Nanocarriers for delivery of siRNA and co-delivery of siRNA and other therapeutic agents

Dual sensitive and temporally controlled camptothecin prodrug liposomes codelivery of siRNA for high efficiency tumor therapy

(2014) Yan Li et al.   BIOMATERIALS

SiRNA-phospholipid conjugates for gene and drug delivery in cancer treatment

(2014) Hongmei Liu et al.   BIOMATERIALS

Matrix metalloproteinase 2-sensitive multifunctional polymeric micelles for tumor-specific co-delivery of siRNA and hydrophobic drugs

(2014) Lin Zhu et al.   BIOMATERIALS

Synergistic inhibition of breast cancer by co-delivery of VEGF siRNA and paclitaxel via vapreotide-modified core–shell nanoparticles

(2014) Qiang Feng et al.   BIOMATERIALS

Liposome-based co-delivery of siRNA and docetaxel for the synergistic treatment of lung cancer

(2014) Mei-Hua Qu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Current issues of RNAi therapeutics delivery and development

(2014) D. Haussecker   JOURNAL OF CONTROLLED RELEASE

EPR: Evidence and fallacy

(2014) Joseph W. Nichols et al.   JOURNAL OF CONTROLLED RELEASE

Prolongation of Life in Rats with Malignant Glioma by Intranasal siRNA/Drug Codelivery to the Brain with Cell-Penetrating Peptide-Modified Micelles

(2014) Takanori Kanazawa et al.   MOLECULAR PHARMACEUTICS

Chitosan Coated Polylactic Acid Nanoparticle-Mediated Combinatorial Delivery of Cisplatin and siRNA/Plasmid DNA Chemosensitizes Cisplatin-Resistant Human Ovarian Cancer Cells

(2014) Anish Babu et al.   MOLECULAR PHARMACEUTICS

A pH-sensitive micelle for codelivery of siRNA and doxorubicin to hepatoma cells

(2014) Yiru Wang et al.   POLYMER

Structural DNA Nanotechnology for Intelligent Drug Delivery

(2014) Jie Chao et al.   Small

Co-Delivery of Doxorubicin and siRNA with Reduction and pH Dually Sensitive Nanocarrier for Synergistic Cancer Therapy

(2014) Weicai Chen et al.   Small

Co-delivery of Doxorubicin and Bmi1 siRNA by Folate Receptor Targeted Liposomes Exhibits Enhanced Anti-Tumor Effects in vitro and in vivo

(2014) Tan Yang et al.   Theranostics

Self-assembling doxorubicin-prodrug nanoparticles as siRNA drug delivery system for cancer treatment: in vitro and in vivo

(2014) Hongmei Liu et al.   Journal of Materials Chemistry B

Engineered nanoparticles interacting with cells: size matters

(2014) Li Shang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Codelivery of an Optimal Drug/siRNA Combination Using Mesoporous Silica Nanoparticles To Overcome Drug Resistance in Breast Cancer in Vitro and in Vivo

(2013) Huan Meng et al.   ACS Nano

Layer-by-Layer Nanoparticles for Systemic Codelivery of an Anticancer Drug and siRNA for Potential Triple-Negative Breast Cancer Treatment

(2013) Zhou J. Deng et al.   ACS Nano

Stable RNA nanoparticles as potential new generation drugs for cancer therapy

(2013) Yi Shu et al.   ADVANCED DRUG DELIVERY REVIEWS

Redox-Responsive Mesoporous Silica Nanoparticles: A Physiologically Sensitive Codelivery Vehicle for siRNA and Doxorubicin

(2013) Xing Ma et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeted co-delivery of docetaxel and siPlk1 by herceptin-conjugated vitamin E TPGS based immunomicelles

(2013) Jing Zhao et al.   BIOMATERIALS

Trilayer micelles for combination delivery of rapamycin and siRNA targeting Y-box binding protein-1 (siYB-1)

(2013) San Zeng et al.   BIOMATERIALS

Codelivery of mTERT siRNA and paclitaxel by chitosan-based nanoparticles promoted synergistic tumor suppression

(2013) Wei Wei et al.   BIOMATERIALS

Inhibition of hepatocellular carcinoma growth using immunoliposomes for co-delivery of adriamycin and ribonucleotide reductase M2 siRNA

