Article
Biochemistry & Molecular Biology
Jing-Yan Gao, Chih-Shiang Chang, Jin-Cherng Lien, Ting-Wei Chen, Jing-Lan Hu, Jing-Ru Weng
Summary: Trytanthrin, a natural compound found in Ban-Lan-Gen, has anti-inflammatory and anti-viral properties. Two derivatives, A1 and A6, showed higher cytotoxicity in HCC cells and targeted multiple aspects of cancer cell growth, making them potential candidates for clinical applications.
Article
Chemistry, Medicinal
Zhuo Han, Xingming Zhao, E. Zhang, Jiahui Ma, Hao Zhang, Jianjiang Li, Weidong Xie, Xia Li
Summary: The study elucidated the mechanism of resistomycin in promoting apoptosis and cell cycle arrest in human hepatocellular carcinoma, indicating that the p38 MAPK signaling pathway may play an important role in this process.
Article
Engineering, Environmental
Liang Zhang, Lilai Shen, Yizhou Huang, Shixuan Cui, Qiming Zhao, Chunlong Zhang, Shulin Zhuang, Guibin Jiang
Summary: This study identified the key signaling cascades involved in oxidative stress in zebrafish larvae and evaluated the cell cycle arrests and associated developmental alterations caused by UV-328 exposure. UV-328 inhibited the p38 MAPK/p53/Gadd45a regulatory circuit, leading to G1 phase cell cycle arrest and abnormal embryo hatching and heart rate.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Ajay Kumar, Sandeep Kaur, Kritika Pandit, Varinder Kaur, Sharad Thakur, Satwinderjeet Kaur
Summary: The study found that the Obea fraction extracted from O. bracteata exhibits strong antioxidant properties and cytotoxicity, showing significant antiproliferative activity against human osteosarcoma MG-63, human neuroblastoma IMR-32, and human lung cancer A549 cell lines. Antioxidant and cytotoxic potential were attributed to the presence of catechin, kaempferol, onosmin A, and epicatechin in the Obea fraction.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yongzhu Zhang, Liqing Yin, Jiajia Dong, Xiudong Xia
Summary: Isoflavones, derived from soybeans, have shown potential neuroprotective effects by increasing cell viability, decreasing reactive oxygen species levels, inhibiting apoptosis, and regulating the cell cycle. They activate Nrf2 protein, inhibit p38 MAPK and AKT-mTOR pathways, and compete with Keap1, suggesting isoflavones could be a potent neuroprotective phytochemical in soybeans and their products.
Article
Biochemistry & Molecular Biology
Yin Shi, Shengfeng Xu, Natalie Y. L. Ngoi, Qi Zeng, Zu Ye
Summary: Hypoxia in the tumor microenvironment, causing excessive ROS and genomic instability, is a hallmark of cancer contributing to self-renewal, metastasis, and therapy resistance. PRL-3, an oncoprotein, has been found to regulate apoptosis resistance by negatively affecting p38 MAPK activity in response to hypoxia stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Chemistry, Medicinal
Xinmei Yang, Xijun Wu, Xiaosen Wu, Lei Huang, Jingrui Song, Chunmao Yuan, Zhixu He, Yanmei Li
Summary: MQ-16 shows significant inhibitory effects on the proliferation of K562 cells and induces cell cycle arrest at the G2/M phase in a time- and concentration-dependent manner. It induces mitochondria-dependent apoptosis by downregulating anti-apoptotic proteins Bcl-2 and Bcl-xL, and causes time- and concentration-dependent DNA fragmentation. Furthermore, MQ-16 affects the expression of PI3K/Akt/mTOR, JAK2/STAT3, and MAPK pathway-related proteins.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Medicine, Research & Experimental
Jia-Peng Lin, Mao-Hua Huang, Zhi-Ting Sun, Lei Chen, Yu-He Lei, Yu-Qing Huang, Ming Qi, Shu-Ran Fan, Shou-Guo Chen, Chi-Wing Chung, Mei-Ching Chan, Jun-Shan Liu, Min Hu, Min-Feng Chen, Wen-Cai Ye, Yue-Yue Chen, Li-Juan Deng
Summary: The study aimed to evaluate the effect of periplocin on inhibiting hepatocellular carcinoma (HCC) and further determine its mechanisms. The findings revealed that periplocin inhibited HCC progression by G2/M arrest, apoptosis, and suppression of myeloid-derived suppressor cells (MDSCs) accumulation through the blockade of the AKT/NF-κB pathway. These results suggest that periplocin has the potential to be developed as an effective therapeutic agent for HCC.
