Article
Cell Biology
Xiao-Wei Zhang, Lin Li, Wen-Qian Hu, Ming-Ning Hu, Yan Tao, Hui Hu, Xiao-Kang Miao, Wen-Le Yang, Qiong Zhu, Ling-Yun Mou
Summary: This study reveals that G protein-coupled receptor neurokinin-1 (NK1R) is significantly upregulated in lung cancer samples and is associated with advanced clinical stages and poor prognosis. NK1R co-expresses with epidermal growth factor receptor (EGFR) and interacts with it in tumor cells. Activation of NK1R promotes lung cancer cell proliferation and migration through EGFR signaling pathways. Inhibition of NK1R suppresses cell proliferation and migration, and knockdown of NK1R slows down tumor growth. The presence of a selective NK1R antagonist enhances the sensitivity of lung cancer cells to specific drugs.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Katarzyna Ratajczak-Wielgomas, Alicja Kmiecik, Piotr Dziegiel
Summary: The expression of POSTN is significantly increased in NSCLC and may serve as an independent prognostic factor. POSTN knockdown inhibits the migration and invasion of lung cancer cells, potentially through modulating the expression of MMP-2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Yunting Zhang, Shaolin Zeng, Tao Wang
Summary: Dysregulated circular RNA circ_0002360 is overexpressed in non-small cell lung cancer (NSCLC) and can competitively bind with microRNAs to raise MMP16 expression, thereby promoting cancer progression.
Article
Multidisciplinary Sciences
Marcello Stanzione, Jun Zhong, Edmond Wong, Thomas J. LaSalle, Jillian F. Wise, Antoine Simoneau, David T. Myers, Sarah Phat, Moshe Sade-Feldman, Michael S. Lawrence, M. Kyle Hadden, Lee Zou, Anna F. Farago, Nicholas J. Dyson, Benjamin J. Drapkin
Summary: This study used patient-derived xenograft models to investigate acquired resistance to olaparib plus temozolomide in small cell lung cancer. The study revealed alterations in cell cycle kinetics and DNA replication, and demonstrated the potential of the serial model approach to investigate and overcome therapy resistance in SCLC. Notably, the study also identified a mechanism of acquired resistance involving up-regulation of translesion DNA synthesis.
Article
Oncology
Biagio Ricciuti, Arielle Elkrief, Joao Alessi, Xinan Wang, Yvonne Li, Hersh Gupta, Daniel M. Muldoon, Arrien A. Bertram, Federica Pecci, Giuseppe Lamberti, Alessandro Di Federico, Adriana Barrichello, Victor R. Vaz, Malini Gandhi, Elinton Lee, Geoffrey I. Shapiro, Hyesun Park, Mizuki Nishino, James Lindsay, Kristen D. Felt, Bijaya Sharma, Andrew D. Cherniack, Scott Rodig, Daniel R. Gomez, Narek Shaverdian, Mehrdad Rakaee, Chaitanya Bandlamudi, Marc Ladanyi, Pasi A. Janne, Adam J. Schoenfeld, Lynette M. Sholl, Mark M. Awad, Michael L. Cheng
Summary: ATM is the most frequently mutated DNA damage and repair gene in non-small cell lung cancer (NSCLC). This study collected and analyzed clinicopathologic, genomic, and treatment data of NSCLC tumors. The results showed that 9.7% of NSCLC samples had deleterious ATM mutations, which were associated with female sex, ever smoking status, non-squamous histology, and higher tumor mutational burden. Patients with concurrent ATM/TP53 mutations showed significantly improved response rate and progression-free survival with PD-(L)1 monotherapy. These findings are important for guiding the interpretation of specific ATM mutations in NSCLC.
CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Huan Ma, Siyu Jiang, Yinan Yuan, Ji Li, Yizhuo Li, Yanping Lv, Tengjiao Du, Jingqian Guan, Xizi Jiang, Lei Tian, Qianqian Zheng, Lianhe Yang, Qingchang Li
Summary: RUNX1, a member of the RUNX family, is involved in the regulation of non-small cell lung cancer. It promotes cell proliferation and migration via the mTOR pathway and may serve as a potential therapeutic target for NSCLC.
