Article
Multidisciplinary Sciences
SunJu NamGoung, Yoosoo Chang, Yejin Kim, Hoon Kim, In Young Cho, Ria Kwon, Ga-Young Lim, Hye Rin Choi, Jeonggyu Kang, Kye-Hyun Kim, Yun Soo Hong, Di Zhao, Hyun-Young Park, Juhee Cho, Eliseo Guallar, Min-Jung Kwon, Seungho Ryu
Summary: This study investigated the relationship between AMH levels and the development of early-onset VMS among premenopausal women. The results showed that lower AMH levels were significantly associated with an increased risk of early-onset VMS. This suggests that AMH levels may play an independent role in predicting early-onset VMS among premenopausal women.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Nathalie Acevedo, Giovanni Scala, Simon Kebede Merid, Paolo Frumento, Soren Bruhn, Anna Andersson, Christoph Ogris, Matteo Bottai, Goran Pershagen, Gerard H. Koppelman, Erik Melen, Erik Sonnhammer, Johan Alm, Cilla Soderhall, Juha Kere, Dario Greco, Annika Scheynius
Summary: The study revealed that DNA methylation is associated with IgE sensitization in early life, with different gene pathways enriched in sensitization to airborne allergens and food allergens. Maternal DNA methylation levels were also found to be associated with IgE sensitization in children, supporting early in utero effects on atopy predisposition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Francesca De Vito, Velia Cassano, Elettra Mancuso, Elena Succurro, Marta Letizia Hribal, Angela Sciacqua, Francesco Andreozzi, Giorgio Sesti, Teresa Vanessa Fiorentino
Summary: Higher pro-NT levels are a predictor of NAFLD independent of other metabolic risk factors.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Daniel P. Beavers, Stephen B. Kritchevsky, Thomas M. Gill, Walter T. Ambrosius, Stephen D. Anton, Roger A. Fielding, Abby C. King, W. Jack Rejeski, Laura Lovato, Mary M. McDermott, Anne B. Newman, Marco Pahor, Michael P. Walkup, Russell P. Tracy, Todd M. Manini
Summary: The study revealed that elevated levels of IL-6 and CRP are associated with an increased risk of major mobility disability (MMD) among older adults with slow gait speed. Furthermore, a combined biomarker model suggests that CRP is particularly associated with MMD when IL-6 levels are elevated.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
George Kuo, Tao-Han Lee, Jia-Jin Chen, Chieh-Li Yen, Pei-Chun Fan, Cheng-Chia Lee, Chih-Hsiang Chang
Summary: The study found that for new incident kidney failure patients requiring hemodialysis, a larger facility size was associated with lower mortality risk. Compared to medical centers, patients in non-center hospitals and clinics had higher mortality and hospitalization risks.
SCIENTIFIC REPORTS
(2021)
Article
Hematology
Ellen-Sofie Hansen, Fridtjof B. Rinde, Magnus S. Edvardsen, Kristian Hindberg, Nadezhda Latysheva, Pal Aukrust, Thor Ueland, Annika E. Michelsen, John-Bjarne Hansen, Sigrid K. Braekkan, Vania M. Morelli
Summary: The results of the study suggest that elevated plasma D-dimer levels are associated with an increased risk of incident VTE. However, the risk estimates were slightly attenuated after adjusting for body mass index and C-reactive protein, indicating that D-dimer may partly reflect underlying conditions related to obesity and inflammation.
THROMBOSIS RESEARCH
(2021)
Article
Allergy
Sabina Warnberg Gerdin, Anine Lie, Anna Asarnoj, Magnus P. Borres, Karin C. Lodrup Carlsen, Martin Fardig, Jon R. Konradsen, Christine Monceyron Jonassen, Caroline-Aleksi Olsson Magi, Eva Maria Rehbinder, Knut Rudi, Havard Ove Skjerven, Anne Cathrine Staff, Cilla Soderhall, Sandra G. Tedner, Marianne van Hage, Riyas Vettukattil, Bjorn Nordlund
Summary: The study found that eczema, dry skin, and high TEWL at 3 months of age were associated with an increased risk of allergic sensitization at 6 months.
