期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 66, 期 33, 页码 8876-8884出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.8b02886
关键词
ceramide; DHA; EPA; glycerol-phospholipids; fish-skin health; sphingolipidomics
资金
- Norwegian Research Council [NFR 224913]
- China Scholarship Council
Membrane lipids, including sphingolipids and glycerol-phospholipids, are essential in maintaining the skin's barrier function in mammals, but their composition in fish skin and their response to diets have not been evaluated. This study investigated the impacts of reducing dietary eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on membrane lipids in the skin of Atlantic salmon through a 26 week feeding regime supplying different levels (0-2.0% of dry mass) of EPA/DHA. Ceramide, glucosylceramide, sphingomyelin, sphingosine, and sphinganine in salmon skin were analyzed for the first time. Higher concentrations of glucosylceramide and sphingomyelin and higher ratios of glucosylceramide/ceramide and sphingomyelin/ceramide were detected in the deficient group, indicating interruptions in sphingolipidomics. Changes in the glycerol-phospholipid profile in fish skin caused by reducing dietary EPA and DHA were observed. There were no dietary impacts on epidermal thickness and mucus-cell density, but the changes in the phospholipid profile suggest that low dietary EPA and DHA may interrupt the barrier function of fish skin.
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