Article
Medicine, Research & Experimental
Zhihua Teng, Jie Yao, Ling Zhu, Lufeng Zhao, Gang Chen
Summary: This study revealed that ZNF655 is abundantly expressed in NSCLC, and its knockdown can inhibit the malignant behaviors of tumor cells, leading to decreased tumorigenesis. ZNF655 may regulate apoptosis of NSCLC cells through the PI3K/Akt and p53 signaling pathways.
Article
Oncology
Juan Li, Aiqin Gao, Fang Zhang, Shuyun Wang, Jingnan Wang, Jing Wang, Shuyi Han, Zijiang Yang, Xiaozheng Chen, Yuying Fang, Guosheng Jiang, Yuping Sun
Summary: ILT3, an immunosuppressive molecule, is enriched in NSCLC cells and promotes tumor cell migration, invasion, and angiogenesis, potentially serving as a poor prognostic factor for NSCLC patients.
Article
Plant Sciences
Mohd Adnan, Arif Jamal Siddiqui, Walid Sabri Hamadou, Mejdi Snoussi, Riadh Badraoui, Syed Amir Ashraf, Arshad Jamal, Amir Mahgoub Awadelkareem, Manojkumar Sachidanandan, Sibte Hadi, Mushtaq Ahmad Khan, Mitesh Patel
Summary: This study demonstrated that ethanol crude extract of S. repanda inhibited the growth, adhesion, migration, and invasion of human non-small-cell lung and colorectal cancer cells. The anti-metastatic properties of S. repanda may be associated with the inhibition of MMP-2/-9 expression. These findings suggest that S. repanda could be a potential source of anti-metastasis agents in cancer therapy.
Article
Cell Biology
Changhui Li, Jiaqi Zhang, Xiaohua Yang, Cheng Hu, Tianqing Chu, Runbo Zhong, Yinchen Shen, Fang Hu, Feng Pan, Jianlin Xu, Jun Lu, Xiaoxuan Zheng, Hai Zhang, Wei Nie, Baohui Han, Xueyan Zhang
Summary: The study has demonstrated the significant role of hsa_circ_0003222 in NSCLC progression and resistance, with its high expression associated with disease stage, metastasis, and patient survival rate. Silencing hsa_circ_0003222 led to reduced stemness-like properties and chemoresistance in tumor cells.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Yitong Xu, Chenglong Wang, Xizi Jiang, Yao Zhang, Hongbo Su, Jun Jiang, Hongjiu Ren, Xueshan Qiu
Summary: KLHL38 plays a promoting role in non-small cell lung cancer, enhancing cell proliferation, migration, and invasion through activating the Akt signaling pathway, and is closely associated with the malignancy of tumors.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Suwen Ou, Haipeng Chen, Hufei Wang, Jinhua Ye, Huidi Liu, Yangbao Tao, Songlin Ran, Xiaoqin Mu, Fangzhou Liu, Shuang Zhu, Kangjia Luo, Zilong Guan, Yinghu Jin, Rui Huang, Yanni Song, Shu-lin Liu
Summary: The study found that Fusobacterium nucleatum (F. nucleatum) can promote migration and metastasis of colorectal cancer (CRC) cells by upregulating Matrix metalloproteinase 7 (MMP7), and F. nucleatum and MMP7 may serve as potential therapeutic targets for suppressing CRC progression and metastasis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Jerome Levallet, Tiphaine Biojout, Celine Bazille, Manon Douyere, Fatemeh Dubois, Dimitri Leite Ferreira, Jasmine Taylor, Sylvain Teulier, Jerome Toutain, Nicolas Elie, Myriam Bernaudin, Samuel Valable, Emmanuel Bergot, Guenaelle Levallet
Summary: The over-activation of NDR2 kinase under hypoxia conditions promotes brain metastasis formation in NSCLC. NDR2 expression serves as a reliable indicator for predicting the risk of metastasis in NSCLC patients.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Hongli Pan, Zhenhua Pan, Fengjie Guo, Fanrong Meng, Lingling Zu, Yaguang Fan, Yang Li, Mengjie Li, Xinxin Du, Xiuwen Zhang, Yi Shao, Mingming Wei, Xuebing Li, Qinghua Zhou
Summary: miR-1915-3p functions as a tumor suppressor in NSCLC by targeting SET, inhibiting tumor migration and invasion. Its expression is regulated by the METTL3/YTHDF2/KLF4 axis.
