Article
Cell Biology
E. Evonne Jean, Olivia Good, Juan M. Inclan Rico, Heather L. Rossi, De'Broski R. Herbert
Summary: Communication between the nervous and immune systems at mucosal barrier sites, particularly the respiratory tract, plays a crucial role in protecting host immunity, sensing and responding to various stimuli to induce airway inflammation. Neuropeptides and neurotransmitters have been found to regulate immune cell responses and influence type 2 immunity in the airway.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Kang Mi Lee, Qiang Fu, Guoli Huai, Kevin Deng, Ji Lei, Lisa Kojima, Divyansh Agarwal, Peter van Galen, Shoko Kimura, Naoki Tanimine, Laura Washburn, Heidi Yeh, Ali Naji, Charles G. Rickert, Christian LeGuern, James F. Markmann
Summary: B lymphocytes play important roles in adaptive immunity and self-tolerance. Activated B cells through TLR4/TLR9 receptors acquire regulatory properties, inhibiting T cell proliferation and preventing allograft rejection.
Article
Medicine, General & Internal
Teresa Reduta, Joanna Bacharewicz-Szczerbicka, Anna Stasiak-Barmuta, Tomasz W. W. Kaminski, Iwona Flisiak
Summary: This study aimed to determine the presence of CD4 T lymphocytes producing intracellular osteopontin (iOPN T cells) and evaluate the different T lymphocyte subsets, including regulatory T cells, in the blood of patients with allergic contact dermatitis (ACD). The results showed that ACD patients had a significantly higher percentage of iOPN T cells compared to healthy controls, even during remission. Additionally, the percentage of CD4CD25 cells increased, while the percentage of regulatory T lymphocytes decreased in patients during the acute stage of ACD. The percentage of CD4CD25 T lymphocytes also positively correlated with the EASI index, suggesting their importance in ACD as effector cells.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Li Zhou, Xuemin He, Peihong Cai, Ting Li, Rongdong Peng, Junlong Dang, Yue Li, Haicheng Li, Feng Huang, Guojun Shi, Chichu Xie, Yan Lu, Yanming Chen
Summary: The study found that TGF-beta-induced Tregs could ameliorate the development of T1D and preserve beta cell function in a mouse model. The preventive effect was associated with the inhibition of Tc1 cell function and rebalancing the Treg/Tc1 cell ratio. The underlying mechanisms involved the combinatorial actions of mTOR and TCF1 mediated by TGF-beta.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tamara T. Haque, Pamela A. Frischmeyer-Guerrerio
Summary: This article discusses cytokines that regulate mast cell-mediated allergic immune responses. Understanding the mechanisms of these cytokines is important for the development of effective treatment methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Atsushi Tsuge, Shunsuke Chiba, Yui Yagura, Mari Okamoto, Satoshi Muto, Shinsuke Hisaka, Mitsuhiko Nose
Summary: Hochuekkito (HET), a traditional Japanese herbal medicine, has been found to exhibit anti-allergic effects through the induction and/or activation of regulatory T cells. This activation is not dependent on antigen sensitization. HET can be potentially used as an immunomodulator for the treatment of allergic diseases.
