期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 66, 期 39, 页码 10205-10214出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.8b03731
关键词
eriodictyol; lipopolysaccharide; neuroinflammation; MAPKs; NF-kappa B
资金
- National Key Research and Development Program of China [2016YFD0 400601]
- Natural Science Basic Research Plan in Shaanxi Province of China [2015JQ2039]
- China Postdoctoral Science Foundation [2015M572603]
- National Natural Science Foundation of China [21403169]
- Fundamental Research Funds for the Central Universities [2452016083]
Eriodictyol, a natural flavonoid mainly distributed in citrus fruits and peanut, has been well-documented with possession of excellent anti-inflammatory, antioxidant, and anticancer bioactivities. This work focus on the protective effects of eriodictyol on LPS-induced neuroinflammation, amyloidogenesis, cognitive impairment, and the potential mechanisms involved. Behavioral tests and histological examinations showed that eriodictyol significantly prevented the memory and neuronal damage triggered by LPS. Consistently, eriodictyol (100 mg/kg) reduced the formation of A beta(1-42) by 28.37 +/- 16.71 pg/mL compared to the LPS group. In addition, high dose eriodictyol (100 mg/kg) also equilibrated the cholinergic system via suppressing AChE activity (0.1996 +/- 0.0831 U/mgprot) and elevating ChAT activity (41.81 +/- 24.72 U/g) as well as ACh level (5.093 +/- 3.531 mu g/mgprot) compared to the LPS group. Western blot results indicated that compared to the LPS group, eriodictyol suppressed LPS-induced filial overactivation (84.29% +/- 27.21%) and regulated inflammatory mediators and cytokines by inhibiting the NE-kappa B and MAPK pathways. These results indicated that eriodictyol alleviated amyloidogenesis and memory impairment triggered by LPS via inhibiting TLR4, MAPKs, and PI3K/Akt, and activating Sirt1 pathways and thus blocking downstream translocation of NF-kappa B, which offers a potential nutritional preventive strategy for neuroinflammation diseases such as Alzheimer's disease (AD).
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