Article
Biochemistry & Molecular Biology
Zhipeng Yu, Li Wang, Sijia Wu, Wenjun Xue, Wenzhu Zhao, Jianrong Li
Summary: This study used a non-targeted metabolomics approach to investigate the anti-hypertensive effects of RVPSL on SHRs. The results suggested that RVPSL potentially alleviated hypertension in SHRs mainly through integrated regulations of metabolism and production of specific metabolites.
Article
Nutrition & Dietetics
Huimin Guo, Yuqiong Hao, Xin Fan, Aurore Richel, Nadia Everaert, Xiushi Yang, Guixing Ren
Summary: In this study, administration of quinoa protein in spontaneously hypertensive rats (SHRs) resulted in decreased blood pressure, altered gut microbiota composition, and similarity in microbial structure to non-hypertension rats. These findings suggest the potential of quinoa protein in lowering blood pressure and ameliorating hypertension-related gut dysbiosis.
Article
Agriculture, Multidisciplinary
Zhipeng Yu, Wenjun Xue, Mingjie Zhou, Li Wang, Sijia Wu, Wenzhu Zhao, Long Ding
Summary: The study revealed that the ACE inhibitory peptide QIGLF derived from egg white may exert antihypertensive effects by improving endothelial dysfunction, providing a theoretical basis for future research and application of ACE inhibitory peptides in the prevention and improvement of hypertension.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Se Yeong Park, Eun Woo Jeong, Yun Sun Yang, Hyun-Joo Kim, Gwang-woong Go, Hyeon Gyu Lee
Summary: Finger millet ethanol extracts (FEs) exhibit lipid-lowering, antioxidant, renin-angiotensin system-controlling, and vascular remodeling-improving effects in spontaneously hypertensive rats (SHRs), significantly reducing systolic blood pressure.
Article
Agriculture, Multidisciplinary
Talia Franco-Avila, Rocio Moreno-Gonzalez, M. Emilia Juan, Joana M. Planas
Summary: The intake of table olives was found to decrease blood pressure in hypertensive rats without affecting body weight, while showing no significant effects on normotensive rats. This could be attributed to the presence of polyphenols and triterpenes in olives, which have been known to have blood pressure-lowering properties.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Nutrition & Dietetics
Shohei Yamaguchi, Yuzumi Hayasaka, Miho Suzuki, Wenhao Wang, Masahiro Koyama, Yasuko Nagasaka, Kozo Nakamura
Summary: This study demonstrates that low-dose orally administered ACh can lower blood pressure in spontaneously hypertensive rats by acting on gastrointestinal M3 muscarinic ACh receptors to increase afferent vagal nerve activity, resulting in decreased sympathetic nervous activity and noradrenaline release.
Article
Food Science & Technology
Jeanett Chavez-Ontiveros, Cuauhtemoc Reyes-Moreno, Giovanni Isai Ramirez-Torres, Oscar Gerardo Figueroa-Salcido, Jesus Gilberto Aramburo-Galvez, Alvaro Montoya-Rodriguez, Noe Ontiveros, Edith Oliva Cuevas-Rodriguez
Summary: This study evaluated the antihypertensive potential of chickpea protein hydrolysates and found that the hydrolysate obtained after extrusion had a stronger antihypertensive effect. This has implications for the design and production of functional foods for preventing hypertension or adjunct treatment.
Article
Immunology
Xiaohua Li, Changhong Ren, Sijie Li, Wenbo Zhao, Peifu Wang, Xunming Ji
Summary: This study investigates the effect of limb remote ischemic conditioning (LRIC) on blood pressure regulation in spontaneously hypertensive rats (SHR) by modulating the hypertensive inflammatory response. The results demonstrate that LRIC lowers blood pressure in SHR by reducing the percentage of monocytes and CD8 T cells, as well as decreasing pro-inflammatory cytokine levels.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Plant Sciences
Ping Zhang, Dongfeng Li, Jinfang Zhu, Jianglan Hu
Summary: This study evaluates the antihypertensive effects of Pleurospermum lindleyanum aqueous extract (PLAE) in spontaneously hypertensive rats (SHRs). It is found that PLAE significantly reduces the systolic blood pressure of SHRs and has protective effects on renal and cardiac injury, reduces the levels of vasoconstrictors, increases nitric oxide and superoxide dismutase activity.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Jingjing Dong, Shen Wang, Xiaoyao Yin, Min Fang, Zhiyong Gong, Yongning Wu
Summary: This study investigated the antihypertensive effect of rice peptide (RP) and revealed its mechanism of action. The results demonstrated that RP could effectively reduce systolic blood pressure in hypertensive rats, potentially through regulating the renin-angiotensin system and nitric oxide release.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Food Science & Technology
Hongbing Fan, Kaiyu Wu, Jianping Wu
Summary: This study found that although the pea-derived tripeptide LRW has stronger ACE inhibitory activity and anti-inflammatory activity, its oral bioavailability is low and it cannot reduce blood pressure in spontaneously hypertensive rats.
