Article
Biochemistry & Molecular Biology
Simon Lin, Subramanya Pandruvada, Hong Yu
Summary: Treatment with S1PR2 antagonist or S1PR2 shRNA enhanced osteogenesis in BMSCs via different signaling pathways, including increased vesicle trafficking-associated proteins and activation of Wnt/Ca2+ signaling, BMP/Smad signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jing Wang, Junqiang Yang, Zonggui Tang, Yongbo Yu, Haiyun Chen, Qian Yu, Dawei Zhang, Chunyan Yan
Summary: A new heteropolysaccharide COP70-1 was purified from the crude polysaccharide CO70 isolated from Curculigo orchioides, which can promote the osteoblastic differentiation of MC3T3-E1 cells by activating the BMP/Smad and Wnt/beta-catenin pathways. It has the potential to treat ovariectomy-induced osteoporosis in rats.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Jae-Yun Jun, Jae-Hyun Kim, Minsun Kim, Sooyeon Hong, Myunghyun Kim, Gwang-Hyun Ryu, Jae Ho Park, Hyuk-Sang Jung, Youngjoo Sohn
Summary: This study investigated the effects of Persicae semen (PS) on osteoblast differentiation and bone union promotion. The results showed that PS can promote fracture recovery by upregulating osteoblast differentiation and bone formation, making it a potential therapeutic alternative for fracture patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Xiaolin Zhang, Xiuli Shao, Ruijia Zhang, Rongli Zhu, Rui Feng
Summary: We identified differential binding genes on euchromatin in DCM induced by LMNA mutation through ChIP-seq technology and integrated analysis with transcriptome data. Five and 60 candidate genes were identified for downstream analysis, leading to the discovery of 4 key genes (CREBBP, PPP2R2B, BMP4, and BMP7) that may regulate DCM through WNT/beta-catenin or TGF beta-BMP pathways. This study provides insights into the molecular pathogenesis mechanisms of DCM caused by LMNA mutations and highlights potential biomarkers and therapeutic targets.
CLINICAL EPIGENETICS
(2021)
Article
Medicine, Research & Experimental
Bingjie Zhou, Min Li, Xiaomin Xu, Lan Yang, Meiling Ye, Yan Chen, Jiayi Peng, Linyu Xiao, Luyao Wang, Shiqi Huang, Ling Zhang, Qing Lin, Zhirong Zhang
Summary: The DGEA-Lipo-DOX platform demonstrated improved antitumor ability in breast cancer treatment through enhanced blood circulation and drug accumulation at tumor sites. Targeting integrin alpha(2)beta(1) by DGEA may represent a potentially safer alternative therapeutic strategy for breast cancer treatment.
MOLECULAR PHARMACEUTICS
(2021)
Review
Cell Biology
Hao Sun, Liang Hu, Zhichao Fan
Summary: Leukocyte recruitment is critical in inflammatory and immune responses, with cell adhesion molecules like the integrin family playing a key role. Integrin beta 2 is commonly expressed in leukocytes and is important for immune responses and inflammation. Research focuses on its specific functions, conformational changes, and signal transduction, as well as similarities between murine and human factors.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Yan-Jie Chen, Shu-Neng Luo, Hao Wu, Ning-Ping Zhang, Ling Dong, Tao-Tao Liu, Li Liang, Xi-Zhong Shen
Summary: This study found that the expression of IRF-2 was downregulated in gastric cancer tissues and was negatively correlated with the prognoses of gastric cancer patients. IRF-2 inhibits tumor growth by regulating the transcription of AMER-1 and the Wnt/β-catenin signaling pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Md Saimon Mia, Yagna Jarajapu, Reena Rao, Sijo Mathew
Summary: This study revealed a novel mechanism of integrin beta 1 in tumor growth by modulating the expression of kindlin-2 and TGF-beta receptor 2 signaling. Loss of integrin beta 1 affects cell proliferation and adhesion in a 3D matrix, thus impacting tumor growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Pallabi Pal, Michelle A. Tucci, Lir-Wan Fan, Ratna Bollavarapu, Jonathan W. W. Lee, Susana M. Salazar M. Marocho, Amol V. Janorkar
Summary: A hydrogel composed of collagen and elastin-like polypeptide encapsulating BMP-2, doxycycline, and 45S5 Bioglass is developed for superior bone healing after cranioplasty. The hydrogel promotes stem cell attachment, proliferation, and differentiation toward the osteogenic lineage, and forms mature mineralized tissue that bridges with the surrounding bone in vivo.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Cell Biology
Xiangyu Lin, Liang Zhu, Jing He
Summary: This article reviews the structure, development, cycle, and molecular regulation of hair follicles, providing new ideas for solving hair follicle-related diseases and forming functional hair follicles.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Food Science & Technology
Yibo Liu, Shiming Li, Hui Liu, Bo Li
Summary: Two peptides from silver carp skin collagen hydrolysates were found to promote osteogenic differentiation and mineralization of MC3T3-E1 cells by positively regulating signaling pathways, indicating their potential as effective dietary supplements to prevent osteoporosis.
