Article
Biology
Jie Wang, Amir Rattner, Jeremy Nathans
Summary: Bacterial meningitis, particularly in infants and the elderly, can lead to serious illness and death. This study investigates the response of different types of meningeal cells to early postnatal E. coli infection in mice. The findings show that the transcriptomes of major meningeal cell types, including endothelial cells, macrophages, and fibroblasts, undergo distinct changes upon infection. Additionally, the study reveals alterations in the distribution of certain proteins and reduced blood-brain barrier integrity in leptomeningeal capillaries. The response to infection is largely driven by TLR4 signaling, and the EC response to E. coli infection is independent of the interaction between macrophages and ECs.
Article
Biochemistry & Molecular Biology
Rosario Baltazar-Lara, Janeth Mora Zenil, Martha Carranza, Jose Avila-Mendoza, Carlos G. Martinez-Moreno, Carlos Aramburo, Maricela Luna
Summary: This study found that growth hormone (GH) can cross the blood-brain barrier and reach the cerebellum under hypoxic conditions, exerting antiapoptotic, antioxidative, anti-inflammatory, neuroprotective, and neuroregenerative effects. In addition, hypoxia caused changes in the size and structure of cerebellar layers, which could be restored by GH treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Zhenguo Yang, Panpan Lin, Bing Chen, Xiaoqi Zhang, Wei Xiao, Shuilong Wu, Chunnian Huang, Du Feng, Wenqing Zhang, Jingjing Zhang
Summary: In stroke patients, autophagy activation leads to abnormal aggregation of CLDN5 in BMECs, causing BBB breakdown. Meanwhile, autophagy also contributes to the degradation of CAV1 and aggregated CLDN5, alleviating BBB impairment.
Article
Biochemistry & Molecular Biology
Xiaopeng Song, Yaxiong Cui, Yanxiao Wang, Yizhe Zhang, Qi He, Zhenyang Yu, Chengfang Xu, Huimin Ning, Yuying Han, Yunting Cai, Xuan Cheng, Jian Wang, Yan Teng, Xiao Yang, Jun Wang
Summary: In this study, the AAV-BR1-CRISPR system was used to specifically knock out target genes in brain endothelial cells of adult mice, demonstrating its effectiveness in rapidly identifying endothelial genes that regulate blood-brain barrier integrity in vivo.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Neurosciences
Christiane S. Hampe, Hiroshi Mitoma
Summary: Cerebellar dysfunction can be caused by various factors, including autoimmune attacks on the cerebellum. Barrier permeability breakdown allows peripheral immune cells uncontrolled access to the central nervous system, leading to autoimmune responses. This review discusses immune surveillance of the CNS in health and disease, as well as specific examples of autoimmune disorders affecting the cerebellum.
Article
Neurosciences
Shifeng Zhang, Mingping Li, Yuemin Qiu, Junyu Wu, Xue Xu, Qian Ma, Zhihui Zheng, Gengxin Lu, Zhezhi Deng, Haiwei Huang
Summary: Radiation-induced damage to the blood-brain barrier (BBB) is the pathological basis of radiation-induced brain injury (RBI). This study reveals that radiation activates astrocytes and leads to the oversecretion of VEGF through the upregulation of the PI3K-AKT pathway, which inhibits cellular autophagy. Blocking this pathway can alleviate both autophagy inhibition and VEGF oversecretion, thereby mitigating BBB damage.
Article
Chemistry, Multidisciplinary
Pengying Wu, Mingting Zhu, Yan Li, Zhen Ya, Yabo Yang, Yuchen Yuan, Wei Dong, Shifang Guo, Shukuan Lu, Lei Zhang, Yujin Zong, Mingxi Wan
Summary: Targeted delivery of drug-loaded nanoparticles to brain tumors faces challenges due to the blood-brain barrier. A novel all-in-one nanoparticles (AMPTL) has been developed, which inhibits autophagy in glioma cells and enhances the therapeutic effects of chemotherapeutic drugs. The combination of BBB opening, autophagy inhibition, and chemotherapy shows promising results in inhibiting tumor growth and improving survival rates in mice with glioma.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Physiology
Ping Yu, Yanyu Li, Gaoliang Zhong, Wen Li, Bing Chen, Jingjing Zhang
Summary: This study found that loss of membranous Claudin-5 led to hypoxia-induced autophagy in cerebrovascular endothelial cells, partially attenuating endothelial cell apoptosis. Mechanism studies showed that membranous Claudin-5 affected the stimulation of HIF-1a and iNOS under hypoxic conditions, leading to suppressed endothelial autophagy. Loss of Claudin-5 also influenced the generation of ROS and expression of Bnip3, contributing to the inhibition of endothelial autophagy under hypoxia.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Marine & Freshwater Biology
Yu Wang, Hongjing Zhao, Yachen Liu, Menghao Guo, Ye Tian, Puyi Huang, Mingwei Xing
Summary: This study investigated the brain damage caused by arsenite exposure in common carp and the protective effects of zinc ion supplementation. Results showed that zinc ion coadministration effectively alleviated oxidative damage, tight junction injuries, nerve conduction depletion, and apoptotic and autophagic cell death induced by arsenite in the brain.
