Article
Biochemistry & Molecular Biology
Peng Wu, Ailian Liu, Yongyan Zhang, Kai Feng, Shuping Zhao, Liangjun Li
Summary: The study revealed that ABA induces upregulation of NnABI4 expression, which in turn promotes NnSS1 expression, enhancing starch accumulation in lotus rhizomes. This provides a crucial theoretical basis for studying the molecular mechanism of ABA regulation of starch synthesis in plants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Hong-Yu Lin, Cheng-Pei Chung, Shih-Min Hsia, Yu-Chia Chang, Wenchang Chiang, Yueh-Hsiung Kuo, Yun-Lian Lin
Summary: Lotus leaves contain valuable functional alkaloids that have inhibitory effects on free radicals and nitric oxide production. Five alkaloids were isolated and identified, with different compounds showing different activities. Compound 5, which accounted for a significant portion of total alkaloids, exhibited the highest DPPH radical-scavenging effect and also inhibited NO production through suppressing iNOS expression. The study suggests that alkaloid extracts from lotus leaves can be used as functional ingredients.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2023)
Article
Food Science & Technology
Yi-Ping Yu, Shu-Jung Lai, Chien-Ru Chang, Wen-Chi Chen, Shih-Hsiung Wu, Chun-Ping Lu
Summary: This study prepared lotus seed protein hydrolysate (LSPH) using Flavourzyme and evaluated its antioxidant activities. The results showed that the low molecular weight fragments generated from Flavourzyme hydrolysis of lotus seed protein have potential as nutraceutical or health promoting supplements due to their antioxidant activities.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Plant Sciences
Stefan Cerbin, Shujun Ou, Yang Li, Yanni Sun, Ning Jiang
Summary: The genome of the sacred lotus contains a high abundance of transposable elements (TEs), with hAT (Ac/Ds) elements being the most prevalent. The presence of non-canonical LTR retrotransposons in such abundance is unprecedented. TEs are particularly enriched in genic regions, leading to significant expansion of intron sizes. Some genes show lower association with TEs, while others are enriched with them, particularly those involved in epigenetic pathways.
Article
Biochemistry & Molecular Biology
Hui-Hsuan Lin, Jen-Ying Hsu, Chiao-Yun Tseng, Xiao-Yin Huang, Hsien-Chun Tseng, Jing-Hsien Chen
Summary: This study investigated the effect of lotus seedpod extract (LSE) on acetaminophen-induced liver toxicity. The results showed that LSE could enhance cell survival, reduce intracellular ROS levels, and decrease apoptosis. The underlying molecular mechanisms involved inhibition of inflammation and restoration of mitochondrial structure. These findings suggest that LSE could be a potential therapeutic option for acetaminophen overdose.
Article
Food Science & Technology
Ketsarin Intui, Pimchanok Nuchniyom, Jiraporn Laoung-on, Churdsak Jaikang, Ranida Quiggins, Paiwan Sudwan
Summary: This study aimed to investigate the effects of white Nelumbo nucifera petal tea on cognitive behavior, hippocampus histology, oxidative stress, and amino acid metabolism in rats poisoned with mancozeb. The results demonstrated that white Nelumbo nucifera petal tea has a neuroprotective effect against mancozeb.
Article
Chemistry, Applied
Jingxian Huang, Zhen Li, Wei Zhang, Zhuoyuan Lv, Shuying Dong, Yan Feng, Rongxia Liu, Yan Zhao
Summary: This study aims to investigate the feasibility of using metabolic profiles and explainable machine learning (ML) to trace the origin of different parts of the lotus. By systematically annotating and quantifying chemical compounds, an ML algorithm can be constructed. The use of the SHaply Additive exPlanation technique helps to understand the model's output, providing an explanatory tool for identifying the origin of lotus parts.
Article
Plant Sciences
Xiaohan Cao, Wenyang Wan, Huimin Mao, Dandan Yin, Xianhui Deng, Huan Yan, Liping Ren
Summary: This study provides the first comprehensive analysis of the Dof transcription factor family in lotus. A total of 29 potential NnDofs were identified through various analyses. The study reveals the expansion mechanism of the NnDofs gene family, speculates their potential functions in lotus development and stress conditions, and identifies salt stress-sensitive genes.
