lu, Lei Chen, Jianhua Yin, Zhi John Lu
Summary: The study utilized sequencing technologies to detect different types of cancer-related RNA variations in plasma, revealing pathways associated with tumorigenesis and metastasis, immune responses, and metabolism. A 3-RNA detection panel for liver cancer was identified, showing promise for detecting AFP-negative and early-stage patients.
Review
Cell Biology
Jing Li, Na Gao, Zhengfan Gao, Wei Liu, Bairen Pang, Xingli Dong, Yong Li, Tianli Fan
Summary: Exosomes play critical roles in promoting chemoresistance in cancer through various mechanisms. Due to their stability, specificity, and sensitivity, exosomes can serve as biomarkers in liquid biopsies to monitor the current status and progression of cancer chemoresistance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sumeng Wang, Ke Zhang, Shanyue Tan, Junyi Xin, Qianyu Yuan, Huanhuan Xu, Xian Xu, Qi Liang, David C. Christiani, Meilin Wang, Lingxiang Liu, Mulong Du
Summary: Cancer is a major cause of death worldwide, prompting research into novel biomarkers for diagnosis. Circulating circRNAs, stably present in body fluids, exhibit distinct expression patterns that can be used to monitor cancer development and progression.
Article
Biochemistry & Molecular Biology
Daniel P. de Bruyn, Michiel Bongaerts, Ramon Bonte, Jolanda Vaarwater, Magda A. Meester-Smoor, Robert M. Verdijk, Dion Paridaens, Nicole C. Naus, Annelies de Klein, George J. G. Ruijter, Emine Kilic, Erwin Brosens
Summary: Using untargeted metabolomics, we identified differential metabolite patterns in UM patients compared to controls. The random forest classifier and leave-one-out cross-validation confirmed the discriminatory ability of these metabolite patterns in distinguishing UM patients from controls, but not in differentiating high-risk and low-risk UM patients. Dysregulation of metabolite patterns may be associated with processes related to malignancies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Maria Jesus Alvarez-Cubero, Elena Arance, Esperanza de Santiago, Pilar Sanchez, Maria Rosario Sepulveda, Raquel Marrero, Jose Antonio Lorente, Jose Maria Gonzalez-Cabezuelo, Sergio Cuenca-Lopez, Jose Manuel Cozar, Fernando Vazquez-Alonso, Luis Javier Martinez-Gonzalez
Summary: In this study, the role of aggressiveness genetic markers for prostate cancer (PC) stratification was investigated. Three novel non-invasive biomarkers (PCA3, S100A4, and MRC2) with increased expression in patients were identified. The combination of S100A4, MRC2, and PCA3 showed improved discriminatory power between patients and controls and between different stages of aggressiveness.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Begona O. Alen, Lara Sofia Estevez-Perez, Maria Otero Alen, Saioa Dominguez Hormaetxe, Laureano Simon, Angel Concha
Summary: TD-EVs play active roles in cancer progression by facilitating communication processes. This study validated the presence of epithelial and stromal markers in RNA of plasmatic EVs for a non-invasive cancer diagnosis system. Results showed significant gene expression differences between healthy donors and cancer patients, indicating the potential of TD-EVs RNA analysis as a diagnostic tool in oncology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Insa M. Schmidt, Mia R. Colona, Bryan R. Kestenbaum, Leonidas G. Alexopoulos, Ragnar Palsson, Anand Srivastava, Jing Liu, Isaac E. Stillman, Helmut G. Rennke, Vishal S. Vaidya, Haojia Wu, Benjamin D. Humphreys, Sushrut S. Waikar
Summary: Analysis of gene expression profiles and the development of Luminex-based assays were used to identify promising non-invasive biomarkers of kidney fibrosis. CDH11, SMOC2, and PEDF were found to be associated with the severity of interstitial fibrosis and tubular atrophy, as well as progression to end-stage kidney disease in independent cohorts of chronic kidney disease patients.
KIDNEY INTERNATIONAL
(2021)
Article
Rheumatology
Andrea Fava, Deepak A. Rao, Chandra Mohan, Ting Zhang, Avi Rosenberg, Paride Fenaroli, H. Michael Belmont, Peter Izmirly, Robert Clancy, Jose Monroy Trujillo, Derek Fine, Arnon Arazi, Celine C. Berthier, Anne Davidson, Judith A. James, Betty Diamond, Nir Hacohen, David Wofsy, Soumya Raychaudhuri, William Apruzzese, Jill Buyon, Michelle Petri
Summary: By analyzing longitudinal urinary proteomic profiles in patients with Lupus Nephritis (LN), this study identified multiple biologic pathways and 237 urinary biomarkers associated with LN. IL-16 was identified as a key factor in LN pathogenesis and a potential target for treatment and biomarker.
ARTHRITIS & RHEUMATOLOGY
(2022)
Review
Oncology
Estela Sanchez-Herrero, Roberto Serna-Blasco, Lucia Robado de Lope, Victor Gonzalez-Rumayor, Atocha Romero, Mariano Provencio
Summary: This article provides an overview of the biological features of circulating tumor DNA (ctDNA), including size, structure, shedding and clearance mechanisms, as well as the pathological factors that determine ctDNA levels. A better understanding of ctDNA biology is crucial for the development of new methods for ctDNA analysis.
FRONTIERS IN ONCOLOGY
(2022)