AQUATIC TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ekaterina Rudnitskaya, Tatiana Kozlova, Alena Burnyasheva, Daniil Peunov, Michail Tyumentsev, Natalia Stefanova, Nataliya Kolosova
Summary: This study investigated the possible influence of early-life vascular dysfunction on Alzheimer's disease (AD) development using OXYS rats as a model. The expression of blood-brain barrier (BBB)-associated genes was found to be altered in the hippocampus and frontal cortex of OXYS rats during the first and second weeks of life. Delayed vascularization and pericyte coating of blood vessels were also observed in OXYS rats. These features may have long-term consequences and contribute to the neurovascular dysfunction observed in OXYS rats late in life, thereby promoting the early development of AD signs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yi-Han Liao, Ya-Hsuan Chan, Hao Chen, Anna E. Yu, Li-Han Sun, Wei-Jen Yao, Lung Yu
Summary: This study found that adult mice with behavioral control and those without behavioral control under the same stress conditions exhibited differences in blood-brain barrier integrity, ventral hippocampal interleukin-6 and autophagic flux levels, and depression-like behavior. Increased autophagic flux plays a permissive role in stress-primed depression-like behavior.
BIOMEDICAL JOURNAL
(2022)
Article
Geriatrics & Gerontology
Liangliang Huang, Yan Chen, Rui Liu, Binbin Li, Xuan Fei, Xiang Li, Ge Liu, Yunman Li, Baohui Xu, Weirong Fang
Summary: Increased expression of P-gp after ischemic injury leads to dysfunction and hyperpermeability of the BBB by suppressing Akt/mTOR-induced endothelial autophagy.
Article
Neurosciences
Wei Li, Jinlong Zou, Junkui Shang, Chenhao Gao, Ruihua Sun, Ruijie Liu, Huixia Cao, Yanliang Wang, Jiewen Zhang
Summary: The blood-brain barrier (BBB) is a complex interface composed of endothelial cells that plays a crucial role in maintaining the proper functioning of the neurons. The mechanism of BBB formation and maintenance remains largely unknown, but recent studies have highlighted the importance of vesicle transcytosis in maintaining the integrity of the BBB.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Joshua Adekunle Babalola, Magdalena Lang, Meekha George, Anika Stracke, Carmen Tam-Amersdorfer, Izaskun Itxaso, Domjan Lucija, Jelena Tadic, Irene Schilcher, Tina Loeffler, Stefanie Flunkert, Manuela Prokesch, Gerd Leitinger, Achim Lass, Birgit Hutter-Paier, Ute Panzenboeck, Gerald Hoefler
Summary: In this study, astaxanthin was found to enhance the clearance of misfolded proteins in the brains of Alzheimer's disease patients, reduce inflammation, and alter the expression levels of transport proteins.
