Article
Plant Sciences
Qi-Rui Hu, Qing-Xin Huang, Huan Hong, Yao Pan, Ting Luo, Jing Li, Ze-Yuan Deng, Fang Chen
Summary: This study investigated the inhibitory effects of Rh2 and Rh2-O on invasion and metastasis of hepatocellular carcinoma, and revealed that these effects were mediated by the c-Jun/COX2/PGE2 pathway. Rh2-O showed stronger effects compared to Rh2.
Article
Biology
Xuexiang Chen, Meigui Huang, Dongmei Liu, Yongze Li, Qiu Luo, Katherine Pham, Minghong Wang, Jing Zhang, Runbin Zhang, Zhixi Peng, Xian Wu
Summary: The study used mouse experiment and Caco-2 cell model to investigate the absorption and transport characteristics of carnosic acid. The findings suggest that the absorption and transport of carnosic acid involve both passive and active transportation. This research provides a valuable insight into the absorption, transport, and metabolic mechanisms of carnosic acid.
Article
Immunology
Han-cheng Wu, Qi-rui Hu, Ting Luo, Wen-cheng Wei, Hui-juan Wu, Jing Li, Liu-feng Zheng, Qun-ying Xu, Ze-yuan Deng, Fang Chen
Summary: The study showed that Rh2-O enhanced the activity of splenic lymphocytes in H22 tumor-bearing mice, with the partial involvement of Tlr4, thus exerting immunomodulatory effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Cheng-Qi Jia, Shu-Yan Wang, Ye Yuan, Yu-Qing Wu, Yan Cai, Jun-Wei Liu, Hai-Qiu Ma
Summary: Vitamin B12 is a vital micronutrient that cannot be synthesized by the human body and needs to be obtained from the diet. Its absorption in the gastrointestinal tract is mediated by intrinsic factor. The present study aims to increase VB12 intestinal absorption using cost-effective excipients and formulations.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Rasmus Blaaholm Nielsen, Rene Holm, Ils Pijpers, Jan Snoeys, Ulla Gro Nielsen, Carsten Uhd Nielsen
Summary: This study investigated the impact of zosuquidar on the permeability and bioavailability of etoposide, revealing a significant discrepancy in effectiveness between in vitro and in vivo settings. The findings offer crucial insights for future formulation development to enhance the absorption of poorly permeable P-glycoprotein substrate drugs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS-X
(2021)
Review
Biochemistry & Molecular Biology
Jiabing An, Ivan Steve Nguepi Tsopmejio, Zi Wang, Wei Li
Summary: This review summarizes the relevant literature on peptides from the past decade, including extraction, modification, and synthesis. The unique beneficial effects of peptides on the skin were extensively explored, providing ideas for peptide development and innovation. Additionally, the knowledge foundation for the clinical application of peptides was laid.
Article
Biochemistry & Molecular Biology
Zijing Shang, Meiling Fan, Jingtian Zhang, Zi Wang, Shuang Jiang, Wei Li
Summary: This study evaluated the ameliorative effect and molecular mechanism of red ginseng extract on D-galactose-induced premature ovarian failure using network pharmacology analysis. Ginsenosides, sugar, and amino acid derivatives in red ginseng were identified as important active ingredients. The study constructed a protein-protein interaction network and identified core targets related to premature ovarian failure. In vivo experiments confirmed that red ginseng extract can increase estradiol levels and reduce follicle-stimulating hormone levels by reducing oxidative stress, apoptosis, and senescence signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Plant Sciences
Si-min Qi, Jing-tian Zhang, Hong-yan Zhu, Zi Wang, Wei Li
Summary: Glaucoma is the second most common blindness in the world, affecting the life quality of patients. Traditional Chinese Medicines (TCM) have become an important content in ophthalmology, characterized by more targets and lower toxicity. This review presents an overview of glaucoma pathogenesis and therapeutic effects of TCM, as well as the application of acupuncture.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Jing-Tian Zhang, Li -Ya Xie, Qiong Shen, Wei Liu, Ming -Han Li, Rui-Yi Hu, Jun-Nan Hu, Zi Wang, Chen Chen, Wei Li
Summary: This study investigated the regulatory effects of Platycodin D (PD) on neurodegeneration caused by reactive oxidative stress (ROS). In vivo and in vitro experiments demonstrated that PD could improve memory, reduce cell apoptosis and ROS production, and inhibit inflammation. PD enhanced the antioxidant ability by activating AMPK. This study suggests that PD may be a potential pharmaceutical agent to treat ROS-induced neurodegeneration.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Yun-yi Hou, Si-min Qi, Jing Leng, Qiong Shen, Shan Tang, Jing-tian Zhang, Jun-nan Hu, Shuang Jiang, Wei Li
Summary: This study investigated the protective effect of lobetyolin (LBT) against cisplatin-induced cytotoxicity in HEK293 cells. Results showed that LBT improved the viability of HEK293 cells, decreased MDA levels, decreased GSH content, and suppressed ROS levels caused by cisplatin. Molecular docking analysis revealed a strong binding affinity between LBT and the NF-κB protein. LBT also inhibited inflammation and apoptosis in HEK293 cells.
