期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 62, 期 36, 页码 9035-9042出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf500882t
关键词
spermine; metabolism; metabolomics; weaning stress; plasma
资金
- National Natural Science Foundation of China [31301986]
- Research Foundation of Education Bureau of Sichuan Province [11ZB061]
- Ministry of Education Chunhui Project of China [Z2010092]
- Specific Research Supporting Program for Discipline Construction in Sichuan Agricultural University
The purpose of this study is to examine the effects of spermine supplementation on weaned rat metabolism. A metabolomic strategy employing high-resolution H-1 NMR spectroscopy and multivariate data analysis was used to investigate rat biological responses to spermine ingestion. Rats received intragastric administration of either 0.2 or 0.4 mu mol/g body weight of spermine or saline for 3 days. Plasma samples taken 48 h after the last spermine ingestion were analyzed. Spermine supplementation significantly increased the plasma levels of 1-methylhistidine, 3-hydroxybutyrate, alanine, glutamate, glycerolphosphocholine, phosphorylcholine, myo-inositol, phenylalanine, lysine, glutamine, trimethylanine, tyrosine, valine, formate, glucose, and lipids. These results suggest that spermine ingestion can alter common systemic metabolic processes, including cell membrane metabolism, lipid metabolism, glucose-alanine cycle metabolism, amino acid metabolism, and gut microbiota metabolism. This study also shows the important role of spermine administration in modulating the metabolism of weaned rats.
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