Article
Biochemistry & Molecular Biology
Qianqian Xu, Peiyu Zhang, Xiaoyan Han, Huwei Ren, Weiyue Yu, Wei Hao, Bowen Luo, Muhammad Imran Khan, Ni Chen
Summary: This study investigates the pivotal role of Nuclear factor-erythroid 2-related factor 2 (NRF2) in the activation of DNA damage repair in lung cancer cells after x-rays exposure. The study shows that NRF2 knockdown disrupts damaged DNA repair and homologous recombination, and NRF2 activation mediates DNA damage response via the MAPK pathway. These findings suggest that NRF2 plays a critical role in the development of radioresistance, which is of great significance for the development of radiotherapies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Chuwei Lin, Aneirin Alan Lott, Wei Zhu, Craig P. Dufresne, Sixue Chen
Summary: This study used metabolomics and proteomics to investigate the metabolites and protein profiles of the mpk4 mutant and the wild type plants. It revealed the involvement of MPK4 in polyamine synthesis and photosynthesis, providing insights into the metabolic networks potentially regulated by MPK4.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Allergy
Yang Yie Sio, Wei Liang Gan, Wing Shan Ng, Sri Anusha Matta, Yee-How Say, Keng Foo Teh, Yi Ru Wong, Smyrna Moti Rawanan Shah, Kavita Reginald, Fook Tim Chew
Summary: This study aimed to characterize the functional roles of asthma-associated ERBB2 single nucleotide polymorphisms (SNPs) by performing genetic association and functional analysis studies. They found that a variant of ERBB2 was associated with allergic asthma and this variant resulted in lower phosphorylation levels of ERBB2 in the MAPK signaling cascade. These findings highlight the involvement of ERBB2 in asthma development through modulation of the MAPK signaling cascade.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2023)
Article
Peripheral Vascular Disease
Mohammad Shafid, Kumaravelu Jagavelu, Hina Iqbal, Pankaj Yadav, Debabrata Chanda, Neeraj Kumar Verma, Jimut Kanti Ghosh, Matthias Gaestel, Kashif Hanif
Summary: MK2 plays a significant role in pulmonary hypertension, and its inhibition may be a novel target for PH treatment. Inhibition of MK2 alleviated right ventricle pressure and hypertrophy in PH rats, improved cardiac function, reversed pulmonary vascular remodeling, and enhanced pulmonary vascular relaxation.
Article
Food Science & Technology
Yu-Hsiang Yu, Yi-Han Lai, Felix Shih-Hsiang Hsiao, Yeong-Hsiang Cheng
Summary: The study reveals that DON induces inflammation in porcine intestinal epithelial cells (IPEC-J2) through phosphorylation of MAPK signaling pathways. However, co-treatment with DON and lipopolysaccharide (LPS) does not further enhance the expression of inflammation and tight junction-associated genes. Mycotoxin adsorbent agents can attenuate DON-induced inflammatory responses in IPEC-J2 cells by modulating the phosphorylation of p38, ERK, and JNK.
Article
Multidisciplinary Sciences
Margherita De Marzio, Ayse Kilic, Enrico Maiorino, Jennifer Mitchel, Chimwemwe Mwase, Michael J. O'Sullivan, Maureen McGill, Robert Chase, Jeffrey J. Fredberg, Jin-Ah Park, Kimberly Glass, Scott T. Weiss
Summary: By conducting compression experiments on bronchial epithelial cells, the genome-wide analysis of UJT revealed different activation stages of intracellular and extracellular molecular networks induced by compression. Furthermore, the study found common genomic patterns associated with ECM remodeling in nonasthmatic and asthmatic bronchial epithelial cells.
Article
Medicine, Research & Experimental
Enkhtuya Radnaa, Lauren Richardson, Brett Goldman, Jared K. Burks, Tuvshintugs Baljinnyam, Natasha Vora, Hui-Juan Zhang, Elizabeth A. Bonney, Arum Han, Ramkumar Menon
Summary: This study investigated the impact of oxidative stress on p38 MAPK signaling and cell fate, using amnion epithelial cells. The results showed that excessive activation of p38 can have adverse effects on cell behavior and tissue homeostasis.