(2013) Jie Gao et al.   BIOMATERIALS

Combinational delivery of c-myc siRNA and nucleoside analogs in a single, synthetic nanocarrier for targeted cancer therapy

(2013) Yuan Zhang et al.   BIOMATERIALS

Polypeptide cationic micelles mediated co-delivery of docetaxel and siRNA for synergistic tumor therapy

(2013) Cuifang Zheng et al.   BIOMATERIALS

Polymeric micelles containing reversibly phospholipid-modified anti-survivin siRNA: A promising strategy to overcome drug resistance in cancer

(2013) G. Salzano et al.   CANCER LETTERS

Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

(2013) U. Prabhakar et al.   CANCER RESEARCH

Integrated Hollow Mesoporous Silica Nanoparticles for Target Drug/siRNA Co-Delivery

(2013) Xing Ma et al.   CHEMISTRY-A EUROPEAN JOURNAL

Codelivery of VEGF siRNA and Gemcitabine Monophosphate in a Single Nanoparticle Formulation for Effective Treatment of NSCLC

(2013) Yuan Zhang et al.   MOLECULAR THERAPY

siRNA-based nanomedicine

(2013) Jing Zhao et al.   Nanomedicine

Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug

(2013) X. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functionalized large pore mesoporous silica nanoparticles for gene delivery featuring controlled release and co-delivery

(2013) Sandy Budi Hartono et al.   Journal of Materials Chemistry B

Enhanced siRNA Delivery and Silencing Gold–Chitosan Nanosystem with Surface Charge-Reversal Polymer Assembly and Good Biocompatibility

(2012) Lu Han et al.   ACS Nano

Safety profile of RNAi nanomedicines

(2012) Scott A. Barros et al.   ADVANCED DRUG DELIVERY REVIEWS

Solid lipid nanoparticles

(2012) Wolfgang Mehnert et al.   ADVANCED DRUG DELIVERY REVIEWS

An Amphiphilic Dendrimer for Effective Delivery of Small Interfering RNA and Gene Silencing In Vitro and In Vivo

(2012) Tianzhu Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reconfigurable Three-Dimensional DNA Nanostructures for the Construction of Intracellular Logic Sensors

(2012) Hao Pei et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nanoparticle-based combination therapy toward overcoming drug resistance in cancer

(2012) Che-Ming Jack Hu et al.   BIOCHEMICAL PHARMACOLOGY

Glycine-Terminated Dendritic Amphiphiles for Nonviral Gene Delivery

(2012) Shashwat Malhotra et al.   BIOMACROMOLECULES

The tumor accumulation and therapeutic efficacy of doxorubicin carried in calcium phosphate-reinforced polymer nanoparticles

(2012) Kyung Hyun Min et al.   BIOMATERIALS

Synergistic treatment of ovarian cancer by co-delivery of survivin shRNA and paclitaxel via supramolecular micellar assembly

(2012) Qinglian Hu et al.   BIOMATERIALS

Vitamin E TPGS as a molecular biomaterial for drug delivery

(2012) Zhiping Zhang et al.   BIOMATERIALS

Lipid modified triblock PAMAM-based nanocarriers for siRNA drug co-delivery

(2012) Swati Biswas et al.   BIOMATERIALS

Cancer treatment and survivorship statistics, 2012

(2012) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

NMR Insights into Dendrimer-Based Host–Guest Systems

(2012) Jingjing Hu et al.   CHEMICAL REVIEWS

Endocytosis at the nanoscale

(2012) Irene Canton et al.   CHEMICAL SOCIETY REVIEWS

Development of siRNA-probes for studying intracellular trafficking of siRNA nanoparticles

(2012) Christopher A. Alabi et al.   Integrative Biology

PLGA nanoparticles codeliver paclitaxel and Stat3 siRNA to overcome cellular resistance in lung cancer cells

(2012) Wu-Chou Su et al.   International Journal of Nanomedicine

Encapsidation of RNA–Polyelectrolyte Complexes with Amphiphilic Block Copolymers: Toward a New Self-Assembly Route

(2012) Laurent Bui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A DNA Nanostructure Platform for Directed Assembly of Synthetic Vaccines

(2012) Xiaowei Liu et al.   NANO LETTERS

Polyelectrolyte Wrapping Layers Control Rates of Photothermal Molecular Release from Gold Nanorods

