Article
Multidisciplinary Sciences
A. E. Tozzi, F. Del Chierico, E. Pandolfi, S. Reddel, F. Gesualdo, S. Gardini, V. Guarrasi, L. Russo, I. Croci, I. Campagna, G. Linardos, C. Concato, A. Villani, L. Putignani
Summary: The study found specific nasopharyngeal microbiome profiles related to pertussis infection, with a reduction in microbial richness during coinfection. Different infectious agents have varying effects on the microbiota, influencing disease severity.
SCIENTIFIC REPORTS
(2021)
Article
Allergy
Tadao Ooka, Yoshihiko Raita, Michimasa Fujiogi, Robert J. Freishtat, Robert E. Gerszten, Jonathan M. Mansbach, Zhaozhong Zhu, Carlos A. Camargo, Kohei Hasegawa
Summary: This study identified three different endotypes of infant bronchiolitis by integrating clinical, virus, and serum proteome data, and found their associations with the risk of developing asthma.
Article
Public, Environmental & Occupational Health
Logan C. Dearborn, Marnie F. Hazlehurst, Christine T. Loftus, Adam A. Szpiro, Kecia N. Carroll, Paul E. Moore, Margaret A. Adgent, Emily S. Barrett, Ruby H. N. Nguyen, Sheela Sathyanarayana, Kaja Z. LeWinn, Nicole R. Bush, Joel D. Kaufman, Catherine J. Karr
Summary: This study found that early life air pollution can influence the development of asthma and wheezing in children aged 4-6 years with a history of bronchiolitis. The research was conducted by observing and evaluating a longitudinal cohort from six US cities, estimating the exposure of these children to fine particulate matter, nitrogen dioxide, and ozone pollution from ages 1 to 3 years, and controlling for other factors. The results showed that for every 2 ppb increase in ozone concentration, the risk of developing asthma in children increased by 1.4 times, and the risk of developing wheezing increased by 1.3 times.
Article
Biochemistry & Molecular Biology
Makiko Nanishi, Aruna Chandran, Xiuhong Li, Joseph B. Stanford, Akram N. Alshawabkeh, Judy L. Aschner, Dana Dabelea, Anne L. Dunlop, Amy J. Elliott, James E. Gern, Tina Hartert, Julie Herbstman, Gurjit K. Khurana Hershey, Alison E. Hipwell, Margaret R. Karagas, Catherine J. Karr, Leslie D. Leve, Augusto A. Litonjua, Cindy T. McEvoy, Rachel L. Miller, Emily Oken, T. Michael O'Shea, Nigel Paneth, Scott T. Weiss, Robert O. Wright, Rosalind J. Wright, Kecia N. Carroll, Xueying Zhang, Qi Zhao, Edward Zoratti, Carlos A. Camargo Jr, Kohei Hasegawa
Summary: Based on large-scale cohort data, this study found that infants hospitalized with bronchiolitis are at a higher risk for developing asthma. There is quantitative heterogeneity in different racial and ethnic groups.
Article
Immunology
Tadao Ooka, Zhaozhong Zhu, Liming Liang, Juan C. Celedon, Brennan Harmon, Andrea Hahn, Eugene P. Rhee, Robert J. Freishtat, Carlos A. Camargo Jr, Kohei Hasegawa
Summary: Through integrated genetics-metabolomics analysis, genetically driven metabolites associated with asthma development and genetic loci associated with both these metabolites and asthma susceptibility were identified in this high-risk population.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Allergy
Makiko Nanishi, Michimasa Fujiogi, Robert J. Freishtat, Claire E. Hoptay, Cindy S. Bauer, Michelle D. Stevenson, Carlos A. Camargo, Kohei Hasegawa
Summary: There is a longitudinal relationship between serum periostin level during bronchiolitis and the subsequent development of asthma in infants. This association is particularly strong among infants with allergic predisposition.