Article
Biochemistry & Molecular Biology
Ya He, Maohong Luo, Shan Lei, Zhirui Zeng, Tengxiang Chen, Yingmin Wu, Dongyan Wang, Long Wang, Lu Wang
Summary: Luteoloside has exhibited anti-inflammatory, antiviral, and antitumor properties. Its effect on neuroblastoma cells was investigated in this study. Luteoloside inhibited the proliferation of neuroblastoma cells by activating the p38 MAPK pathway, indicating its potential as an anticancer drug for treating neuroblastoma.
Article
Multidisciplinary Sciences
Wei Zhao, Yongxia Lao, Yang Liu, Jiqin Niu, Zhihui Xiao, Palanisamy Arulselvan, Jian Shen
Summary: This study demonstrated that escin possesses potent antioxidant capacity and inhibits the viability of OC A2780 cells by increasing lipid peroxidation, promoting ROS accumulation and apoptotic cell death, while suppressing the p38 MAPK/ERK signaling pathway.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Toxicology
Yanan Li, Huiming Yang, Huiming Nong, Fan Wang, Yajie Wang, Yue Xu, Junhong Zhang, Hao Zhao, Zhixin Cao, Qianqian Yang, Jianfeng Li
Summary: The expression of HMGCR in cochlear hair cells and HEI-OC1 cells and its role in cisplatin-induced ototoxicity were studied. HMGCR was found to be widely expressed in auditory cells and exerted a protective effect against cisplatin-induced ROS injury, regulating p38 MAPK-dependent apoptosis and autophagy.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Nutrition & Dietetics
Abuyaseer Abusaliya, Se Hyo Jeong, Pritam Bhagwan Bhosale, Hun Hwan Kim, Min Yeong Park, Eunhye Kim, Chung Kil Won, Kwang Il Park, Jeong Doo Heo, Hyun Wook Kim, Meejung Ahn, Je Kyung Seong, Gon Sup Kim
Summary: Previous research has established that plant-based compounds, particularly flavonoids, have significant anti-inflammatory and anti-cancer properties. Prunetrin, a glycosyloxyisoflavone derived from Prunus sp., has shown promising results in an anti-cancer study with liver cancer cells. It decreases cell viability, arrests the cell cycle, induces apoptosis through the mitochondrial pathway, and inhibits the mTOR/AKT signaling pathways.
Article
Multidisciplinary Sciences
Cuiting Lv, Aihua Lan, Xiao Fan, Caiguo Huang, Gong Yang
Summary: Asperolides A (AA), a new tetranorlabdane diterpenoid, has been shown to inhibit the proliferation of lung cancer cells and bone metastasis of breast cancer cells. In this study, researchers found that AA can induce apoptosis and cell cycle arrest in hepatoma cells. It specifically inhibits the proliferation of Huh-7 cells, compared to HepG-2 and L02 cells. The activation of ERK and JNK by AA contributes to cell survival, while the phosphorylation of p53 at S33 by p38 activation plays a crucial role in AA-induced apoptosis and G2/M cell cycle arrest in Huh-7 cells. The activation of the p53-Y220C mutant by p38 reactivates the wild-type function of the mutant p53 protein, leading to increased sensitivity of Huh-7 cells to AA. These findings provide valuable insights into the molecular mechanisms of AA as a potential mutant p53 rescue drug.
