Article
Multidisciplinary Sciences
Bara Lo, Nathalie Marty-Gasset, Helene Manse, Cecile Canlet, Renaud Domitile, Herve Remignon
Summary: This study examined the differences in liver metabolism between low-weight and high-weight liver samples. The results showed that increased liver weight is associated with higher glucose uptake, greater lipid synthesis, and a decline in the level of export of triglycerides and cholesterol from the liver. Furthermore, the increase in liver weight could lead to a decrease in aerobic energy metabolism efficiency and an increase in oxidative stress.
Article
Physiology
Zohre Mozduri, Nathalie Marty-Gasset, Bara Lo, Ali Akbar Masoudi, Mireille Morisson, Cecile Canlet, Julien Arroyo, Agnes Bonnet, Cecile M. D. Bonnefont
Summary: This study aimed to identify biomarkers of liver weight and technological yield in duck foie gras using non-invasive biomarkers. Significant biomarkers were identified, with lactate being the most important biomarker in the study.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Physiology
Zohre Mozduri, Bara Lo, Nathalie Marty-Gasset, Ali Akbar Masoudi, Julien Arroyo, Mireille Morisson, Cecile Canlet, Agnes Bonnet, Cecile M. D. Bonnefont
Summary: This study identified biomarkers of foie gras qualities, showing a negative correlation between liver weight and technological yield. The metabolism of heavy livers tends to reduce carbohydrate and amino acid metabolisms, affecting the technological quality of foie gras.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Chemistry, Applied
Luigia Di Stasio, Leonardo Sciammaro, Salvatore De Caro, Maria Victoria Salinas, Maria Cecilia Puppo, Gianfranco Mamone
Summary: In this study, the proteome composition of pistachio seeds was investigated using various proteomics analyses. The results identified proteins belonging to the cupin protein family and allergens, and also compared the proteomes of different pistachio varieties.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Agriculture, Dairy & Animal Science
Wanli Yang, Xingyong Chen, Congcong Wei, Yutong Zhao, Zhengquan Liu, Zhaoyu Geng
Summary: The period between 28 and 42 days of age is crucial for Muscovy ducks, during which the metabolism and antioxidant function of the liver are significantly enhanced.
Article
Biochemistry & Molecular Biology
Alfio Spina, Rosaria Saletti, Simona Fabroni, Antonio Natalello, Vincenzo Cunsolo, Michele Scarangella, Paolo Rapisarda, Michele Canale, Vera Muccilli
Summary: In this study, the nutritional composition of different varieties of lupin seeds was analyzed, revealing high levels of protein, dietary fiber, and low starch content. Lupin oil also demonstrated various nutrients and antioxidant activity. Proteomic analysis showed substantial equivalence among cultivars of the same species.
Article
Biochemistry & Molecular Biology
Karol Pawlowski, Jose A. A. Pires, Yannick Faulconnier, Christophe Chambon, Pierre Germon, Celine Boby, Christine Leroux
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Chemistry, Applied
Diane de La Pomelie, Vronique Sante-Lhoutellier, Thierry Sayd, Laetitia Theron, Philippe Gatellier
Article
Biochemistry & Molecular Biology
Helene Gateau, Vincent Blanckaert, Brigitte Veidl, Odile Burlet-Schiltz, Carole Pichereaux, Audrey Gargaros, Justine Marchand, Benoit Schoefs
Summary: This study successfully extracted proteins from living cells of the green microalga using a pulsed electric field treatment, and found that the conditions at 1 kV cm(-1) represented a good compromise between protein extraction efficiency and culture survival.
BIOELECTROCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Fernando Sorroche, Violette Morales, Saida Mouffok, Carole Pichereaux, Marie Garnerone, Lan Zou, Badrish Soni, Marie-Anne Carpene, Audrey Gargaros, Fabienne Maillet, Odile Burlet-Schiltz, Verena Poinsot, Patrice Polard, Clare Gough, Jacques Batut
Article
Physiology
Bara Lo, Nathalie Marty-Gasset, Carole Pichereaux, Celine Bravo, Helene Manse, Renaud Domitile, Herve Remignon
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Food Science & Technology
Annick Barre, Carole Pichereaux, Mathias Simplicien, Odile Burlet-Schiltz, Herve Benoist, Pierre Rouge
Summary: The study focused on the diversity of proteins in edible insects, most of which are allergens widely distributed in different groups of arthropods (mites, insects, crustaceans) and mollusks.
Article
Biochemistry & Molecular Biology
Marine Gueugneau, Cecile Coudy-Gandilhon, Christophe Chambon, Julien Verney, Daniel Taillandier, Lydie Combaret, Cecile Polge, Stephane Walrand, Frederic Roche, Jean-Claude Barthelemy, Leonard Feasson, Daniel Bechet
Summary: The study found that healthy aging in old men is associated with upregulation of apoptosis and immune function, as well as downregulation of glycolysis and protein catabolism, while metabolic syndrome is mainly characterized by upregulation of proteolysis and downregulation of oxidative phosphorylation. This indicates potential muscle biomarkers for healthy aging and metabolic syndrome in old men.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Claire Rosnoblet, Pauline Chatelain, Agnes Klinguer, Herve Begue, Pascale Winckler, Carole Pichereaux, David Wendehenne
Summary: The study demonstrates the importance of Cdc48 in regulating the ubiquitin-proteasome system in plants, especially in the immune response process. Additionally, Cdc48 also impacts the quantity and quality of proteasome subunits, thereby affecting protein degradation and cell death.