Article
Hematology
Rajeev Malhotra, Christopher J. Nicholson, Dongyu Wang, Vijeta Bhambhani, Samantha Paniagua, Charles Slocum, Haakon H. Sigurslid, Christian L. Lino Cardenas, Rebecca Li, Sophie L. Boerboom, Yin-Ching Chen, Shih-Jen Hwang, Chen Yao, Fumito Ichinose, Donald B. Bloch, Mark E. Lindsay, Gregory D. Lewis, Jayashri R. Aragam, Udo Hoffmann, Gary F. Mitchell, Naomi M. Hamburg, Ramchandran S. Vasan, Emelia J. Benjamin, Martin G. Larson, Warren M. Zapol, Susan Cheng, Jason D. Roh, Christopher J. O'Donnell, Christopher Nguyen, Daniel Levy, Jennifer E. Ho
Summary: This study finds an association between ucMGP levels and arterial stiffness, as well as future HFpEF. Experimental studies using mice also support the link between Mgp heterozygosity and arterial stiffness. These findings suggest a potential role of therapeutic targeting MGP in HFpEF.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Cristina Garcia-Beltran, Artur Navarro-Gascon, Abel Lopez-Bermejo, Tania Quesada-Lopez, Francis de Zegher, Lourdes Ibanez, Francesc Villarroya
Summary: METRNL is a hormone factor that has beneficial effects on metabolic and cardiovascular systems. It is found to be high in the first year of life and correlates with brown adipose tissue activity and metabolic status.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Emmy Fredriksson, Stina Boden, Magnus Domellof, Christina E. West
Summary: This study suggests that consumption of acidic fruit pouches in infancy is not associated with allergic phenotypes or IgE sensitization in early childhood.
Article
Multidisciplinary Sciences
Mitsumasa Hida, Ryota Imai, Misa Nakamura, Hidetoshi Nakao, Kodai Kitagawa, Chikamune Wada, Shinji Eto, Masatoshi Takeda, Masakazu Imaoka
Summary: This study aims to investigate the predictors of low physical activity levels in individuals with chronic pain and determine the accuracy of an artificial neural network algorithm used for analysis. The results show that a history of falls is a predictor of low physical activity levels in community-dwelling older adults with chronic pain. The study emphasizes the importance of fall prevention in improving physical activity levels in this population.
SCIENTIFIC REPORTS
(2023)
Article
Nutrition & Dietetics
Karen P. Best, Tim J. Green, Dian C. Sulistyoningrum, Thomas R. Sullivan, Susanne Aufreiter, Susan L. Prescott, Maria Makrides, Monika Skubisz, Deborah L. O'Connor, Debra J. Palmer
Summary: In a cohort study of 561 mother-infant pairs from Western Australia, late-pregnancy serum UMFA and total folate concentrations were found to have little evidence of association with allergic disease risk in offspring at 1 year of age in a high-risk population for allergies.
JOURNAL OF NUTRITION
(2021)
Article
Allergy
Qi Feng, Klaus Bonnelykke, Weronica E. Ek, Bo L. Chawes, Shuai Yuan, Ching Lung Cheung, Gloria H. Y. Li, Raymond Y. H. Leung, Bernard M. Y. Cheung
Summary: The study investigated the causal association between serum 25(OH)D levels and risk of allergic rhinitis and allergic sensitization using a two-sample Mendelian randomization approach. The findings showed no evidence of a causal link between 25(OH)D levels and the risk of allergic rhinitis, allergic sensitization, and non-allergic rhinitis in a European-ancestry population. This challenges the previous belief that vitamin D supplementation is effective in preventing allergic diseases.
