Article
Medicine, General & Internal
Xiang Lu, Hao Wang, Jingqi Zhang, Kexin Jin, Ling Ma, Yan Wang, Shixing Yang, Xiaochun Wang, Quan Shen, Tianji Zhou, Hui Xu, Wen Zhang
Summary: The imbalance of gut microbiota affects the immune development and regulation of individuals, leading to immune dysregulation and the development of atopic dermatitis (AD). This study assessed the composition of the virome in the gut of AD patients and healthy controls, revealing differences in diversity between the two groups. Finds provide a new perspective for understanding the effect of the gut microecological environment on AD.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Annalisa Astolfi, Francesca Cipriani, Daria Messelodi, Matilde De Luca, Valentina Indio, Costanza Di Chiara, Arianna Giannetti, Lorenza Ricci, Iria Neri, Annalisa Patrizi, Giampaolo Ricci, Andrea Pession
Summary: This study revealed that children with atopic dermatitis carrying FLG mutations are at higher risk of developing severe food allergies, such as anaphylaxis. Peanut and hazelnut were identified as high-risk foods for patients with FLG mutations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Niki Papapostolou, Paraskevi Xepapadaki, Stamatis Gregoriou, Michael Makris
Summary: Atopic dermatitis is a chronic inflammatory skin disorder with complex underlying mechanisms. Food allergy can trigger exacerbations of atopic dermatitis, while atopic dermatitis predisposes to food allergy. Management of atopic dermatitis should focus on skin care and appropriate treatments, with thorough allergy evaluation in case of suspected food allergy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Allergy
Jessica W. Hui-Beckman, Elena Goleva, Evgeny Berdyshev, Donald Y. M. Leung
Summary: Atopic dermatitis (AD) and food allergy (FA) are closely related and one-third of AD children develop concomitant FA. Epithelial barrier dysfunction is important in both diseases. Genetic factors such as filaggrin mutations and IL-4 receptor alpha chain polymorphisms are associated with increased risk. In addition, several environmental exposures lead to reduced filaggrin and contribute to skin barrier dysfunction. Staphylococcus aureus colonization appears to contribute to AD and FA as well as activating the type 2 immune response. Comprehensive multiomic studies have identified distinct atopic endotypes with unique characteristics, providing an opportunity for improved diagnosis and prevention of atopy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Allergy
Evgeny Berdyshev, Elena Goleva, Irina Bronova, Anna-Sofia Bronoff, Bryce C. Hoffman, Marco A. Ramirez-Gama, Shannon L. Garcia, Debra Crumrine, Peter M. Elias, Christine B. Cho, Donald Y. M. Leung
Summary: The nonlesional skin of children with atopic dermatitis and peanut allergy is associated with decreased skin cis-UCA and PCA content, as well as alterations in the ratio of certain ceramide products. The presence of peanut allergy in children with atopic dermatitis appears to have a distinct impact on skin barrier abnormalities.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Allergy
Youjia Zhong, Miny Samuel, Hugo van Bever, Elizabeth Huiwen Tham
Summary: Prophylactic use of emollients initiated in early infancy may prevent AD, especially in high-risk populations and when used continuously. However, emollients may delay rather than prevent the development of AD. No protective effects on FA were found.
Article
Allergy
Lucy E. Bradshaw, Laura A. Wyatt, Sara J. Brown, Rachel H. Haines, Alan A. Montgomery, Michael R. Perkin, Sandra Lawton, Tracey H. Sach, Joanne R. Chalmers, Matthew J. Ridd, Carsten Flohr, Joanne Brooks, Richard Swinden, Eleanor J. Mitchell, Stella Tarr, Nicola Jay, Kim S. Thomas, Hilary Allen, Michael J. Cork, Maeve M. Kelleher, Eric L. Simpson, Stella T. Lartey, Susan Davies-Jones, Robert J. Boyle, Hywel C. Williams
Summary: The study found that daily emollient application during the first year of life does not prevent atopic dermatitis, food allergy, asthma, or hay fever. The difference in incidence rates of atopic dermatitis, food allergy, asthma, and hay fever between the emollient group and the control group was relatively small.