Article
Environmental Sciences
Shouhui Dai, Jing Qiu, Min Wang
Summary: The study revealed significant differences in the accumulation characteristics and chiral signatures of PCBs in lotus roots under different exposure concentrations, indicating that exposure concentrations can influence the enantioselective accumulation of chiral PCBs in lotus roots.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Plant Sciences
Jie Xiang, Rifat Nowshin Raka, Luocheng Zhang, Junsong Xiao, Hua Wu, Zhiqian Ding
Summary: Procyanidins from lotus seedpods have inhibitory effects on the activities of α-amylase, α-glucosidase, and PTP1B. The inhibition increases with the degree of polymerization and the existence of galloyl or gallocatechin units.
PLANT FOODS FOR HUMAN NUTRITION
(2022)
Review
Oncology
Anupam Bishayee, Palak A. Patel, Priya Sharma, Shivani Thoutireddy, Niranjan Das
Summary: Lotus is an aquatic perennial crop widely used as herbal medicine and functional food in Asia. It contains various bioactive compounds and has been traditionally used for treating fever, inflammation, and hypertension. This review critically evaluates the potential of lotus phytochemicals in cancer prevention and therapy, highlighting their mechanisms of action. The bioavailability, pharmacokinetics, and toxicity of lotus-derived phytochemicals, as well as current limitations and future research directions, are also discussed.
Article
Cell Biology
Chong Li, Yongpeng He, Yue Yang, Yuting Gou, Shuting Li, Rui Wang, Shi Zeng, Xin Zhao
Summary: The study identified various flavonoids in lotus leaf flavonoid extract (LLFE) and demonstrated its antioxidant and anti-inflammatory effects both in vitro and in vivo. LLFE reduced oxidative damage in cells and mice, increased antioxidant enzyme levels, and modulated cytokine expression levels, showing potential for therapeutic applications.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Food Science & Technology
Ting Min, Keyan Lu, Jinhui Chen, Lifang Niu, Qiong Lin, Yang Yi, Wenfu Hou, Youwei Ai, Hongxun Wang
Summary: Melatonin treatment was found to delay browning process of lotus root slices, improve antioxidant capacity, and suppress the growth of spoilage organisms. Metabolites involved in flavonoid biosynthesis, phenylpropanoid biosynthesis, tyrosine metabolism, and phenylalanine metabolism were also affected. These findings highlight the significance of melatonin in maintaining the freshness and quality of fresh-cut lotus root slices.
Review
Food Science & Technology
Zhenyu Wang, Yong Cheng, Maomao Zeng, Zhaojun Wang, Fang Qin, Yongzhi Wang, Jie Chen, Zhiyong He
Summary: Lotus leaves are widely used in food and health products, showing promising health-promoting activities such as anti-diabetes, anti-obesity, and anti-inflammation. However, more research and long-term clinical trials are needed to further understand their therapeutic effectiveness and applications.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Food Science & Technology
Jiaheng Li, Jiyong Shi, Tingting Wang, Xiaowei Huang, Xiaobo Zou, Zhihua Li, Di Zhang, Wen Zhang, Yiwei Xu
Summary: This study found that pulsed electric field (PEF) pretreatment significantly enhances water loss and NaCl gain in pickled lotus root slices, as well as improves appearance, flavor, and pickled degree of the samples. Therefore, PEF pretreatment is expected to be used before pickling processing to improve mass transfer efficiency and reduce costs.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Hyeong Seok Kim, Wookyeong Song, Wonho Choo, Sungyoung Lee, Youngmin Han, Claudio Bassi, Roberto Salvia, Giovanni Marchegiani, Christopher L. Wolfgang, Jin He, Alex B. Blair, Michael D. Kluger, Gloria H. Su, Song Cheol Kim, Ki-Byung Song, Masakazu Yamamoto, Takashi Hatori, Ching-Yao Yang, Hiroki Yamaue, Seiko Hirono, Sohei Satoi, Tsutomu Fujii, Satoshi Hirano, Wenhui Lou, Yasushi Hashimoto, Yasuhiro Shimizu, Marco Del Chiaro, Roberto Valente, Matthias Lohr, Dong Wook Choi, Seong Ho Choi, Jin Seok Heo, Fuyuhiko Motoi, Ippei Matsumoto, Woo Jung Lee, Chang Moo Kang, Yi-Ming Shyr, Shin-E Wang, Ho-Seong Han, Yoo-Seok Yoon, Marc G. Besselink, Nadine C. M. van Huijgevoort, Masayuki Sho, Hiroaki Nagano, Sang Geol Kim, Goro Honda, Yinmo Yang, Hee Chul Yu, Jae Do Yang, Jun Chul Chung, Yuichi Nagakawa, Hyung Il Seo, Seungyeoun Lee, Hongbeom Kim, Wooil Kwon, Taesung Park, Jin-Young Jang