Article
Pharmacology & Pharmacy
Mengling Xia, He Cao, Jing Zheng, Yinan Yao, Fei Xu, Guohua Lu, Yongmin Ma, Jianying Zhou
Summary: GMQ3 is a promising novel small molecule compound for lung cancer treatment, as it can inhibit cell proliferation, migration, and induce apoptosis through multiple pathways, with a main effect through the p38-MAPK/SIRT1 pathway in inhibiting cell proliferation and inducing apoptosis.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Environmental Sciences
Jing Wu, Chenglin Yang, Mengran Yang, Zengenni Liang, You Wu, Xiangyi Kong, Hui Fan, Siqi Wang, Can Ning, Wenguang Xiao, Ye Jin, Jine Yi, Zhihang Yuan
Summary: Citrinin induces liver injury by activating the ROS-ER stress-AMPK signaling pathway, exacerbating liver damage through inhibition of cell cycle and promotion of apoptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Agricultural Engineering
Hui-Chi Huang, Wen-Te Chang, Yi-Hsuan Wu, Bo-Cheng Yang, Mo-Rong Xu, Ming-Kuem Lin, Hsi-Jien Chen, Jai-Hong Cheng, Meng-Shiou Lee
Summary: In this study, microbial fermentation of Hibiscus sabdariffa L. calyx extract was used to enhance its phytochemical constituents and biological activity, resulting in increased antioxidant activity and phenolic content, especially with Galactomyces geotrichum inoculation. The optimized fermentation conditions included 1% eHS addition and static culture method. High performance liquid chromatography (HPLC) and enzymatic activity analysis showed that the improved biological activities of fermented eHS were mainly due to increased levels of phenolic compounds, flavonoids, anthocyanin and its aglycone derivatives. This is the first report to demonstrate the use of microbial fermentation to improve the biological functionalities of fermented eHS.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Medicine, General & Internal
Jai-Hong Cheng, Wen-Yi Chou, Ching-Jen Wang, Ka-Kit Siu, Jei-Ming Peng, Yi-No Wu, Meng-Shiou Lee, Chien-Yiu Huang, Jih-Yang Ko, Shun-Wun Jhan
Summary: This study demonstrated the effects of extracorporeal shockwave therapy (ESWT) on rat knee osteoarthritis (OA) and its associated pathological changes. The results revealed that ESWT had better outcomes in the medial group compared to the lateral group. The study also identified correlations between the modified Mankin score, tidemark roughness, and calcified cartilage thickness.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Plant Sciences
Wen-Wei Hsiao, K. J. Senthil Kumar, Hui-Ju Lee, Nai-Wen Tsao, Sheng-Yang Wang
Summary: Calocedrus formosana wood essential oil (CFEO) and its bioactive components exhibit anti-melanogenic activity and have the potential to be used in the development of skin whitening products.
Article
Chemistry, Medicinal
Sheng-Yi Chen, Yi-Hao Hsu, Sheng-Yang Wang, Ying-Yin Chen, Cheng-Jie Hong, Gow-Chin Yen
Summary: The study demonstrates that lucidone can enhance cell apoptosis, inhibit autophagic protein expression, and suppress multidrug resistance protein 1 through the HMGB1/RAGE/PI3K/Akt pathway, thereby improving chemosensitivity in pancreatic ductal adenocarcinoma.
PHYTOTHERAPY RESEARCH
(2022)
Article
Forestry
Nai-Wen Tsao, Yen-Chi Lin, Yen-Hsueh Tseng, Shih-Chang Chien, Sheng-Yang Wang
Summary: This study identified the main compounds of exudates from 13 conifers in Taiwan, revealing that the main volatiles were alpha-pinene, beta-ocimene, beta-pinene, sabinene, and caryophyllene. It also found that the nonvolatile compounds were diterpenoids, classified into three types. The analysis results of conifers' epigenetics by GC-MS and HSQC were similar to traditional taxonomy classification, indicating the usefulness of this technology in classifying conifers. Additionally, certain conifers showed strong antifungal activity against white-rot and brown-rot fungi.
