Article
Biochemistry & Molecular Biology
Duanyang Wang, Maki Nagata, Masako Matsumoto, Yhiya Amen, Dongmei Wang, Kuniyoshi Shimizu
Summary: This study evaluated the bioactivities of different parts of Hibiscus sabdariffa L. and found that hibiscus acid has the potential to promote extracellular matrix synthesis, exhibit anti-inflammatory activity, and counter oxidative stress.
Review
Immunology
Qi Jin, Tongtong Liu, Yuan Qiao, Donghai Liu, Liping Yang, Huimin Mao, Fang Ma, Yuyang Wang, Liang Peng, Yongli Zhan
Summary: Diabetic nephropathy (DN) can cause end-stage renal disease. Oxidative stress plays a crucial role in the development of DN, leading to various pathological processes and promoting inflammation. Polyphenols, such as quercetin, resveratrol, curcumin, and phenolic acid, have shown antioxidant and anti-inflammatory effects by targeting Nrf2, SIRT1, HMGB1, NF-κB, and NLRP3. However, further research is needed to fully understand the molecular mechanisms and clinical applications of polyphenols in DN.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Jing-Hsien Chen, Pei-Tzu Wu, Charng-Cherng Chyau, Pei-Hsuan Wu, Hui-Hsuan Lin
Summary: The aim of this study was to examine the inhibitory effect of Hibiscus sabdariffa leaf extracts (HLE) and ellagic acid (EA) on renal fibrosis. The results showed that EA-enriched HLE reduced renal mesangial cell injury and fibrosis in hyperuricemic nephropathy (HN) by regulating the TGF-beta/Smad signaling pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Felix Leao Rodriguez-Fierros, Veronica Guarner-Lans, Maria Elena Soto, Linaloe Manzano-Pech, Eulises Diaz-Diaz, Elizabeth Soria-Castro, Maria Esther Rubio-Ruiz, Francisco Jimenez-Trejo, Israel Perez-Torres
Summary: The study suggests that treatment with 2% HSL extract may alleviate renal dysfunction caused by metabolic syndrome, improve renal function by increasing antioxidant activity, and reducing oxidative stress.
Article
Cell Biology
Linaloe Manzano-Pech, Veronica Guarner-Lans, Maria Elena Soto, Eulises Diaz-Diaz, Sara Caballero-Chacon, Roberto Diaz-Torres, Felix Leao Rodriguez-Fierros, Israel Perez-Torres
Summary: This study evaluated the impact of excessive and chronic consumption of different percentages of Hibiscus sabdariffa L. (HSL) infusions on oxidative stress markers in healthy rats. The results showed that excessive consumption of HSL could increase total antioxidant capacity and lead to a proinflammatory state and hypertension.
Article
Plant Sciences
Yajie Wang, Yue Chen, Yanan Jia, Zihan Xue, Zhongqin Chen, Min Zhang, Pharkphoom Panichayupakaranant, Shuyu Yang, Haixia Chen
Summary: Chrysophyllum cainito leaves have promising antioxidant, hypoglycemic, and antiglycation activities, making them a potential candidate for treating diabetes and associated chronic diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Abdoudramane Sanou, Kiessoun Konate, Roger Dakuyo, Kabore Kabore, Hemayoro Sama, Mamoudou Hama Dicko
Summary: This study investigated the physicochemical, phytochemical, and antioxidant properties of two varieties of Hibiscus sabdariffa. The red phenotype showed the best nutritional and therapeutic potential, making it an interesting candidate for the pharmaceutical and food industries.
Article
Chemistry, Applied
Hector A. Romero Hernandez, Tomy J. Gutierrez, Juscelino Tovar, Luis A. Bello-Perez
Summary: Native and OSA-esterified corn starches were used to manufacture starch-polyphenol V-type complexes using aqueous extract of Roselle as a source of polyphenols. The complexes were formed through hydrogen bond and hydrophobic interactions between the starch and polyphenols. The presence of Roselle extract increased the retrogradation tendency of starch, allowing the production of starchy materials with high resistant starch content and low digestion rate.