(2012) Jingyu Huang et al.   NANO LETTERS

Ultrastable synergistic tetravalent RNA nanoparticles for targeting to cancers

(2012) Farzin Haque et al.   Nano Today

Co-delivery of doxorubicin and siRNA using octreotide-conjugated gold nanorods for targeted neuroendocrine cancer therapy

(2012) Yuling Xiao et al.   Nanoscale

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

(2012) Hyukjin Lee et al.   Nature Nanotechnology

Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery

(2012) D. N. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities

(2012) Z. Cheng et al.   SCIENCE

Dendronized Gold Nanoparticles for siRNA Delivery

(2012) Sung Tae Kim et al.   Small

Optically Traceable Solid Lipid Nanoparticles Loaded with siRNA and Paclitaxel for Synergistic Chemotherapy with In situ Imaging

(2012) Ki Hyun Bae et al.   Advanced Healthcare Materials

The Business of RNAi Therapeutics in 2012

(2012) Dirk Haussecker   Molecular Therapy-Nucleic Acids

Multifunctional Nanogels for siRNA Delivery

(2011) Michael H. Smith et al.   ACCOUNTS OF CHEMICAL RESEARCH

In Vivo Sustained Release of siRNA from Solid Lipid Nanoparticles

(2011) Tatsiana Lobovkina et al.   ACS Nano

Solid Lipid–PEI Hybrid Nanocarrier: An Integrated Approach To Provide Extended, Targeted, and Safer siRNA Therapy of Prostate Cancer in an All-in-One Manner

(2011) Hui-Yi Xue et al.   ACS Nano

Simultaneous Delivery of siRNA and Paclitaxel via a “Two-in-One” Micelleplex Promotes Synergistic Tumor Suppression

(2011) Tian-Meng Sun et al.   ACS Nano

Self-Assembled Multivalent DNA Nanostructures for Noninvasive Intracellular Delivery of Immunostimulatory CpG Oligonucleotides

(2011) Jiang Li et al.   ACS Nano

Cationic drug-derived nanoparticles for multifunctional delivery of anticancer siRNA

(2011) Rae Sung Chang et al.   BIOMATERIALS

Octa-functional PLGA nanoparticles for targeted and efficient siRNA delivery to tumors

(2011) Jiangbing Zhou et al.   BIOMATERIALS

Current progress of siRNA/shRNA therapeutics in clinical trials

(2011) John C. Burnett et al.   Biotechnology Journal

Catanionic solid lipid nanoparticles carrying doxorubicin for inhibiting the growth of U87MG cells

(2011) Yung-Chih Kuo et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Cationic solid lipid nanoparticles for co-delivery of paclitaxel and siRNA

(2011) Yong Hee Yu et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Cyclodextrin-based siRNA delivery nanocarriers: a state-of-the-art review

(2011) Kiran Chaturvedi et al.   Expert Opinion on Drug Delivery

Polyethylene glycol-polyethylenimine-tetrachloroplatinum (IV): A novel conjugate with good abilities of antitumor and gene delivery

(2011) Lu Zhao et al.   JOURNAL OF APPLIED POLYMER SCIENCE

Phase I/II Study of Trastuzumab in Combination With Everolimus (RAD001) in Patients With HER2-Overexpressing Metastatic Breast Cancer Who Progressed on Trastuzumab-Based Therapy

(2011) Phuong K. Morrow et al.   JOURNAL OF CLINICAL ONCOLOGY

Innovative strategy for treatment of lung cancer: targeted nanotechnology-based inhalation co-delivery of anticancer drugs and siRNA

(2011) Oleh Taratula et al.   JOURNAL OF DRUG TARGETING

Degradable Self-Assembling Dendrons for Gene Delivery: Experimental and Theoretical Insights into the Barriers to Cellular Uptake

(2011) Anna Barnard et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synergistic Induction of Apoptosis in Brain Cancer Cells by Targeted Codelivery of siRNA and Anticancer Drugs

(2011) Cheoljin Kim et al.   MOLECULAR PHARMACEUTICS

Systemic Delivery of siRNA via LCP Nanoparticle Efficiently Inhibits Lung Metastasis

(2011) Yang Yang et al.   MOLECULAR THERAPY

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

Thermodynamically stable RNA three-way junction for constructing multifunctional nanoparticles for delivery of therapeutics