Summary: A novel nomogram based on radiologic findings of intraductal papillary mucinous neoplasms (IPMN) was developed and compared with existing American and Korean/Japanese nomograms. The results showed that this nomogram performed better than the American nomogram and was comparable to the Korean/Japanese nomogram. This nomogram would be clinically helpful in situations where tumor markers are not available.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Cell Biology
Sheng-Mao Wu, Yee-Jee Jan, Shih-Chuan Tsai, Hung-Chuan Pan, Chin-Chang Shen, Cheng-Ning Yang, Shu-Hua Lee, Shing-Hwa Liu, Li-Wei Shen, Chien-Shan Chiu, Jack L. Arbiser, Menghsiao Meng, Meei-Ling Sheu
Summary: This study found that Honokiol can prevent the metastatic dissemination of gastric cancer cells by inhibiting HDAC3 activity/expression. The results suggest that Honokiol inhibits HDAC3 activity by suppressing the activation of the NF-Bp65/CEBPβ signaling pathway, thereby inhibiting the migration and invasion of cancer cells. In addition, Honokiol increases the expression of ER stress markers, inhibits the expression of EMT-associated epithelial markers, and decreases Wnt/β-catenin activity, thereby blocking the metastasis of gastric cancer.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jhe-Wei Lin, Yi-Chun Lin, Jui-Ming Liu, Shing-Hwa Liu, Kai-Min Fang, Ren-Jun Hsu, Chun-Fa Huang, Kai-Yao Chang, Kuan- Lee, Kai-Chih Chang, Chin-Chuan Su, Ya-Wen Chen
Summary: This study aimed to investigate the toxic effects of Norketamine (NK) and the potential mechanisms underlying NK-induced urothelial cell injury. The results showed that NK exposure significantly reduced cell viability, induced apoptosis, and caused mitochondrial dysfunction and endoplasmic reticulum (ER) stress. Additionally, NK exposure activated JNK, ERK1/2, and p38 signaling pathways and increased intracellular calcium concentrations. The findings suggest that regulating [Ca2+](i)/ERK signaling pathways may be a promising strategy for treating NK-induced urothelial cystitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ching-Yao Yang, Shing-Hwa Liu, Chin-Chuan Su, Kai-Min Fang, Tsung-Yuan Yang, Jui-Ming Liu, Ya-Wen Chen, Kai-Chih Chang, Haw-Ling Chuang, Cheng-Tien Wu, Kuan- Lee, Chun-Fa Huang
Summary: Methylmercury exposure leads to cytotoxicity in pancreatic beta-cells, affecting insulin secretion and cell viability. The mechanism involves activation of mitochondrial and endoplasmic reticulum stress pathways, resulting in apoptosis. Additionally, methylmercury induces JNK activation and reactive oxygen species generation, exacerbating cell damage and insulin secretion dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Shing-Hwa Liu, Yu-Xuan Chen, Huei-Ping Tzeng, Meng-Tsan Chiang
Summary: Low-carbohydrate and high-fat diets can cause lipid metabolism disturbance and fat accumulation, but fish oil supplementation can improve these adverse effects.
Article
Oncology
Li-Ching Lin, Wen-Kuan Huang, Chueh-Chuan Yen, Ching-Yao Yang, Meng-Ta Sung, Sean M. N. Wong, Daniel T. T. Chua, Sarah W. M. Lee, Jen-Shi Chen, Chun-Nan Yeh
Summary: The use of ripretinib in patients with advanced/metastatic GIST in Taiwan and Hong Kong showed efficacy consistent with the INVICTUS study, with low albumin levels and disease progression after ripretinib use being identified as unfavorable factors for PFS. Ripretinib was generally well-tolerated, with hair loss being the most common adverse event.
