Article
Engineering, Biomedical
Jian Chen, Xiaobo Wang, Ying Zhang, Shouren Zhang, Huili Liu, Jinxiang Zhang, Han Feng, Bo Li, Xinyu Wu, Yongju Gao, Baocheng Yang
Summary: The carrier-free Fe(III)-ART nanoparticles, triggered by intracellular GSH, release ART and Fe3+, catalyzing the endoperoxide of ART to generate C-centered free radicals. This application demonstrates superior anticancer efficacy and contributes to activatable MRI-guided chemodynamic therapy.
Article
Multidisciplinary Sciences
Lucrezia Angeli, Ksenia Morozova, Matteo Scampicchio
Summary: This study proposes a rapid and sensitive method for determining the absolute rate constant of the reaction between fast antioxidants and DPPH center dot. The method involves a stopped-flow spectrophotometric system that monitors the decay of DPPH center dot during its interaction with antioxidants. Kinetic parameters including second order kinetics and side reactions were determined for various antioxidants. Overall, this method is simple, rapid, and suitable for studying the activity and capacity of different molecules, as well as food samples rich in fast antioxidants like fruit juices.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Organic
Maria L. Alfieri, Alice Cariola, Lucia Panzella, Alessandra Napolitano, Marco d'Ischia, Luca Valgimigli, Orlando Crescenzi
Summary: This study provides evidence for the addition mechanism of thiol compounds to quinones and discovers an anomalous 1,6-type regiochemistry compared to the usual 1,4-nucleophilic addition. These findings would prompt a revision of the commonly accepted mechanisms for thiol-quinone conjugation and stimulate further research in this field.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Andres Alvarez-Armenta, David O. Corona-Martinez, Ramon Pacheco-Aguilar, Alonso A. Lopez-Zavala, Rogerio R. Sotelo-Mundo, Guillermina Garcia-Sanchez, Juan Carlos Ramirez-Suarez
Summary: Meat greening is caused by microbiological contamination and lipid oxidation during storage, and the abnormal pigmentation is related to the production of sulfmyoglobin (SulfMb). Spectral studies have shown that SulfMb is likely produced from the increase of free radicals during thermal treatment. The reaction of SulfMb production is catalyzed by the release of heme iron and involves the oxidation of cysteine and reactive oxygen species.
Article
Biochemistry & Molecular Biology
Misa Muraoka, Saki Yoshida, Moeka Ohno, Hideyuki Matsuura, Kazuya Nagano, Yoshihiko Hirata, Masayoshi Arai, Kazumasa Hirata
Summary: Gamma-glutamyl-cysteine (gamma-EC) acts as a precursor for glutathione (GSH) biosynthesis and serves as a substrate for certain GSH metabolic enzymes, providing amino acids necessary for GSH formation, thereby contributing to antioxidant defense properties.
Article
Engineering, Environmental
You Zhang, Wenhong Fan, Xiaomin Li, Wen-Xiong Wang, Shu Liu
Summary: In this study, nanobubble technology and hydrogen water were combined for the first time to remove reactive oxygen species caused by environmental stress. Hydrogen nanobubbles showed remarkable capability in removing H2O2 and O(2)(center dot- ), and increasing the activity and expression of antioxidant enzymes.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Mikhail Feofanov, Vladimir Akhmetov, Ryo Takayama, Konstantin Amsharov
Summary: A novel catalyst-free approach to benzoannulated oxygen-containing heterocycles from fluorinated oligophenylenes is reported, utilizing potassium tert-butoxide as an O2- synthon. The radical nature of the reaction enables nucleophilic substitution and facilitates de-tert-butylation, allowing for multiple annulations and the synthesis of ladder-type O-heteroacenes and oligodibenzofurans.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Analytical
Nahyun Kwon, Chang Su Lim, Gyeongju Ko, Jeongsun Ha, Dayoung Lee, Jun Yin, Hwan Myung Kim, Juyoung Yoon
Summary: A GSH-specific fluorescent probe targeting NMDA receptors with high selectivity was developed in this study, allowing for successful monitoring of GSH in neuronal cells and hippocampal tissues. This probe could potentially serve as a practical imaging tool to explore the function of GSH and related biological processes in the brain.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Varsha Chandrakar, Kavita Tapadia, Saurabh Kumar Gupta
Summary: An environmentally friendly and low-cost method for producing silver nanoparticles using latex extract of Ficus benghalensis was reported. The resulting nanoparticles showed spherical shape and strong affinity to biothiols, allowing for selective determination of L-cysteine and glutathione with rapid aggregation. The proposed method demonstrated high detection sensitivity, accuracy, and applicability in biological samples.
