Review
Biochemistry & Molecular Biology
Aadil Javed, Mahdieh Yarmohammadi, Kemal Sami Korkmaz, Teresa Rubio-Tomas
Summary: Gastric cancer is characterized by uncontrolled growth and metastasis of gastric epithelial cells, which is predominantly in adenocarcinoma form. The regulation of gastric cell growth is influenced by key cell cycle regulators, including Cyclins and Cyclin-dependent kinases (CDKs). Dysregulation of these molecules can lead to disturbances in cell cycle dynamics and the development of gastric cancer. Numerous studies have examined the roles of Cyclins and CDKs in gastric cancer, and this review aims to compile evidence of upstream regulators that activate or inhibit Cyclins and CDKs. It serves as a comprehensive resource for future studies and hypothesis generation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Peixin Dong, Nikolaus Gassler, Mohammad Taheri, Aria Baniahmad, Nader Akbari Dilmaghani
Summary: This article summarizes the important role of Cyclin-dependent kinases (CDK) in cancer, emphasizing the significance of understanding CDK function and mechanisms for future cancer therapies targeting these kinases.
CANCER CELL INTERNATIONAL
(2022)
Review
Oncology
Mitra Zabihi, Ramin Lotfi, Amir-Mohammad Yousefi, Davood Bashash
Summary: CDKs, cyclins, and CKIs play important roles in the cell cycle regulatory machinery, and dysregulation of their expression or function can contribute to tumorigenesis. While designing CDK inhibitors to target tumor cells shows promise, the non-canonical functions of CDKs pose challenges in their application. This review aims to explore the biology of CDKs and their contribution to tumorigenesis, and discuss the pros and cons of CDK inhibition in the treatment of human cancers.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Deniz Pirincci Ercan, Florine Chretien, Probir Chakravarty, Helen R. Flynn, Ambrosius P. Snijders, Frank Uhlmann
Summary: The budding yeast has become dependent on G(1) cyclin specificity to couple cell cycle progression to essential morphogenetic events, according to the study on the relative contributions of qualitative and quantitative Cdk control in Saccharomyces cerevisiae.
Both qualitative and quantitative models of cell cycle control are reflected in budding yeast, suggesting the importance of cyclin specificity in cell cycle regulation.
Review
Oncology
Shazia Sofi, Umar Mehraj, Hina Qayoom, Shariqa Aisha, Syed Mohammad Basheeruddin Asdaq, Abdullah Almilaibary, Manzoor A. Mir
Summary: Breast cancer is one of the most common malignancies worldwide, and dysregulation of the cell cycle is an important factor in its development. Cyclin-dependent kinases (CDKs) play a crucial role in the progression and treatment of breast cancer.
Review
Pharmacology & Pharmacy
Oana-Maria Thoma, Markus F. Neurath, Maximilian J. Waldner
Summary: CDKs play a key role in cell cycle regulation, with aberrant expression potentially leading to cancer development. CDK inhibitors, such as CDK4/6 inhibitors, are being investigated as novel cancer therapies.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tomas Kyca, Lucia Pavlikova, Viera Bohacova, Anton Misak, Alexandra Poturnayova, Albert Breier, Zdena Sulova, Mario Seres
Summary: Bortezomib showed varying effects on different cell variants, but these effects were not sufficient to decrease cell sensitivity to bortezomib.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Ting-Yu Chang, Kunal Nepali, Yi-Ying Chen, Yu-Chen S. H. Yang, Kai-Cheng Hsu, Yun Yen, Shiow-Lin Pan, Jing-Ping Liou, Sung-Bau Lee
Summary: The study identifies MPT0L184 as a novel HDAC inhibitor that can induce premature mitosis and potentially combat drug resistance in cancers.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Oncology
Alessandra Merlini, Valeria Pavese, Giulia Manessi, Martina Rabino, Francesco Tolomeo, Sandra Aliberti, Lorenzo D'Ambrosio, Giovanni Grignani
Summary: Effective treatment of advanced/metastatic bone and soft tissue sarcomas remains a medical challenge. CDK inhibitors have shown potential therapeutic effects in various cancer types, including sarcomas. This review explores the molecular basis and therapeutic implications of CDK inhibitors in sarcoma treatment and discusses the possibility of combination therapies with conventional treatments, targeted therapy, and immunotherapy to integrate CDK inhibition in sarcoma treatment.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Alexis P. Perez, Marta H. Artes, David F. Moreno, Josep Clotet, Marti Aldea
Summary: Cells maintain their size to maximize fitness and survival. In budding yeast cells, a sizer mechanism regulates cell cycle entry. This study reveals that intertwined APC and SCF degradation machineries, along with specific adaptor proteins, drive cyclic accumulation of G(1) Cdk in the nucleus, which is important for cell cycle progression.