Article
Oncology
Xiao Liu, Rui Li, Xiao Chen, Jie Yao, Qingxiang Wang, Jinghong Zhang, Yuanyuan Jiang, Yiqing Qu
Summary: In this study, the researchers conducted a comprehensive pancancer analysis of SYT7, revealing its role in tumor exosome secretion and its mechanism in promoting invasion and metastasis of NSCLC cells through the activation of the mTOR signaling pathway.
Review
Food Science & Technology
Lvting Fan, Qin Ye, Wenjing Lu, Di Chen, Cen Zhang, Lihan Xiao, Xianghe Meng, Yi-Chieh Lee, Hui-Min David Wang, Chaogeng Xiao
Summary: This article provides an overview of the structural characteristics, physiological functions, and applications of slow digestion starch (SDS) and resistant starch (RS) in the food industry. It also compares the preparation methods of functional starch from different plant sources. The lack of standardization in experimental methods has led to significant differences in research results, hindering the development of starch processing technology.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Surgery
Hao-Wei Kou, Chun-Nan Yeh, Chun-Yi Tsai, Chao-Wei Lee, Jun-Te Hsu, Shang-Yu Wang, Ming-Chin Yu, Wen-Hsin Chen, Chien-Chih Chiu, Tsann-Long Hwang
Summary: Sutureless omentopexy is a safe and reliable technique that reduces the risk of catheter dysfunction caused by omental wrapping, providing clinical benefits.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Biotechnology & Applied Microbiology
Wei-Chih Lien, Xin-Ran Zhou, Ya-Jyun Liang, Congo Tak-Shing Ching, Chia-Yih Wang, Fu- Lu, Huei-Cih Chang, Feng-Huei Lin, Hui-Min David Wang
Summary: Nanoceria (cerium oxide nanoparticles [CNPs]) may prevent the development of urological chronic pelvic pain syndrome (UCPPS) by scavenging reactive oxygen species (ROS) and downregulating SerpinB2, thus modulating the immune response in UCPPS.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Richa Pandey, Feng-Shuo Yang, Vyshnav Punnath Sivasankaran, Yu-Lun Lo, Yi-Ting Wu, Chia-Yu Chang, Chien-Chih Chiu, Zi-Xian Liao, Li-Fang Wang
Summary: This study developed a gene delivery method using magnetic nanoparticles as carriers to deliver miRNA34a and downregulate PD-L1 expression in cancer cells. The results showed successful delivery of miRNA34a using magnetic nanoparticles and significant knockdown of the PD-L1 gene.
Article
Oncology
Wei-Ting Chen, Yuan-Hsin Tsai, Peggy Tan, Fei-Ting Hsu, Hui-Min David Wang, Wei-Chin Lin, Feng-Huei Lin, Ching-Te Wu
Summary: Osteosarcoma is a common bone malignancy with high metastatic characteristics and poor prognosis. Fluoxetine, an anti-depressant, has been shown to have antitumor potential. In this study, fluoxetine was found to induce cytotoxicity and apoptosis in osteosarcoma cells, while also suppressing metastasis and angiogenesis by targeting STAT3.
ANTICANCER RESEARCH
(2023)
Review
Immunology
Sheng-Kai Hsu, Yi-En Chen, En-De Shu, Ching-Chung Ko, Wen-Tsan Chang, I. -Ling Lin, Chia-Yang Li, Rovelyn P. Gallego, Chien-Chih Chiu
Summary: Gasdermins (GSDMs) are a family of proteins encoded by six paralogous genes in humans, which play key roles in apoptosis and immune response. They can form pores and release proinflammatory cytokines and damage-associated molecular patterns on the cell membrane, thereby regulating anti-tumor immune response. In addition, GSDMs also play non-apoptotic roles in tumor development. Therefore, GSDMs may be potential therapeutic targets.