Article
Cell Biology
Fatih Karadeniz, Jung Hwan Oh, Hyun Jin Jo, Youngwan Seo, Chang-Suk Kong
Summary: M3G treatment stimulates osteoblast differentiation and inhibits adipocyte differentiation in hBM-MSCs, respectively through the Wnt/BMP and PPAR gamma pathways. These findings suggest the therapeutic potential of M3G in regulating bone marrow stromal cell differentiation for osteoporosis treatment.
Review
Pharmacology & Pharmacy
Angelo Corti, Giulia Anderluzzi, Flavio Curnis
Summary: In this review, the research on the interaction between CgA and its fragments with receptors is discussed. The structural requirements, biological effects, mechanisms, and potential therapeutic applications of the interactions between CgA-related peptides and neuropilin-1 and integrins are reviewed.
Article
Cell Biology
Ruimin Chang, Xiaoxiong Xiao, Yao Fu, Chunfang Zhang, Xiaoyan Zhu, Yang Gao
Summary: In this study, ITGB1-DT was identified as a prognosis-related and oncogenic lncRNA in LUAD through activating the ITGB1-DT/ITGB1/Wnt/beta-catenin/MYC positive feedback loop, implicating it as a potential prognostic biomarker and therapeutic target for LUAD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Physiology
Xiaoyang Tong, Chenyu Zhu, Lifei Liu, Mei Huang, Jiake Xu, Xi Chen, Jun Zou
Summary: Sostdc1, a protein with antagonist effects on BMP and Wnt signaling, plays a crucial role in bone metabolism and the progression of cancer.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Geriatrics & Gerontology
ZuFu Lu, Liting Jiang, Pooria Lesani, WenJie Zhang, Ning Li, Danyang Luo, Yusi Li, Yulin Ye, Ji Bian, Guocheng Wang, Colin R. Dunstan, XinQuan Jiang, Hala Zreiqat
Summary: This study shows that nicotinamide mononucleotide (NMN) could partially reverse the negative effects of tumor necrosis factor-alpha (TNF-α) on osteoblasts, including inducing senescence, reducing differentiation ability, and affecting mitochondrial function. In addition, NMN can protect cells from aging damage by increasing mitophagy activity.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Engineering, Environmental
Haifeng Liu, Xiaojun Yan, Jingwei Jiu, Jiao Jiao Li, Yuanyuan Zhang, Guishan Wang, Dijun Li, Lei Yan, Yanan Du, Bin Zhao, Bin Wang
Summary: Current approaches for treating spinal cord injury (SCI) mainly involve cell transplantation, but the complex microenvironment created by SCI reduces cell activity and leads to poor therapeutic outcomes. Researchers have developed functional tissue constructs using self-assembled mesenchymal stem cell (MSC) microtissues, which show improved cellular activity and increased secretion of nerve regeneration-related factors. These microtissues have shown therapeutic effects in a rat model of complete spinal cord transection, potentially through mechanisms related to the regulation of response mediator protein 2 (CRMP2) phosphorylation and inhibition of the inflammatory response.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Orthopedics
Xiaoke Li, Lei Yan, Dijun Li, Zijuan Fan, Haifeng Liu, Guishan Wang, Jingwei Jiu, Ziquan Yang, Jiao Jiao Li, Bin Wang
Summary: This review provides a meta-analysis of the literature on the causes of graft failure after ACL reconstruction. Traumatic reinjury is the most common failure mode, followed by technical error and biological failure. Among technical errors, femoral tunnel malposition is the leading cause of failure. Traumatic reinjury is the predominant factor in ACL failure among European populations and recent studies, while technical errors are more common in Asian populations, earlier studies, and surgeries using the TT technique. Biological factors are more likely to result in ACL failure in hamstring autografts compared to BPTB autografts.