Article
Biochemistry & Molecular Biology
Jonas Muhr, Daniel W. Hagey
Summary: The regulation of stem cell behavior is achieved through reciprocal regulation between the cell cycle machinery and differentiation factors. Activities of different cell cycle phases bias cells towards stem cell maintenance or differentiation, and direct mechanistic links between these processes have been established. Understanding the interconnections between these processes in pluripotent and neural stem cells can help explain their behavior in health and disease.
Article
Veterinary Sciences
Gholamreza Mesbah, Fatemeh Namazi, Fatemeh T. Shamsabadi, Zahra Maleki, Mehrab Nasirikenari, Majid Shahbazi
Summary: The inhibitory effect of G1 cyclins was evaluated in nude mice, and it was found that the treatment led to a significant reduction in tumor weight and volume. Additionally, histopathological analysis showed more apoptotic cells in the treated mice compared to the control group.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Teresa Vargas-Cortez, Estefany Damaris Guerrero-Molina, Javier Axosco-Marin, Jorge Manuel Vazquez-Ramos, Aurora Lara-Nunez
Summary: This study demonstrates that Cyclin/cyclin-dependent kinase (CDK) heterodimers can interact with glycolytic enzymes HXK7 and GAP, and phosphorylate them to alter their activities. CDKB1;1 directly interacts with HXK7 and GAP, decreasing their activities; while CycD2;2, CycB2;1, and CDKA;1 do not affect the activities of HXK7 and GAP. These findings suggest that cell cycle regulators can modulate carbon channeling in glycolysis through two different mechanisms.
Article
Pharmacology & Pharmacy
Ying Hou, Rong Liu, Mengwei Xia, Chong Sun, Bingling Zhong, Jie Yu, Nana Ai, Jin-Jian Lu, Wei Ge, Bo Liu, Xiuping Chen
Summary: NAN triggers G1 phase cell cycle arrest and caspase-independent apoptosis in CRC cells through downregulation of cyclin D1 and inhibition of eEF1A-targeted translation.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Chemistry, Medicinal
Deendyal Bhurta, Sandip B. Bharate
Summary: This article critically analyzed the chemical diversity of CDK inhibitors, with amino-pyrimidine being the most represented scaffold. The discussion included selectivity aspects among CDKs, dose-limiting toxicities in clinical trials, and the most advanced clinical candidates. The article also touched on the changing paradigm towards selective inhibitors and provided an overview of ATP-binding pockets of all druggable CDKs.
MEDICINAL RESEARCH REVIEWS
(2022)
Article
Chemistry, Applied
Hua-Tsung Lin, An- Yeh, Tuan-Hua David Ho, Min-Hsiung Pan, Shih Hsin Chen
Summary: Cassava starch was modified with amylomaltase (AMase) to investigate its structural changes and retrogradation properties. The AMase treatment resulted in an increase in molecular weight and a reorganization of chain distributions in amylose and amylopectin. The extent of retrogradation was influenced by the enzyme/substrate ratio and reaction time. A new insight into the structural characteristics of the modified starch and its long-term retrogradation was gained through the analysis of the long-to-short chain ratio, the enzyme/substrate ratio, and reaction time.