FOOD HYDROCOLLOIDS
(2023)
Review
Biochemistry & Molecular Biology
Oke-Oghene Philomena Akpoveso, Emeka Emmanuel Ubah, Gideon Obasanmi
Summary: The global prevalence of diabetes is increasing due to urbanization and an aging population, leading to an increase in diabetic vascular complications. There is a need for safe and effective alternative therapies, with natural products like polyphenols showing potential. Polyphenols can reduce oxidative stress and hyperglycemia, preventing diabetic complications. This review summarizes the effects of polyphenols on endogenous antioxidant systems and discusses therapeutic strategies for diabetic vascular complications.
Article
Biochemistry & Molecular Biology
Yan Liu, Wei Chen, Chenrui Li, Li Li, Ming Yang, Na Jiang, Shilu Luo, Yiyun Xi, Chongbin Liu, Yachun Han, Hao Zhao, Xuejing Zhu, Shuguang Yuan, Li Xiao, Lin Sun
Summary: DsbA-L plays an important role in ameliorating tubular injury in diabetic nephropathy by improving peroxisomal function.
Article
Cell Biology
Manoj Kumar Mishra, Jianxiong Wang, Reza Mirzaei, Rigel Chan, Helvira Melo, Ping Zhang, Chang-Chun Ling, Aldo Bruccoleri, Lin Tang, V. Wee Yong
Summary: Iron deposition in the brain of multiple sclerosis patients is toxic to neurons and current therapies are ineffective in countering this toxicity. However, a distinct extract from Hibiscus sabdariffa was found to protect neurons from iron toxicity, highlighting its potential as a therapeutic tool for multiple sclerosis.
Review
Immunology
Francis U. Umeoguaju, Benson C. Ephraim-Emmanuel, Joy O. Uba, Grace E. Bekibele, Nwondah Chigozie, Orish Ebere Orisakwe
Summary: Hibiscus sabdariffa calyx water decoction extract can significantly lower the levels of inflammatory immune mediators, showing potential in treating disorders involving hyperactive immune system or chronic inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Plant Sciences
T-Thu Nguyen, Andree Voilley, Thi Thu Thuy Tran, Yves Wache
Summary: This study evaluates the potential of yeast hulls in stabilizing the color of anthocyanins. The results show that yeast hulls can effectively protect anthocyanins from the influence of temperature, light, and humidity.
PLANT FOODS FOR HUMAN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Ixchell Y. Sedillo-Torres, alvaro O. Hernandez-Rangel, Yolanda Gomez-y-Gomez, Daniel Cortes-Avalos, Blanca Estela Garcia-Perez, Juan C. Villalobos-Rocha, Cesar H. Hernandez-Rodriguez, Luis Gerardo Zepeda-Vallejo, Paulina Estrada-de los Santos, Maria Elena Vargas-Diaz, Jose Antonio Ibarra
Summary: An organic extract of Hibiscus sabdariffa L. containing hibiscus acid was found to inhibit motility and reduce the secretion of virulence factors in Salmonella enterica serovars Typhi and Typhimurium. The compound was not toxic to eukaryotic cells and could reduce the invasion of Salmonella Typhimurium in epithelial cells. Initial studies suggested that the mode of action of hibiscus acid might involve the disruption of membrane proton balance.
Article
Multidisciplinary Sciences
Di Liu, Zheli Ding, Esmat F. Ali, Ahmed M. S. Kheir, Mamdouh A. Eissa, Omer H. M. Ibrahim
Summary: The addition of biochar and compost significantly improved soil quality and nutrient availability under saline irrigation, leading to enhanced growth and yield of roselle plants. Mixing biochar and compost showed superior results compared to individual application of each amendment, suggesting the recommendation of their combined use for roselle plants irrigated with saline water.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Kai-Fan Tsai, Pai-Chin Hsu, Chien-Te Lee, Chia-Te Kung, Yi-Chin Chang, Lung-Ming Fu, Yu-Che Ou, Kuo-Chung Lan, Tzung-Hai Yen, Wen-Chin Lee
Summary: This study investigated the association between cadmium exposure and chronic kidney disease (CKD). Urinary cadmium levels were found to be positively correlated with urinary kidney injury molecule-1 (KIM-1) levels, indicating early renal injury. Age was also independently associated with urinary cadmium levels.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Environmental Sciences
Po-Hsun Chuang, Kai-Fan Tsai, I-Kuan Wang, Ya-Ching Huang, Lan-Mei Huang, Shou-Hsuan Liu, Cheng-Hao Weng, Wen-Hung Huang, Ching-Wei Hsu, Wen-Chin Lee, Tzung-Hai Yen
Summary: This retrospective observational study aimed to investigate the prevalence of abnormal blood aluminum levels in dialysis patients and their association with various factors. The results suggest that abnormal blood aluminum levels are associated with the use of sevelamer, elevated platelet count, triglyceride levels, and cardiothoracic ratio.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Genetics & Heredity
Man-Gang Lee, Yung-Kuo Lee, Shih-Chung Huang, Chen-Lin Chang, Chou-Yuan Ko, Wen-Chin Lee, Tung-Yuan Chen, Shiow-Jyu Tzou, Cheng-Yi Huang, Ming-Hong Tai, Yu-Wei Lin, Mei-Lang Kung, Ming-Chao Tsai, Yung-Lung Chen, Yi-Chen Chang, Zhi-Hong Wen, Chao-Cheng Huang, Tian-Huei Chu
Summary: This study uses bioinformatics analysis to investigate the role of DLK2 in ccRCC. The results suggest that DLK2 may serve as a novel biomarker and therapeutic target for ccRCC.