Article
Medicine, General & Internal
Federica Gelato, Luca Mastorino, Ekaterina Stepkina, Giovanni Cavaliere, Simone Ribero, Pietro Quaglino, Michela Ortoncelli
Summary: This retrospective study compares the efficacy of dupilumab therapy in patients with intrinsic and extrinsic atopic dermatitis (AD) and finds no significant differences in treatment outcome between the two groups, suggesting that dupilumab is equally effective regardless of IgE levels.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Agriculture, Dairy & Animal Science
Ana Rostaher, Yasser Morsy, Claude Favrot, Stefan Unterer, Manuela Schnyder, Michael Scharl, Nina Maria Fischer
Summary: This study compares the gut microbiota of allergic and healthy dogs and finds significant differences between the two groups. These results suggest that alterations in gut microbiota diversity and composition may be associated with canine atopic dermatitis (AD).
Article
Medicine, General & Internal
Mattia Giovannini, Marta Bolis, Simona Barni, Giulia Liccioli, Lucrezia Sarti, Susanna Morelli, Matteo Pontone, Benedetta Pessina, Leonardo Tomei, Claudia Valleriani, Elio Novembre, Francesca Mori
Summary: This study describes the management of an infant with severe atopic dermatitis (AD) and multiple food sensitizations. A low-dose, gradual controlled oral food challenge (OFC) was performed to introduce sensitized foods into the infant's diet without allergic reactions. There is a need for extensive research in the field to improve evidence-based practices.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Food Science & Technology
Jae Won Lee, Ee Taek Hwang
Summary: Atopic dermatitis is a chronic inflammatory disease characterized by itching. The pathogenesis and etiology of atopic dermatitis are not fully understood, but tetrahydrocurcumin has been shown to alleviate the symptoms of this condition.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Allergy
Peter Schmid-Grendelmeier, Melinda J. Gooderham, Karin Hartmann, George N. Konstantinou, Marc Fellmann, Christopher Koulias, Claire Clibborn, Pinaki Biswas, Patrick M. Brunner
Summary: This article evaluated the efficacy and safety of abrocitinib in patients with moderate-to-severe atopic dermatitis and allergic comorbidities. The results showed that abrocitinib was effective and safe in managing atopic dermatitis in patients with or without allergic comorbidities.
Article
Immunology
Yuhan Xia, Han Cao, Jie Zheng, Lihong Chen
Summary: Atopic march refers to the increase in asthma and food allergy after atopic dermatitis. The downregulation of claudin-1 expression level, which forms tight junctions in the skin, airways, and GI tract, may contribute to the progression of allergic inflammation in these organs. Low expression of claudin-1 has been observed in patients with atopic dermatitis, asthma, and food allergy, and knockdown of claudin-1 exacerbates allergic inflammation in mouse models. Further validation is needed, but impaired claudin-1 expression level may be a risk factor and diagnostic marker for atopic march.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pediatrics
Nunzia Maiello, Pasquale Comberiati, Arianna Giannetti, Giampaolo Ricci, Rossella Carello, Elena Galli
Summary: Recent evidence suggests that the linear progression of the atopic march does not capture the heterogeneity of allergic phenotypes. Atopic dermatitis often serves as the first manifestation of the atopic march. Improved understanding of the pathogenesis of atopic dermatitis could be crucial in preventing the progression of atopic march.
Article
Allergy
Kiwako Yamamoto-Hanada, Tohru Kobayashi, Masashi Mikami, Hywel C. Williams, Hirohisa Saito, Mayako Saito-Abe, Miori Sato, Makoto Irahara, Yumiko Miyaji, Fumi Ishikawa, Kunihiko Tsuchiya, Risa Tamagawa-Mineoka, Yuri Takaoka, Yutaka Takemura, Sakura Sato, Hiroyuki Wakiguchi, Miyuki Hoshi, Osamu Natsume, Fumiya Yamaide, Miwako Seike, Yukihiro Ohya, PACI Study Collaborators
Summary: This study found that enhanced early skin treatment is more effective in preventing hen's egg allergy compared to conventional reactive treatment. However, it also resulted in lower body weight and height. Therefore, modifications to the enhanced treatment protocol should be made for daily practice to avoid adverse effects.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Biology
Marc Ditzhaus, Jon Genuneit, Arnold Janssen, Markus Pauly
Summary: We propose inference procedures for general factorial designs with time-to-event endpoints, which allows working without restrictive model assumptions as proportional hazards and can detect the crossing points of survival or hazard curves.
