Review
Biochemistry & Molecular Biology
Kozo Nakai, Daisuke Tsuruta
Summary: Oxygen in the atmosphere is vital for human life, but the metabolites ROS, produced in excess, can exacerbate skin aging and inflammation. Excessive exposure to air pollutants and other harmful substances can stimulate the production of ROS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Joanna Nowaczyk, Barbara Poniedzialek, Piotr Rzymski, Dominika Sikora, Mariola Ropacka-Lesiak
Summary: This study aimed to evaluate platelet parameters in pregnant women with fetal growth restriction (FGR) and their relationship with hemodynamic abnormalities. The study found that FGR patients had impaired oxidative metabolism in platelets, which may lead to oxidative stress and impaired platelet function.
Article
Clinical Neurology
Moinay Kim, Joonho Byun, Yeongu Chung, Si Un Lee, Ji Eun Park, Wonhyoung Park, Jung Cheol Park, Jae Sung Ahn, Seungjoo Lee
Summary: Administering ROS scavengers to patients with acute ICH significantly reduced PHE volume, shortened time to reach target Richmond Agitation Sedation Scale, and reduced length of stay in the intensive care unit.
Article
Medicine, Research & Experimental
Caio Pupin Rosa, Thiago Caetano Andrade Belo, Natalia Cristina de Melo Santos, Evandro Neves Silva, Juciano Gasparotto, Patricia Paiva Corsetti, Leonardo Augusto de Almeida
Summary: Intracellular production of reactive oxygen species (ROS) plays a significant role in both the lethal effects on microorganisms and the regulation of inflammation and metabolism. Various microorganisms have been found to modulate the assembly or disruption of inflammasomes through ROS production. This process is a significant milestone in our understanding of the immunology of intracellular pathogens.
Article
Biochemistry & Molecular Biology
Anton G. Rogov, Tatiana N. Goleva, Khoren K. Epremyan, Igor I. Kireev, Renata A. Zvyagilskaya
Summary: Mitochondria are considered the primary source of ROS in cells, with ROS-induced ROS release triggered in cardiac myocytes under excessive oxidative stress. Using Dipodascus magnusii yeast cells, it was found that prooxidant-induced oxidative stress begins in mitochondria before spreading to the whole cell, with mitochondrial ROS leading to mitochondrial fragmentation.
Article
Engineering, Biomedical
Bijun Zhu, Jiangjiexing Wu, Tong Li, Songtao Liu, Junheng Guo, Yijun Yu, Xinyi Qiu, Yue Zhao, Haoran Peng, Jinli Zhang, Leiying Miao, Hui Wei
Summary: In this study, the use of MVF nanozyme as a precise regulator of ROS in periodontitis is proposed. By selectively eliminating H2O2, the most prominent ROS, MVF contributes to limiting inflammation, regulating immune microenvironment, promoting periodontal regeneration, and stimulating osteogenic differentiation of periodontal stem cells. MVF regulates ROS through the Nrf2/HO-1 pathway and promotes osteogenic differentiation through the PI3K/Akt pathway. Nanozymes have the potential to be an important precision medicine tool in periodontitis therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen
Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Masuko Ushio-Fukai, Dipankar Ash, Sheela Nagarkoti, Eric J. Belin de Chantemele, David J. R. Fulton, Tohru Fukai
Summary: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play important roles as signaling molecules at physiological levels, but excess levels are associated with cardiovascular disease. Cells regulate ROS and RNS levels by controlling metabolic pathways, with implications for disease treatment strategies.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Yoon-Seok Seo, Jung-Min Park, Jae-Hyeong Kim, Moo-Yeol Lee
Summary: Smoking is a significant risk factor for various diseases due to the production of excessive reactive oxygen species (ROS). This review focuses on how cigarette smoke promotes the formation of ROS and provides key mechanisms involved.
Article
Engineering, Environmental
Steven Lelieveld, Jake Wilson, Eleni Dovrou, Ashmi Mishra, Pascale S. J. Lakey, Manabu Shiraiwa, Ulrich Poeschl, Thomas Berkemeier
Summary: Air pollutants such as aerosols and ozone can cause the generation of reactive oxygen species in the human respiratory tract, leading to oxidative stress and adverse health effects.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sulagna Dutta, Pallav Sengupta, Sanghamitra Das, Petr Slama, Shubhadeep Roychoudhury
Summary: Reactive nitrogen species (RNS) play important roles in male reproduction, but excessive levels can impair fertility by affecting testicular functions and compromising semen quality. High RNS levels lead to abnormalities in germ cells and gametes, and severely impact maturation and fertilization processes. Conventional semen analyses are not reliable predictors for assisted reproductive technology outcomes in cases of male infertility, highlighting the need for novel assessment and treatment methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Katerina Hadrava Vanova, Chunzhang Yang, Leah Meuter, Jiri Neuzil, Karel Pacak
Summary: Pheochromocytoma (PHEO) and paraganglioma (PGL) are rare neuroendocrine tumors derived from neural crest cells, with a subset of patients at risk for metastatic disease, especially those with succinate dehydrogenase subunit B mutations. These tumors exhibit redox imbalance, suggesting therapeutic strategies targeting reactive oxygen species production may be promising.
