期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 62, 期 18, 页码 3852-3866出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf4050759
关键词
colon cancer; fruits and vegetables; berries; DNA damage; biomarker; (poly)phenols
资金
- National Processed Raspberry Council
- Scottish Government Rural and Environment Science and Analytical Services Division
- Climafruit (Interreg IVB)
- EUBerry (EU FP7 KBBE) [4265942]
- BACHBERRY (EU FP7 KBBE) [613793]
The etiology of colorectal cancer (CRC), a common cause of cancer-related mortality globally, has strong associations with diet. There is considerable epidemiological evidence that fruits and vegetables are associated with reduced risk of CRC. This paper reviews the extensive evidence, both from in vitro studies and animal models, that components of berry fruits can modulate biomarkers of DNA damage and that these effects may be potentially chemoprotective, given the likely role that oxidative damage plays in mutation rate and cancer risk. Human intervention trials with berries are generally consistent in indicating a capacity to significantly decrease oxidative damage to DNA, but represent limited evidence for anticarcinogenicity, relying as they do on surrogate risk markers. To understand the effects of berry consumption on colorectal cancer risk, future studies will need to be well controlled, with defined berry extracts, using suitable and clinically relevant end points and considering the importance of the gut microbiota.
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