Article
Psychology, Developmental
Gonzalo Duran-Pacheco, Mariabeth Silkey, Michelle Johnson, Chuang Liu, Susanne Clinch, Kiely Law, Georg Loss
Summary: This study found that the severity of autism spectrum disorder (ASD) has a significant impact on families, specifically on caregiver strain and child sleep quality. Caregiver sleep quality is influenced by ASD severity through child sleep quality and caregiver strain. Interventions aimed at improving child sleep quality or reducing caregiver strain could have positive effects on families of children with ASD.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Correction
Psychology, Developmental
Mariabeth Silkey, Gonzalo Duran-Pacheco, Michelle Johnson, Chuang Liu, Susanne Clinch, Kiely Law, Georg Loss
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Review
Pediatrics
Linda P. Siziba, Sebastian Huhn, Elisabeth Puetz, Caroline Baier, Raphael S. Peter, Corinna Gebauer, Samantha Griffin, Sophie Wedekind, Natalie Shenker, Jon Genuneit
Summary: This scoping review provides an overview of the current state and emerging trends in donor human milk banking. The predominant topics identified were milk type and composition, and there is a lack of research on the associations between different milk types and infant outcomes. Further research is needed to explore the appropriateness of different funding sources and to foster collaborations between academics, clinicians, and milk banks in low-income or middle-income countries to improve access to donor human milk.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Hematology
C. Schuetz, J. Gerke, M. Ege, J. Walter, M. Kusters, A. Worth, J. A. Kanakry, D. Dimitrova, B. Wolska-Kusnierz, K. Chen, E. Unal, M. Karakukcu, O. Pashchenko, J. Leiding, T. Kawai, P. J. Amrolia, D. Berghuis, J. Buechner, D. Buchbinder, M. J. Cowan, A. R. Gennery, T. Gungor, J. Heimall, M. Miano, I. Meyts, E. C. Morris, J. Riviere, S. O. Sharapova, P. J. Shaw, M. Slatter, M. Honig, P. Veys, A. Fischer, M. Cavazzana, D. Moshous, A. Schulz, M. H. Albert, J. M. Puck, A. C. Lankester, L. D. Notarangelo, B. Neven
Summary: Patients with hypomorphic mutations in the RAG1 or RAG2 gene can present with various clinical phenotypes, such as Omenn syndrome or atypical combined immunodeficiency. Hematopoietic stem cell transplantation (HSCT) is a potential cure for these patients, but information about its outcomes is limited. We report on a global cohort of 60 patients with hypomorphic RAG variants who underwent HSCT, with 78% experiencing infections (29% active at HSCT), 72% developing autoimmunity, and 18% having granulomas before transplantation. These complications often lead to organ damage. Eight individuals (13%) were diagnosed through newborn screening or family history. HSCT was performed at a median age of 3.4 years (range 0.3-42.9 years) from matched unrelated donors, matched sibling or matched family donors, or mismatched donors in 48%, 22%, and...
Article
Allergy
Amandine Divaret-Chauveau, Frederic Mauny, Alexander Hose, Martin Depner, Marie-Laure Dalphin, Vincent Kaulek, Cindy Barnig, Bianca Schaub, Elisabeth Schmausser-Hechfellner, Harald Renz, Josef Riedler, Juha Pekkanen, Anne M. Karvonen, Martin Taubel, Roger Lauener, Caroline Roduit, Dominique Angele Vuitton, Erika von Mutius, Silvia Demoulin-Alexikova
Summary: This study describes the latent class trajectories of cough from one to 10 years old and analyzes their association with wheezing, atopy, and allergic diseases. The results show that persistent coughs and early persistent coughs are positively associated with atopic respiratory diseases and food allergy. Growing up on a farm is negatively associated with early persistent cough.