Article
Biochemistry & Molecular Biology
An-nan Zhang, Nan Li, Zhuo-chang Chen, Ya-li Guo, Cui-jie Tian, Dong-jun Cheng, Xue-yi Tang, Xiao-yu Zhang
Summary: Objective of this study was to investigate the effect of amygdalin, an active ingredient in bitter almonds, on TGF-beta-induced EMT in bronchial epithelial cells and elucidate the underlying mechanisms. The results showed that amygdalin treatment relieved airway wall remodeling and decreased the expressions of EMT markers. Furthermore, amygdalin inhibited TGF-beta-induced EMT through regulating the expression of HPSE.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Allergy
Scott P. Ginebaugh, Matthias Hagner, Anuradha Ray, Serpil C. Erzurum, Suzy A. A. Comhair, Loren C. Denlinger, Nizar N. Jarjour, Mario Castro, Prescott G. Woodruff, Stephanie A. Christenson, Eugene R. Bleecker, Deborah A. Meyers, Annette T. Hastie, Wendy C. Moore, David T. Mauger, Elliot Israel, Bruce D. Levy, Sally E. Wenzel, Matthew J. Camiolo
Summary: This study investigated the transcriptional response of bronchial epithelial cells to inhaled corticosteroids. It was found that a subset of asthma patients with poor hormone treatment response had worse lung function and quality of life. Furthermore, the response to hormone treatment could be predicted using blood samples.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Cell Biology
Chang-Ning Fu, Jia-Wen Song, Zhi-Peng Song, Qian-Wen Wang, Wen-Wu Bai, Tao Guo, Peng Li, Chao Liu, Shuang-Xi Wang, Bo Dong
Summary: Statin-induced skeletal injury is mediated by the excessive expression of miR-1a, leading to decreased MAP3K1 gene expression and subsequent apoptosis of skeletal muscle cells.
Article
Pharmacology & Pharmacy
Omar Hamed, Radhika Joshi, Mahmoud M. Mostafa, Mark A. Giembycz
Summary: This study found that the effects of formoterol on inflammatory gene expression in airway epithelia are mediated by PKA and involve the cooperation of PKA-Cα and PKA-Cβ.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Cell Biology
Shuai Wang, Zongyang Qiu, Yingnan Hou, Xiya Deng, Wei Xu, Tingting Zheng, Peihan Wu, Shaofang Xie, Weixiang Bian, Chong Zhang, Zewei Sun, Kunpeng Liu, Chao Shan, Aifu Lin, Shibo Jiang, Youhua Xie, Qiang Zhou, Lu Lu, Jing Huang, Xu Li
Summary: This study found that AXL may serve as a novel receptor for SARS-CoV-2, playing an important role in promoting viral infection of the human respiratory system. AXL expression level is closely correlated with SARS-CoV-2 S level and could be a potential target for future clinical intervention strategies.
Article
Biochemistry & Molecular Biology
Vikram Jeet Singh, Bharti Sharma, Pooja A. Chawla
Summary: The article focuses on the MAPK signaling pathway and the role of different heterocyclic compounds with nitrogen, sulfur, and oxygen in blocking the MAPK signaling pathway. Heterocyclic compounds are important due to their high potency and selectivity against various targets involved in the MAPK signaling pathway for cancer management. The potential of these compounds in inhibiting MAPK cascade and recent advancements in developing MAPK signaling pathway inhibitors are discussed in detail.
BIOORGANIC CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
T. G. Sahana, Ke Zhang
Summary: Amyotrophic lateral sclerosis is a fatal motor neuron degenerative disease with multiple genetic and non-genetic risk factors. Cellular stress plays a significant role in ALS conditions, with the MAPK pathway being implicated in the disease pathogenesis and potential drug targeting.
Article
Agriculture, Multidisciplinary
Kai-yuan Ji, Ru-jun Wen, Zheng-zhou Wang, Qian-qian Tian, Wei Zhang, Yun-hai Zhang
Summary: In mammals, miRNAs regulate the expression of target genes and play crucial roles in various biological processes. The expression levels of miR-370-5p differ significantly in sheep with different hair colors, but its function is not clear. This study investigated the roles of miR-370-5p in sheep melanocytes and found that its overexpression significantly inhibited cell proliferation (P<0.01), tyrosinase activity (P=0.001), and melanin production (P<0.001).
JOURNAL OF INTEGRATIVE AGRICULTURE
(2023)