Article
Pharmacology & Pharmacy
David L. L. Goldblatt, Gabriella Valverde Ha, Shradha Wali, Vikram V. V. Kulkarni, Michael K. K. Longmire, Ana M. M. Jaramillo, Rosha P. P. Chittuluru, Adrienne Fouts, Margarita Martinez-Moczygemba, Jonathan T. T. Lei, David P. P. Huston, Michael J. J. Tuvim, Burton F. F. Dickey, Scott E. E. Evans
Summary: Allergic asthma is a chronic inflammatory respiratory disease characterized by eosinophilic infiltration and increased mucus production. Research has shown that a combination treatment of Pam2 and ODN can reduce allergic immune responses and lower sensitivity to allergens.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Irene Veneziani, Claudia Alicata, Lorenzo Moretta, Enrico Maggi
Summary: Toll-like receptors (TLRs) are described as homo- or heterodimeric proteins mainly in antigen presenting cells like dendritic cells (DCs), but recent studies have discovered their expression and role also in natural killer (NK) cells. The activation and function of TLRs can be modulated directly or indirectly by TLR agonists. The interplay between DCs and NK cells, mediated by cell-to-cell contact and soluble factors, promotes DC maturation and NK cell activation. Based on this concept, TLR-based immunotherapy targeting the NK-DC axis has been proposed to modulate the tumor microenvironment, improve DC antigen presentation, and enhance NK cell cytotoxicity against tumor cells.
IMMUNOLOGY LETTERS
(2023)
Article
Biology
Malgorzata Anna Cichon, Karin Pfisterer, Judith Leitner, Lena Wagner, Clement Staud, Peter Steinberger, Adelheid Elbe-Buerger
Summary: This study reveals the involvement of RTN1A in regulating the cell structure and immune response of LCs in the skin. Through experimental models in human epidermis and transgenic cells, it was found that inhibition of RTN1A function leads to dendrite retraction and inhibition of migration in LCs. Additionally, stimulation of TLRs results in a significant decrease in RTN1A expression and clustering of LCs. These findings highlight the important role of RTN1A in maintaining LC residency and tissue homeostasis.
Review
Chemistry, Multidisciplinary
Xin Zhi, Peipei Yang, Yunxue Xu, Zhifei Dai, Xiuli Yue, Linxue Qian
Summary: This review discusses the functions of Toll-like receptors (TLRs) in the tumor microenvironment and the pathways that activate immune responses. It also summarizes recent developments in nanotechnology for immunomodulation with TLR agonists. Nanotechnology can improve the efficacy of TLR agonist-based immunotherapy and address its limitations.
Review
Immunology
Hrishi Venkatesh, Sean I. Tracy, Michael A. Farrar
Summary: CD4 T cells initially described as helpers for immune response have now been found to have various subsets with different functions, including cytotoxic capabilities. These cytotoxic CD4 T cells have been observed in viral infections, autoimmunity, cancer, and gut dysbiosis. Regulatory CD4 T cell subsets such as Tregs and Tr1 cells also possess cytotoxic potential and play important roles in maintaining stem cell niches and anti-cancer immune responses. This review provides an overview of cytotoxic CD4 T cell development and discusses their role in intestinal stem cell maintenance and anti-cancer immunity.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Suprabhat Mukherjee, Ritwik Patra, Payam Behzadi, Andrea Masotti, Alessandro Paolini, Meysam Sarshar
Summary: Toll-like receptors (TLRs) play crucial roles in the immune responses by recognizing pathogen-expressed molecules and molecules released from damaged cells. They are considered promising targets for the treatment of inflammation-associated diseases, autoimmune diseases, microbial infections, and cancer. Various TLR-targeting compounds and antibodies have shown efficacy in protecting against different types of cancers. However, improper dosing or administration may lead to detrimental outcomes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Genetics & Heredity
Canan Eroglu Gunes, Fatma Secer Celik, Mucahit Secme, Levent Elmas, Yavuz Dodurga, Ercan Kurar
Summary: In this study, it was observed that oleandrin has an effect on genes and miRNAs associated with TLR pathway in melanoma cells. The pathways of TLRs and hsa-miR-146a-5p and hsa-miR-21-5p may participate in the molecular mechanism of action of oleandrin.
Review
Oncology
Yang Xun, Hua Yang, Bozena Kaminska, Hua You
Summary: Glioma is a fast proliferating and highly invasive brain tumor that is difficult to treat and often recurs. Toll-like receptors play dual roles in the glioma microenvironment, eliciting both anti-tumoral and pro-tumoral responses. Targeting TLRs in glioma treatment may provide new strategies for immunotherapy.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Review
Immunology
Yang Yang, Hongyi Li, Christina Fotopoulou, Paula Cunnea, Xia Zhao
Summary: This article reviews the role of Toll-like receptors (TLRs) in immune reactions and their potential in cancer treatment. TLR-targeted strategies have shown the ability to regulate the tumor microenvironment and have become part of standard care in some cases. However, challenges and further research are still needed for the development of TLR-targeted therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Eileena F. Giurini, Mary Beth Madonna, Andrew Zloza, Kajal H. Gupta
Summary: In this review, we discuss the role of Toll-like receptors (TLRs) in cancer and their potential as a target for immunotherapy. TLRs are transmembrane receptors involved in innate immunity and can recognize molecules derived from microbes and damaged cells. Activation of TLRs can lead to either pro-tumoral effects or anti-tumoral effects, depending on the TLR and tumor type. Understanding the effects of TLR stimulation in cancer is crucial for developing effective immunotherapeutic strategies against cancer.