Review
Cell Biology
Wen-Chin Lee, Chien-Hua Chiu, Tian-Huei Chu, Yu-Shu Chien
Summary: This review discusses the correlation between HIF-PHIs and cancer development in treating anemia in CKD patients, and proposes monitoring strategies and WT1 inhibition to reduce the risk of cancer progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pai-Chin Hsu, Chih-Han Liu, Wen-Chin Lee, Chien-Hsing Wu, Chien-Te Lee, Chien-Hao Su, Yu-Chin Lily Wang, Kai-Fan Tsai, Terry Ting-Yu Chiou
Summary: This study found that the use of offending drugs, AKI severity, and early dialysis requirement were independent predictors of AKD severity. Higher AKD severity was associated with negative outcomes in post-AKI patients.
Article
Environmental Sciences
Hsiu-Yung Pan, Fu-Jen Cheng, Kuo-Chen Huang, Chia-Te Kung, Wan-Ting Huang, Huey-Ling You, Shau-Hsuan Li, Chin-Chou Wang, Wen-Chin Lee, Ping-Chi Hsu
Summary: This study demonstrated the adverse effects of TBEP exposure on male reproductive function in rats, including abnormal sperm morphology, increased production of superoxide anion and hydrogen peroxide, as well as disruption of testicular structure.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Chien-Te Lee, Wei-Hung Kuo, You-Lin Tain, Yi Wang, Wen-Chin Lee
Summary: This study found that exogenous BMP7 administration can improve disturbed CKD-MBD and vascular calcification in adenine-induced chronic uremic rats. The treatment shows potential in alleviating renal dysfunction, hyperphosphatemia, hyperparathyroidism, and skeletal structural abnormalities.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Chiang-Chi Huang, Hui-Ying Liu, Tsuen-Wei Hsu, Wen-Chin Lee
Summary: This review discusses the role of mitochondria in urothelial carcinoma and provides an update on mitochondria-targeted therapies.
Article
Environmental Sciences
Kai-Fan Tsai, Fu-Jen Cheng, Wan-Ting Huang, Chia-Te Kung, Chien-Te Lee, Ben-Chung Cheng, Jin-Bor Chen, Shau-Hsuan Li, Chin-Chou Wang, Liang-Jen Wang, Yu-Che Ou, Wen-Chin Lee
Summary: This study found that there is universal exposure to OPFRs in the CKD population, with high urinary detection rate. The urinary concentration of BCEP was independently correlated with lower eGFR, and the concentration of BBOEP was independently correlated with overt proteinuria in CKD patients. Additionally, lifestyle factors such as seafood consumption and age were associated with urinary concentrations of OPFR compounds.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Chemistry, Medicinal
Ting-Chun Liu, Chien-Ning Hsu, Wen-Chin Lee, Shih-Wei Wang, Chiang-Chi Huang, Yueh-Ting Lee, Chung-Ming Fu, Jin-Bor Chen, Lung-Chih Li
Summary: Osteoporosis and cardiovascular disease are correlated with increased morbidity and mortality in elderly women. This study compared mortality rate and cardiovascular events between denosumab and raloxifene in osteoporotic women. The results showed that denosumab is superior to raloxifene in lowering risks of all-cause mortality and certain ischemic strokes.