INTERNATIONAL ORTHOPAEDICS
(2023)
Article
Chemistry, Multidisciplinary
Huiyan Li, Huilin Zhang, Xiaofang He, Peiran Zhao, Tong Wu, Jinxuan Xiahou, Yelin Wu, Yanyan Liu, Yang Chen, Xingwu Jiang, Guanglei Lv, Zhenwei Yao, Jian Wu, Wenbo Bu
Summary: A communication interception strategy is developed to block spatiotemporal crosstalk between lysosomes and endoplasmic reticulum (ER) using amorphous-core@crystalline-shell Fe@Fe3O4 nanoparticles (ACFeNPs). This strategy induces autophagy and ER stress, leading to a significant therapeutic effect for cancer treatment.
ADVANCED MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Jiaojiao Li, Jianyu Zhang, Pin Meng
Summary: A systematic evaluation was conducted to assess the effectiveness and safety of safinamide in the treatment of levodopa-induced motor complications of Parkinson's disease. Five randomized controlled trials with a total of 2061 PD patients were included in the analysis, and the results showed that safinamide is effective and safe for the treatment of PD motor complications caused by levodopa.
BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS
(2023)
Article
Cell & Tissue Engineering
Dijun Li, Guishan Wang, Jiarong Li, Lei Yan, Haifeng Liu, Jingwei Jiu, Xiaoke Li, Jiao Jiao Li, Bin Wang
Summary: This review provides an up-to-date summary of preclinical studies on tissue engineering treatments for tendinopathy using biomaterials in animal models. The review presents novel perspectives on the use of different animal species, injury sites, follow-up times, biomaterial selection, supplementation factors, and reporting of results. The findings of this review give valuable insights into the advancement of biomaterial-based tissue engineering strategies in animal models and their potential clinical translation.
TISSUE ENGINEERING PART B-REVIEWS
(2023)
Article
Cell & Tissue Engineering
Xiaoke Li, Dijun Li, Jiarong Li, Guishan Wang, Lei Yan, Haifeng Liu, Jingwei Jiu, Jiao Jiao Li, Bin Wang
Summary: This review provides an up-to-date and comprehensive overview of preclinical and clinical studies that tested cell-based treatments for meniscus regeneration. It presents novel perspectives on studies published in the past 30 years, giving consideration to the cell sources and dose selection, delivery methods, extra stimulation, animal models and injury patterns, timing of outcome assessment, and histological and biomechanical outcomes, as well as a summary of findings for individual studies. These unique insights will help to shape future research on the repair of meniscus lesions and inform the clinical translation of new cell-based tissue engineering strategies.
TISSUE ENGINEERING PART B-REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Peter L. H. Newman, Queenie Yip, Pierre Osteil, Tim A. Anderson, Jane Q. J. Sun, Daryan Kempe, Mate Biro, Jae-Won Shin, Patrick P. L. Tam, Hala Zreiqat
Summary: Multicellular patterning in stem-cell-derived tissue models is often achieved through self-organizing activities triggered by external morphogenetic stimuli. However, these tissue models exhibit stochastic behavior, leading to limited reproducibility and non-physiological structures. To improve multicellular patterning, researchers have developed a method for creating complex tissue microenvironments with programmable mechano-chemical cues. These cues, including peptides, proteins, morphogens, and defined stiffness, spatially guide tissue patterning processes, such as mechanosensing and cell differentiation. By designing niches, the authors successfully engineered bone-fat assembly and germ layer tissues. Microstructured cell niches enable the spatial programming of tissue patterning processes, enhancing the organization and composition of engineered tissues.
Article
Orthopedics
Shengjie Dong, Fengyao Mei, Jiao jiao Li, Dan Xing
Summary: This study aimed to investigate the global trends and network visualization in research of prosthetic joint infection (PJI). A bibliometric analysis was conducted on PJI publications extracted from the Science Citation Index-Expanded database. The results showed a gradual increase in the number of publications and research interests globally. The USA made the highest contributions in PJI research, with the highest H-index and most citations. The areas of focus in PJI research include bacterial pathogenic mechanisms, TJA complications, risk factors and epidemiology, diagnosis, and revision management. There is expected to be a significant increase in the number of PJI publications in the coming years.
ORTHOPAEDIC SURGERY
(2023)
Review
Orthopedics
Fengyao Mei, Jiao Jiao Li, Jianhao Lin, Diange Zhou, Dan Xing
Summary: This case report presents a 74-year-old Asian woman with bilateral Charcot knees who underwent bilateral knee replacements and experienced pain relief and improved range of motion after 2 years without postoperative complications or prosthesis loosening.