Article
Nutrition & Dietetics
Hui Chen, Yu Chen, Huizhen Zheng, Xingwei Xiang, Lu Xu
Summary: In this study, a novel peptide AEYLCEAC with high ACE inhibitory activity was identified from oyster hydrolysates. It exhibited stronger binding to ACE compared to the positive drug phosphoinic tripeptide. In vitro experiments showed that AEYLCEAC had the highest ACE inhibition rate with a competitive inhibitory type. Molecular docking analysis revealed that the ACEI activity of AEYLCEAC was mainly attributed to its hydrogen bonding interactions with the active pockets of ACE. In addition, AEYLCEAC effectively reduced blood pressure in hypertensive rats.
FRONTIERS IN NUTRITION
(2022)
Article
Agriculture, Multidisciplinary
Songmin Cao, Zixu Wang, Lujuan Xing, Lei Zhou, Wangang Zhang
Summary: This study evaluated the effects of bovine bone gelatin-derived peptides (BGPs) on hypertension in rats and found that they significantly reduced blood pressure and improved dyslipidemia, suggesting their potential as a nutraceutical for hypertension and dyslipidemia.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Endang Kumolosasi, Cheng Chen Wei, Anis Zafiqa Abdullah, Nur Syahirah Abd Manap, Woon Lee Lee, Mohd Hanif Yusuf, Lo Shin Ying, Fhataheya Buang, Mazlina Mohd Said, Hazni Falina Mohamad, Malina Jasamai
Summary: The study found that Moringa oleifera leaf extracts have hypotensive, diuretic, and ACE inhibitory activities, effective in spontaneously hypertensive rats but not in normotensive rats. These active extracts have the potential to be developed as dietary supplements for pre-hypertensive individuals.
Article
Biochemistry & Molecular Biology
Meng-Lu Xu, Bo Peng, Juan Bai, Lu Li, Yan Du, Zhi-Qiang Wang, Sha-Sha Li, Xiao-Xi Liu, Yuan-Yuan Dong, Jun-Zhe Wu, Ling-Xiao Xiong, Lei Chen, Hong-Bao Li, Hong-Li Jiang
Summary: This study found that diosgenin attenuates hypertension by modulating the gut microbiota and improving the gut-brain axis. It can prevent elevated blood pressure and cardiac hypertrophy, as well as improve the gut microbiota composition and intestinal integrity.
Article
Entomology
Qi Xue, Ericmar Avila Dos Santos, Guy Smagghe, Moises Joao Zotti, Clauvis Nji Tizi Taning
Summary: This review focuses on the engineering approaches that have been successfully employed to modify insect viruses and different microbes for the production and delivery of dsRNA. It discusses different viral vector systems and microbe-based production and delivery systems. The review also provides future perspectives on the development of improved delivery systems for insect pest control.
ENTOMOLOGIA GENERALIS
(2023)
Article
Agronomy
Jonathan Willow, Ana I. I. Silva, Clauvis Nji Tizi Taning, Guy Smagghe, Eve Veromann
Summary: Due to the growth of the medical Cannabis industry, this article discusses recent advancements in RNA interference (RNAi)-based crop protection research and development that can be applied to medical Cannabis cultivation. The increasing pest pressure in both indoor and outdoor Cannabis production systems, along with the need for effective nonchemical pest control methods for medical purposes, is considered. The development of RNAi strategies for protecting medical Cannabis is believed to play a significant role in maximizing success in this expanding industry. However, there are still knowledge gaps concerning the biosafety of RNA pesticides from a human toxicological perspective, given the medical context of Cannabis product use. Furthermore, further research is required to optimize Cannabis transformation and micropropagation, explore cutting-edge RNAi techniques for different Cannabis-pest scenarios, and investigate the combined application of RNAi and biological control methods in medical Cannabis cultivation.
