Article
Dermatology
Hend Gamil, Magda Assaf, Mohamad Khater, Manal Fawzy
Summary: In this study, abnormal expression of AQP-3 was found in the lesional and perilesional skin of vitiligo patients. This abnormality may contribute to keratinocyte apoptosis and subsequent melanocyte death, leading to the development of vitiligo.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nobutomo Ikarashi, Nanaho Mizukami, Chenchen Pei, Ryogo Uchino, Izumi Fujisawa, Natsuko Fukuda, Risako Kon, Hiroyasu Sakai, Junzo Kamei
Summary: In type 2 diabetes, the level of skin water channel protein AQP3 decreases, potentially leading to xeroderma, while anti-inflammatory drugs may be beneficial for diabetic xerosis.
Article
Biochemistry & Molecular Biology
Gi-Hwan Jung, Jae-Han Lee, So-Hee Han, Joong-Seok Woo, Eun-Young Choi, Su-Ji Jeon, Eun-Ji Han, Soo-Hyun Jung, Young-Seok Park, Byung-Kwon Park, Byeong-Soo Kim, Sang-Ki Kim, Ji-Youn Jung
Summary: This study investigated the anticancer effect and mechanism of Chrysin against oral cancer. The results showed that Chrysin induced apoptosis and autophagy in oral cancer cells via the MAPK pathway, with autophagy exerting a cytoprotective effect. This study highlights the therapeutic potential of Chrysin for oral cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Inorganic & Nuclear
Huzaifa Yasir Khan, Sabiha Parveen, Imtiyaz Yousuf, Sartaj Tabassum, Farukh Arjmand
Summary: Metal complexes of non-steroidal anti-inflammatory drugs (NSAIDs) have gained attention in anti-tumor drug therapy. By selecting suitable metal ions and coordination geometries, NSAID-metal conjugates can be fine-tuned for targeted therapies. Metal complexes exhibit intriguing behavior in vivo, interacting with intracellular molecules and targeting cancer cells, thus playing a significant role in cell inhibition processes.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Dermatology
Qingde Zhou, Jianxiang Gong, Jianing Bi, Xuanxin Yang, Li Zhang, Chao Lu, Lijia Li, Min Chen, Jianqiu Cai, Rongshuai Yang, Xiaokun Li, Zhiming Li, Xiaojie Wang
Summary: KGF-2 has been found to attenuate scar formation while promoting wound healing. This is achieved by inhibiting the expression of STAP-2 and reducing the accumulation of collagen fibers through cell signaling.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pandurangan Subash-Babu, Alanoud Aladel, Taghreed N. Almanaa, Sahar Abdulaziz AlSedairy, Ali A. Alshatwi
Summary: Using ononitol monohydrate from Cassia tora can inhibit the proliferation of human colorectal cancer cells by suppressing inflammatory gene expression and increasing the expression of tumor-suppressor genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Xu Li, Ying Zhu, Tianyang Zhao, Xueting Zhang, Honghao Qian, Jia Wang, Xiaohan Miao, Liting Zhou, Na Li, Lin Ye
Summary: The objective of this study was to investigate the effects of the COX-2/PGE2 pathway on MEHP-induced cell apoptosis in ovarian granulosa cells. The results showed that MEHP significantly decreased cell viability and increased apoptosis levels. PGE2 levels were markedly reduced and the expression levels of related genes were altered. Over-expression of COX-2 alleviated apoptosis and slightly increased PGE2 levels. This indicates that MEHP causes cell apoptosis in rat ovarian granulosa cells by down-regulating ovulation-related gene levels via the COX-2/PGE2 pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Chemistry, Medicinal
Nahed Nasser Eid El-Sayed, Taghreed M. Al-Otaibi, Assem Barakat, Zainab M. Almarhoon, Mohd. Zaheen Hassan, Maha I. Al-Zaben, Najeh Krayem, Vijay H. Masand, Abir Ben Bacha
Summary: Oxidative stress, COX-2, LDHA, and hyperglycemia are interconnected contributing pathways in the development and progression of colon cancer. Compounds synthesized and evaluated in this study showed potential antioxidant, enzyme inhibitory, and cytotoxic activities. Some derivatives demonstrated cytotoxic effects through modulation of apoptosis regulators and cell cycle arrest.