JOURNAL OF NATURAL MEDICINES
(2023)
Article
Immunology
Weiqian Chen, Weishan Huang, Youqiu Xue, Ye Chen, Wenbin Qian, Jilin Ma, Avery August, Julie Wang, Song Guo Zheng, Jin Lin
Summary: This study found that Nrp-1 is not only a marker for tTreg, but also a marker for a new subset of iTreg with enhanced suppressive function, indicating the potential application of Nrp-1(+)iTreg cell therapy for autoimmune and inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jing Song, Warren Anderson, Alex Hu, Kazushige Obata-Ninomiya, Steven F. Ziegler, David J. Rawlings, Jane H. Buckner
Summary: This study utilized gene editing to knock out the CBLB gene in human CD4+ T cells, revealing that CBLB knockout resulted in hyperproliferation and excessive IL-2 production in CD4+ T cells. The knockout cells showed resistance to Treg suppression and were able to overcome Treg inhibition by producing high levels of cytokines, promoting the proliferation and activation of T effector cells.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Surgery
Rongrong Gao, Ang Li, Sen Li, Xiangrong Li, Shuye Zhang, Xiaoyan Zhang, Jianqing Xu
Summary: Induced regulatory T (iTreg) cells play a crucial role in immune tolerance and controlling chronic inflammation. A novel engineering strategy has been developed to generate stably induced regulatory T (SI T-reg) cells that maintain their regulatory properties and possess potent immunosuppressive functions even in unfavorable environments. These findings suggest that SI T-reg cells hold great promise for future clinical applications and provide a rational therapeutic approach for transplant rejection.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Immunology
Helen Carrasco Hope, Gabriella Pickersgill, Pierpaolo Ginefra, Nicola Vannini, Graham P. Cook, Robert J. Salmond
Summary: TGFβ inhibits CD8(+) T cell activation by suppressing Myc-dependent metabolic reprogramming.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Takashi MaruYama, Shuhei Kobayashi, Hiroko Nakatsukasa, Yuki Moritoki, Daiki Taguchi, Yoichi Sunagawa, Tatsuya Morimoto, Atsuko Asao, Wenwen Jin, Yuji Owada, Naoto Ishii, Yoshiharu Iwabuchi, Akihiko Yoshimura, WanJun Chen, Hiroyuki Shibata
Summary: Regulatory T cells (Tregs) orchestrate antitumor immune responses, with TGF-beta promoting Treg generation through NF-kappa B/p300 and SMAD signaling pathways. GO-Y030 inhibits Treg generation and stability by blocking these pathways, resulting in potent anticancer effects in vivo tumor models.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yixin Luo, Zhenlai Zhu, Bing Li, Xiaocui Bai, Hui Fang, Pei Qiao, Jiaoling Chen, Chen Zhang, Dalong Zhi, Erle Dang, Gang Wang
Summary: This study revealed the proinflammatory role of keratin 17 (K17) in the pathogenesis of allergic contact dermatitis (ACD), as well as the underlying molecular mechanisms involving the activation and translocation of signaling proteins and the production of proinflammatory mediators.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Tomoko Hirano, Tetsuya Honda, Shuto Kanameishi, Yuki Honda, Gyohei Egawa, Akihiko Kitoh, Saeko Nakajima, Atsushi Otsuka, Takashi Nomura, Teruki Dainichi, Tomonori Yaguchi, Takashi Inozume, Tatsuki R. Kataoka, Koji Tamada, Kenji Kabashima
Summary: The PD-1/PD-L1 pathway negatively regulates CD8(+) T cell activation in the skin through mast cells (MCs), which are found to highly express PD-L1 and play a crucial role in modulating inflammatory responses.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Immunology
Joshua M. Moreau, Maria Velegraki, Chelsea Bolyard, Michael D. Rosenblum, Zihai Li
Summary: TGF-beta 1 plays a crucial role in the development and function of T-reg, although its pleiotropic and context-dependent activity makes it complicated.
SCIENCE IMMUNOLOGY
(2022)
Article
Cell Biology
Galina Shurin, Kavita Vats, Oleg Kruglov, Yuri L. Bunimovich, Michael R. Shurin
Summary: Nerve-cancer crosstalk is controlled by Schwann cells, which can be stimulated by tumor cells to produce prostaglandin E. This inhibits the proliferation of activated T cells and leads to T cell exhaustion. Understanding this pathway is important for the development of cancer therapies.
Article
Hematology
Xiaoxiao Wang, Wenru Su, Yan Gao, Yanfen Feng, Xiaoxia Wang, Xiaoqing Chen, Yunwei Hu, Yutong Ma, Qiuxiang Ou, Dan Liang, Huiqiang Huang
Summary: Sequencing of circulating tumor DNA (ctDNA) from vitreoretinal lymphoma (VRL) patients can aid in diagnosis and treatment monitoring, with aqueous humor (AH) samples being a substitute for vitreous fluid (VF) samples. Genetic alterations in VRL differ from other types of primary central nervous system lymphoma, and the response to ibrutinib treatment is less effective.