Article
Biochemistry & Molecular Biology
Hyeongyeong Kim, Hyung Joo Suh, Ki-Bae Hong, Eun-Jin Jung, Yejin Ahn
Summary: The protective effects of a mixture of cysteine and glutathione against ethanol-induced hangover and liver damage were investigated. The mixture improved alcohol-induced behavior and enhanced ethanol-metabolizing enzyme activity. It also reduced the levels of serum alcohol and acetaldehyde, and regulated the expression of antioxidant enzymes through the Nrf2 pathway.
Article
Biochemistry & Molecular Biology
Wazifa Afrin, Shigeki Furuya, Kohji Yamamoto
Summary: This study identified the presence of glutamate-cysteine ligase (GCL) in silkworms, which is involved in the synthesis of glutathione (GSH) by catalyzing the ligation of glutamate and cysteine using ATP and Mg2+. High levels of bmgcl mRNA and GSH were observed in the silkworm fat body, indicating their potential role in oxidative stress resistance.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Agriculture, Dairy & Animal Science
Laryssa G. Barrozo, Lais R. F. M. Paulino, Bianca R. Silva, Efigenia C. Barbalho, Danisvania R. Nascimento, Miguel F. Lima Neto, Jose R. Silva
Summary: NAC, as an antioxidant, plays a crucial role in promoting GSH biosynthesis and regulating cell proliferation. Studies on in vitro culture, oocyte maturation, embryonic development, and cryopreservation show beneficial effects of NAC in protecting cells from oxidative stress damage.
ANIMAL REPRODUCTION SCIENCE
(2021)
Article
Chemistry, Physical
Wan-ping Chen, Run-quan Wang, Yue-rong Zhang, Kai Song, Yuan Tian, Jia-xian Li, Guo-ying Wang, Gao-feng Shi
Summary: In this article, the scavenging ability of hypericin on hydroxyl radicals was evaluated, and the reaction mechanism of the scavenging process was investigated. The spatial structure and electrostatic potential calculations revealed that the phenolic hydroxyl group of hypericin is the active site for the reaction with hydroxyl radicals. The results suggest that hypericin 7-OH and 7'-OH have the highest activity in scavenging hydroxyl radicals, followed by 5-OH and 5'-OH, and finally 4-OH (4'-OH).
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Jayaprakash Meena, Kannappan Santhakumar, Annamalai Senthil Kumar
Summary: The study demonstrates the in situ electrochemical reaction-assisted entrapment of redox-active betanin molecular species from native beetroot plants. The researchers have successfully characterized and analyzed the material using various techniques and have shown its biomimicking electron-transfer functionality and potential pH sensor applications.