Article
Andrology
Payam Mohammadi, Seyed Alireza Mesbah-Namin, Mansoureh Movahedin
Summary: This study found that lower expression of AQP3 and higher expression of CASP3 were associated with decreased sperm motility in asthenozoospermic individuals. Additionally, higher CASP3 activity may indicate active apoptosis in individuals with asthenozoospermia. The DNA-damaged sperm count was higher in asthenozoospermic individuals and showed a negative correlation with AQP3 and CASP3 activity.
Article
Cell Biology
Bin Xie, JunQi Yang, Jun Zhang
Summary: This study investigated the combined effect of chrysin, an apigenin analog with high therapeutic potential, and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on Saos-2 and MG-63 cells. The results showed that chrysin synergistically increased the cytotoxic effects of TRAIL and sensitized the cells to TRAIL-induced apoptosis by decreasing the expression levels of antiapoptotic genes. This suggests that chrysin can sensitize osteosarcoma cells to TRAIL through the death receptor pathway, and the combinational therapy of these agents may improve the clinical efficacy of TRAIL-induced apoptosis in patients with osteosarcoma.
CELL BIOLOGY INTERNATIONAL
(2022)
Article
Environmental Sciences
Basma Ghazi Eid
Summary: Chrysin has protective effects on estradiol-induced endometrial hyperplasia, exerting anti-proliferative, anti-oxidant, and anti-inflammatory effects partially through increasing PPAR alpha activity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Food Science & Technology
Sang-Ah Seo, Hyun-Jung Park, Min-Gi Han, Ran Lee, Ji-Soo Kim, Ji-Hoo Park, Won-Young Lee, Hyuk Song
Summary: The study shows that fermented colostrum whey can increase the proliferation of HaCaT cells and significantly enhance the expression of AQP-3. This effect may be achieved through the activation of JNK and p38 MAPK.
FOOD SCIENCE OF ANIMAL RESOURCES
(2021)
Review
Oncology
Marjan Talebi, Mohsen Talebi, Tahereh Farkhondeh, Jesus Simal-Gandara, Dalia M. Kopustinskiene, Jurga Bernatoniene, Saeed Samarghandian
Summary: Chrysin has been shown to have multiple beneficial pharmacological activities, exerting therapeutic effects on various cancers. Further studies are needed to enhance its bioavailability and evaluate its efficacy in clinical trials.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Jae-Han Lee, Eun-Seon Yoo, So-Hee Han, Gi-Hwan Jung, Eun-Ji Han, Eun-Young Choi, Su-Ji Jeon, Soo-Hyun Jung, BumSeok Kim, Sung-Dae Cho, Jeong-Seok Nam, Changsun Choi, Jeong-Hwan Che, Ji-Youn Jung
Summary: This study investigated the anticancer effects of Chrysin in human melanoma cells and found that it can inhibit cell viability by inducing apoptosis and autophagy. The response to autophagy varies in different cell types, and Chrysin also affects the mTOR/S6K pathway.
Article
Biochemistry & Molecular Biology
Mohamed El-Sherbiny, Hoda Atef, Ghada M. Helal, Rasha Hamed Al-Serwi, Hany A. Elkattawy, Gehan Ahmed Shaker, Eman Said, Moaz Abulfaraj, Marzough A. Albalawi, Nehal M. Elsherbiny
Summary: Aging is a natural physiological process that negatively affects various body organs and well-being. The use of Vitamin K2 shows promise in improving liver function and suppressing inflammatory and fibrotic biomarkers.