Article
Biochemistry & Molecular Biology
Barrett D. Allen, Charles L. Limoli
Summary: Exposure to radiation during the treatment of CNS tumors leads to detrimental damage of the blood brain barrier (BBB) in normal tissue, while the irregular vasculature of the blood tumor barrier (BTB) causes tumor tissue to become resistant to radiation.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Mohammad Mehdi Ommati, Ali Mobasheri, Yanqin Ma, Dongmei Xu, Zhongwei Tang, Ram Kumar Manthari, Narges Abdoli, Negar Azarpira, Yu Lu, Issa Sadeghian, Abolghasem Mousavifaraz, Ali Nadgaran, Ahmad Nikoozadeh, Sahra Mazloomi, Pooria Sayar Mehrabani, Mohammad Rezaei, Hu Xin, Yang Mingyu, Hossein Niknahad, Reza Heidari
Summary: This study evaluated the role of taurine in cholestasis-related lung injury. The results showed that taurine could attenuate inflammation, alleviate oxidative stress, and improve lung histopathological changes.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Article
Food Science & Technology
Yingjun Hu, Zipeng Yan, Yang He, Yan Li, Meng Li, Yuanyuan Li, DingLi Zhang, Yangfei Zhao, Mohammad Mehdi Ommati, Jundong Wang, Meijun Huo, Jinming Wang
Summary: Excessive fluoride exposure can lead to oxidative stress in the kidney. Selenium, as an antioxidant, can potentially protect the kidney from fluoride-induced injury in rats. The supplementation of 1-2 mg/L selenium effectively ameliorated fluoride-induced renal injury through oxidative stress and apoptosis-related pathways, possibly through the activation of the Nrf2/HO-1/NQO1 signaling pathway.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mohammad Mehdi Ommati, Samira Sabouri, Hossein Niknahad, Abdollah Arjmand, Sepideh Alidaee, Sahra Mazloomi, Asma Najibi, Heresh Rezaei, Alireza Ghiasvand, Parinaz Ahmadi, Ahmad Nikoozadeh, Forouzan Khodaei, Narges Abdoli, Negar Azarpira, Reza Heidari
Summary: Cholestasis is a clinical complication that affects the liver, but other organs, including the lungs, can also be impacted. Cholestasis-induced lung injury can lead to severe complications such as respiratory distress, pulmonary infections, and tissue fibrosis. This study investigated the role of carnosine in protecting against cholestasis-induced lung injury. It was found that carnosine significantly reduced oxidative stress, inflammation, tissue fibrosis, and histopathological changes in the lungs of cholestatic animals.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Obstetrics & Gynecology
Mohammad Mehdi Ommati, Samira Sabouri, Socorro Retana-Marquez, Hassan Nategh Ahmadi, Abdollah Arjmand, Sepideh Alidaee, Sahra Mazloomi, Alireza Akhlagh, Narges Abdoli, Hossein Niknahad, Akram Jamshidzadeh, Yanqin Ma, Negar Azarpira, Yaser Asefi, Reza Heidari
Summary: Lead (Pb) exposure can cause toxic effects on the male reproductive system, including oxidative stress and mitochondrial impairment. Taurine (TAU) has positive effects on oxidative stress and mitochondrial function. This study evaluated the effects of TAU on Pb-induced reproductive toxicity in mice. TAU significantly improved oxidative stress biomarkers, sperm mitochondrial function, and the expression of genes involved in steroidogenesis, suggesting its effectiveness as a protective agent against Pb-induced reproductive toxicity.
REPRODUCTIVE SCIENCES
(2023)
Correction
Pharmacology & Pharmacy
Mohammad Mehdi Ommati, Samira Sabouri, Hossein Niknahad, Abdollah Arjmand, Sepideh Alidaee, Sahra Mazloomi, Asma Najibi, Heresh Rezaei, Alireza Ghiasvand, Parinaz Ahmadi, Ahmad Nikoozadeh, Forouzan Khodaei, Narges Abdoli, Negar Azarpira, Reza Heidari
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Review
Immunology
Noushin Mashatan, Reza Heidari, Mana Altafi, Amir Amini, Mohammad Mehdi Ommati, Masoud Hashemzaei
Summary: Bacterial vaginosis is the main cause of abnormal vaginal discharges and dysbiosis in women during their reproductive years, with a prevalence of 30% to 50%. Probiotics, defined as viable microorganisms that positively affect host health, are used as a treatment option. Lactobacillus species, dominant in a healthy vagina, can lower the pH and produce hydrogen peroxide, preventing the growth of other microorganisms. Probiotics and prebiotics show potential for optimizing, maintaining, and restoring vaginal microflora.
PATHOGENS AND DISEASE
(2023)
Article
Environmental Sciences
Ye Jin, Bian-Hua Zhou, Jing Zhao, Mohammad Mehdi Ommati, Shuai Wang, Hong-Wei Wang
Summary: This study established fluoride-exposed ovariectomized and non-ovariectomized rat models and found that ovariectomy played a vital role in causing osteosclerosis and osteoporosis in skeletal fluorosis. The study also provided insights into the pathogenesis of skeletal fluorosis.