Article
Ophthalmology
Jianfeng Yu, Pengfei Li, Zhuang Li, Yingqi Li, Jiawei Luo, Wenru Su, Dan Liang
Summary: The study found that tofacitinib can inhibit the polarization of M1 macrophages and delay CGR by inhibiting STAT1 activation. This suggests that tofacitinib is an effective drug for treating CGR.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Biology
Wen Shi, Jinguo Ye, Zhuoxing Shi, Caineng Pan, Qikai Zhang, Yuheng Lin, Yuanting Luo, Wenru Su, Yingfeng Zheng, Yizhi Liu
Summary: Using single-cell analysis, this study reveals transcriptomic and epigenomic changes in patients with the autoimmune disorder Vogt-Koyanagi-Harada disease (VKH), showing highly activated and pro-inflammatory immune cells, particularly the conventional dendritic cells (cDCs) that play a crucial role in inflammation regulation.
COMMUNICATIONS BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Runping Duan, Lihui Xie, He Li, Rong Wang, Xiuxing Liu, Tianyu Tao, Shizhao Yang, Yuehan Gao, Xianchai Lin, Wenru Su
Summary: The study provides a comprehensive single-cell transcriptional atlas of immune cells under CsA therapy, revealing the reverse effects of CsA on cell composition, genomic expression, cell trajectory, and cell-cell communication. It was found that CsA reverses the changes in disease-related immune cell proportions, regulates key pathogenic factors, and may enhance the immunosuppressive function of Tregs. CsA also has an impact on plasma B cells differentiation and immunoglobulin secretion. Comparisons with glucocorticoids suggest that CsA may have a more premium rescue effect in attenuating the pathogenicity of autoreactive T cells.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Ophthalmology
Bingying Lin, Yangyang Li, Nan Jiang, Siyu Huang, Wenru Su, Yehong Zhuo
Summary: The study found that IL-35 can reduce retinal damage, decrease RGC death, and thinning of the IPL in retinal I/R. It also demonstrated the significant attenuation of pyroptosis in the retina. IL-35 was shown to have an inhibitory effect on pyroptosis in microglial cells and could directly suppress primary RGC apoptosis induced by OGD/R.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jingyi Peng, Jiayi Jin, Wenru Su, Wanwen Shao, Weihua Li, Zhiquan Li, Huan Yu, Yongxin Zheng, Liuxueying Zhong
Summary: Traumatic optic neuropathy (TON) is a significant cause of vision loss and irreversible blindness worldwide. The study demonstrates that HMGB1 mediates NLRP3 inflammasome via NF-kB to participate in retinal inflammatory injury after ONC. Intravitreal injection of BoxA has the potential therapeutic benefits for the effective treatment of RGC death to prevent TON.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Oncology
Xiaoqing Chen, Yunwei Hu, Wenru Su, Shizhao Yang, Xiaoxiao Wang, Ping Zhang, Xiaoyu Hong, Chuqiao Liang, Zhuyun Qian, Ziqiang Li, Yong Tao, Huiqiang Huang, Dan Liang
CANCER COMMUNICATIONS
(2022)
Review
Pharmacology & Pharmacy
Yuhan Su, Tianyu Tao, Xiuxing Liu, Wenru Su
Summary: This review summarizes the diverse roles of the JAK-STAT signaling pathway in ocular homeostasis and non-infectious uveitis (NIU) pathology, and discusses the safety and efficacy of JAK inhibitors for treating NIU and potential approaches for treatment optimization.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
He Li, Lihui Xie, Lei Zhu, Zhaohuai Li, Rong Wang, Xiuxing Liu, Zhaohao Huang, Binyao Chen, Yuehan Gao, Lai Wei, Chang He, Rong Ju, Yizhi Liu, Xialin Liu, Yingfeng Zheng, Wenru Su
Summary: In this study, single-cell RNA sequencing was performed on experimental autoimmune uveitis (EAU) to investigate its cellular dynamics and pathogenic mechanism. Disease-associated alterations in cell composition and transcriptional regulation were identified, along with a disease-related molecule called PIM1. Inhibiting PIM1 was found to decrease the proportion of Th17 cells and increase the proportion of Treg cells, as well as reduce the pathogenicity of Th17 cells. These findings suggest that PIM1 may serve as a potential therapeutic target for uveitis.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Binyao Chen, Shizhao Yang, Lei Zhu, Xuening Peng, Daquan He, Tianyu Tao, Wenru Su