FOOD HYDROCOLLOIDS
(2023)
Article
Agriculture, Multidisciplinary
Wei-Sheng Lin, Tai-Ling Chueh, Kalyanam Nagabhushanam, Chi -Tang Ho, Min-Hsiung Pan
Summary: This study evaluated the effects of Piceatannol (PIC) and 3'-hydroxypterostilbene (HPSB) on DSS-induced colitis in mice. The findings showed that both PIC and HPSB attenuated inflammation by inhibiting specific pathways and reducing inflammasome activation. PIC was also effective in modulating tight junctions. Additionally, both PIC and HPSB altered the composition of gut microbiota. These results suggest that PIC may be more effective in maintaining gut barrier integrity than HPSB and could be a promising ingredient for colitis prevention.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Food Science & Technology
Yen-Chun Koh, Lee-Han Kuo, Ya-Yun Chang, Yen-Chen Tung, Yi-Chen Lo, Min-Hsiung Pan
Summary: This study investigates the anti-aging potential of fermented black soybean and adlay (FBA) supplements. The results show that FBA supplementation prevents muscle loss, reduces aging biomarkers, improves gut microbial dysbiosis, and reverses the reduced ability of microbiota in aged mice. These findings suggest that FBA has significant anti-aging effects and can be developed as a functional food for healthy aging.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Review
Agriculture, Multidisciplinary
Yen-Chun Koh, Chi-Tang Ho, Min-Hsiung Pan
Summary: Mitochondrial dysfunction can lead to cell death, and it has recently been recognized as a strategy for cancer prevention and treatment using chemotherapy drugs or phytochemicals. However, most drugs currently available cannot specifically target cancer cells and may have negative effects on normal cells. Studies have shown that phytochemicals like resveratrol can improve various diseases associated with dysfunctional or damaged mitochondria by regulating mitophagy, reducing oxidative stress, preserving membrane potential, inducing mitochondrial biogenesis, balancing fusion and fission, and enhancing electron transport chain functionality. Limited research suggests that phytochemicals may also protect against cytotoxicity caused by certain cancer drugs that damage mitochondria. Additionally, mitochondrial dysfunction has been linked to COVID-19 and long COVID, and curcumin has shown positive effects on these conditions. Therefore, this review examines the potential benefits of resveratrol and curcumin for cancer treatment/prevention and disease amelioration. It also discusses the potential of phytochemicals as adjuvant treatments for COVID-19 and long COVID by targeting mitochondrial rescue. The review aims to provide new insights into disease treatment using phytochemicals targeting mitochondria.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Yuhong Mao, Wenting Huang, Rongju Jia, Yangyang Bian, Min-Hsiung Pan, Xiuyun Ye
Summary: This study aimed to examine the impact of protein features on the properties of nanoparticles assembled using the pH-shifting approach, and to understand the underlying mechanism. Four legume protein isolates were fractionated into natural aqueous-soluble and aqueous-insoluble fractions, which served as shell and core for the nanoparticles, respectively. Using zein as the core instead of the aqueous-insoluble fractions improved size uniformity, and particle size could be precisely controlled by adjusting core/shell ratios. Proteomic analysis and computational characterization revealed that hydrophobicity, rather than molecular weight or surface charge, predominantly determined particle size. Molecular docking, structural analysis, and dissociation tests showed that the assembly of zein/aqueous-soluble-based nanoparticles was primarily driven by hydrophobic interactions. This study provides valuable insights into the correlation between protein features and the properties of pH-driven-assembled nanoparticles, enabling precise control over particle size.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Chun-Han Chang, You-Tsz Lien, Wei-Sheng Lin, Kalyanam Nagabhushanam, Chi-Tang Ho, Min-Hsiung Pan
Summary: Evidence suggests that dietary intake of polycyclic aromatic hydrocarbons (PAHs) from food processing can lead to the development of colorectal cancer (CRC) by inducing cellular DNA damage. In this study, piceatannol (PIC) was found to effectively inhibit B[a]P-induced cytochrome P450 1B1 (CYP1B1) protein expression in human colon epithelial cells and alleviate DNA damage. PIC also exhibited antioxidative effects by increasing glutathione (GSH) content and scavenging reactive oxygen species (ROS) induced by B[a]P. Furthermore, PIC activated the Nrf2 signaling pathway and upregulated phase II detoxification enzymes and antioxidative enzymes. These findings suggest that PIC has the potential to prevent CRC by protecting against DNA damage and modulating the metabolism and detoxification of B[a]P.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Food Science & Technology
Chiung-Jung Wen, Yen-Chun Koh, Yen-Chen Tung, Pin-Yu Ho, Shu-Chen Hsieh, Yi-Chen Lo, Jaw-Shiun Tsai, Min-Hsiung Pan
Summary: This study aims to explore the relationship between serum metabolites and gut microbiota in non-robust older adults as a potential diagnostic biomarker. The results show significant differences in gut microbial composition between robust and non-robust subjects, particularly with the abundance of Escherichia/Shigella. Moreover, the abundance of Escherichia/Shigella is positively correlated with the levels of discriminant metabolites. These findings indicate the clear interrelation between gut microbiota and serum metabolites in non-robust older adults, suggesting Escherichia/Shigella as a potential biomarker candidate for robustness sub-phenotypic identification.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Food Science & Technology
Yen-Chun Koh, Dickson Chok, Chun-Han Chang, Chia-Cheng Wei, Chia-Tung Wu, Ko-Chun Cheng, Kalyanam Nagabhushanam, Chi-Tang Ho, Min-Hsiung Pan
Summary: This study aims to evaluate the preventive effect of piceatannol on glutamate-induced neurodegeneration via mitochondrial rescue. The results show that piceatannol can prevent glutamate-induced apoptosis, reduce mitochondrial reactive oxygen species accumulation, promote mitochondrial biogenesis, and preserve mitochondrial functionality. Piceatannol effectively protects dopaminergic neurons from degradation and preserves their controlled responses.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Donporn Wongwaiwech, Sudthida Kamchonemenukool, Chi-Tang Ho, Shiming Li, Nutthaporn Majai, Tepsuda Rungrat, Kawee Sujipuli, Min-Hsiung Pan, Monthana Weerawatanakorn
Summary: Crude rice bran oils from different rice cultivars and extraction methods have varying levels of nutraceuticals. The health benefits of rice bran oil in lowering cholesterol are due in part to non-nutrient nutraceuticals such as ?-oryzanol, phytosterols, and policosanols. In this study, the nutraceutical composition and antioxidant properties of crude rice bran oils extracted using different technologies were compared. The results showed that subcritical liquefied dimethyl ether extraction produced oils with higher yield and higher levels of phenolic compounds, ?-oryzanol, phytosterols, and policosanols compared to conventional hexane extraction and supercritical CO2 extraction. Overall, the choice of extraction method significantly affected the composition and properties of the crude rice bran oil.