PEST MANAGEMENT SCIENCE
(2023)
Article
Agronomy
Silva Sulg, Gabriella Kovacs, Jonathan Willow, Riina Kaasik, Guy Smagghe, Gabor L. Lovei, Eve Veromann
Summary: A field experiment in Estonia showed that if the distance from the previous year's oilseed rape (OSR) crop is over 500 meters, the infestation rates of pollen beetles and cabbage seed weevils in the current OSR fields are significantly reduced. The biocontrol provided by parasitic wasps is not greatly affected by distance. Spatial and temporal separation of OSR fields can effectively reduce pest pressure.
PEST MANAGEMENT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Patrick Willems, Valerie Van Ruyskensvelde, Takanori Maruta, Robin Pottie, Alvaro D. Fernandez-Fernandez, Jarne Pauwels, Matthew A. Hannah, Kris Gevaert, Frank Van Breusegem, Katrien Van der Kelen
Summary: Alternative splicing is an important gene regulatory process in plants, and its inhibition can alleviate cell death and enhance tolerance to oxidative stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Qun Yang, Guy Smagghe, An Staes, Kris Gevaert, Kristof De Schutter
Summary: Protein glycosylation is an important post-translational modification that affects protein properties. Insects utilize alpha-1,6-fucosyltransferase (FucT6) to modify N-glycan structures on glycoproteins. Silencing FucT6 in Nilaparvata lugens nymphs caused developmental failure and high mortality, highlighting its requirement during nymphal development. Silencing FucT6 in adults did not result in lethality, but parental RNAi led to complete failure in egg hatching, with FucT6 gene expression peaking during kata-trepsis event. This study emphasizes the crucial role of FucT6-mediated glycosylation in embryonic development and provides insights into N-glycosylation in insects.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tina Tuerlings, Amanda Hettiarachchi, Marie Joossens, Benoit Geslin, Nicolas J. J. Vereecken, Denis Michez, Guy Smagghe, Peter Vandamme
Summary: The study characterized the gut microbiota of invasive bee Megachile sculpturalis from native and invaded regions. The microbiota communities in bees from invaded regions were similar and different from those in Japan. Core amplicon sequence variants (ASVs) represented micro-organisms commonly present in bee-associated niches. The absence of known bee pathogens and presence of microparasite infections suggest a potential role of pathogen pressure and natural enemies in the invasion success of M. sculpturalis.
INSECT MOLECULAR BIOLOGY
(2023)
Article
Chemistry, Analytical
Maxime Gavage, Kaatje Van Vlierberghe, Marc Dieu, Patsy Renard, Thierry Arnould, Kris Gevaert, Marc De Loose, Christof Van Poucke, Anne-Catherine Huet, Nathalie Gillard
Summary: This interlaboratory study evaluated the potential of MS for food allergen detection and quantification using a standard addition quantification strategy and a stable isotope-labeled concatemer as an internal standard. Nine laboratories participated in the study and were able to detect allergens with sufficient sensitivity, although egg detection was more challenging. The encouraging results of this study contribute to harmonization among laboratories testing for allergens.
JOURNAL OF AOAC INTERNATIONAL
(2023)
Article
Ecology
Nicolas Leclercq, Leon Marshall, Geoffrey Caruso, Kerry Schiel, Timothy Weekers, Luisa G. Carvalheiro, Holger H. Dathe, Michael Kuhlmann, Denis Michez, Simon G. Potts, Pierre Rasmont, Stuart P. M. Roberts, Guy Smagghe, Peter Vandamme, Nicolas J. Vereecken
Summary: This study aims to depict the large-scale biodiversity patterns of wild bees in Europe and identify understudied species and areas for targeted conservation actions. The findings suggest that wild bee diversity is higher in xeric, warm areas and that protecting taxonomic richness may require different strategies than protecting phylogenetic diversity.