Article
Immunology
Grzegorz Chodaczek, Philippe P. Pagni, Gustaf Christoffersson, Sowbarnika S. Ratliff, Monika Toporkiewicz, Agnieszka S. Wegrzyn, Matthias von Herrath
Summary: In this study, Treg dynamics were modulated using Toll-like receptor agonists, revealing that Tregs show enhanced migration towards TLR2 signals. This finding may have implications for clinical Treg induction protocols.
JOURNAL OF AUTOIMMUNITY
(2021)
Review
Biochemistry & Molecular Biology
Katarzyna Wicherska-Pawlowska, Tomasz Wrobel, Justyna Rybka
Summary: The innate immune system recognizes pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) through pattern recognition receptors (PRRs), activating immune cells and initiating inflammatory and immune responses. This system also plays a role in cancer immunosurveillance, with potential for natural and synthetic agonists of PRRs to be used as adjuvants in cancer immunotherapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Lingling Huang, Xiaoyan Ge, Yang Liu, Hui Li, Zhiyue Zhang
Summary: Toll-like receptor agonists (TLRa) as vaccine adjuvant candidates have become a hot topic in cancer immunomodulation research. However, current systemic deliveries of TLRa have limitations, and TLRa-loaded nanoparticles are considered a promising strategy to improve therapeutic outcomes.
Article
Chemistry, Multidisciplinary
Yanyun Hao, Hui Li, Xiaoyan Ge, Yang Liu, Xia Li, Yutong Liu, Hongfei Chen, Shiying Zhang, Jing Zou, Lingling Huang, Fabao Zhao, Dongwei Kang, Bruno G. De Geest, Zhiyue Zhang
Summary: In this study, a polymeric nano-immunomodulator was developed to selectively activate the immune system in tumors, enhancing T lymphocyte infiltration without causing immune-related adverse effects. It shows promising potential for safe systemic targeting delivery.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Ziyin N. Huang, Cassandra E. Callmann, Lisa E. Cole, Shuya Wang, Chad A. Mirkin
Summary: This study presents a method for synthesizing SNAs that can activate multiple TLR pathways simultaneously, leading to enhanced immunostimulation in various antigen-presenting cells. The codelivery of TLR agonists using SNAs provides a strategy for potently activating immune cells and increasing the efficiency of their activation.
Article
Allergy
W. Peng, N. Novak
CLINICAL AND EXPERIMENTAL ALLERGY
(2015)
Article
Immunology
Wenming Peng, William Grobe, Gisela Walgenbach-Bruenagel, Sabine Flicker, Chunfeng Yu, Marc Sylvester, Jean-Pierre Allam, Johannes Oldenburg, Natalio Garbi, Rudolf Valenta, Natalija Novak
JOURNAL OF IMMUNOLOGY
(2017)
Article
Immunology
Chun-Feng Yu, Wen-Ming Peng, Martin Schlee, Winfried Barchet, Anna Maria Eis-Hubinger, Waldemar Kolanus, Matthias Geyer, Sebastian Schmitt, Folkert Steinhagen, Johannes Oldenburg, Natalija Novak
JOURNAL OF IMMUNOLOGY
(2018)
Article
Allergy
J. -P. Allam, Y. Duan, J. Winter, G. Stojanovski, F. Fronhoffs, M. Wenghoefer, T. Bieber, W. -M. Peng, N. Novak
Article
Allergy
W. M. Peng, C. F. Yu, W. Kolanus, A. Mazzocca, T. Bieber, S. Kraft, N. Novak
Article
Allergy
N. Novak, W. M. Peng, T. Bieber, C. Akdis
Article
Hematology
Wen-Ming Peng, Laura Maintz, Jean-Pierre Allam, Ulrike Raap, Ines Guetgemann, Jutta Kirfel, Eva Wardelmann, Sven Perner, Wei Zhao, Rolf Fimmers, Klaus Walgenbach, Johannes Oldenburg, Lawrence B. Schwartz, Natalija Novak
Review
Allergy
Wenming Peng, Natalija Novak
CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY
(2014)
Article
Immunology
Wen-Ming Peng, Laura Maintz, Jean-Pierre Allam, Natalija Novak
EUROPEAN JOURNAL OF IMMUNOLOGY
(2013)
Review
Allergy
Natalija Novak, Thomas Bieber, Wen-Ming Peng
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2010)
Article
Allergy
William Grobe, Wenming Peng, Jean-Pierre Allam, Chun-Feng Yu, Natalija Novak
Article
Andrology
Amir Shervin Djourabchi Borojerdi, Thomas Welchowski, Wenming Peng, Alexa Buchen, Natalija Novak, Gerhard Haidl, Yong-Gang Duan, Jean-Pierre Allam
Review
Allergy
Natalijia Novak, Wenming Peng, Mirjam C. Naegeli, Christina Galvan, Isabel Kolm-Djamei, Charlotte Brueggen, Beatriz Cabanillas, Peter Schmid-Grendelmeier, Alba Catala
Summary: COVID-19 caused by SARS-CoV-2 can lead to respiratory symptoms as well as skin lesions and vascular system abnormalities in some patients. Understanding and identifying these skin manifestations and vascular changes are crucial for diagnosis and treatment of COVID-19 patients.
Editorial Material
Dermatology
Wenming Peng, Bartlomiej Kwiek, Chunfeng Yu, Natalio Garbi, Jean-Pierre Allam, Johannes Oldenburg, Natalija Novak
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Letter
Allergy
Wenming Peng, Said Benfadal, Chunfeng Yu, Jorg Wenzel, Johannes Oldenburg, Natalija Novak