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
(2023)
Review
Oncology
Sheng-Kai Hsu, Mahendra Jadhao, Wei-Ting Liao, Wen-Tsan Chang, I-Ling Lin, Chien-Chih Chiu
Summary: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal malignancy that is often diagnosed at a late stage, leading to poor clinical outcomes despite advances in cancer therapeutics. Exosomes, small extracellular vesicles, have been found to have specific surface markers that can distinguish PDAC patients from healthy individuals. Detectable in various bodily fluids, exosomes hold promise as liquid biopsies for early detection and monitoring of PDAC. This review highlights the role of exosomes in PDAC progression and their potential as diagnostic and prognostic biomarkers.
Article
Immunology
Chien-Chih Chiu, Kai-Chun Cheng, Yi-Hsiung Lin, Chen-Xi He, Yung-Ding Bow, Chia-Yang Li, Chang-Yi Wu, Hui-Min David Wang, Shwu-Jiuan Sheu
Summary: Chronic hyperglycemia leads to retinal degeneration and disorders like diabetic retinopathy. In this study, a model of prolonged high-glucose exposure was established to investigate its effects on RPE cells. The results showed that prolonged high-glucose exposure caused oxidative stress, DNA damage, and premature senescence in RPE cells.
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
(2023)
Article
Oncology
Yung-Ding Bow, Ching-Chung Ko, Wen-Tsan Chang, Sih-Yan Chou, Chun-Tzu Hung, Jau-Ling Huang, Chih-Hua Tseng, Yeh-Long Chen, Ruei-Nian Li, Chien-Chih Chiu
Summary: This study found that DFIQ not only promotes apoptosis in non-small cell lung cancer cells, but also sensitizes cells to ferroptosis by disrupting autophagic flux, leading to the accumulation of dysfunctional mitochondria. Ferroptosis is a novel therapeutic target in cancer therapy and DFIQ has the potential to enhance the effects of treatment in non-small cell lung cancer.
CANCER CELL INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Jen-Yang Tang, Ya-Ting Chuang, Jun-Ping Shiau, Ching-Yu Yen, Fang-Rong Chang, Yi-Hong Tsai, Ammad Ahmad Farooqi, Hsueh-Wei Chang
Summary: This review focuses on the regulating effects of natural products on miRNAs to assess the potential impacts of radiomodulation and exosome biogenesis for both the radiosensitization of cancer cells and the radioprotection of non-cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Kai-Chun Cheng, Chien-Chih Chiu, Kuo-Jen Chen, Yo-Chen Chang
Summary: This study aimed to investigate the safety and effectiveness of intravitreal aflibercept in patients with acute nonarteritic anterior ischemic optic neuropathy (NAION). The results showed that intravitreal aflibercept significantly improved visual acuity and resolved disc edema in patients with acute NAION, suggesting it may be an alternative treatment. However, further large-scale investigations are needed to evaluate the long-term therapeutic benefit and safety.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cell Biology
Howida M. Nail, Chien-Chih Chiu, Chung-Hang Leung, Mahmoud M. M. Ahmed, Hui-Min David Wang
Summary: Extracellular communication plays a crucial role in an organism's survival, and one method of communication is through extracellular vesicles called exosomes. These vesicles contain important molecules such as lipids, proteins, DNA, mRNA, and microRNAs, and are secreted by all types of cells, including immune cells and tumor cells. The tumor microenvironment is a complex network that supports tumor growth and includes various components, including exosomes and cytokines. This review focuses on the latest discoveries regarding the communication of the immune system and other cell types, specifically examining the role of exosomal microRNAs in macrophages, dendritic cells, B lymphocytes, and T lymphocytes, as well as their impact on the tumor microenvironment and immunomodulation.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Article
Chemistry, Medicinal
Pin-Keng Shih, Pei-Yuan Lee, Hui Min David Wang, Chung Yi Chen
CHEMISTRY OF NATURAL COMPOUNDS
(2023)
Article
Chemistry, Applied
Cam Thi Hong Tran, Hui-Min David Wang, Le Thi Hong Anh, Chitsan Lin, Chun-Yung Huang, Chia-Hung Kuo
Summary: This study evaluates the impact of beta-cyclodextrin on the properties of bitter gourd extract under different heating conditions. It is found that beta-cyclodextrin mitigates the effect of heat treatment on the bitter gourd extract, improving its thermal stability and creating opportunities for its incorporation into heat-processed products.