Review
Biochemistry & Molecular Biology
Prima Buranasin, Hiromi Kominato, Koji Mizutani, Risako Mikami, Natsumi Saito, Kohei Takeda, Takanori Iwata
Summary: Diabetes mellitus is associated with periodontal disease and affects the efficacy of periodontal treatment. Increased reactive oxygen species (ROS) production in periodontal tissues of diabetic patients contributes to insulin resistance and impairs wound healing and tissue repair. Antioxidants and insulin resistance ameliorants may improve wound healing by inhibiting ROS production. This review comprehensively examines the latest evidence on ROS generation in periodontal tissues, particularly related to microbial challenge and diabetes, and discusses the impact of oxidative stress on wound healing in periodontal and dental implant therapies, as well as the potential benefits of administering antioxidants and anti-insulin resistance medications to counteract ROS production and inflammation.
Article
Chemistry, Applied
Shanshan Li, Hong Chen, Wei Cheng, Kuan Yang, Lisha Cai, Linfeng He, Lei Du, Yuntao Liu, Aiping Liu, Zhen Zeng, Cheng Li
Summary: The study found that arabinoxylan (AX) can improve the physical and oxidative stability of oil-in-water emulsions, reducing peroxide value and thiobarbituric acid reactive substance concentration. The antioxidant capacity of AX in emulsions varies depending on its source, with AX from rice bran showing slightly better results.
Article
Environmental Sciences
James Olukayode Olopade, Oluwaseun Ahmed Mustapha, Olanrewaju Ifeoluwa Fatola, Ejiro Ighorodje, Oluwabusayo Racheal Folarin, Funmilayo Eniola Olopade, Irene Chizubelu Omile, Adedunsola Ajike Obasa, Ademola Adetokunbo Oyagbemi, Matthew Ayokunle Olude, Alana Maureen Thackray, Raymond Bujdoso
Summary: Pollution by heavy metals poses a threat to public health, especially the brain. This study used African giant rats as sentinel hosts to evaluate the impact of heavy metal accumulation on the brain. Zinc, copper, and iron were found to be the major heavy metals in the brain and serum of the rats, with iron levels being the highest in animals from oil-polluted areas. Brain pathology, including inflammation and oxidative stress, was most severe in rats from the most polluted region. The study suggests that local and contextual neuropathologies can result from environmental pollution, and highlights the African giant rat as a suitable sentinel for ecotoxicological studies.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Shana J. Cameron, Farah Hosseinian, William G. Willmore
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Biochemistry & Molecular Biology
Nasim Meshginfar, Alireza Sadeghi Mahoonak, Farah Hosseinian, Apollinaire Tsopmo
JOURNAL OF FOOD BIOCHEMISTRY
(2019)
Article
Food Science & Technology
Aynur Gunenc, Owen Rowland, Hengguang Xu, Alejandro Marangoni, Farah Hosseinian
LWT-FOOD SCIENCE AND TECHNOLOGY
(2019)
Article
Food Science & Technology
Yasmina Ait Chait, Aynur Gunenc, Farida Bendali, Farah Hosseinian
LWT-FOOD SCIENCE AND TECHNOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Yasmina Ait Chait, Aynur Gunenc, Farah Hosseinian, Farida Bendali
Summary: From 98 Lactobacillus strains isolated from Algerian homemade cheeses, 14 strains were selected for their anti-Escherichia coli and anti-Staphylococcus aureus activities, with 3 identified as Lactobacillus brevis exhibiting potential colonization capability and cholesterol-lowering activity. These results demonstrate the probiotic potential of Algerian artisanal cheeses and the potential use of L. brevis strains as probiotics for human use.
FOLIA MICROBIOLOGICA
(2021)
Review
Chemistry, Applied
Kelly Dornan, Aynur Gunenc, B. Dave Oomah, Farah Hosseinian
Summary: Odd chain fatty acids and odd chain phenolic lipids are considered candidate biomarkers for dietary analysis, with their ingestion being inversely related to chronic disease risks. Studying and understanding their role in disease prevention is essential, as low levels of dietary intake of these odd chain molecules may be linked to higher risks of chronic diseases or mortality. Additional research is needed to explore the relationship between reduced intake of odd chain fatty acids and phenolic lipids and susceptibilities to chronic diseases.
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Hengguang Xu, Aynur Gunenc, Farah Hosseinian
Summary: This study investigated the effects of ultrasound and autoclave on inulin properties in Jerusalem artichoke and chicory. The results showed that ultrasound treatment can effectively reduce the degree of polymerization of inulin, making it a promising method for designing various food formulations. Further research is needed to explore the relationship between inulin solution viscosity and depolymerization caused by ultrasound treatment.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Apollinaire Tsopmo, Farah Hosseinian
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Food Science & Technology
Feijie Li, Aynur Gunenc, Farah Hosseinian
FOOD PRODUCTION PROCESSING AND NUTRITION
(2020)
Article
Chemistry, Multidisciplinary
Moufida A. Oueslati, Justin Renaud, Rigane Ghayth, Aynur Gunenc, Ridha Ben Salem, Sadok Boukhchina, Farah Hussainian, Paul M. Mayer
REVUE ROUMAINE DE CHIMIE
(2019)
Article
Chemistry, Multidisciplinary
Moufida A. Oueslati, Aynur Gunenc, Ghayth Rigane, Hanen Ghazghazi, Caroline Valencia, Ridha Ben Salem, Sadok Boukhchina, Williamn G. Willmore, Farah Hosseinian
REVUE ROUMAINE DE CHIMIE
(2019)