CLINICAL AND EXPERIMENTAL ALLERGY
(2021)
Article
Hematology
Christabel Esi Damoah, Omri Snir, Kristian Hindberg, Peter Garred, Judith K. Ludviksen, Sigrid K. Braekkan, Vania M. Morelli, Tom Eirik Mollnes, John-Bjarne Hansen
Summary: This study investigated the association between plasma MASP-2 levels and future risk of VTE. The findings suggest that high plasma MASP-2 levels are causally associated with VTE risk. Genetic variants linked to MASP-2 levels were also identified.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Hematology
Tobias Frischmuth, Kristian Hindberg, Pal Aukrust, Thor Ueland, Sigrid K. Braekkan, John-Bjarne Hansen, Vania M. Morelli
Summary: This study aimed to investigate the association between plasma PAI-1 levels and the risk of future incident VTE, as well as to explore the potential mediation of PAI-1 on the VTE risk in obesity.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Allergy
Christopher M. Warren, Emily Brown, Julie Wang, Elizabeth C. Matsui
Summary: This article highlights the importance of comprehensive diversity and representation of affected populations in allergy/immunology research to ensure the generalizability and scientific utility of the study findings. The article also shares best practices for study design, recruitment, retention, and data analysis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Urology & Nephrology
Sarah J. Kizilbash, Michael D. Evans, Blanche M. Chavers, Clifford Kashtan
Summary: There are racial disparities in age at transplant and long-term graft survival for patients with Alport syndrome in the United States. The age at transplant has increased over time for Whites, but not for Black and Hispanic patients.
CLINICAL NEPHROLOGY
(2022)
Article
Allergy
Torie L. Grant, Meredith C. McCormack, Roger D. Peng, Corinne A. Keet, Ana M. Rule, Meghan F. Davis, Michelle Newman, Susan Balcer-Whaley, Elizabeth C. Matsui
Summary: This study aimed to investigate the effectiveness of home environmental control strategies on persistent asthma in low-income, Black children. The results showed that the addition of home environmental control strategies did not reduce indoor allergen concentrations or the need for controller medication compared to controller medication titration alone.
Article
Cardiac & Cardiovascular Systems
Mark McGill, Kishore R. R. Raja, Michael Evans, Gurumurthy Hiremath, Rebecca Ameduri, Shanti Narasimhan
Summary: This study aimed to assess the correlation between serum N-terminal pro b-type natriuretic peptide levels and both non-invasive measurements and invasive mean right atrial pressure in paediatric heart transplant patients. The results showed a correlation between serum N-terminal pro b-type natriuretic peptide levels and inferior vena cava collapsibility index, inferior vena cava diameter index, and mean right atrial pressure. Non-invasive measurements can serve as a reliable tool in assessing right heart filling pressures and cardiac function in this population.
CARDIOLOGY IN THE YOUNG
(2023)
Article
Allergy
Allison J. Burbank, Michelle L. Hernandez, Akilah Jefferson, Tamara T. Perry, Wanda Phipatanakul, Jill Poole, Elizabeth C. Matsui
Summary: Environmental justice refers to the right of all people to live in a healthy environment, be protected against environmental hazards, and participate in decisions that impact their communities. Disproportionate exposure to hazards associated with allergic diseases in communities of color and low-income populations has resulted in health disparities, fueled by systemic racism and discriminatory practices. Achieving environmental justice requires investing in at-risk communities to improve access to safe housing, clean air and water, employment opportunities, education, nutrition, and healthcare, ultimately leading to greater health equity in allergic diseases.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Allergy
Torie Grant, Travis Lilley, Meredith C. McCormack, Paul J. Rathouz, Roger Peng, Corinne A. Keet, Ana Rule, Meghan Davis, Susan Balcer-Whaley, Michelle Newman, Elizabeth C. Matsui
Summary: This study investigated the association between indoor exposures and air trapping in urban children with asthma. The results showed that mouse allergen exposure was associated with air trapping, while other indoor exposures were not.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Pediatrics
Stephanie P. P. Kerkvliet, Carlos J. Perez J. Perez Kerkvliet, Ziou Jiang, Michael Evans, Sarah J. J. Kizilbash
Summary: In pediatric kidney transplant, recipients requiring interpreter services have fewer post-transplant interactions with their healthcare team (fewer hospitalizations and more no-show visits) and lower 5-year patient survival compared with recipients not requiring interpreters.