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Review
Immunology
Claudia C. Beerweiler, Rebecca K. Masanetz, Bianca Schaub
Summary: Air pollution and immune-related diseases are increasing worldwide. A comprehensive investigation of environmentally induced immune regulation is needed. This review summarizes the current knowledge on harmful or protective environmental factors and their routes of exposure, as well as the interaction with the immune system.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Respiratory System
Mustafa Abdo, Anne-Marie Kirsten, Erika von Mutius, Matthias Kopp, Gesine Hansen, Klaus F. Rabe, Henrik Watz, Frederik Trinkmann, Thomas Bahmer, ALLIANCE study grp
Summary: This study determines the minimal clinically important differences (MCIDs) for frequently used impulse oscillometry (IOS) measures in patients with asthma, and highlights the importance of small airway function as an endpoint beyond forced expiratory volume in 1 s (FEV1).
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Pediatrics
Deborah Kurz, Stefanie Braig, Jon Genuneit, Dietrich Rothenbacher
Summary: This study examines how pre-pandemic family circumstances are related to different aspects of child health during the COVID-19 pandemic. The results show that family circumstances, gender, and the pandemic have varying impacts on children's mental health and lifestyle.
CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH
(2023)
Article
Allergy
T. Adam, A. Divaret-Chauveau, C. Roduit, K. Adel-Patient, A. Deschildre, C. Raherison, M. A. Charles, S. Nicklaus, B. de Lauzon-Guillain
Summary: This study examines the correlation between complementary feeding practices in early childhood and allergic diseases. It finds that delayed introduction of complementary feeding beyond 6 months is associated with an increased risk of food allergy. Additionally, a low diversity score in the diet at 8 months is linked to a higher risk of asthma, and the absence of two or more allergenic foods introduced by 10 months is associated with an increased risk of rhinoconjunctivitis and food allergy.
Article
Allergy
Mari Sasaki, Mathilda Sundberg, Remo Frei, Ruth Ferstl, Kristina N. Heye, Erik P. Willems, Cezmi A. Akdis, Roger Lauener, Caroline Roduit
Summary: This study investigates the use of electrical impedance spectroscopy to detect skin barrier dysfunction in children with AD. Based on the EIS/AD score, EIS algorithm is able to clearly differentiate healthy skin and clinically unaffected skin of 4 months to 3-year-old children with active AD. EIS/AD score is also different between healthy skin, skin of children with non-active AD (before onset or after onset of AD but without active symptoms) and active AD.
Article
Infectious Diseases
Nicole Maison, Jimmy Omony, Sophia Rinderknecht, Laura Kolberg, Melanie Meyer-Buehn, Erika von Mutius, Johannes Huebner, Ulrich von Both
Summary: Following COVID-19 lockdown measures, respiratory tract infections increased worldwide, specifically affecting children's hospitals. Changes in the epidemiological pattern of respiratory viral infections were observed, with a higher number of virus detections and a shift in the pattern of infections.
Editorial Material
Allergy
Philippe Eigenmann, Ayobami Akenroye, Marina Atanaskovic Markovic, Fabio Candotti, Motohiro Ebisawa, Jon Genuneit, Oemer Kalayci, Doris Kollmann, Agnes Sze Yin Leung, Rachel L. Peters, Carmen Riggioni
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Letter
Allergy
Jasmijn A. Schrumpf, Dennis K. Ninaber, Christoph Mueller, Bettina Rankl, Erika von Mutius, Hermelijn H. Smits, Pieter S. Hiemstra
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Review
Allergy
Kristina Laubhahn, Bianca Schaub
Summary: Childhood asthma involves complex interactions among various factors, including immune aspects and environmental influences. Early identification of asthma tendencies or risks is crucial for understanding the transition from wheezing to asthma. Favorable immune regulation during early childhood can induce persistent changes in immune cell behavior. Exploration of immune mechanisms driving disease progression will contribute to the development of preventive strategies and personalized treatments, reducing the burden of asthma on children, families, and society.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)