Article
Respiratory System
Maria Booth Nielsen, Borge G. Nordestgaard, Marianne Benn, Yunus colak
Summary: This study found that high plasma adiponectin is observationally associated with an increased risk of asthma, but genetic evidence could not support a causal association between plasma adiponectin and asthma.
Article
Geriatrics & Gerontology
Viola Vaccarino, Minxuan Huang, Zeyuan Wang, Qin Hui, Amit J. Shah, Jack Goldberg, Nicholas Smith, Belal Kaseer, Nancy Murrah, Oleksiy M. Levantsevych, Lucy Shallenberger, Emily Driggers, J. Douglas Bremner, Yan Sun
Summary: While no association was found between DNAm age acceleration and cognitive function scores at baseline, a longitudinal analysis showed that for each additional year of age acceleration using Horvath's method, there was a 3% decline in composite executive function scores and a 2.5% decline in memory function scores within twin pairs. These results suggest that middle-aged men with older DNAm age compared to their twin brothers experienced a faster rate of cognitive decline over the subsequent 11.5 years, highlighting the role of epigenetic modifications in cognitive aging.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Allergy
Esme J. Baan, Emmely W. de Roos, Marjolein Engelkes, Maria de Ridder, Lars Pedersen, Klara Berencsi, Dani Prieto-Alhambra, Francesco Lapi, Melissa K. Van Dyke, Peter Rijnbeek, Guy G. Brusselle, Katia M. C. Verhamme
Summary: This study reveals the differences in characteristics among patients with childhood, adult, and late-onset asthma. Compared to childhood asthma, adult-onset asthma patients are more likely to be overweight/obese, while late-onset asthma patients are more likely to have nasal polyposis, overweight/obesity, gastroesophageal reflux disease, and diabetes. There is a significant association between late-onset asthma and uncontrolled asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Clinical Neurology
Gauruv Bose, Brian C. Healy, Christian Barro, Bonnie Glanz, Hrishikesh A. Lokhande, Mariann Polgar-Turcsanyi, Charles R. G. Guttmann, Rohit Bakshi, Howard L. Weiner, Tanuja Chitnis
Summary: For patients with multiple sclerosis (MS) who have a disease duration of more than 10 years, an earlier age at onset is associated with worse outcomes at age 50, including higher disability, increased risk of secondary-progressive MS, more brain lesions, worse brain parenchymal fraction, and higher likelihood of unemployment due to MS.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Allergy
Syed A. Shah, Holly Tibble, Rebecca Pillinger, Susannah McLean, Dermot Ryan, Hilary Critchley, David Price, Catherine M. Hawrylowicz, Colin R. Simpson, Ireneous N. Soyiri, Francis Appiagyei, Aziz Sheikh, Bright Nwaru
Summary: In a 17-year study, researchers found an association between hormonal replacement therapy (HRT) and a reduced risk of late onset asthma in menopausal women, with a dose-response relationship showing that longer duration of HRT use was linked to a greater reduction in asthma onset risk.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Sport Sciences
Channa E. Marsh, Hannah J. Thomas, Louise H. Naylor, Lawrence G. Dembo, Katrina J. Scurrah, Daniel J. Green
Summary: Cardiac adaptation to exercise is modality-specific, and individuals who have a low response to one mode of exercise may have a high response to another. Genetic impact on adaptation to exercise is limited in this study.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Respiratory System
Annette Evans, Daniel Farewell, Joanne Demmler, Amrita Bandyopadhyay, Colin Victor Eric Powell, Shantini Paranjothy
Summary: The study suggests that children with inpatient asthma admissions are at higher risk of not attaining expected educational levels at age 6-7, while lower respiratory tract infection GP contacts are an independent predictor of poor educational outcomes. School absence may mediate the relationship between inpatient asthma admissions and educational attainment.
Article
Cardiac & Cardiovascular Systems
Bengt Zoller, MirNabi Pirouzifard, Peter J. Svensson, Bjorn Holmquist, Emelie Stenman, Robert C. Elston, Yeunjoo E. Song, Jan Sundquist, Kristina Sundquist
Summary: This nationwide segregation analysis of VTE indicates that familial aggregation of VTE may be attributed to genetic factors. Heritability was higher in men and younger individuals, suggesting a multifactorial threshold inheritance model.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Clinical Neurology
Juan J. Madrid-Valero, Maria Rubio-Aparicio, Alice M. Gregory, Julio Sanchez-Meca, Juan R. Ordonana
Summary: Twin studies consistently show that genetic factors play a significant role in explaining variance for insomnia, with a mean heritability estimate of 0.39. However, there is considerable heterogeneity among studies, highlighting the need for further research to identify variables that may explain this variation.
