Article
Food Science & Technology
Svetlana Lyashenko, Dmitri Fabrikov, Maria Jose Gonzalez Fernandez, Francisco Gomez- Mercado, Rosalia Lopez Ruiz, Aleksandr Fedorov, Gerard de Belair, Miguel Urrestarazu, Ignacio Rodriguez-Garcia, Miriam Alvarez-Corral, Jose Luis Guil Gurrero
Summary: This study investigated the phenolic compound composition and antiproliferative activities of Borago seeds, showing different phenolic components among various Borago species, with the highest total phenolics and rosmarinic acid content found in B. officinalis from warmer southern regions. The inhibitory effects of Borago extracts on cancer cells were dose- and time-dependent, but some compounds lacking antiproliferative activity were also present in the extracts.
Article
Biochemistry & Molecular Biology
Ana C. Goncalves, Ana R. Costa, Jose D. Flores-Felix, Amilcar Falcao, Gilberto Alves, Luis R. Silva
Summary: This study assessed the anti-inflammatory potential of phenolic-targeted fractions of the Saco cherry for the first time. The cherry fractions were found to decrease nitric oxide levels, exhibit cytotoxicity against gastric adenocarcinoma cells, and effectively protect cancer cells against oxidative injury, with the total cherry extract being the most effective.
Review
Biochemistry & Molecular Biology
Giusy Rita Caponio, Tamara Lippolis, Valeria Tutino, Isabella Gigante, Valentina De Nunzio, Rosa Anna Milella, Marica Gasparro, Maria Notarnicola
Summary: Nutraceuticals have gained popularity due to their physiological and potential health effects. This review focuses on the major constituents of the Mediterranean diet and their effects on human health, specifically in the gastrointestinal tract. It provides a deeper understanding of nutraceuticals' therapeutic purpose and suggests personalized dietary components for adjuvant therapies.
Article
Food Science & Technology
Ning Cui, Cheng Yang, Xuemei Chen, Jian Zhang, Lianfu Zhang
Summary: The study aimed to compare the anti-oxidative stress and anti-inflammatory effects of all-E-lutein and its 9Z and 13Z isomers using the Caco-2 cell model. All three lutein isoforms were able to significantly reduce the secretion of IL-8 and TNF-alpha when exposed to H2O2, with 9Z-lutein and 13Z-lutein showing higher protection at lower concentrations. Furthermore, the lutein isomers up-regulated antioxidant enzymes and glutathione levels. In the anti-inflammatory assay, 9Z-lutein and all-E-lutein exhibited greater effectiveness in reducing IL-8 secretion compared to 13Z-lutein. This study provides evidence for the potential health benefits of Z-luteins.
Article
Food Science & Technology
Jun Wu, Keke Ma, Haoran Li, Yifan Zhang, Xiaona Wang, Naeem Abbas, Caiping Yin, Yinglao Zhang
Summary: This study investigated the effects of ten phenolic acids on the stability of lutein and found that rosmarinic acid, gallic acid, caffeic acid, and tannic acid significantly improved lutein stability. FTIR and NMR analyses revealed that lutein could interact with these phenolic acids through hydrogen bonds and van der Waals forces.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ramesh Kumar Saini, Ji-Woo Yu, Min-Ho Song, Hui-Yeon Ahn, Jung-Hoon Lee, Young-Soo Keum, Ji-Ho Lee
Summary: This research provides information on the contents and composition of important lipophilic constituents in leaf mustard, including carotenoids, tocols, phytosterols, and fatty acids. Among the four cultivars studied, Cheong had the highest levels of carotenoids and tocols, while Red frill contained the most n-3 PUFAs and antioxidants.