Review
Immunology
Dominika Ambrozej, Heidi Makrinioti, Abigail Whitehouse, Nikolas Papadopoulos, Marek Ruszczynski, Aleksander Adamiec, Jose A. Castro-Rodriguez, Khalid Alansari, Tuomas Jartti, Wojciech Feleszko
Summary: Severe bronchiolitis is a heterogeneous disease and requires personalized treatment. Molecular markers can guide more effective pharmacological management and prevent chronic respiratory sequelae.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pediatrics
Gustavo Nino, Carlos E. Rodriguez-Martinez, Maria J. Gutierrez
Summary: Early-life microbial exposure plays a crucial role in respiratory diseases, with associations between neonatal bacterial colonization and respiratory infections/asthma, and viral/bacterial exposures affecting immune development. Further human-based studies on newborns and infants are necessary to understand the timing and key pathways involved in airway immune response development and modulation by early microbiota and virus exposures.
Article
Public, Environmental & Occupational Health
Ruth J. Geller, Janice A. Espinola, Ronaldo C. Fabiano Filho, Kohei Hasegawa, Jonathan M. Mansbach, Ashley F. Sullivan, Carlos A. Camargo Jr
Summary: This study compared research definitions of childhood asthma based on parent-reported data. The strict asthma definition had the highest specificity and positive predictive value, while the flexible definition showed weaker associations with known asthma risk factors. The parent report of clinician-diagnosed asthma correlates well with known asthma risk factors.
ANNALS OF EPIDEMIOLOGY
(2021)
Article
Pediatrics
Karen Galta Sorensen, Knut oymar, Ingvild Dalen, Thomas Halvorsen, Ingvild Bruun Mikalsen
Summary: This study found that blood eosinophil levels during bronchiolitis in infancy were associated with atopy, asthma, and lung function in young adults. However, these associations did not differ between respiratory syncytial virus (RSV) bronchiolitis and non-RSV bronchiolitis.
Review
Respiratory System
Scott M. Matson, M. Kristen Demoruelle, Mario Castro
Summary: This article discusses the involvement of airway disease in patients with rheumatoid arthritis, highlights clinical research issues, and discusses future research directions and a screening algorithm for patients.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Allergy
Yoshihiko Raita, Carlos A. Camargo, Yury A. Bochkov, Juan C. Celedon, James E. Gern, Jonathan M. Mansbach, Eugene P. Rhee, Robert J. Freishtat, Kohei Hasegawa
Summary: By analyzing clinical, RV species, nasopharyngeal microbiome, cytokine, and metabolome data, we identified 4 distinct endotypes of RV bronchiolitis, with infants in one endotype characterized by RV-C infection, Moraxella-dominant microbiota, and high T2 cytokine response showing a higher risk for developing recurrent wheeze and asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Immunology
Heidi Makrinioti, Andrew Bush, James Gern, Sebastian Lennox Johnston, Nikolaos Papadopoulos, Wojciech Feleszko, Carlos A. Camargo, Kohei Hasegawa, Tuomas Jartti
Summary: Bronchiolitis is a common cause of hospitalization in infants and is associated with a higher risk of childhood asthma development. The mechanisms underlying asthma development following bronchiolitis hospitalization are complex and involve immune responses to respiratory viruses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pediatrics
Mi-Jin Kang, Hee-Sung Ahn, So-Yeon Lee, Jeonghun Yeom, Kyunggon Kim, Soo-Jong Hong
Summary: Proteomic analysis was used to compare biomarker differences between children with asthma and PIBO. Findings revealed that TGF-beta 1 and periostin were unique biomarkers for PIBO and asthma in children, respectively. The mechanism regulated by IKBKB may have therapeutic relevance for PIBO and asthma.
PEDIATRIC PULMONOLOGY
(2022)
Article
Environmental Sciences
Hao-Wei Chung, Hui-Min Hsieh, Chung-Hsiang Lee, Yi-Ching Lin, Yu-Hsiang Tsao, Ming-Chu Feng, Chih-Hsing Hung
Summary: This study found that exposure to air pollutants, especially PM10, PM2.5, SO2, and NO, is significantly associated with an increased risk of developing preschool asthma in infants with a history of acute bronchiolitis.
ENVIRONMENTAL HEALTH
(2023)