Article
Agriculture, Multidisciplinary
Yu Xiao, Min-hsiung Pan, Yi-shiou Chiou, Zhenshun Li, Shudong Wei, Xiaoli Yin, Baomiao Ding
Summary: The interaction mechanism between nanoliposomes (NL) and soybean protein isolate (SPI) was studied. It was found that NL formed complexes with beta-conglycinin (7S) and glycinin (11S), resulting in static quenching of the endogenous fluorescence emissions of 7S and 11S, and increased polarity of the SPI fluorophore. The interaction between NL and SPI was exothermic, altered the secondary structures of 7S/11S, exposed more hydrophobic groups on protein surfaces, and had a large zeta potential to ensure system stability. Hydrophobic forces, hydrogen bonds, and salt bridge played important roles in the interaction, which were mainly influenced by the protein characteristics such as amino acid composition, surface hydrophobicity, and advanced structure. These findings provide a deeper understanding of the interaction mechanism between NL and SPI.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Chun Ming How, Ko-Chun Cheng, Yong-Shan Li, Min-Hsiung Pan, Chia-Cheng Wei
Summary: This study investigated the effects of chronic exposure to Benzo[a]pyrene (BaP) on aging in Caenorhabditis elegans, and found that BaP exposure aggravated protein aggregation, shortened lifespan, and worsened age-related decline in motility and pharyngeal pumping. In addition, BaP exposure increased the expression of heat shock proteins and reduced survival under heat stress. However, dietary supplementation with Tangeretin (TAN) alleviated the BaP-induced decline in motility, pumping, and protein accumulation, and restored heat shock proteins' expression levels.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Food Science & Technology
Yen-Chun Koh, Shin-Jhih Lin, Kai-Yu Hsu, Kalyanam Nagabhushanam, Chi-Tang Ho, Min-Hsiung Pan
Summary: The study suggests that PSB and PIN, two analogs of resveratrol, can enhance thermogenesis and mitochondrial biogenesis, thus improving obesity and gut microbiota dysbiosis. PSB has a greater effect than PIN in activating the SIRT1 pathway.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Yen-Chun Koh, Lee-Han Kuo, Yen-Chen Tung, Monthana Weerawatanakorn, Min-Hsiung Pan
Summary: Gut microbial indicators in aged mice have been identified, and these indicators are associated with human diseases and relevant metabolic processes.
Article
Food Science & Technology
Kai-Yu Hsu, Chi-Tang Ho, Min-Hsiung Pan
Summary: Turmeric is a medicinal plant commonly used in Chinese and Indian traditional medicine. It has various health benefits due to the active components called curcuminoids. This article reviews the composition of turmeric and the properties of curcumin, highlighting its antioxidant, anti-inflammatory, anti-diabetic, anti-colorectal cancer, and other physiological activities. It also discusses the challenges of using curcumin and provides three novel application strategies to overcome these limitations.
JOURNAL OF FOOD AND DRUG ANALYSIS
(2023)
Article
Agriculture, Multidisciplinary
Chun Ming How, Ko-Chun Cheng, Yong-Shan Li, Min-Hsiung Pan, Chia-Cheng Wei
Summary: This study finds that chronic exposure to Benzo[a]pyrene (BaP) has negative effects on aging, and Tangeretin (TAN) supplementation can alleviate the aging toxicity induced by BaP.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)