Review
Biochemistry & Molecular Biology
Afnan, Ammara Saleem, Muhammad Furqan Akhtar, Ali Sharif, Bushra Akhtar, Rida Siddique, Ghulam Md Ashraf, Badrah S. Alghamdi, Saif A. Alharthy
Summary: Phenolic acids are a prevalent class of bioactive chemicals found in plants, with various bioactivities such as anticancer, anti-inflammatory, and cardioprotective effects. Their strong antioxidant properties and modulation of oxidative stress and signal transduction pathways contribute to their therapeutic potential. Further research is needed to fully understand their mechanisms of action and evaluate their efficacy in human disease therapy.
Article
Biochemistry & Molecular Biology
Wenjie Yu, Fengjie Sun, Ruixin Xu, Meng Cui, Yongquan Liu, Quanyuan Xie, Limin Guo, Chenxian Kong, Xin Li, Xiali Guo, Liping Luo
Summary: This study comprehensively investigated the physicochemical parameters, chemical composition, and antioxidant capacity of Castanopsis honey (CH), as well as evaluated its anti-inflammatory effects. The results showed that CH has high quality and contains various compounds and phenols, which exhibit significant antioxidant and anti-inflammatory activities.
Article
Biochemistry & Molecular Biology
Ramona Pap, Edina Pandur, Gergely Janosa, Katalin Sipos, Attila Agocs, Jozsef Deli
Summary: Lutein exerts protective effects by suppressing H2O2-induced ROS, influencing iron utilization, and altering the secretion of anti-inflammatory and pro-inflammatory cytokines in BV-2 cells.
Article
Food Science & Technology
B. I. Martinez-Mendoza, A. Peredo-Lovillo, H. E. Romero-Luna, M. Jimenez-Fernandez
Summary: This study aimed to improve the health-promoting properties of soursop and passion fruit pulps through controlled yeast fermentation. Fermented pulps showed increased viable cell counts and antioxidant activities. Various compounds were identified in the fermented pulps, demonstrating the potential for generating new functional foods.
Article
Plant Sciences
Sarah Neves do Nascimento, Jose Luiz Mazzei, Joao Batista de Freitas Tostes, Batista de Freitas Tostes, Marcos Jun Nakamura, Ligia Maria Marino Valente, Raquel Curtinhas de Lima, Priscila Conrado Guerra Nunes, Elzinandes Leal de Azeredo, Luis Angel Berrueta, Blanca Gallo, Antonio Carlos Siani
Summary: Miconia albicans is widely used in Brazil as a remedy for rheumatoid arthritis and to alleviate symptoms caused by Chikungunya virus. This study found that certain components of this plant have inhibitory effects on CHIKV.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Food Science & Technology
Alan A. Ruiz-Hernandez, Ofelia Rouzaud-Sandez, Juana Frias, Fernando Ayala-Zavala, Humberto Astiazaran-Garcia, Norma J. Salazar-Lopez, Carmen M. Lopez-Saiz, Sandra C. De la Ree-rodriguez, Maribel Robles Sanchez
Summary: This study developed cookies using irradiated sorghum sprouts with UV-A LED light as potential functional ingredients. The cookies showed higher phenolic content and antioxidant activity compared to those prepared with sorghum flour. They also exhibited better anti-inflammatory potential by reducing nitric oxide production in cells. These findings suggest that these cookies could be a promising food for addressing overweight, obesity, and related diseases.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Huan Liu, Dan Liu, Ming-Yan Jiang, Xu-Dong Zhao, Rong-Tao Li, Hong-Mei Li
Summary: Seven undescribed and 26 known iridoids were isolated from Valeriana jatamansi roots and rhizomes, some of which exhibited stronger inhibition of NO production. Among them, Valeriandoid F and Jatamanvaltrate K showed the most significant inhibitory effects.
