期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 60, 期 48, 页码 11919-11927出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf3030584
关键词
Vitis vinifera; grapevine; oligomeric stilbenes; resveratrol; antiproliferative activity; low-speed rotary countercurrent chromatography
资金
- German Federal Ministry of Education and Research [0315373D]
An activity-guided isolation of bioactive stilbenes has been carried out with the grapevine-shoot extract Vineatrol 30. After hexane precipitation of the polymeric constituents, the stilbene mixture was separated on a preparative scale using low-speed rotary countercurrent chromatography (LSRCCC). The antiproliferative activity of the separated LSRCCC fractions was then screened in the human cancer cell line A-431, and trans-resveratrol, trans-epsilon-viniferin, r-2-viniferin, hopeaphenol, and miyabenol C were identified as active principles. In addition, a new class of stilbene derivatives, which exhibit a gamma-lactam ring structure and exert a weak growth-inhibiting activity in A-431 cells, has been identified.
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