Article
Microbiology
Pan Zhuang, Haoyu Li, Wei Jia, Qiyang Shou, Ya'er Zhu, Lei Mao, Wenqiao Wang, Fei Wu, Xiaoqian Chen, Xuzhi Wan, Yuqi Wu, Xiaohui Liu, Yin Li, Fanghuan Zhu, Lilin He, Jingnan Chen, Yu Zhang, Jingjing Jiao
Summary: The study found that DHA and EPA can significantly alleviate hyperglycemia and insulin resistance by altering the gut microbiome and metabolites, thereby improving symptoms of diabetes, with EPA showing a more pronounced effect.
Article
Cardiac & Cardiovascular Systems
Frank Qian, Nathan Tintle, Paul N. Jensen, Rozenn N. Lemaitre, Fumiaki Imamura, Tobias Rudholm Feldreich, Sarah Oppeneer Nomura, Weihua Guan, Federica Laguzzi, Eunjung Kim, Jyrki K. Virtanen, Marinka Steur, Christian S. Bork, Yoichiro Hirakawa, Michelle L. O'Donoghue, Aleix Sala-Vila, Andres V. Ardisson Korat, Qi Sun, Eric B. Rimm, Bruce M. Psaty, Susan R. Heckbert, Nita G. Forouhi, Nicholas J. Wareham, Matti Marklund, Ulf Riserus, Lars Lind, Johan Arnlov, Parveen Garg, Michael Y. Tsai, James Pankow, Jeffrey R. Misialek, Bruna Gigante, Karin Leander, Julie A. Pester, Christine M. Albert, Maryam Kavousi, Arfan Ikram, Trudy Voortman, Erik B. Schmidt, Toshiharu Ninomiya, David A. Morrow, Antoni Bayes-Genis, James H. O'Keefe, Kwok Leung Ong, Jason H. Y. Wu, Dariush Mozaffarian, William S. Harris, David S. Siscovick
Summary: This study aimed to determine the associations of blood or adipose tissue levels of EPA, DPA, and DHA with incident AF. Using participant-level data from 17 prospective cohort studies, it was found that levels of omega-3 fatty acids, including EPA, DPA, DHA, and EPA+DHA, were not associated with increased risk of incident AF.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Medicine, Research & Experimental
Linda Ljungblad, Filip Bergqvist, Conny Tummler, Samanthi Madawala, Thale Kristin Olsen, Teodora Andonova, Per-Johan Jakobsson, John Inge Johnsen, Jana Pickova, Birgitta Strandvik, Per Kogner, Helena Gleissman, Malin Wickstrom
Summary: The study demonstrated that omega 3-LCPUFA had negative effects on medulloblastoma cells, reducing their viability, clonogenic ability, and inducing apoptosis. DHA showed a tumor growth-inhibiting effect in vivo and decreased inflammatory factors in tumor tissues.
Article
Food Science & Technology
Fernanda de Melo Ramos, Vivaldo Silveira Junior, Ana Silvia Prata
Summary: The study demonstrated that vacuum spray drying technology can provide better protection against lipid oxidation for active materials, while spray drying technology had poorer performance and lower encapsulation efficiency.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Nutrition & Dietetics
Timo Drobner, Theresa S. Braun, Michael Kiehntopf, Peter Schlattmann, Stefan Lorkowski, Christine Dawczynski
Summary: This study aimed to investigate the impact of various factors on the conversion of ALA obtained from linseed oil into its long-chain metabolites and its effect on cardiovascular risk markers. The results showed that ALA, C-20:4n3, and EPA concentrations increased in erythrocytes in all groups, while DHA and n-3 index decreased in the HLA, LLA, and control groups. Only the MF and control groups showed an increase in C-22:5n3. Additionally, an increase in LA was found in the HLA, LLA, and control groups, while C-20:3n6, arachidonic acid, C-22:4n6, and C-22:5n6 decreased. Conversion into EPA was higher in men and in subjects with low EPA status. ALA supplementation did not have clear effects on blood lipids and glucose metabolism parameters, consistent with the literature.
Article
Biochemistry & Molecular Biology
Shuai-Shuai Fu, Min Wen, Ying-Cai Zhao, Hao-Hao Shi, Yu-Ming Wang, Chang-Hu Xue, Zi-Hao Wei, Tian-Tian Zhang
Summary: A study found that dietary supplementation with EPA-pPE can significantly change the fatty acid composition in the brain and liver, especially in increasing the content of DHA. EPA-pPE has a more significant effect on increasing DHA compared to EPA-PC, making it a good nutritional supplement to increase DHA levels in n-3 PUFA-deficient offspring's brains.
Article
Chemistry, Medicinal
Ji-Su Kim, Hyun-Ju Kim, Eun-Byeol Lee, Ji-Hye Choi, Jieun Jung, Hwan-Hee Jang, Shin-Young Park, Ki-Chan Ha, Yu-Kyung Park, Jong-Cheon Joo, Sung-Hyen Lee
Summary: This study investigated the effects of Allium hookeri (AH) on glycemia in prediabetic subjects. The results showed that AH supplementation moderately reduced blood glucose and insulin levels, and improved insulin sensitivity.