Article
Plant Sciences
Ru Wang, Jia Zeng, Lu Chen, Lianlian Sun, Yihai Wang, Jingwen Xu, Xiangjiu He
Summary: The study found that WT-29 isolated from Wedelia exhibits anti-inflammatory and anti-allergic effects mainly through the regulation of NF kappa B, MAPK pathways, and autophagy. This suggests that WT-29 may have potential as an anti-inflammatory and anti-allergic agent, and could be used as a medicine or health benefit product.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Chemistry, Applied
Daoyan Wu, Liwei Chen, Jean Teh, Edric Sim, Joergen Schlundt, Patricia L. Conway
Summary: This study investigated the anti-inflammatory effects of different sourced honeys and their impact on elderly gut microbiota. The results showed that these honeys suppressed inflammation, modulated gut microbiota, and provided health benefits.
Article
Multidisciplinary Sciences
Jessica Ayensu, Reginald Annan, Herman Lutterodt, Anthony Edusei, Loh Su Peng
Article
Food Science & Technology
Haiqiu Huang, Quynhchi Pham, Cindy D. Davis, Liangli Yu, Thomas T. Y. Wang
FOOD SCIENCE & NUTRITION
(2020)
Article
Multidisciplinary Sciences
Linda Afriyie Gyimah, Reginald Adjetey Annan, Charles Apprey, Anthony Edusei, Linda Nana Esi Aduku, Odeafo Asamoah-Boakye, Wisdom Azanu, Herman Lutterodt
Summary: The study found that inadequate dietary diversity is common among pregnant adolescents in Ghana, mainly associated with rural living, food insecurity, and poverty. Recommendations include providing livelihood support and nutrition education to improve dietary quality and address the consequences of poor dietary diversity.
Article
Multidisciplinary Sciences
Afua Afreh Mantey, Reginald Adjetey Annan, Herman Erick Lutterodt, Peter Twumasi
Summary: The study found a relationship between nutrition and cognition in school-aged children, with girls performing potentially worse than boys and maternal education level being associated with children's cognitive performance. Iron deficiency anemia was shown to impact cognitive performance in these children, highlighting the need for nutritional strategies to reduce anemia.
Article
Multidisciplinary Sciences
Reginald Adjetey Annan, Linda Afriyie Gyimah, Charles Apprey, Anthony Kwaku Edusei, Odeafo Asamoah-Boakye, Linda Nana Esi Aduku, Wisdom Azanu, Herman E. Lutterodt
Summary: Iron Deficiency Anaemia (IDA) is common among pregnant teenagers in Ghana, with factors such as malaria tablet intake during antenatal care, maternal hunger, maternal MUAC, deficient systemic supply of iron, depleted body iron stores, ZPP, and ZPP/Hb ratio contributing to its prevalence. Urgent interventions are needed to address the causes of IDA among pregnant teenagers.
Article
Nutrition & Dietetics
Lu Yu, Robert W. Li, Haiqiu Huang, Quynhchi Pham, Liangli Yu, Thomas T. Y. Wang
Summary: The LNCaP athymic xenograft model is commonly utilized for studying the effects of experimental treatments on prostate cancer, but the biological characteristics of LNCaP cells pre/post-implantation remain unclear. This study compared transcriptome profiles of LNCaP cells before and after implantation, revealing shifts in androgen responsiveness and signaling pathways. Understanding these changes is critical for interpreting the efficacy of experimental treatments.
Article
Biochemistry & Molecular Biology
Ekpor Anyimah-Ackah, Isaac Williams Ofosu, Herman Erick Lutterodt, Godfred Darko
Summary: The study aimed to analyze metal contamination in food samples from gold mining areas in Ghana and assess the impact of metal exposure through dietary intake. It found that maize diets were the main pathway for exposure to toxic elements such as arsenic and lead, while risks of deficiency and overage of essential elements were also identified.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Food Science & Technology
Ekpor Anyimah-Ackah, Isaac W. Ofosu, Herman Erick Lutterodt, Godfred Darko, David Okoh Kpeglo
Summary: The study aimed to determine natural radioactivity levels in total diets in an area with excessive mining activities. Results showed most radionuclides had activity concentrations below global reference values. K-40 in diets was the highest contributor to the committed effective dose, and excess cancer risks were within the protective range.