SLEEP MEDICINE REVIEWS
(2021)
Article
Allergy
Brandy M. Byrwa-Hill, Tricia L. Morphew, Albert A. Presto, James P. Fabisiak, Sally E. Wenzel
Summary: Living in an environmentally just tract increases the likelihood of severe and uncontrolled asthma, which is influenced by age at onset, disease duration, and traffic-related air pollution.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Jakob Skov, Ralf Kuja-Halkola, Patrik K. E. Magnusson, Soffia Gudbjornsdottir, Olle Kampe, Sophie Bensing
Summary: Type 1 diabetes and Hashimoto's thyroiditis often coexist in individuals and families, with shared genetic and environmental factors contributing to their etiology. Twins have a higher risk of developing both diseases compared to the general population. Genetic factors account for a portion of the overlap, while unique environmental factors also play a significant role.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Allergy
Elise Margaretha Adriana Slob, Cristina Longo, Susanne J. H. Vijverberg, Toos C. E. M. van Beijsterveldt, Meike Bartels, Jouke Jan Hottenga, Marielle W. Pijnenburg, Gerard H. Koppelman, Anke-Hilse Maitland-van der Zee, Conor Dolan, Dorret Boomsma
Summary: Based on analysis of twin data, this study found a high genetic correlation between asthma-like symptoms at age 3 and asthma at age 7, indicating a high persistence of asthma development between early childhood and school age.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Clinical Neurology
April C. E. van Gennip, Thomas T. van Sloten, Aurore Fayosse, Severine Sabia, Archana Singh-Manoux
Summary: This study suggests that developing cardiovascular disease in midlife increases the risk of dementia in later life, but maintaining a healthy lifestyle following a CVD diagnosis can mitigate this risk.
ALZHEIMERS & DEMENTIA
(2023)
Article
Sport Sciences
Rikhard Maki-Heikkila, Jussi Karjalainen, Jari Parkkari, Heini Huhtala, Maarit Valtonen, Lauri Lehtimaki
Summary: This comparative study found that the prevalence of asthma is approximately 2.5 times higher in cross-country skiers compared to the control group, with a later onset of asthma. Most skiers with asthma have well-controlled symptoms and are on regular maintenance treatment.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Simon Haworth, Anders Esberg, Ralf Kuja-Halkola, Pernilla Lundberg, Patrik K. E. Magnusson, Ingegerd Johansson
Summary: The study found that periodontitis is a moderately heritable disease and periodontal traits derived from electronic records can be used as an attractive target for future genetic association studies.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Medical Laboratory Technology
Serena Lillo, Trine Rennebod Larsen, Leif Pennerup, Kirsten Ohm Kyvik, Jens Sondergaard, Steen Antonsen
Summary: While some interventions led to a decrease in the number of tests, there was no indication of improved adherence to guidelines. In some cases, these interventions may have resulted in underutilization of the test, and thus should be used with caution.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Neurosciences
Frederik Norregaard Pedersen, Lonny Stokholm, Frans Pouwer, Katrine Hass Rubin, Tunde Peto, Ulrik Frydkjaer-Olsen, Anne Suhr Thykjaer, Nis Andersen, Jens Andresen, Toke Bek, Morten La Cour, Steffen Heegaard, Kurt Hojlund, Ryo Kawasaki, Javad Nouri Hajari, Kirsten Ohm Kyvik, Caroline Schmidt Laugesen, Katja Christina Schielke, Rafael Simo, Jakob Grauslund
Summary: Individuals with diabetes without DR were less likely to develop AD compared to persons without diabetes. However, individuals with DR had a 34% higher risk of incident AD, which raise the question whether screening for cognitive impairment should be done among individuals with DR.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Nicolai Obling, Bojidar Rangelov, Vibeke Backer, John R. Hurst, Uffe Bodtger
Summary: This study aimed to investigate the co-existence of small airways disease (SAD) and upper airway symptoms in patients with chronic obstructive pulmonary disease (COPD). The results showed a high prevalence of SAD in COPD patients, but no association between upper airway symptoms and small airways disease was found.
