期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 59, 期 10, 页码 5702-5706出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf2003943
关键词
Chinese herb; Phellinus merrillii; alpha-glucosidase; aldose reductase; hispidin derivatives; flavonoid
资金
- National Science Council [NSC 97-2313-B-039-001-MY3]
- China Medical University (CMU) [CMU95-PH-11, CMU96-113, CMU97-232]
- Taiwan Department of Heath Clinical Trial and Research Center of Excellence [DOH100-TD-B-111-004]
- Cancer Research Center of Excellence [DOH100-TD-C-111-005]
The inhibitory activity from the isolated component of the fruiting body Phellinus merrillii (PM) was evaluated against alpha-glucosidase and lens aldose reductase from Sprague Dawley male rats and compared to the quercetin as an aldose reductase inhibitor and, acarbose as an alpha-glucosidase inhibitor. The ethanol extracts of PM (EPM) showed the strong alpha-glucosidase and aldose reductase activities. alpha-Glucosidase and aldose reductase inhibitors were identified as hispidin (A), hispolon (B), and inotilone (C), which were isolated from EtOAc-soluble fractions of EPM. The above structures were elucidated by their spectra and comparison with the literatures. Among them, hispidin, hispolon, and inotilone exhibited potent against alpha-glucosidase inhibitor activity with IC50 values of 297.06 +/- 2.06, 12.38 +/- 0.13, and 18.62 +/- 0.23 mu g/ml,, respectively, and aldose reductase inhibitor activity with IC50 values of 48.26 +/- 2.48, 9.47 +/- 0.52, and 15.37 +/- 0.32 mu g/mL, respectively. These findings demonstrated that PM may be a good source for lead compounds as alternatives for antidiabetic agents currently used. The importance of finding effective antidiabetic therapeutics led us to further investigate natural compounds.
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