Article
Fisheries
David Huyben, Teresa Grobler, Chessor Matthew, Marta Bou, Bente Ruyter, Brett Glencross
Summary: The requirement for omega-3 long-chain polyunsaturated fatty acids for Atlantic salmon is relative to the dietary lipid level, with high n-3 diets contributing to increased body weight and weight gain.
Article
Agriculture, Dairy & Animal Science
Paulo H. de Mello, Bruno C. Araujo, Victor H. Marques, Giovana S. Branco, Renato M. Honji, Renata G. Moreira, Artur N. Rombenso, Maria C. Portella
Summary: This study investigated the effects of different lipid classes on the physiological and morphological responses of dusky groupers. The results showed that including different lipid classes in the diet can improve fish fillet quality. Additionally, the study found that DHA and EPA have an impact on the morphophysiology of dusky grouper juveniles, providing valuable insights for establishing this fish species as a produced species worldwide.
Article
Pharmacology & Pharmacy
Chao Xuan, Qing-Wu Tian, Hui Li, Jun-Jie Guo, Guo-Wei He, Li-Min Lun
Summary: This study investigated the profile of fatty acids in the serum of EOCAD patients and identified a significant association between decreased levels of DHA, DPA, and EPA with EOCAD. Results indicated that elevated serum DHA level was an independent protective factor for EOCAD and MI. These findings contribute to understanding the cardiovascular effects of fatty acids, particularly the protective effects of omega-3 polyunsaturated fatty acids.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2021)
Article
Environmental Sciences
Ursula Strandberg, Minna Hiltunen, Jari Syvaeranta, Eti E. Levi, Thomas A. Davidson, Erik Jeppesen, Michael T. Brett
Summary: Climate change and eutrophication are key stressors for shallow freshwater ecosystems and have significant impacts on phytoplankton community structure. This study found that nutrient treatment had a significant effect on phytoplankton EPA and DHA concentrations, while warming had a marginal effect. The changes in EPA and DHA concentrations were mostly related to the phytoplankton community structure and biomass.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Sa Guo, Hui Ouyang, Wendi Du, Junmao Li, Mi Liu, Shilin Yang, Mingzhen He, Yulin Feng
Summary: The study demonstrates that Gynura procumbens (GP) can improve type 2 diabetes by activating the PI3K/Akt signaling pathway to improve insulin resistance and glucose metabolism.
Article
Nutrition & Dietetics
Felix Castillo Salinas, Alicia Montaner Ramon, Felix-Joel Castillo Ferrer, Adria Domingo-Carnice, Begona Cordobilla, Joan Carles Domingo
Summary: This study examines the differences in fatty acid profile between preterm and term neonates at birth and after 1 month. The findings indicate that preterm neonates have a deficiency in fatty acids at birth, which persists for the first month of life. This highlights the importance of adding DHA to milk banking and supplementing breastfeeding mothers with DHA.
Article
Biochemistry & Molecular Biology
L. Ljungblad, H. Gleissman, G. Hedberg, M. Wickstrom, N. Eissler, J. Pickova, J. I. Johnsen, K. Tedroff, B. Strandvik, P. Kogner
Summary: The study suggests that Ω-3 fatty acids can be used as a complementary treatment in cancer therapy, but the optimal dosage for children in remission needs further investigation. The dose-finding study showed that individualized supplementation based on body surface area can decrease variation in fatty acid levels among patients.