RESPIRATORY MEDICINE
(2022)
Article
Allergy
Kjell Erik Julius Hakansson, Martino Renzi-Lomholt, Vibeke Backer, Charlotte Suppli Ulrik
Summary: The purpose of this study was to investigate the prevalence and risk factors for antidepressant use in asthma patients compared to the background population. The results revealed a significantly higher use of antidepressant drugs in asthma patients, even after adjusting for known risk factors. Female sex, higher age, being divorced or never married, having lower education level and lower income were associated with higher odds of antidepressant use. The study suggests that living with asthma carries a psychological burden, leading to increased use of antidepressants.
JOURNAL OF ASTHMA AND ALLERGY
(2022)
Article
Endocrinology & Metabolism
Karri Silventoinen, Weilong Li, Aline Jelenkovic, Reijo Sund, Yoshie Yokoyama, Sari Aaltonen, Maarit Piirtola, Masumi Sugawara, Mami Tanaka, Satoko Matsumoto, Laura A. Baker, Catherine Tuvblad, Per Tynelius, Finn Rasmussen, Jeffrey M. Craig, Richard Saffery, Gonneke Willemsen, Meike Bartels, Catharina E. M. van Beijsterveldt, Nicholas G. Martin, Sarah E. Medland, Grant W. Montgomery, Paul Lichtenstein, Robert F. Krueger, Matt McGue, Shandell Pahlen, Kaare Christensen, Axel Skytthe, Kirsten O. Kyvik, Kimberly J. Saudino, Lise Dubois, Michel Boivin, Mara Brendgen, Ginette Dionne, Frank Vitaro, Vilhelmina Ullemar, Catarina Almqvist, Patrik K. E. Magnusson, Robin P. Corley, Brooke M. Huibregtse, Ariel Knafo-Noam, David Mankuta, Lior Abramson, Claire M. A. Haworth, Robert Plomin, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Glen E. Duncan, Dedra Buchwald, S. Alexandra Burt, Kelly L. Klump, Clare H. Llewellyn, Abigail Fisher, Dorret Boomsma, Thorkild I. A. Sorensen, Jaakko Kaprio
Summary: Using genetic twin design, this study analyzed the genetic correlations of BMI and height in children and adolescents, finding that the genetic correlations of BMI decreased with increasing age between assessments, especially from early to middle childhood, while the genetic correlations of height remained strong across all ages.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Respiratory System
Anders Pitzner-Fabricius, Vanessa L. Clark, Vibeke Backer, Peter G. Gibson, Vanessa M. McDonald
Summary: Exercise capacity in severe asthma is associated with asthma control and BMI. In females, asthma control and BMI are significantly associated with exercise capacity. In males, asthma control is associated with exercise capacity, but no other clinical or biological factors reached statistical significance.
Article
Biochemical Research Methods
Martin Ostergaard, Soren Jessen, Erik Soren Halvard Hansen, Vibeke Backer, Tina Panchal, Sandra Baldwin, Peter Daley-Yates, Morten Hostrup
Summary: The 2023 Prohibited List permits athletes to use a standard dose of 25 mu g daily of the beta(2)-agonist vilanterol. However, there is limited data on its urine pharmacokinetics, making it challenging to distinguish therapeutic use from supratherapeutic use. A study was conducted on 25 trained individuals to examine the urine concentrations of vilanterol and its metabolites after inhalation of different doses. The findings suggest that current urine concentration thresholds are insufficient, but a higher decision limit of 6 ng center dot ml(-1) is proposed to minimize the risk of false-positive results while still detecting supratherapeutic use.
DRUG TESTING AND ANALYSIS
(2023)
Article
Biochemical Research Methods
Tina Panchal, Sandra Baldwin, Martin Ostergaard, Erik Soeren Halvard Hansen, Vibeke Backer, Morten Hostrup, Peter Daley-Yates
Summary: This study developed a bioanalytical method to detect the concentration of the ultra-long-acting beta(2)-agonist vilanterol and its metabolites GSK932009 and GW630200 in urine, aiming to potentially monitor its therapeutic and prohibited use in sport.