JOURNAL OF BIOGEOGRAPHY
(2023)
Review
Medicine, General & Internal
Laurence Verstraeten, Rutger Den Abt, Bart Ghesquiere, Ina Jochmans
Summary: This scoping review summarizes the current knowledge on kidney metabolism during hypothermic perfusion preservation. A total of 52 papers were included in this review, which covered studies on dogs, rabbits, pigs, and humans published between 1970 and 2023. The studies reported the use of different perfusates, oxygenation levels, kidney injury levels, and devices, and examined the perfusate and tissue metabolites. The findings suggest that kidneys remain metabolically active during hypothermic perfusion, regardless of the perfusion settings. However, the understanding of kidney metabolism during hypothermic perfusion is still incomplete and influenced by various factors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Biotechnology & Applied Microbiology
Ruobing Guan, Tong Li, Guy Smagghe, Xuexia Miao, Haichao Li
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biodiversity Conservation
Paulo de Sousa, Andre Henriques, Sara E. Silva, Luisa G. Carvalheiro, Guy Smagghe, Denis Michez, Thomas J. Wood, Octavio S. Paulo
Summary: We used a population genomic approach to study three wild bee species in the Iberian Peninsula and found genetic differentiation and diversity across different locations. The results showed a consistent pattern across species, suggesting the presence of refugia within the region. The genetic differentiation and diversity were influenced by life-history traits and past climate changes, indicating the importance of the Iberian refugia as a biodiversity hotspot.
Review
Microbiology
Dongdong Liu, Guy Smagghe, Tong-Xian Liu
Summary: This review examines the use of entomopathogenic fungi (EPF) as potential alternatives to synthetic insecticides, with a focus on Beauveria bassiana and Metarhizium anisopliae. The paper discusses the global application of B. bassiana- and M. anisopliae-based biopesticides and investigates the mechanism by which EPF interacts with insects, including the penetration of the cuticle and subsequent host death. The interactions between EPF and the insect microbiome, as well as the enhancement of the insect immune response, are summarized. Recent research suggesting a role for N-glycans in eliciting an immune response and reducing insect midgut permeability is also presented. Overall, this paper provides an overview of EPF in insect control and highlights recent developments in the interaction between fungi and insect immunity.
Article
Biochemistry & Molecular Biology
Henry Shaykins Mwaka, Lander Bauters, Josephine Namaganda, Shirley Marcou, Priver Namanya Bwesigye, Jerome Kubiriba, Guy Smagghe, Wilberforce Kateera Tushemereirwe, Godelieve Gheysen
Summary: The burrowing nematode Radopholus similis is a major problem in banana cultivation, causing extensive root damage and toppling disease. This study showed that soaking R. similis in double-stranded RNA of specific nematode genes suppressed its reproduction. By transforming a banana cultivar with constructs for expression of RNA against these genes, the researchers found that the transgenic plants had lower nematode multiplication and root damage compared to non-transgenic controls or plants expressing nonendogenous gene RNA. This suggests that RNAi can effectively protect banana against R. similis damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Horticulture
Constantin Dushimimana, Katrijn Van Laere, Titus Magomere, Guy Smagghe, Stefaan P. O. Werbrouck
Summary: Polyploidy was induced in Melia volkensii through treatment of cotyledons with oryzalin. Treatment for 3 hours resulted in 40% tetraploids, and pre-treatment with thidiazuron increased the tetraploid production rate to 52.5%.
Article
Microbiology
Juliana Botero, Atena Sadat Sombolestani, Margo Cnockaert, Charlotte Peeters, Wim Borremans, Luc De Vuyst, Nicolas J. Vereecken, Denis Michez, Guy Smagghe, German Bonilla-Rosso, Philipp Engel, Peter Vandamme
Summary: This study provides insights into the diversity and function of Commensalibacter bacteria in various insect species. Through analysis of their whole-genome sequences, it was found that Commensalibacter strains can be classified into four species, which share similar genetic pathways for central metabolism. However, there are differences in genome size, G+C content, amino acid metabolism, and carbohydrate-utilizing enzymes among these species. Notably, the study on the Western honey bee symbiont, C. melissae, revealed its unique characteristics such as reduced genome size and a large number of species-specific gene clusters.