FRONTIERS IN ONCOLOGY
(2022)
Article
Toxicology
Yao-Pang Chung, Te- Weng, Ding-Cheng Chan, Rong-Sen Yang, Shing-Hwa Liu
Summary: This study found that TBT exposure can induce human chondrocyte senescence and accelerate mouse articular cartilage aging. TBT affects signaling pathways and has an impact on cell secretory phenotype, leading to changes in protein expression and mRNA expression.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Oncology
Chien-Hui Chan, Li-Wen Chiou, Tsai-Yu Lee, Yun-Ru Liu, Tsung-Han Hsieh, Ching-Yao Yang, Yung-Ming Jeng
Summary: The activation of PAK through cell-matrix interaction mediates resistance to sotorasib through the activation of MAPK and PI3K pathways.
BRITISH JOURNAL OF CANCER
(2023)
Article
Geriatrics & Gerontology
Hsien-Chun Chiu, Rong-Sen Yang, Te- Weng, Chen-Yuan Chiu, Kuo-Cheng Lan, Shing-Hwa Liu
Summary: This study demonstrates the significant inhibitory effects of low-dose TBT on myogenic differentiation and induction of myotube atrophy. It also shows that TBT exposure decreases muscle regeneration ability, reduces muscle mass and impairs muscle function. These findings suggest that low-dose TBT may be an environmental risk factor for muscle regeneration inhibition, atrophy/wasting, and disease-related myopathy.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Biochemistry & Molecular Biology
Wen-Shin Song, Tai-Ho Hung, Shing-Hwa Liu, Yin-Ting Zheng, Hsin-Mei Lin, Feng-Yi Yang
Summary: Systemic inflammation is linked to intestinal inflammation and neuroinflammation through the gut-brain axis. Low-intensity pulsed ultrasound (LIPUS) has neuroprotective and anti-inflammatory effects. This study demonstrates that abdominal LIPUS stimulation attenuates LPS-induced colonic inflammation and neuroinflammation, offering new insights into the treatment of neuroinflammation-related brain disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Chen-Yu Lin, Te- Weng, Jui-Zhi Loh, Ding-Cheng Chan, Chih-Kang Chiang, Kuan-Yu Hung, Shing-Hwa Liu
Summary: Low-intensity pulsed ultrasound (LIPUS) is a therapeutic ultrasound that can aid in bone fracture repair and soft tissue healing. This study aimed to investigate the protective potential of LIPUS on CKD-associated muscle wasting. The results showed that LIPUS treatment effectively improved muscle strength, prevented muscle mass loss, and reduced muscle atrophy-related protein expression in CKD mice.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kuo-Cheng Lan, Pei-Jin Peng, Ting-Yu Chang, Shing-Hwa Liu
Summary: This study aimed to explore the role of AGEs in renal function decline in the elderly and the protective effect of resveratrol, and to compare it with aminoguanidine as an AGEs inhibitor. The results showed that the administration of D-galactose significantly increased serum levels of AGEs and renal function markers, which could be reversed by treatment with aminoguanidine or resveratrol. These findings suggest that resveratrol could alleviate AGEs-related renal dysfunction through the improvement of renal cellular senescence, apoptosis, and fibrosis.
Article
Infectious Diseases
Feng-Chen Chen, Ahmad Khaldun Ismail, Yan-Chiao Mao, Chih-Hsiung Hsu, Liao-Chun Chiang, Chang-Chih Shih, Yuan-Sheng Tzeng, Chin-Sheng Lin, Shing-Hwa Liu, Cheng-Hsuan Ho
Summary: Snakebite patients bitten by Protobothrops mucrosquamatus commonly experience pain, swelling and blister formation. The effectiveness of FHAV in treating local tissue injury is still uncertain. A study conducted from 2017 to 2022 found that patients with greater swelling and higher severity received higher doses of FHAV and had longer remission times. The study also suggested that monitoring the deceleration of swelling progression can help clinicians decide on FHAV administration.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Li-Ting Tsai, Te- Weng, Ting-Yu Chang, Kuo-Cheng Lan, Chih-Kang Chiang, Shing-Hwa Liu
Summary: The accumulation of the uremic toxin indoxyl sulfate (IS) is a key pathological feature of chronic kidney disease (CKD). Exposure to IS can induce ferroptosis, characterized by iron accumulation, impaired antioxidant system, elevated reactive oxygen species (ROS) levels, and lipid peroxidation. IS triggers intracellular iron accumulation and ROS generation, leading to the induction of ferroptosis, senescence, ER stress, and injury/fibrosis in CKD kidneys.