Article
Genetics & Heredity
Shih-Chung Huang, Chao-Cheng Huang, Chou-Yuan Ko, Cheng-Yi Huang, Ching-Han Liu, Yung-Kuo Lee, Tung-Yuan Chen, Chao-Wen Hsueh, Shiow-Jyu Tzou, Ming-Hong Tai, Tsung-Hui Hu, Ming-Chao Tsai, Wen-Chin Lee, Yu-Cheng Ho, Cheng-Chun Wu, Yi-Chen Chang, Jung-Jui Chang, Kai-Hsi Liu, Chiao-Ching Li, Zhi-Hong Wen, Chen -Lin Chang, Tian-Huei Chu
Summary: TNNT1, which is upregulated in colon and breast cancers, is also found to be upregulated in hepatocellular carcinoma (HCC). This study investigates the expression and biological functions of TNNT1 in HCC, and finds that TNNT1 overexpression is associated with advanced stage, high grade, metastasis, vascular invasion, recurrence, and poor survival outcome in HCC patients. TNNT1 is also involved in the epithelial-mesenchymal transition (EMT) processes in HCC, and its neutralization suppresses oncogenic behaviors and EMT in hepatoma cells. Therefore, TNNT1 may serve as a non-invasive biomarker and drug target for HCC management, providing new insight for HCC diagnosis and treatment.
Article
Virology
Po-Chun Chen, Chiang-Chi Huang, Chung-Ming Fu, Yi-Chin Chang, Po-Jung Wu, Wen-Chin Lee, Chien-Te Lee, Kai-Fan Tsai
Summary: The study investigates the effectiveness of SARS-CoV-2 vaccine boosters in hemodialysis patients receiving oral antiviral agents. The analysis demonstrates that vaccine boosters significantly decrease the risk of composite events in these patients, regardless of booster vaccine types.
Article
Biochemistry & Molecular Biology
Po-Yen Kuo, Kai-Fan Tsai, Po-Jung Wu, Pai-Chin Hsu, Chien-Hsing Wu, Wen-Chin Lee, Hsiu-Yu Fang, Chih-Yuan Fang, Sheng-Ying Chung, Yung-Lung Chen, Terry Ting-Yu Chiou
Summary: Patients undergoing cardiac catheterization have a high risk of developing acute kidney injury (AKI) and subsequent acute kidney disease (AKD). This study aimed to evaluate the association between AKD and urinary renal biomarkers in this population. Serial measurements of urinary renal biomarkers were obtained from 94 patients during different post-procedure periods. Results showed that 42.55% of the patients developed AKD during the late post-procedure period. Early changes in urinary interleukin-18 and gelsolin levels were independently associated with subsequent AKD.
Article
Environmental Sciences
Chi-Ang Liang, Shu-Sen Chang, Hsien-Yi Chen, Kai-Fan Tsai, Wen-Chin Lee, I-Kuan Wang, Chao-Yu Chen, Shou-Hsuan Liu, Cheng-Hao Weng, Wen-Hung Huang, Ching-Wei Hsu, Tzung-Hai Yen
Summary: Limited literature has analyzed the outcome of human poisoning with methomyl and cypermethrin pesticide mixture. A study conducted at Chang Gung Memorial Hospital from 2002 to 2018 found that patients with methomyl and cypermethrin poisoning had higher rates of acute respiratory failure, aspiration pneumonia, acute kidney injury, and multiple organ failure compared to other groups. Further research is needed to better understand the toxicity of methomyl and cypermethrin pesticide mixture poisoning.
Article
Health Care Sciences & Services
Chih-Hao Chen, Yao-Te Tsai, Chun-An Chou, Shao-Jen Weng, Wen-Chin Lee, Li-Wei Hsiao, Natan Derek, Chang-Pu Ko
Summary: This study aims to reduce patient waiting time at outpatient clinics for metabolism and nephrology outpatients by adjusting the settings of blood collection counters. Through a discrete-event simulation, the experimental results showed that the strategic changes successfully reduced the number of patients waiting and the waiting time, providing valuable insights for selecting cost-effective operational strategies for hospital.
INQUIRY-THE JOURNAL OF HEALTH CARE ORGANIZATION PROVISION AND FINANCING
(2022)