(2011) Dan Shu et al.   Nature Nanotechnology

Challenges and opportunities for structural DNA nanotechnology

(2011) Andre V. Pinheiro et al.   Nature Nanotechnology

Iniparib plus Chemotherapy in Metastatic Triple-Negative Breast Cancer

(2011) Joyce O'Shaughnessy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cationic Liposomal Co-delivery of Small Interfering RNA and a MEK Inhibitor for Enhanced Anticancer Efficacy

(2011) Seung Hee Kang et al.   PHARMACEUTICAL RESEARCH

Enhanced Gene Delivery and siRNA Silencing by Gold Nanoparticles Coated with Charge-Reversal Polyelectrolyte

(2010) Shutao Guo et al.   ACS Nano

Engineering RNA for Targeted siRNA Delivery and Medical Application

(2010) Peixuan Guo et al.   ADVANCED DRUG DELIVERY REVIEWS

DNA nanomedicine: Engineering DNA as a polymer for therapeutic and diagnostic applications

(2010) Michael J. Campolongo et al.   ADVANCED DRUG DELIVERY REVIEWS

Gold Nanoparticles for Biology and Medicine

(2010) David A. Giljohann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nanomaterials Based on DNA

(2010) Nadrian C. Seeman   Annual Review of Biochemistry

Effective Stabilization and Delivery of siRNA: Reversible siRNA−Phospholipid Conjugate in Nanosized Mixed Polymeric Micelles

(2010) Tiziana Musacchio et al.   BIOCONJUGATE CHEMISTRY

The synergistic effect of hierarchical assemblies of siRNA and chemotherapeutic drugs co-delivered into hepatic cancer cells

(2010) Nuo Cao et al.   BIOMATERIALS

Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications

(2010) Anupa R. Menjoge et al.   DRUG DISCOVERY TODAY

Improved Intratumoral Oxygenation Through Vascular Normalization Increases Glioma Sensitivity to Ionizing Radiation

(2010) Mackenzie C. McGee et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Cancer Trends in China

(2010) P. Zhao et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Systemic siRNA delivery using biocompatible calcium phosphate nanoparticles

(2010) Kinam Park   JOURNAL OF CONTROLLED RELEASE

Endocytosis of nanomedicines

(2010) Gaurav Sahay et al.   JOURNAL OF CONTROLLED RELEASE

Upconversion Nanoparticle-Based FRET System for Study of siRNA in Live Cells

(2010) Shan Jiang et al.   LANGMUIR

Leukemia-selective uptake and cytotoxicity of CPX-351, a synergistic fixed-ratio cytarabine:daunorubicin formulation, in bone marrow xenografts

(2010) Wah-Seng Lim et al.   LEUKEMIA RESEARCH

Combination Drug Delivery Strategy for the Treatment of Multidrug Resistant Ovarian Cancer

(2010) Payam Zahedi et al.   MOLECULAR PHARMACEUTICS

Nanoparticles Targeted With NGR Motif Deliver c-myc siRNA and Doxorubicin for Anticancer Therapy

(2010) Yunching Chen et al.   MOLECULAR THERAPY

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

The emerging field of RNA nanotechnology

(2010) Peixuan Guo   Nature Nanotechnology

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

The nanosilica hazard: another variable entity

(2010) Dorota Napierska et al.   Particle and Fibre Toxicology

Lipid-like materials for low-dose, in vivo gene silencing

(2010) K. T. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effective Gene Silencing by Multilayered siRNA-Coated Gold Nanoparticles

(2010) Seung Koo Lee et al.   Small

Laser-Activated Gene Silencing via Gold Nanoshell−siRNA Conjugates

(2009) Gary B. Braun et al.   ACS Nano

Lipid-based systemic delivery of siRNA

(2009) Yu-Cheng Tseng et al.   ADVANCED DRUG DELIVERY REVIEWS

PEGylated Calcium Phosphate Nanocomposites as Smart Environment-Sensitive Carriers for siRNA Delivery

