期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 60, 期 36, 页码 8924-8929出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf301147n
关键词
alpha-amylase; alpha-glucosidase; enzyme inhibition; tea; grape seed extract; catechins; diabetes
资金
- USANA Health Sciences, Inc. (Salt Lake City, UT)
This study evaluated the inhibitory effects of plant-based extracts (grape seed, green tea, and white tea) and their constituent flavan-3-ol monomers (catechins) on alpha-amylase and alpha-glucosidase activity, two key glucosidases required for starch digestion in humans. To evaluate the relative potency of extracts and catechins, their concentrations required for SO and 90% inhibition of enzyme activity were determined and compared to the widely used pharmacological glucosidase inhibitor, acarbose. Maximum enzyme inhibition was used to assess relative inhibitory efficacy. Results showed that grape seed extract strongly inhibited both alpha-amylase and alpha-glucosidase activity, with equal and much higher potency, respectively, than acarbose. Whereas tea extracts and catechin 3-gallates were less effective inhibitors of alpha-amylase, they were potent inhibitors of alpha-glucosidase. Nongallated catechins were ineffective. The data show that plant extracts containing catechin 3-gallates, in particular epigallocatechin gallate, are potent inhibitors of alpha-glucosidase activity and suggest that procyanidins in grape seed extract strongly inhibit alpha-amylase activity.
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