期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 60, 期 4, 页码 1128-1134出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf2042505
关键词
perfluorooctanoic acid; beef cattle; absorption; elimination; pharmacokinetics; residues
资金
- FSIS-ARS Interagency [FSIS-IA-9-102]
Perfluoroalkyl substances (PFASs), such as perfluorooctanoic acid (PFOA), are environmentally persistent industrial chemicals often found in biosolids. Application of these biosolids to pastures raises concern about the accumulation of PFOA in the edible tissues of food animals. Because data on the absorption, distribution, metabolism, and excretion (ADME) of PFOA in cattle were unavailable, a study was conducted to determine pharmacokinetic parameters following a single oral exposure (1 mg/kg body weight of C-14-PFOA) in four Lowline Angus steers. Radiocarbon was quantified in blood, urine, and feces for 28 days and in tissues at the time of slaughter (28 days) by liquid scintillation counting (LSC) or by combustion analysis with LSC with confirmation by liquid chromatography-tandem mass spectrometry (LC-MS/MS). C-14-PFOA was completely absorbed and excreted (100.7 +/- 3.3% recovery) in the urine within 9 days of dosing. The plasma elimination half-life was 19.2 +/- 3.3 h. No C-14-PFOA-derived radioactivity was detected in edible tissues. Although PFOA was rapidly absorbed, it was also rapidly excreted by steers and did not persist in edible tissues, suggesting meat from cattle exposed to an acute dose of PFOA is unlikely to be a major source of exposure to humans.
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