Article
Biochemistry & Molecular Biology
Po-Hsuan Lu, Jen-Yu Wang, Ling-Ya Chiu, Yi-Ting Huang, Chi-Feng Hung, Nan-Lin Wu
Summary: Syk is involved in UVB-induced skin inflammation, and inhibiting Syk may have potential photoprotective effects against UVB-induced skin inflammation.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Chi-Cheng Huang, Chih-Yi Liu, Chi-Jung Huang, Yao-Chun Hsu, Heng-Hui Lien, Jia-Uei Wong, Feng-Chuan Tai, Wen-Hui Ku, Chi-Feng Hung, Jaw-Town Lin, Ching-Shui Huang, Han-Sun Chiang
Summary: Pancreatic adenocarcinoma (PAC) is the 8th leading cause of cancer-related deaths in Taiwan, and its incidence is increasing. Targeted next-generation sequencing can identify somatic mutations in PAC patients, providing insights into the molecular changes and potential therapeutic options.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Kun-Chieh Yeh, Chi-Feng Hung, Hui-Ling Lee, Ting-Yang Hsieh, Su-Jane Wang
Summary: Soybean meal extract can improve memory function and increase the expression of presynaptic proteins and protein kinases, while also impacting the gut microbiota.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tzu-Kang Lin, Chi-Feng Hung, Jing-Ru Weng, Ting-Yang Hsieh, Su-Jane Wang
Summary: This study found that Kaempferol 3-rhamnoside (KR) can inhibit 4-aminopyridine (4-AP)-evoked glutamate release. The inhibitory effect of KR is linked to the omission of external Ca2+ or the depletion of glutamate in synaptic vesicles, as well as the suppression of P/Q-type Ca2+ channel activity. Additionally, KR reduces the increase in Ca2+ concentration and the phosphorylation of CaMKII and its substrate synapsin I.
Article
Biochemistry & Molecular Biology
Pa-Fan Hsiao, Yi-Ting Huang, Po-Hsuan Lu, Ling-Ya Chiu, Tzu-Han Weng, Chi-Feng Hung, Nan-Lin Wu
Summary: This study investigates the expression and regulation of TXNIP in psoriasis, as well as its role in skin keratinocyte differentiation and EGFR signaling.
Review
Biochemistry & Molecular Biology
Wen-Chin Ko, Su-Jane Wang, Chien-Yu Hsiao, Chen-Ting Hung, Yu-Jou Hsu, Der-Chen Chang, Chi-Feng Hung
Summary: Gold is considered a symbol of nobility and its properties make it attractive for a wide range of applications. Gold nanoparticles, with their unique size-dependent properties, have shown potential in biomedical testing, disease diagnosis, and gene detection. The use of gold nanoparticles in targeting cancer cells and their antioxidant and anti-inflammatory effects have been widely studied and show promise in various diseases.
Article
Biochemistry & Molecular Biology
Chia-Chen Wang, Chien-Yu Hsiao, Yu-Jou Hsu, Horng-Huey Ko, Der-Chen Chang, Chi-Feng Hung
Summary: Atopic dermatitis, a common and incurable skin condition, could potentially be prevented or treated with cycloheterophyllin, a compound derived from Artocarpus heterophyllus. This compound has shown anti-inflammatory and antioxidant properties, reducing cytokine release and alleviating symptoms of inflammation and itching. Furthermore, it can promote the recovery of the skin barrier.
Article
Biology
Jia-Feng Chang, Hsiao-Ling Kuo, Shih-Hao Liu, Chih-Yu Hsieh, Chih-Ping Hsu, Kuo-Chin Hung, Ting-Ming Wang, Chang-Chin Wu, Kuo-Cheng Lu, Wei-Ning Lin, Chi-Feng Hung, Wen-Chin Ko
Summary: Uremic vascular calcification (UVC) is closely related to oxidative injury, cell death, and osteocytic conversion. Scavenging ROS may attenuate inflammasome activation and eicosanoid inflammation in the UVC process. Therefore, reducing ROS and PCS could be an effective therapeutic strategy for UVC-related cardiovascular events.
Article
Plant Sciences
Kung-Ju Chen, Yu-Ling Huang, Liang-Mou Kuo, Yi-Ting Chen, Chi-Feng Hung, Pei- Wen Hsieh
Summary: This study demonstrated that casuarinin isolated from the root of M. malabathricum can act as a NE inhibitor and improve FUIIM by modulating inflammation, intestinal barrier dysfunction, and gut microbiota dysbiosis.