JOURNAL OF CONSUMER PROTECTION AND FOOD SAFETY
(2021)
Article
Cell Biology
Hang Ma, Yingying Guo, Haoneng Tang, Chien-Te K. Tseng, Lei Wang, Huifang Zong, Zhenyu Wang, Yang He, Yunsong Chang, Shusheng Wang, Haiqiu Huang, Yong Ke, Yunsheng Yuan, Mingyuan Wu, Yuanyuan Zhang, Aleksandra Drelich, Kempaiah Rayavara Kempaiah, Bi-Hung Peng, Ailin Wang, Kaiyong Yang, Haiyang Yin, Junjun Liu, Yali Yue, Wenbo Xu, Shuangli Zhu, Tianjiao Ji, Xiaoju Zhang, Ziqi Wang, Gang Li, Guangchun Liu, Jingjing Song, Lingling Mu, ZongShang Xiang, Zhangyi Song, Hua Chen, Yanlin Bian, Baohong Zhang, Hui Chen, Jiawei Zhang, Yunji Liao, Li Zhang, Li Yang, Yi Chen, John Gilly, Xiaodong Xiao, Lei Han, Hua Jiang, Yueqing Xie, Qiang Zhou, Jianwei Zhu
Summary: This study identified a monoclonal antibody, 2G1, that can neutralize SARS-CoV-2 variants and has strong tolerance to mutations. The antibody binds to the tip of the spike protein, blocking its interaction with ACE2. In animal models, 2G1 protected against clinical illness and reduced viral burden.
Article
Immunology
Tong Wu, Zhangyi Song, Haiqiu Huang, Tanja Jakos, Hua Jiang, Yueqing Xie, Jianwei Zhu
Summary: A novel immunotoxin GT5 targeting GPC3 was found to effectively inhibit hepatocellular tumor growth, showing promising therapeutic potential.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Linda Afriyie Gyimah, Reginald Adjetey Annan, Charles Apprey, Odeafo Asamoah-Boakye, Linda Nana Esi Aduku, Wisdom Azanu, Herman E. Lutterodt, Anthony Kwaku Edusei
Summary: The study found that most pregnant adolescents did not meet the recommended nutrient intake, and adverse birth outcomes were associated with poor nutritional status, with undernutrition being linked to low birth weight and preterm births.
HUMAN NUTRITION & METABOLISM
(2021)
Article
Chemistry, Multidisciplinary
Ekpor Anyimah-Ackah, Isaac Williams Ofosu, Herman Erick Lutterodt, Godfred Darko
Summary: Cocoa consumption, driven by the health benefits of mineral nutrients, is increasing globally. However, this study found that cocoa beans contain concentrations of mercury, lead, and molybdenum that exceed international regulatory thresholds. The presence of these toxic elements can be traced back to soil uptake and atmospheric deposition pollution mechanisms from mining activities. Additionally, the study showed that the potential risks associated with lead in cocoa beans, including cancer risk and low margin of exposure, outweigh the beneficial elements present in cocoa beans.
CHEMISTRY AFRICA-A JOURNAL OF THE TUNISIAN CHEMICAL SOCIETY
(2021)
Article
Nutrition & Dietetics
Jessica Ayensu, Christopher Larbie, Reginald Adjetey Annan, Herman Lutterodt, Anthony Edusei, Su Peng Loh, Ernest Amponsah Asiamah
JOURNAL OF NUTRITION AND METABOLISM
(2020)
Article
Nutrition & Dietetics
Megan E. Parker, Stephanie Zobrist, Herman E. Lutterodt, Cyril R. Asiedu, Chantal Donahue, Connor Edick, Kimberly Mansen, Gretel Pelto, Peiman Milani, Shobhita Soor, Amos Laar, Cyril M. Engmann
Review
Food Science & Technology
Ekpor Anyimah-Ackah, Isaac W. Ofosu, Herman E. Lutterodt, Godfred Darko
FOOD QUALITY AND SAFETY
(2019)