期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 62, 期 13, 页码 2872-2880出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf405630h
关键词
cytokines; peritoneal macrophages; ex vivo models; quercetin; quercetin-3-glucuronide; lipopolysaccharide
资金
- National Science Council, Taipei, Taiwan, ROC [NSC99-2628-B-005-004-MY3]
This study investigated the prophylactic or therapeutic effects of quercetin (Q) and its metabolite quercetin-3-glucuronide (Q3G) on lipopolysaccharide (LPS)-induced inflammation in mouse peritoneal macrophages ex vivo. Changes in pro- and antiinflammatory cytokine secretion profiles were determined. The results showed that Q or Q3G in vitro treatments lower than 50 mu M did not exhibit cytotoxicity on macrophages. At noncytotoxic doses, Q and Q3G, particularly Q, administration in a prophylactic ex vivo model increased pro-/antiinflammatory cytokine secretion ratios by macrophages in the absence or presence of LPS. Quercetin, but not Q3G, administration in a therapeutic ex vivo model decreased pro-/antiinflammatory cytokine secretion ratios in the absence or presence of LPS. Our results indicated that Q and Q3G administrations in a prophylactic manner might act as an immunostimulatory agent, but Q presented better ability than Q3G. Quercetin might have a therapeutic, but not prophylactic, effect on spontaneous or LPS-induced inflammation in vivo.
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