ORTHOPAEDIC SURGERY
(2023)
Article
Materials Science, Biomaterials
Zhengjiang Xu, Yuan Zhang, Danping Lu, Guofang Zhang, Yang Li, Zufu Lu, Fei Wang, Guocheng Wang
Summary: Accumulation of senescent cells in the elderly has a negative impact on bone homeostasis, and it is important to mitigate cell senescence and reduce oxidative stress for improved bone fracture healing in elderly patients. This study developed a nanoformulation of resveratrol (RSV) using a biocompatible zeolitic imidazolate framework-8 (ZIF-8) nanoparticle, which effectively addressed the issues of oxidation and bioavailability. The ZIF-8/RSV nanoformulation showed promising results in alleviating cellular senescence and enhancing cell functions, suggesting its potential for bone fracture treatment in the elderly.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Engineering, Biomedical
Charenpreet Virdi, Zufu Lu, Hala Zreiqat, Young Jung No
Summary: This study demonstrates that high-water content polyvinyl alcohol hydrogels can achieve a tensile strength exceeding 1.0 MPa through a combination of physical crosslinking, mechanical drawing, freeze drying, and hierarchical design.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Review
Engineering, Biomedical
Haiyan Li, Keerthi Subramanian Iyer, Lei Bao, Jiali Zhai, Jiao Jiao Li
Summary: Granular microporous hydrogels made of non-spherical microgels show enhanced characteristics compared to traditional nanoporous hydrogels, promoting cell viability, migration, and tissue regeneration. These hydrogels have higher macroporosity and improved mechanical properties, allowing for better alignment and differentiation of cells in anisotropic tissue. The development of these hydrogels is gaining increasing interest in regenerative medicine.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Cell & Tissue Engineering
V. Shang, J. Li, C. B. Little, J. J. Li
Summary: Osteoarthritis (OA) is a chronic condition that causes pain and disability, and there is currently no cure. Mesenchymal stromal cells (MSCs) have been used in clinical trials for treating OA because of their ability to produce anti-inflammatory and trophic signals. However, these studies have shown short-term benefits rather than sustained effects. This study aimed to understand why the efficacy of MSC injections for OA is inconsistent. The results suggest that MSCs may not provide long-term effects in correcting the OA joint environment due to adopting the diseased phenotype of the surrounding tissues.
EUROPEAN CELLS & MATERIALS
(2023)
Article
Surgery
Jiaxiang Gao, Dan Xing, Jiaojiao Li, Tong Li, Cheng Huang, Weiguo Wang
Summary: Computer-assisted navigation system (CAS) and robotic assisted surgery (RAS) have been widely used in joint arthroplasty, and this study aimed to evaluate the current trends and seasonality of public interest in CAS and RAS arthroplasty over the past 10 years and forecast their future development. The study found that public interest in RAS arthroplasty has been continuously increasing, while CAS arthroplasty showed a downtrend. The popularity of RAS is expected to continue to increase in the next 10 years, while CAS is expected to remain stable with a slight downtrend.
JOURNAL OF ROBOTIC SURGERY
(2023)
Article
Nanoscience & Nanotechnology
Daniela Rubanova, Svitlana Skoroplyas, Alena Libanska, Eva Randarova, Josef Bryja, Michaela Chorvatova, Tomas Etrych, Lukas Kubala
Summary: This study explored the use of nanocarriers to deliver dexamethasone for treating rheumatoid arthritis. The results showed that this method increased the accumulation of dexamethasone in the arthritic area, had a dose-dependent healing effect, and reduced the accumulation of the RA mediator RANKL. This study provides a feasible strategy for improving rheumatoid arthritis therapy.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Article
Nanoscience & Nanotechnology
Thanpisit Lomphithak, Apiwit Sae-Fung, Simone Sprio, Anna Tampieri, Siriporn Jitkaew, Bengt Fadeel
Summary: In this study, iron-doped hydroxyapatite (FeHA) was evaluated as a potential nanomedicine approach for treating PDAC. The results showed that FeHA, in combination with a sublethal dose of the GPX4 inhibitor RSL3, could trigger ferroptosis in KRAS mutant PANC-1 cells while sparing normal human cells. The induction of ferroptosis by FeHA plus RSL3 was found to be dependent on the metalloreductase STEAP3 in PDAC cells.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Review
Nanoscience & Nanotechnology
Marco Felipe Salas-Orozco, Ana Cecilia Lorenzo-Leal, Idania de Alba Montero, Nuria Patino Marin, Miguel Angel Casillas Santana, Horacio Bach
Summary: The emergence of antibiotic-resistant bacteria in severe infections is a growing concern, particularly in hospital environments. Metal-based nanomaterials have shown potential as an alternative to combat these bacteria, but there is a risk of bacterial resistance and environmental accumulation.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