JOURNAL OF WOOD SCIENCE
(2022)
Article
Environmental Sciences
K. J. Senthil Kumar, M. Gokila Vani, Sheng-Yang Wang
Summary: This study found that limonene can protect skin cells from damage and aging caused by solar ultraviolet B (UVB) radiation. This protective effect is achieved by increasing the expression of endogenous antioxidants and activating the Nrf2-dependent antioxidant defense system. In addition, limonene can also inhibit UVB-induced hyperpigmentation and maintain the stability of tight junction proteins.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kotapati Kasi Viswanath, Song-Yi Kuo, Ying-Wen Huang, Nai-Wen Tsao, Chung-Chi Hu, Na-Sheng Lin, Sheng-Yang Wang, Yau-Heiu Hsu
Summary: This study uncovers the interaction between virus-responsive promoter and the corresponding transcription factor in plants, and reveals that NbMYB30 can affect the expression of the AGO5 gene and the accumulation of viruses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Wen-Hsuan Chen, Anthony Bain, Sheng-Yang Wang, Yi-Chiao Ho, Hsy-Yu Tzeng
Summary: The vegetative and reproductive growth of plants play a crucial role in regulating the interactions within an ecosystem. In the case of plant-insect interactions, plants use visual and chemical cues to signal their reproductive period. Ficus mutualism, however, relies solely on chemical cues for the figs to attract pollinating wasps. This study examines the phenological pattern and volatile compound emissions of Ficus septica in Central Taiwan. The results show that the fig species displays continuous growth throughout the year, with a decrease in winter. The emissions of odor blends from male and female trees are similar, but with seasonal variations, and are influenced by the size of the wasp population.
Article
Chemistry, Medicinal
Gyaltsen Dakpa, Kanthasamy Jayabal Senthil Kumar, Nai-Wen Tsao, Sheng-Yang Wang
Summary: This study investigated the metabolic alterations induced by SARS-CoV-2 spike protein and the regulatory effect of antcin A on these changes. The results showed that antcin A significantly reversed the altered metabolites mediated by the SARS-CoV-2 protein and inhibited the up-regulation of related receptors.
PHYTOTHERAPY RESEARCH
(2023)
Article
Plant Sciences
Chieh-Yin Chen, Pei-Chen Wu, Nai-Wen Tsao, Yen-Hsueh Tseng, Fang-Hua Chu, Sheng-Yang Wang
Summary: The study on the leaves and extracts of Cinnamomum insularimontanum demonstrated good anti-inflammatory activity, suggesting its potential for the development of healthcare products.
Article
Pharmacology & Pharmacy
Yu-Tung Ho, I-Hsuan Liu, Shang-Tzen Chang, Sheng-Yang Wang, Hui-Ting Chang
Summary: Agathis species are widely distributed in Southeast Asia, Australasia, South Pacific islands, etc. They have been traditionally used as folk medicines. This study analyzed the chemical composition of Agathis dammara (Lamb.) Rich. leaf essential oil and found that it has an antimelanogenesis effect.
Article
Plant Sciences
Nai-Wen Tsao, Ying-Hsuan Sun, Fang-Hua Chu, Shih-Chang Chien, Sheng-Yang Wang
Summary: The relationship between lignan biosynthesis and programmed cell death (PCD) of ray parenchyma cells during the heartwood formation of Taiwania was investigated. The PCD of ray parenchyma cells and the synthesis of lignans are two important processes involved in heartwood formation and both are regulated by genes. The genotoxic induces the PCD of tracheids, while biological factors like fungi, bacteria, and viruses induce the PCD of ray parenchyma cells, which could lead to oxidative stress. The accumulation of savinin in ray parenchyma cells is found to cause PCD, as confirmed by in vitro experiments and the production of taiwanin A, the marker of heartwood formation.
Article
Biochemistry & Molecular Biology
Po-Heng Tsai, Pei-Chen Wu, Hui-Ru Li, K. J. Senthil Kumar, Sheng-Yang Wang
Summary: This study investigated the antidepressant effect of Hirami lemon and its underlying mechanisms. The results showed that the fruit extract and essential oil of Hirami lemon could reverse depression and anxiety-like behaviors induced by chronic mild stress and restore gut microbiota dysbiosis. Furthermore, analysis of the chemical components of Hirami lemon revealed the presence of various compounds. Therefore, Hirami lemon has the potential to serve as a source of natural antidepressant agents.