PLANT CELL AND ENVIRONMENT
(2021)
Article
Biology
Laura Plassart, Ramtin Shayan, Christian Montellese, Dana Rinaldi, Natacha Larburu, Carole Pichereaux, Carine Froment, Simon Lebaron, Marie-Francoise O'donohue, Ulrike Kutay, Julien Marcoux, Pierre-Emmanuel Gleizes, Celia Plisson-Chastang
Summary: The research shows that the dual key lock mechanism involving RIO1 and RPS26 ensures the precise timing of pre-40S particle conversion into translation-competent ribosomal subunits by displacing DIM2 from the 18S rRNA 30 end and triggering final cleavage by NOB1.
Article
Food Science & Technology
Laetitia Theron, Aline Bonifacie, Jeremy Delabre, Thierry Sayd, Laurent Aubry, Philippe Gatellier, Christine Ravel, Christophe Chambon, Thierry Astruc, Jacques Rouel, Veronique Sante-Lhoutellier, Matthieu Refregiers, Frank Wien
Summary: Food processing can impact the structure and chemical state of proteins, potentially leading to oxidation and impairment of properties, affecting protein digestibility. This study aims to understand how oxidative processes influence the structure and activity of pepsin during digestion.
Article
Nutrition & Dietetics
Christophe Chambon, Eric Neyraud, Thierry Sayd, Pauline Bros, Romane Di Biagio, Frank Hyvrier, Catherine Feart, Perrine Andre, Fernando Rodriguez-Artalejo, Esther Lopez-Garcia, Esther Garcia-Esquinas, David Gomez-Cabrero, Gordon Proctor, Martine Morzel
Summary: The study aimed to evaluate whether the saliva protein composition of elderly individuals can reflect their dietary habits and investigated the impact of type 2 diabetes on the saliva-diet correlation. Results showed that the saliva proteome composition was associated with the intake level of certain food groups, especially vegetables, fruits, sweet snacks, and red meat. The study also identified some biological processes consistently affected by diet.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Plant Sciences
Valerie Nicolas-Frances, Jordan Rossi, Claire Rosnoblet, Carole Pichereaux, Siham Hichami, Jeremy Astier, Agnes Klinguer, David Wendehenne, Angelique Besson-Bard
Summary: Arabidopsis thaliana protein tyrosine phosphatase 1 (AtPTP1) acts as a repressor of H2O2 production and regulates the activity of MAPKs. Exogenous H2O2 and NO directly inhibit the protein activity of AtPTP1, and the effect of NO is mediated by S-nitrosation, which protects the protein from H2O2-induced oxidation.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Cell Biology
Bertrand Fabre, Sebastien A. Choteau, Carine Duboe, Carole Pichereaux, Audrey Montigny, Dagmara Korona, Michael J. Deery, Mylene Camus, Christine Brun, Odile Burlet-Schiltz, Steven Russell, Jean-Philippe Combier, Kathryn S. Lilley, Serge Plaza
Summary: Recent studies have found that many small proteins are overlooked during the annotation of protein-coding genes. These alternative proteins, which have short open reading frames or are monocistronic, have failed to be properly characterized. Some of these alternative proteins have been shown to have biological activity and are involved in a wide range of functions. However, the exploration of the alternative proteome is limited to a small number of species. In this article, a deep peptidomics workflow was used to identify 401 alternative proteins in the fruit fly Drosophila melanogaster. Subcellular localization, protein domains, and short linear motifs were predicted for 235 of these alternative proteins, providing insight into their specific functions. Several alternative proteins were found to have higher abundances than their canonical counterparts, suggesting that they are the main products of their corresponding genes. Additionally, 14 alternative proteins were found to have developmentally regulated expression patterns and 10 were induced upon heat-shock treatment of embryos, indicating stage or stress-specific production of alternative proteins.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Christophe Chambon, Thierry Sayd, Sylvie Bourillon, Laetitia Theron, Vincent Niderkorn
Summary: The protein degradation of alfalfa hay after tannin supplementation was monitored, and the digestomic dataset revealed the protein regions protected by tannin supplementation, providing valuable information for studying protein use efficiency by ruminants.
Article
Chemistry, Applied
Stephane Portanguen, Charlotte Dumoulin, Anne Duconseille, Maia Meurillon, Jason Sicard, Laetitia Theron, Christophe Chambon, Thierry Sayd, Pierre-Sylvain Mirade, Thierry Astruc
Summary: The increasing number of people around the world suffering from chewing disorders necessitates the design of foods adapted to their needs. Glycation could be considered as one of the possible texturing methods. This study focuses on the impact of initial water content and Bloom index on the glycation reaction and texture of gelatin gels, highlighting the importance of controlling these factors for food texturing.
FOOD HYDROCOLLOIDS
(2023)