ENVIRONMENTAL POLLUTION
(2023)
Article
Food Science & Technology
Huifeng Luo, Rongxiu Liu, Yilin Lang, Jinhui Zhao, Cuicui Zhuang, Jundong Wang, Chen Liang, Jianhai Zhang
Summary: This study aims to explore the role of melatonin in mitigating fluoride-induced male reproductive toxicity through the IL-17A pathway, and identify potential targets. Wild type and IL-17A knockout mice were used, and the results showed that melatonin supplementation alleviated fluoride-induced impairment of spermatogenesis and maturation process, protecting the morphology of testis and epididymis. Tesk1 and Pten were identified as candidate targets from 29 regulation genes.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mohammad Mehdi Ommati, Ali Mobasheri, Hossein Niknahad, Mohammad Rezaei, Sepideh Alidaee, Abdollah Arjmand, Sahra Mazloomi, Narges Abdoli, Issa Sadeghian, Samira Sabouri, Mohsen Saeed, Khadijeh Mousavi, Asma Najibi, Reza Heidari
Summary: Ammonium ion (NH4+) is suspected to be the main molecule responsible for neurological complications in hepatic encephalopathy. This study investigated the effects of the NMDA receptor antagonist ketamine on hyperammonemic mice and found that it significantly improved locomotor activity, biomarkers of oxidative stress, and decreased proinflammatory cytokines. These findings suggest that ketamine may have neuroprotective mechanisms against NH4+-induced neurotoxicity.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Environmental Sciences
Panhong Wu, Kaidong Yang, Zilong Sun, Yangfei Zhao, Ram Kumar Manthari, Jundong Wang, Jinling Cao
Summary: This study investigated the mechanism of fluoride-induced autoimmune reaction and the role of interleukin-17A (IL-17A) in this process, as well as the reversibility of fluoride-induced testicular toxicity. The results showed that fluoride exposure caused decreased sperm quality, damaged testis histopathology, increased expression levels of inflammatory cytokines, appearance of autoantibodies in sera and their deposition in testis, altered expression of immune-related genes, and activation of IL-17A signaling cascade. IL-17A knockout or self-recovery alleviated these changes and restored most of the fluoride-induced differences.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Integrative & Complementary Medicine
Ahmad Gholami, Nima Montazeri-Najafabady, Yousef Ashoori, Kimia Kazemi, Reza Heidari, Navid Omidifar, Iman Karimzadeh, Mohammad Mehdi Ommati, Seyedeh Narjes Abootalebi, Nasim Golkar
Summary: This study aimed to evaluate the efficacy of Limosilactobacillus fermentum (L. fermentum) and its postbiotic in an animal model of cisplatin-induced chronic kidney disease (CKD). The results showed that the administration of L. fermentum probiotic and its postbiotic significantly improved renal function by reducing blood urea nitrogen (BUN) and creatinine levels, decreasing oxidative stress and lipid peroxidation, and increasing the antioxidant capacity in the kidneys. Interestingly, the postbiotic showed greater effectiveness than the probiotic in some assays. Probiotics and postbiotics are considered as promising alternative supplements for CKD.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Pharmacology & Pharmacy
Mohammad mehdi Ommati, Hossein Niknahad, Asma Najibi, Abdollah Arjmand, Sepideh Alidaee, Sahra Mazloomi, Parinaz Ahmadi, Alireza Ghiasvand, Maral Javadi, Jamal Yazdani, Samira Sabouri, Heresh Rezaei, Negar Azarpira, Reza Heidari
Summary: Cholestasis-induced lung injury is a severe complication that could lead to tissue fibrosis and respiratory distress. This study found that the level of inflammatory cells, pro-inflammatory cytokines, and IgG in the bronchoalveolar lavage fluid (BALF) of bile duct-ligated mice reached their maximum level on day 28 after surgery. AGM significantly ameliorated cholestasis-induced lung injury.
Article
Environmental Sciences
Xin Hu, Xiaohong Yuan, Mingyu Yang, Mingsheng Han, Mohammad Mehdi Ommati, Yanqin Ma
Summary: Arsenic contamination in drinking water is a global public health problem and may act as an environmental risk factor for anxiety disorders. This study aimed to evaluate anxiety-like behaviors in mice exposed to arsenic trioxide and explore the link between the GABAergic system and behavioral manifestations.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Hossein Niknahad, Pooria Sayar Mehrabani, Abdollah Arjmand, Sepideh Alidaee, Sahra Mazloomi, Parinaz Ahmadi, Narges Abdoli, Mohsen Saeed, Mohammad Rezaei, Mohammad Mehdi Ommati, Reza Heidari
Summary: The aim of this study was to evaluate the effect of taurine on erythrocytes in cirrhotic rats. Results showed that taurine significantly improved erythrocyte parameters and mitigated erythrocyte damage and anemia induced by cirrhosis.
CLINICAL AND EXPERIMENTAL HEPATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mohammad Mehdi Ommati, Narges Abdoli, Meisam Firoozi, Alireza Akhlagh, Sahra Mazloomi, Khadijeh Mousavi, Hossein Niknahad, Reza Heidari
Summary: Cholestasis-induced lung injury is influenced by oxidative stress and inflammatory responses, while sildenafil's effects on phosphodiesterase inhibition and inflammation play a protective role in the lungs of cholestatic animals.
PHARMACEUTICAL SCIENCES
(2023)