期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 11, 期 6, 页码 1575-1584出版社
ELSEVIER
DOI: 10.1016/j.nano.2015.03.006
关键词
Nanomedicine; Nanoparticle; Stimuli-responsive liposome; Controlled drug delivery; Nucleic acid therapeutics
资金
- Tier-1 Academic Research Funds by Singapore Ministry of Education [RG 64/12]
- Start-up Funds by Lee Kong Chian School of Medicine, Nanyang Technological University
Nucleic acid therapeutics (NATs) are valuable tools in the modulation of gene expression in a highly specific manner. So far, NATs have been actively pursued in both pre-clinical and clinical studies to treat diseases such as cancer, infectious and inflammatory diseases. However, the clinical application of NATs remains a considerable challenge owing to their limited cellular uptake, low biological stability, off-target effect, and unfavorable pharmacokinetics. One concept to address these issues is to deliver NATs within stimuli-responsive liposomes, which release their contents of NATs upon encountering environmental changes such as temperature, pH, and ion strength. In this case, before reaching the targeted tissue/organ, NATs are protected from degradation by enzymes and immune system. Once at the area of interest, localized and targeted delivery can be achieved with minimal influence to other parts of the body. Here, we discuss the latest developments and existing challenges in this field. (C) 2015 Elsevier Inc. All rights reserved.
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