Article
Chemistry, Multidisciplinary
Naresh M. Venneti, Ganesh Samala, Rana M. I. Morsy, Lawrence G. Mendoza, Albert Isidro-Llobet, Janine K. Tom, Subha Mukherjee, Michael E. Kopach, Jennifer L. Stockdill
Summary: Peptides are increasingly important as pharmaceutical targets, and there is a critical need for efficient and green methods for their preparation. The lack of an industrially viable peptide desulfurization method has been a key deficiency in the synthetic toolbox. This study presents a phosphine-only photodesulfurization method that is clean, high-yielding, and requires minimal amounts of phosphine, providing complete control to the chemist.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Shin-ichi Nagaoka, Tatsunobu Kokubo, Hiroyuki Teramae, Umpei Nagashima
JOURNAL OF CHEMICAL EDUCATION
(2018)
Article
Biochemistry & Molecular Biology
Kazuo Mukai, Eri Ishikawa, Aya Ouchi, Shin-ichi Nagaoka, Koichi Abe, Tomomi Suzuki, Katsuhiro Izumisawa
Article
Chemistry, Physical
Takuhiro Kakiuchi, Kyouhei Ikeda, Kazuhiko Mase, Shin-ichi Nagaoka
Article
Chemistry, Physical
Kazuo Mukai, Kanae Nagai, Aya Ouchi, Tomomi Suzuki, Katsuhiro Izumisawa, Shin-Ichi Nagaoka
INTERNATIONAL JOURNAL OF CHEMICAL KINETICS
(2019)
Article
Chemistry, Physical
Shin-ichi Nagaoka, Naofumi Nakayama, Hiroyuki Teramae, Umpei Nagashima
Article
Chemistry, Multidisciplinary
Hisako Sato, Kazuyoshi Takimoto, Masaru Kato, Shin-ichi Nagaoka, Kenji Tamura, Akihiko Yamagishi
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
(2020)
Article
Chemistry, Physical
Shin-ichi Nagaoka, Osamu Takahashi, Yasumasa Hikosaka
Correction
Chemistry, Multidisciplinary
Shin-ichi Nagaoka, Yoshinori Yamasaki, Hiroyuki Teramae, Umpei Nagashima, Tatsunobu Kokubo
JOURNAL OF CHEMICAL EDUCATION
(2020)
Article
Chemistry, Multidisciplinary
Yoshikazu Shinde, Shutaro Yamamoto, Kazuo Mukai, Shin-ichi Nagaoka
Article
Chemistry, Physical
Shin-ichi Nagaoka, Yuki Bandoh, Satoki Matsuhiroya, Kazumasa Inoue, Umpei Nagashima, Keishi Ohara
Summary: Substitution and solvent effects on the activities of singlet-oxygen quenching, free-radical scavenging, and excited-state proton-transfer in hydroxyflavones were investigated. Different substitutions at the 5-position and 7-position can affect these activities in ethanol solution. The addition of water can also influence the activities of excited-state proton-transfer and free-radical scavenging.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2021)
Correction
Chemistry, Physical
Shin-ichi Nagaoka, Yuki Bandoh, Satoki Matsuhiroya, Kazumasa Inoue, Umpei Nagashima, Keishi Ohara
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2021)
Article
Chemistry, Physical
Shin-ichi Nagaoka, Nanaho Nomoto, Tomohiko Tasaka, Umpei Nagashima, Takatoshi Matsumoto, Keishi Ohara
Summary: The effects of solvent on the antioxidant reactions of vitamin E were investigated using stopped-flow and laser spectroscopies. The results showed that the rate constant of the aryloxyl-radical scavenging reaction by vitamin E increased with the addition of water, while the rate constant of the singlet-oxygen quenching reaction reached a maximum at around 10% water concentration and then decreased. The findings suggest that the antioxidant activities of vitamin E depend on its position in biomembranes.
INTERNATIONAL JOURNAL OF CHEMICAL KINETICS
(2022)
Article
Chemistry, Physical
Tomohiko Tasaka, Takatoshi Matsumoto, Umpei Nagashima, Shin-ichi Nagaoka
Summary: The quenching reaction of singlet oxygen (1O2) by vitamin E (& alpha;-tocopherol) was studied using density functional theory. A mechanism for the reaction was proposed based on computational results. The reaction involves partial electron transfer from & alpha;-tocopherol to 1O2, formation of an exciplex, and physical quenching from 1O2 to 3O2 by & alpha;-tocopherol.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Chemistry, Applied
Kazuo Mukai, Masayuki Hirata, Junya Ito, Taiki Shiomi, Kiyotaka Nakagawa, Shin-ichi Nagaoka
JOURNAL OF OLEO SCIENCE
(2020)
Article
Chemistry, Applied
Kazuo Mukai, Ayaka Ohara, Junya Ito, Masayuki Hirata, Eri Kobayashi, Kiyotaka Nakagawa, Shin-ichi Nagaoka
JOURNAL OF OLEO SCIENCE
(2019)