Article
Biochemistry & Molecular Biology
Ya-Chu Tsai, Hsun-Hao Chang, Sheng-Chieh Chou, Thomas W. Chu, Yu-Jou Hsu, Chien-Yu Hsiao, Yuan-Hsin Lo, Nan-Lin Wu, Der-Chen Chang, Chi-Feng Hung
Summary: Alpha-boswellic acid has shown efficacy in reducing inflammation, improving skin hydration, and reducing cytokine expression, suggesting its potential as a component in the development of anti-atopic dermatitis drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Chao-Yi Chen, Yi-Feng Yang, Paul C. Wang, Liang Shan, Stephen Lin, Po-Jung Chen, Yi-Jung Chen, Han-Sun Chiang, Jaw-Town Lin, Chi-Feng Hung, Yao-Jen Liang
Summary: This study confirmed the relationship between simvastatin and pancreatic cancer by using different cell lines and animal models. Simvastatin significantly decreased the viability of pancreatic cancer cells and may arrest the cell cycle. In animal models, pre-treated pancreatic cancer cells with simvastatin showed slower tumor growth and decreased tumor/body weight ratio. Additionally, pancreatic cancer cells presented different growth patterns in different animal-induced models.
Article
Oncology
Cheng-Kuang Yang, Chi-Rei Yang, Yen-Chuan Ou, Chen-Li Cheng, Hao-Chung Ho, Kun-Yuan Chiu, Shian-Shiang Wang, Jian-Ri Li, Chuan-Shu Chen, Chi-Feng Hung, Cheng-Che Chen, Shu-Chi Wang, Chia-Yen Lin, Sheng-Chun Hung
Summary: Patients with high-risk and very high-risk prostate cancer who undergo prostatectomy have a high risk of biochemical recurrence (BCR). This retrospective observational study aimed to identify the risk factors for BCR after radical prostatectomy in these patients. The study found that patients in the very high-risk group had a lower BCR-free survival rate and even if their PSA levels were undetectable initially after surgery, they still had a high risk of BCR. Preoperative MRI imaging stage and PSA density were found to be predictors of short-term BCR after prostatectomy.
Article
Chemistry, Medicinal
Chieh-Chen Huang, Yuan-Hsin Lo, Yu-Jou Hsu, Yuan-Bin Cheng, Chia-Chi Kung, Cher-Wei Liang, Der-Chen Chang, Kang-Ling Wang, Chi-Feng Hung
Summary: Atopic dermatitis (AD, eczema) is a common skin condition that primarily affects children and adults, but current treatments have limited effectiveness and side effects. This study investigated the potential use of epi-oxyzoanthamine, a bioactive compound derived from Formosan zoanthid, for treating AD. In vitro and in vivo experiments showed that epi-oxyzoanthamine inhibited cytokine expression and reduced skin inflammation, indicating its potential as an alternative treatment for AD. Overall, the study highlights the importance of exploring new therapies for atopic dermatitis.
Article
Surgery
Chi-Feng Hung, Tsung-Wei Wang, Cheng-Kuang Yang, Yung-Cheng Yang, Yeong-Chin Jou, Yen-Chuan Ou
Summary: This study aimed to determine the 10-year survival rate and clinical prognostic factors of men with newly diagnosed bone metastatic prostate cancer treated with hormone therapy. The results showed that the posttreatment nadir serum PSA level significantly influenced patient survival.
FORMOSAN JOURNAL OF SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Chih-Cheng Lin, Hsiu-Hua Lin, Hsiang Chang, Lu-Te Chuang, Chih-Yu Hsieh, Shing-Hwa Lu, Chi-Feng Hung, Jia-Feng Chang
Summary: This study compared the effects of different tea processes on immune modulation and oxidative stress in macrophages. The results showed that purple shoot tea has potential prophylactic benefits for reducing inflammation and regulating cytokine expression. Purple shoot green tea, in particular, exhibited strong antioxidant properties. Tea extracts were able to reduce inflammation and modulate immune cell responses by regulating cytokine expression.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