DRUG TESTING AND ANALYSIS
(2023)
Article
Dermatology
Courtney K. Wallingford, Anastassia Demeshko, Asha Krishnankutty Krishnakripa, Darren J. Smit, David L. Duffy, Brigid Betz-Stablein, Annette Pflugfelder, Kasturee Jagirdar, Elizabeth Holland, Graham J. Mann, Clare A. Primiero, Tatiane Yanes, Josep Malvehy, Celia Badenas, Cristina Carrera, Paula Aguilera, Catherine M. Olsen, Sarah Ward, Nikolas K. Haass, Richard A. Sturm, Susana Puig, David C. Whiteman, Matthew H. Law, Anne E. Cust, Miriam Potrony, H. Peter Soyer, Aideen M. McInerney-Leo
Summary: Genetic characterization can improve cost-effectiveness of melanoma screening. The interactions between MC1R RHC variants and MITF E318K in melanoma risk have not been well explored. This study found that while all MC1R RHC genotypes increase melanoma risk in E318K(-) individuals, only the MC1R R genotype increases melanoma risk in E318K(+) individuals.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Clinical Neurology
Andreas Vinther Thomsen, Oula Puonti, David Gaist, Kirsten Ohm Kyvik, Kristoffer Madsen, Axel Thielscher, Hartwig Roman Siebner, Messoud Ashina, Anders Hougaard
Summary: In this study, we compared the distances between visual cortical areas and overlying dura mater in female patients with migraine aura without headache and female patients with migraine aura with headache. The results showed no significant differences in distances or volumes between the two groups. Therefore, we conclude that there may not be a direct connection between migraine aura and headache.
Article
Public, Environmental & Occupational Health
Christine Stabell Benn, Nelly Amenyogbe, Anders Bjorkman, Jorge Dominguez-Andres, Eleanor N. Fish, Katie L. Flanagan, Sabra L. Klein, Tobias R. Kollmann, Kirsten Ohm Kyvik, Mihai G. Netea, Naja Hulvej Rod, Frederik Schaltz-Buchholzer, Frank Shann, Liisa Selin, Sanne M. Thysen, Peter Aaby
Summary: The current framework for testing and regulating vaccines needs to be updated to consider the non-specific effects of vaccines, which can affect all-cause mortality and morbidity in ways that are not explained by the prevention of the targeted disease. Immunological studies have provided mechanisms that explain how vaccines might modulate the immune response to unrelated pathogens. Non-specific effects are often greater in female individuals. Currently, these effects are not routinely captured in clinical trials or post-licensure safety surveillance, but a new framework is proposed to address this issue.
Article
Dermatology
Mitchell S. Stark, Richard A. Sturm, Yan Pan, Darren J. Smit, Varsha Kommajosyula, Katie J. Lee, Kasturee Jagirdar, Catriona McLean, David L. Duffy, H. Peter Soyer, Victoria J. Mar
Summary: This study performed a rare-variant allele analysis, identifying some genes associated with nodular melanoma (NM), including PTCH1, ARID2, and GHR. Rare variants in the SMO gene, which interacts with PTCH1, were also found, suggesting a potential contribution of the Hedgehog pathway to NM risk.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Serena Lillo, Trine Rennebod Larsen, Kirsten Ohm Kyvik, Jens Sondergaard, Steen Antonsen
Summary: GPs in the Region of Southern Denmark were randomly assigned to interventions aimed at maximizing their use of Vitamin D tests. A survey study was conducted to examine GPs' assessment of these interventions. The results showed that guidelines were found helpful by half of the GPs and feedback reports were often read. Pop-up alerts were accepted for frequently used tests, but there were concerns about the interruptive alert appearing every time a Vitamin D test was requested.
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
(2023)
Article
Allergy
Silvia Cabrera Guerrero, Kjell Erik Julius Hakansson, Vibeke Backer, Charlotte Suppli Ulrik, Deepa Rastogi
Summary: This study found that childhood asthma is associated with caregiver depression, which leads to poor asthma control. Sociodemographic risk factors contribute to caregiver depression among children with asthma, even in universal healthcare settings.
JOURNAL OF ASTHMA AND ALLERGY
(2023)
Article
Respiratory System
Kjell Erik Julius Hakansson, Silvia Cabrera Guerrero, Vibeke Backer, Charlotte Suppli Ulrik, Deepa Rastogi
Summary: This study investigated the disease and healthcare access of children and adolescents with asthma in Denmark and found that there was a significant unmet need for specialist care, particularly among those with poorly controlled asthma, even in a free healthcare system.
RESPIRATORY RESEARCH
(2023)