(2009) Mingzhen Zhang et al.   ADVANCED MATERIALS

Light-Induced Content Release from Plasmon-Resonant Liposomes

(2009) Timothy S. Troutman et al.   ADVANCED MATERIALS

Nanogels as Pharmaceutical Carriers: Finite Networks of Infinite Capabilities

(2009) Alexander V. Kabanov et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeted intracellular codelivery of chemotherapeutics and nucleic acid with a well-defined dendrimer-based nanoglobular carrier

(2009) Todd L. Kaneshiro et al.   BIOMATERIALS

The use of nanoparticle-mediated targeted gene silencing and drug delivery to overcome tumor drug resistance

(2009) Yogesh B. Patil et al.   BIOMATERIALS

Co-delivery of siRNA and paclitaxel into cancer cells by biodegradable cationic micelles based on PDMAEMA–PCL–PDMAEMA triblock copolymers

(2009) Caihong Zhu et al.   BIOMATERIALS

Solid lipid nanoparticles for applications in gene therapy: a review of the state of the art

(2009) Maria Luisa Bondì et al.   Expert Opinion on Drug Delivery

Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery

(2009) Jun Li et al.   JOURNAL OF CONTROLLED RELEASE

Gene Regulation with Polyvalent siRNA−Nanoparticle Conjugates

(2009) David A. Giljohann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spectrally Tunable Leakage-Free Gold Nanocontainers

(2009) Yongdong Jin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regulating Immune Response Using Polyvalent Nucleic Acid−Gold Nanoparticle Conjugates

(2009) Matthew D. Massich et al.   MOLECULAR PHARMACEUTICS

Layer-by-Layer Assembled Gold Nanoparticles for siRNA Delivery

(2009) Asmaa Elbakry et al.   NANO LETTERS

The promises and pitfalls of RNA-interference-based therapeutics

(2009) Daniela Castanotto et al.   NATURE

In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses

(2009) Marcin Kortylewski et al.   NATURE BIOTECHNOLOGY

Multifunctional nanoarchitectures from DNA-based ABC monomers

(2009) Jong B. Lee et al.   Nature Nanotechnology

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

(2009) Aimee L. Jackson et al.   NATURE REVIEWS DRUG DISCOVERY

Co-delivery of Doxorubicin and Bcl-2 siRNA by Mesoporous Silica Nanoparticles Enhances the Efficacy of Chemotherapy in Multidrug-Resistant Cancer Cells

(2009) Alex M. Chen et al.   Small

Gold Nanoparticles Capped with Polyethyleneimine for Enhanced siRNA Delivery

(2009) Wen-Jing Song et al.   Small

Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers☆

(2008) I SLOWING et al.   ADVANCED DRUG DELIVERY REVIEWS

The performance of docetaxel-loaded solid lipid nanoparticles targeted to hepatocellular carcinoma

(2008) Zhenghong Xu et al.   BIOMATERIALS

Resistance to chemotherapy: new treatments and novel insights into an old problem

(2008) S Raguz et al.   BRITISH JOURNAL OF CANCER

Calcium carbonate nanoparticle delivering vascular endothelial growth factor-C siRNA effectively inhibits lymphangiogenesis and growth of gastric cancer in vivo

(2008) X-w He et al.   CANCER GENE THERAPY

Growth Inhibition and Radiosensitization of Glioblastoma and Lung Cancer Cells by Small Interfering RNA Silencing of Tumor Necrosis Factor Receptor-Associated Factor 2

(2008) M. Zheng et al.   CANCER RESEARCH

Mechanisms and strategies to overcome chemotherapy resistance in metastatic breast cancer

(2008) Helen M. Coley   CANCER TREATMENT REVIEWS

Misinterpreting the Therapeutic Effects of Small Interfering RNA Caused by Immune Stimulation

(2008) Marjorie Robbins et al.   HUMAN GENE THERAPY

Resolution of liver cirrhosis using vitamin A–coupled liposomes to deliver siRNA against a collagen-specific chaperone

(2008) Yasushi Sato et al.   NATURE BIOTECHNOLOGY

Dicer, Drosha, and Outcomes in Patients with Ovarian Cancer

(2008) William M. Merritt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural analysis of DNA complexation with cationic lipids

(2008) R. Marty et al.   NUCLEIC ACIDS RESEARCH

Characterization of the intracellular dynamics of a non-degradative pathway accessed by polymer nanoparticles

(2007) Samuel K. Lai et al.   JOURNAL OF CONTROLLED RELEASE