PEDIATRIC NEPHROLOGY
(2023)
Review
Allergy
Cassie L. Shipp, Peter J. Gergen, James E. Gern, Elizabeth C. Matsui, Theresa W. Guilbert
Summary: Asthma is a common and complex disease, particularly in children, characterized by reversible airflow obstruction. The phenotypic differences in children with asthma may influence comorbidities and treatment choices. Prenatal factors such as maternal diet and microbiome, as well as postnatal microbial exposures and colonization, contribute to the risk of asthma and allergic diseases.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Medicine, General & Internal
Craig Evan Pollack, Laken C. Roberts, Roger D. Peng, Pete Cimbolic, David Judy, Susan Balcer-Whaley, Torie Grant, Ana Rule, Stefanie Deluca, Meghan F. Davis, Rosalind J. Wright, Corinne A. Keet, Elizabeth C. Matsui
Summary: Children with asthma who participated in a housing mobility program and moved to low-poverty neighborhoods experienced significant improvements in asthma symptom days and exacerbations. This suggests that programs to counter housing discrimination can reduce childhood asthma morbidity.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Immunology
Elise F. Palzer, Erika S. Helgeson, Michael D. Evans, David M. Vock, Arthur J. Matas
Summary: In kidney donors, postdonation complications such as preeclampsia, gestational hypertension, or gestational diabetes are associated with long-term risks of developing hypertension or diabetes.
Article
Virology
Mark K. Devries, Yury A. Bochkov, Michael D. Evans, James E. Gern, Daniel J. Jackson
Summary: In 2014, enterovirus D68 (EV-D68), previously associated with mild respiratory illness, caused a severe outbreak of respiratory illness and paralysis. A comparison of viral binding and replication in different cell cultures showed that recent EV-D68 isolates had increased replication efficiency and induced a stronger inflammatory response compared to the prototype Fermon strain from 1962. However, host factors are likely the main determinants of illness severity.
Article
Dentistry, Oral Surgery & Medicine
Michelle C. Arnett, Danna R. Paulson, Michael D. Evans, Christine M. Blue, Yvette G. Reibel
Summary: Brief-motivational interviewing (MI) is more successful than traditional oral hygiene instructions (OHI) in promoting discussions on oral home care behaviors, oral diseases/conditions, lifestyle behaviors, nutrition, emotional/mental health, and general health.
INTERNATIONAL JOURNAL OF DENTAL HYGIENE
(2023)
Article
Urology & Nephrology
Anne M. Kouri, Tiffany N. Caza, Laurence H. Beck Jr, Jason M. Misurac, Michael D. Evans, Carrie L. Phillips, Michael T. Eadon, Christopher P. Larsen, Sharon P. Andreoli, Lihong Bu, Michelle N. Rheault, Myda Khalid
Summary: PMN is uncommon in children and data on its clinical course are scarce. This study retrospectively analyzed the clinical presentation and outcomes data of 21 children with PMN and identified novel antigens in their biopsy specimens. Approximately 60% of pediatric PMN cases were positive for a novel antigen and the clinical prognosis was generally favorable.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Psychology, Multidisciplinary
Katherine Diaz Vickery, Becky R. Ford, Lillian Gelberg, Zobeida Bonilla, Ella Strother, Susan Gust, Edward Adair, Victor M. Montori, Mark Linzer, Michael D. Evans, John Connett, Michele Heisler, Patrick J. O'Connor, Andrew M. Busch
Summary: Compared to stably housed peers, individuals experiencing homelessness have poorer glycemic control and higher morbidity and mortality rates. The high prevalence of behavioral health comorbidities and trauma contribute to access barriers and poor outcomes. There is limited evidence on behavioral approaches to support individuals experiencing homelessness with diabetes.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Pediatrics
Sarah J. Kizilbash, Michael D. Evans, David M. Vock, Srinath Chinnakotla, Blanche M. Chavers
Summary: This study found that kidney transplantation in children under the age of 2 is associated with improved patient survival and reduced dialysis exposure compared to waiting until the age of 2 for transplantation.
PEDIATRIC TRANSPLANTATION
(2023)