JOURNAL OF NATURAL MEDICINES
(2023)
Review
Biochemistry & Molecular Biology
Shuai Zhang, Chuanbo Ding, Xinglong Liu, Yingchun Zhao, Qiteng Ding, Shuwen Sun, Jinping Zhang, Jiali Yang, Wencong Liu, Wei Li
Summary: This review summarizes the extraction, isolation and purification, structural characteristics, and biological activities of ginseng, American ginseng, and Panax notoginseng polysaccharides. These polysaccharides have various biological activities including antioxidants, antitumor, immunomodulatory, antidiabetic, intestinal protection, and skin repair.
Article
Food Science & Technology
Jian-Qiang Wang, Xiang-Xiang Liu, Jun-Jie Zhang, Chao Jiang, Si-Wen Zheng, Zi Wang, Da-Yong Li, Wei Li, Dong-fang Shi
Summary: This study investigated the potential protective mechanism of arabinogalactan (AG) on acute kidney injury (AKI) induced by cisplatin in mice. The results showed that pretreatment with AG could reduce kidney injury and oxidative stress induced by cisplatin, as well as restore the expression of anti-apoptotic proteins and decrease the expression of pro-apoptotic proteins in renal tissues.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Agriculture, Multidisciplinary
Nan Li, Ruiyan Wang, Wenwen Li, Qian Du, Zeyuan Deng, Yawei Fan, Liufeng Zheng
Summary: This study revealed the anti-inflammatory properties of vitexin in a mouse model of colitis and its ability to enhance the expression of barrier-associated proteins. Through thermal proteome profiling and molecular docking, OLA1 was identified as a potential protein target for vitexin. Further experiments demonstrated that OLA1 can increase Nrf2 protein expression, thereby mediating the anti-inflammatory effects of vitexin.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Nan Li, Ruiyan Wang, Zeyuan Deng, Jianqun Zhou, Wenwen Li, Qian Du, Liufeng Zheng
Summary: Sucrose is shown to be a stable metal-ion chelating agent that can enhance the absorption of metal ions. This study explores the structure of the zinc-sucrose complex and its ability to promote zinc absorption in cells and mice. The complex increases zinc uptake and transport, upregulates genes and proteins involved in zinc absorption, and interacts with zinc transport proteins. These findings offer valuable insights into the mechanisms of zinc absorption and suggest potential applications in treating zinc deficiency.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Agriculture, Multidisciplinary
Liuying Zhu, Hongyan Li, Ting Luo, Zeyuan Deng, Jing Li, Liufeng Zheng, Bing Zhang
Summary: Human milk oligosaccharides (HMOs), a unique group of oligosaccharides found in human milk, have gained great interest due to their positive effects on infant health. However, the clinical application of HMOs is challenging due to their specificity to human milk and the associated difficulties and high costs. This article compares oligosaccharides in human and other mammalian milk, summarizes the synthetic strategies for accessing HMOs, reviews the potential use and molecular mechanisms of HMOs in different diseases, and discusses the current challenges and prospects of HMOs in basic research and application.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Yangzheng He, Yong Sun, Jing Li, Xiaoyu Peng, Wei Li, Yu Gao, Jiaqi Wang, Xinggang Ni, Lina Pan, Zeyuan Deng
Summary: Although formula-fed infants are more prone to obesity than breastfed ones, this study found that administering human milk fat substitutes (HMFS) did not affect body weight in rats, but significantly decreased body fat content. The study also revealed the potential mechanism by which HMFS affects body fat buildup and promotes lipid metabolism in the liver. These findings underscore the nutritional benefits of HMFS for infants.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Plant Sciences
Qiong Shen, Si-min Qi, Jing-tian Zhang, Min-han Li, Ying-ping Wang, Zi Wang, Wei Li
Summary: This study aimed to investigate the improvement effects and regulatory mechanisms of Platycodin D (PD) on kidney injury in diabetic nephropathy. The results showed that PD can lower blood glucose and insulin resistance levels, improve lipid levels and renal function, and inhibit the development of diabetic nephropathy by regulating NF-cB and apoptotic signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Teng Wei, Dengfeng Tan, Shengyue Zhong, Hong Zhang, Zeyuan Deng, Jing Li
Summary: The most abundant triacylglycerol (TAG) in Chinese human milk is 1-oleate-2-palmitate-3-linoleate (OPL), which is different from other countries where 1,3-oleate-2-palmitate (OPO) is the most abundant TAG. This study investigated the effects of an OPL-supplemented diet on mice's nutritional outcomes and found that high OPL (HOPL) diet improved lipid metabolism and gut bacteria, reducing the level of pro-inflammatory cytokines. Furthermore, the study revealed a relationship between gut bacteria, lipidome profile, and nutritional outcomes.
Article
Agriculture, Multidisciplinary
Teng Wei, Dengfeng Tan, Shengyue Zhong, Hong Zhang, Zeyuan Deng, Jing Li
Summary: This study investigated the differences in absorption and metabolism between OPO and OPL and found that OPL was associated with higher blood lipid and cholesterol concentrations. However, mice fed with OPO and OPL showed lower body weight and lipid levels in the liver.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Yangzheng He, Yong Sun, Jing Li, Xiaoyu Peng, Wei Li, Yu Gao, Jiaqi Wang, Xinggang Ni, Lina Pan, Zeyuan Deng
Summary: This study aimed to investigate the impact of human milk fat substitutes (HMFS) on lipid metabolism in first-weaned Sprague Dawley rats. The findings showed that HMFS administration did not affect body weight but significantly decreased body fat content. Lipidome analysis revealed changes in glycerophospholipid levels in the liver of HMFS-fed rats. Furthermore, HMFS administration promoted lipid metabolism in the rat liver at both the gene and protein levels.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)