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
(2021)
Review
Medicine, General & Internal
R. Preston Mason, Robert H. Eckel
Summary: Elevated TG levels are associated with cardiovascular risk, but lowering TG does not effectively reduce this risk. New research shows that IPE can reduce the occurrence of cardiovascular events, possibly due to its broad pleiotropic actions on on-treatment eicosapentaenoic acid levels.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Bungo Shirouchi, Shuhei Yanagi, Chinami Okawa, Maiko Koga, Masao Sato
Article
Biotechnology & Applied Microbiology
Akane Kanasaki, Tetsuo Iida, Koji Murao, Bungo Shirouchi, Masao Sato
Article
Biochemistry & Molecular Biology
Shota Hori, Takayuki Abe, Dong Geun Lee, Satoru Fukiya, Atsushi Yokota, Nao Aso, Bungo Shirouchi, Masao Sato, Satoshi Ishizuka
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2020)
Article
Multidisciplinary Sciences
Yasutake Tanaka, Masahiro Ono, Motonori Miyago, Takahisa Suzuki, Yurika Miyazaki, Michio Kawano, Makoto Asahina, Bungo Shirouchi, Katsumi Imaizumi, Masao Sato
Article
Biochemistry & Molecular Biology
Zhe Jiang, Takuya Hayashi, Kentaro Kashima, Kayo Kurotani, Bungo Shirouchi, Tetsuya Mizoue, Masao Sato
Article
Biochemistry & Molecular Biology
Ja-Young Lee, Hidehisa Shimizu, Masahito Hagio, Satoru Fukiya, Masamichi Watanabe, Yasutake Tanaka, Ga-Hyun Joe, Hitoshi Iwaya, Reika Yoshitsugu, Keidai Kikuchi, Misaki Tsuji, Nanako Baba, Takuma Nose, Koji Tada, Taketo Hanai, Shota Hori, Akari Takeuchi, Yumiko Furukawa, Bungo Shirouchi, Masao Sato, Tadasuke Ooka, Yoshitoshi Ogura, Tetsuya Hayashi, Atsushi Yokota, Satoshi Ishizuka
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2020)
Article
Food Science & Technology
Wei-Ting Tsai, Yuki Nakamura, Taiki Akasaka, Yoshinori Katakura, Yasutake Tanaka, Bungo Shirouchi, Zhe Jiang, Xingyu Yuan, Masao Sato
Summary: Soyasaponins, triterpenoid glycosides found in soybean, show anti-obesity effects by suppressing adipocyte differentiation and lipogenesis, reducing body weight, adipose tissue weight, and hepatic triacylglycerol accumulation.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Agriculture, Multidisciplinary
Xingyu Yuan, Yutaro Minobe, Yasutake Tanaka, Yumi Fukuda, Yumiko Furukawa, Motonori Miyago, Takuya Mizokami, Wei-Ting Tsai, Zhe Jiang, Li-Tao Tong, Taiki Akasaka, Bungo Shirouchi, Yoshiko Toyosawa, Toshihiro Kumamaru, Masao Sato
Summary: The study showed that dietary LGC-1, which is rich in alpha-globulin, significantly reduced serum cholesterol levels in ExHC rats, possibly by partially inhibiting bile acid and cholesterol synthesis in the liver.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Biochemistry & Molecular Biology
Zhe Jiang, Yuki Kimura, Bungo Shirouchi, Yasutake Tanaka, Wei-ting Tsai, Xingyu Yuan, Masao Sato
Summary: The study revealed that egg white protein hydrolysates (EWH) have a significant improvement on nonalcoholic fatty liver (NAFL) in rats, with EWH reducing liver triacylglycerol (TAG) levels more effectively and rapidly compared to egg white protein (EWP). EWH also promoted hepatic TAG secretion, showing a potential therapeutic effect on NAFL induced by orotic acid (OA).
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ai Takeyama, Asami Teramoto, Tianyu Wang, Takuya Hayashi, Yasutake Tanaka, Masao Sato, Bungo Shirouchi
Summary: This study found that dietary LysoPL affects lymphatic fat transport, especially in reducing cholesterol transport significantly. Compared to a phospholipid diet, both sn-1 and sn-2 LysoPL diets decreased the lymphatic transport of cholesterol, but had no effect on PL and TAG transport; in addition, LysoPL also affected the solubility of cholesterol in bile acid micelles.
Article
Biochemistry & Molecular Biology
Bungo Shirouchi, Ayano Fukuda, Taiki Akasaka
Summary: Choline, betaine, and L-carnitine can be converted into trimethylamine (TMA) by gut microbiota and further oxidized into trimethylamine-N-oxide (TMAO). Elevated TMAO levels can have negative effects on human health. This study investigated the effects of different choline compounds on plasma TMAO levels and gut microbiota in rats. The results showed that dietary phosphatidylcholine (PC) did not increase plasma TMAO levels, while glycerophosphocholine (GPC) and choline chloride (CC) significantly increased TMAO levels. In terms of gut microbiota, certain species were found to be positively or negatively correlated with plasma TMAO levels. This study suggests that dietary PC, unlike GPC or CC, does not contribute to the increase in plasma TMAO levels in rats.
Article
Biochemistry & Molecular Biology
Bungo Shirouchi, Yuri Kawahara, Yuka Kutsuna, Mina Higuchi, Mai Okumura, Sarasa Mitsuta, Norio Nagao, Kazunari Tanaka
Summary: This study investigated the effects of marine microalga Chaetoceros gracilis on lipid abnormalities in rats fed a high-sucrose cholesterol-containing diet. The results showed that C. gracilis could alleviate hepatic lipid accumulation, increase muscle weight, and improve serum HDL cholesterol levels, suggesting its potential use as a food resource.
Article
Chemistry, Applied
Satoshi Wanezaki, Shintaro Saito, Nao Inoue, Nobuhiko Tachibana, Bungo Shirouchi, Masao Sato, Teruyoshi Yanagita, Koji Nagao
JOURNAL OF OLEO SCIENCE
(2020)
Review
Chemistry, Applied
Bungo Shirouchi, Ryosuke Matsuoka
JOURNAL OF OLEO SCIENCE
(2019)
Correction
Nutrition & Dietetics
Bungo Shirouchi, Rikako Yamanaka, Shoji Tanaka, Fagyun Kawatou, Takuya Hayashi, Ai Takeyama, Akiko Nakao, Ryoko Goromaru, Masako Iwamoto, Masao Sato
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
(2021)
