期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
卷 122, 期 6, 页码 1074-1081出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2008.09.042
关键词
Atopic dermatitis; skin barrier function; innate immune system; adaptive immune system; filaggrin; T(H)2 cells; T(H)17 cells; immunotherapy; proof-of-concept trial
Recent insights into the relevance of the epidermal barrier function and its interaction with components of the innate and adaptive immune responses in patients with atopic dermatitis (AD) give rise to a number of novel potential treatment options. In particular, the identification of loss-of-function mutations in the barrier protein filaggrin and of a diminished expression of certain antimicrobial peptides in AD skin stimulates new concepts to think beyond the T(H)1/T(H)2 paradigm. This review will focus on these most recent discoveries and will discuss new and corresponding proof-of-concept trials in patients with AD. It will further speculate on novel ways to restore the homeostasis among the 3 major components in AD skin suspected to be clinically relevant. (J Allergy Clin Immunol 2008;122:1074-81.)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据