Summary: This study assessed the efficacy and safety of adalimumab in treating refractory non-infectious scleritis. The results showed that combining adalimumab with conventional therapy led to faster remission, reduced disease flares, and accelerated withdrawal of glucocorticoids.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Rong Wang, Lei Zhu, He Li, Xuening Peng, Sichen Zhao, Wenru Su
Summary: Mycophenolate mofetil (MMF), an immunosuppressive agent, has a general inhibitory effect on the activation of immune cells and can reverse some transcriptional changes induced by autoimmune uveitis (EAU). It can also inhibit the differentiation and pathogenic cytokine production of T and B cells, as well as the antigen processing and presentation ability of B cells. The therapeutic effect of MMF is driven by multiple molecules rather than a single one.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Letter
Ophthalmology
Tianyu Tao, Daquan He, Xuening Peng, Zhaohao Huang, Wenru Su
Summary: This study retrospectively followed up two BU patients with a history of BS for 2 and 10 years, respectively, and found that upadacitinib successfully treated BU, improving visual acuity, controlling intraocular inflammation, and resolving macular edema in both patients. One female patient showed mildly abnormal blood test results and slight liver enzyme elevation after 6 months of upadacitinib treatment, but no serious adverse events were reported in either patient during follow-up. Upadacitinib may be an important future option for managing recurrent and recalcitrant cases of BU, especially in patients with chronic ocular inflammation and macular edema resistant to conventional therapies.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Haixiang Huang, Zhuang Li, Jun Huang, Yanyan Xie, Zhiqiang Xiao, Yunwei Hu, Guanyu Chen, Minzhen Wang, Zuoyi Li, Qian Chen, Wenjie Zhu, Wenru Su, Yan Luo, Xiaoqing Chen, Dan Liang
Summary: In this study, researchers investigated the role of apolipoprotein A1 (APOA1) in experimental autoimmune uveitis (EAU), a representative animal model of human uveitis. They found that APOA1 administration ameliorated EAU by regulating the expansion and infiltration of pathogenic T cells, as well as the production of inflammatory cytokines. The results suggest that APOA1 could be a therapeutic alternative for autoimmune uveitis.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Cell Biology
Zhaohuai Li, Mei Wang, Jia Tan, Lei Zhu, Peng Zeng, Xiaozhen Chen, Lihui Xie, Runping Duan, Binyao Chen, Tianyu Tao, Rong Wang, Xianggui Wang, Wenru Su
Summary: This study used single-cell RNA sequencing to investigate the transcriptional changes in cellular components of the orbital connective tissue in individuals with thyroid-associated ophthalmopathy (TAO). The study found that lipofibroblasts with RASD1 expression play a significant role in inflammation and adipogenesis during TAO. ACKR1(+) endothelial cells and adipose tissue macrophages may also be involved in TAO pathogenesis. Additionally, CD8(+)CD57(+) cytotoxic T lymphocytes were identified as another source of interferon-y, which actively contributes to TAO pathogenesis. Cell-cell communication analysis revealed increased activity of CXCL8/ACKR1 and TNFSF4/TNFRSF4 interactions in TAO.
CELL REPORTS MEDICINE
(2022)
Article
Biochemical Research Methods
Xiuxing Liu, Jianjie Lv, Huishi Wang, Yingfeng Zheng, Wenru Su
Summary: A validated and streamlined mass cytometry workflow is presented, which utilizes fixed staining and optimized barcode staining patterns to analyze the complex immune system in clinical blood samples, while reducing batch effects.